• Title/Summary/Keyword: Stepping Down

Search Result 34, Processing Time 0.022 seconds

A Pilot Randomized Trial of As-Needed Budesonide-Formoterol for Stepping Down Controller Treatment in Moderate Asthma with Complete Remission

  • Nakwan, Narongwit;Ruklerd, Thidarat;Taptawee, Pattarawadee
    • Tuberculosis and Respiratory Diseases
    • /
    • v.85 no.3
    • /
    • pp.227-236
    • /
    • 2022
  • Background: The use of low-dose inhaled corticosteroid-formoterol as reliever monotherapy has recently been recommended in the asthma treatment guidelines. However, the efficacy of this treatment strategy has not yet been determined during the stepping-down period in moderate asthma. This study aimed to evaluate the feasibility of reducing treatment to as-needed budesonide-formoterol (BFM) in moderate asthma with complete remission. Methods: We randomly assigned 31 patients (8 males and 23 females with a mean age of 57.2 years) with complete remission of asthma by inhaled BFM (160/4.5 ㎍) twice daily to receive BFM (160/4.5 ㎍) as needed (16 patients), or budesonide (BUD) (200 ㎍) twice daily (15 patients). The study was an open-label study done for 48 weeks, with the primary outcome as the cumulative percentages of patients with treatment failure (asthma exacerbation or loss of asthma control or lack of satisfaction after using medications) in the two groups. Results: Six patients (42%) using as-needed BFM had treatment failure, as compared with three patients (21.4%) using BUD maintenance (hazards ratio for as-needed BFM, 1.77; 95% confidential interval, 0.44-7.12; p=0.41). The changes in forced expiratory volume in 1 second were -211.3 mL with as-needed BFM versus -97.8 mL with BUD maintenance (difference, 113.5 mL; p=0.75) and the change in fractional exhaled nitric oxide was significantly higher in both groups, at 8.68 parts per billion (ppb) in the as-needed BFM group and 2.5 ppb. in the BUD maintenance group (difference, 6.18 ppb; p=0.049). Conclusion: Compared with BUD maintenance, there were no significant differences in treatment failure rate in patients who received as-needed BFM during the stepping down period in moderate asthma. However, they showed reduced lung function and relapsed airway inflammation. The results are limited by imprecision, and further large RCTs are needed.

Evolutionary Biological and Up-down Theoretical Interpretation on Balancing Medicine of Temporomandibular Joint (턱관절균형의학의 진화론 및 승강론적 해석)

  • Chi, Gyoo Yong
    • Journal of TMJ Balancing Medicine
    • /
    • v.8 no.1
    • /
    • pp.6-10
    • /
    • 2018
  • In order to propose a fundamental and appliable theories for balancing therapy of temporomandibular joint (TMBT), evolutionary proofs and up-down theories in evolutionary biology and Korean medicine were investigated. Balancing therapy of temporomandibular joint treats disorder and diseases of the whole body through straightening of the abnormal linking between temporomandibular joint and axis. Although the mechanism of this therapy contains many merits like multicellular integrity and coadjustment, ease of balance and alert forward mobility by the bipedal stepping and evolution to Homo sapiens, increasing disadvantages of balancing pressure of right and left in the lengthened perpendicular axis and the balancing load of temporomandibular joint and axis following the reactional change of dental occlusion are deeply related and considered in this therapy. As for up-down theory, crossing of heavenly qi and earth qi centering on cervical joint is presented as the first mechanism for TMBT, and the other ones like in-out and up-down qi activity of tripple energizer, up-down of essence-qi-spirit in the three backbone barrier and three cinnabar field, up-down of yin-yang-water-fire of viscera and bowels can be related too.

  • PDF

The Relationships Between Valgus Collapse Knee Position and Quadriceps Activity During a Single Limb Step Down in Female Subjects (젊은 여성의 한쪽 다리 스텝다운 동작 시 슬관절 외반 정도와 대퇴사두근 근활성도 간의 상관관계)

  • Lee, Se-Hee;Moon, Young;Song, Ji-Hyun;Kim, Suhn-Yeop;Jang, Hyun-Jeong
    • The Journal of Korean Academy of Orthopedic Manual Physical Therapy
    • /
    • v.18 no.2
    • /
    • pp.41-47
    • /
    • 2012
  • Background: This study was designed to investigate the correlation between electromyography (EMG) activities in the vastus medialis oblique (VMO) vs vastus lateralis (VL) activity ratio and the valgus collapse knee position while stepping down. Methods: Twenty healthy women volunteered to participate in this study. We measured the frontal-plane projections of the knee valgus angle, knee valgus distance, and hip adduction angle by using a digital camcorder. After 3 repetitions of the step down (dominant side) exercise, the findings of the static and dynamic phases were analyzed. EMG activities data of the VMO:VL activity ratio were recorded during the step down exercise and were normalized to the maximal voluntary isometric contraction (MVIC) of the quadriceps. A paired t-test was used to compare the findings of the static and dynamic phases. We analyzed the Spearman's rank order correlation coefficient between the and VMO:VL ratio. Results: Hip adduction angle, knee valgus angle, VMO activity, VL activity, VMO:VL activity ratio were statistically higher in the dynamic phase than in the static phase (p<.05). Frontal-plane projections of knee valgus angle were significantly correlated with hip adduction angle (r=.459, p<.05) and knee valgus distance (r=.505, p<.05). However, the EMG activity ratio of the VMO and the VL did not show a significant change during step down exercise with respect to hip adduction angle (p=.875), knee valgus angle (p=.618), and knee valgus distance (p=.701). Conclusion: The results from this study indicate that frontal-plane projections of knee valgus angle were associated with hip adduction angle and knee valgus distance. On the basis of these results, the knee valgus distance may be used to determine the valgus collapse knee position while stepping down.

  • PDF

An 18-Pulse Full-Wave AC-DC Converter for Power Quality Improvement

  • Singh, Bhim;Gairola, Sanjay
    • Journal of Power Electronics
    • /
    • v.8 no.2
    • /
    • pp.109-120
    • /
    • 2008
  • In this paper, a novel delta/double-fork transformer based 18-pulse full-wave AC-DC converter is designed, modeled, simulated and developed to feed isolated DC varying loads. The proposed AC-DC converter is used for low voltage and large current DC loads in applications such as electrowinning, where isolation is required mainly for stepping down the supply voltage. The proposed converter improves power quality at AC mains and meets IEEE-519 standard requirements at varying loads.

Punching Position Control by Vision System (비전을 이용한 펀칭위치 제어 시스템)

  • 이성철;이영춘;심기중
    • Proceedings of the Korean Society of Precision Engineering Conference
    • /
    • 2004.10a
    • /
    • pp.981-984
    • /
    • 2004
  • This paper is about the development of Automatic FPC punching instrument. FPC(flexible printed circuit) is used to detect the contact position of K/B and button like a cellular phone. Depending on the quality of the printed ink and position of reference punching point to the FPC, the resistance and current are varied to the malfunctioning values. The size of reference punching point is 2mm and the above. Because the punching operation is done manually, the accuracy of the punching degree is varied with operator's condition. Recently, The punching accuracy has deteriorated severely to the 2mm punching reference hall so that assembly of the K/B has hardly done. To improve this manual punching operation to the FPC, automatic FPC punching system is introduced. Precise mechanical parts like a 5-step stepping motor and ball screw mechanism are designed and tested and low cost PC camera is used for the sake of cost down instead of using high quality vision systems for the FA. Test algorithm shows good results to the designed automatic punching system.

  • PDF

Comparative Analysis of Biomechanical Factors in Performing Techniques of 1/1Turn, Stretched, and Tucked on the Old Vaulting Horse and the New Vaulting Table (신.구형도마에서 1/1Turn, Stretched, Tucked 기술수행 시 운동역학적 분석)

  • Kim, Ji-Tae;Heo, Seong-Gyu
    • Korean Journal of Applied Biomechanics
    • /
    • v.16 no.4
    • /
    • pp.135-145
    • /
    • 2006
  • The aim of this study was to find out the differences of biomechanical factors from touching down the vaulting board to landing when techniques of 1/1Turn, stretched, and Tucked were performed on the old vaulting horse and on the new vaulting table. Three national representative men gymnasts were sampled for this study. Three dimension motion analyses by means of six Sony PD-150 video cameras with the velocity of 60 fps were used. As a result of analyzing the kinetic data from two kind of vaulting table, the following conclusions were made. 1. There was not significant differences of angular momentum between the old and the new vaulting table in all three techniques except the phase of stepping on the vaulting board and contacting the vaulting horse in the Tucked technique. IN the two phases above, the angular momentum in the new vaulting table was greater than that of the old vaulting horse. 2. There were few significant differences between the old and the new vaulting horses in the horizontal and vertical reaction force according to techniques when stepping was performed. However, it appeared tendency that the horizontal and vertical reaction force in the new vaulting table was a little greater than that of the old vaulting horse when the 1/1Turn, the Stretched and the Tucked were performed.

Automatic Punching System for FPC using Machine Vision (비전 기반의 FPC용 자동 펀칭시스템)

  • Lee Young-Choon;Lee Seong-Cheol
    • Journal of the Korean Society for Precision Engineering
    • /
    • v.22 no.12 s.177
    • /
    • pp.77-86
    • /
    • 2005
  • This paper is about the development of Automatic FPC(flexible printed circuit) punching instrument for the improvement of working condition and cost saving. FPC is used to detect the contact position of keyboard and button like a cellular phone. Depending on the quality of the printed ink and position of reference punching point to the FPC, the resistance and current are varied to the malfunctioning values. The size of reference punching point is 2mm and the above. Because the punching operation is done manually, The punching accuracy is varied with operator's condition. Recently, The punching accuracy has deteriorated severely to the 2mm punching reference hall so that assembly of the K/B has hardly done. To improve this manual punching operation to the FPC, automatic FPC punching system is introduced. Precise mechanical parts like a 5-step stepping motor and ball screw mechanism are designed and tested and low cost PC camera is used fur the sake of cost down instead of using high quality vision systems for the factory automation. Test algorithms and programs showed good results to the designed automatic punching system and led to the increasement of productivity and huge cost down to law material like FPC by avoiding bad quality.

A Model for the Forecasting Methodology of Radio Spectrum Demand (국내 전파자원 수요예측 모형)

  • 장희선;신현철;김한주
    • Journal of the Korea Society of Computer and Information
    • /
    • v.7 no.1
    • /
    • pp.94-102
    • /
    • 2002
  • In this paper, we present a forecasting model for the spectrum demand which will be used for the mid/long-term spectrum forecasting in Korea. In specific, we present the bottom-up model with considering the customer not the previous top-down method. The Proposed model consists of service definition. classification of service characteristics, drawing representative service characteristic , forecasting of service demand, mapping with spectrum resource, verification and spectrum forecasting. The carried actions in each step is described in detail. For the validation of the model an example for the PCS environments is shown. traverse stepping stones for a variety of legitimate reasons.

  • PDF

천체 망원경의 자동화 : I. 컴퓨터 제어와 자동 관측을 위한 기본 설계 및 하드웨어의 제작

  • Gang, Yong-U;Lee, Hyeong-Mok;Yun, Gap-Su
    • Publications of The Korean Astronomical Society
    • /
    • v.6 no.1
    • /
    • pp.62-75
    • /
    • 1991
  • The small sized telescope can be best used if the control and observation can be made remotely and fully automatically by the aid of computers. We discuss the possible ways of automating the existing telescopes of various designs using personal computers. 'We have specifically designed the parts necessary to automate 16 inch Cassegrain Telescope at Pusan University Observatory. The degree of automation we have set for the present work is the interactive. remote observation including opening and shutting down of dome slit. The observational modes we have in mind are photoelectric photometry and CCD imaging. The basic components of the hardware are interface card for 16 or 32 bit IBM PC family of computers, relay switches for the control of telescope movements, stepping motor controller card for the control of observational equipments, and AID converter unit that accepts signal from sensors for the environment conditions such as temperature, wind speeds, precipitation, etc. We also have designed and built a photoelectric photometer that can be fully controlled by the command of a computer. Such observational equipment is also essential in order that the remote observation can be realized.

  • PDF

Numerical Study of Biomimetic Foil Propulsion (생체 모방익 추진에 대한 수치적 연구)

  • Han, Cheol-Heui;Lee, Hak-Jin;Cho, Jin-Soo
    • Transactions of the Korean Society of Mechanical Engineers B
    • /
    • v.30 no.9 s.252
    • /
    • pp.866-872
    • /
    • 2006
  • A numerical study on the propulsive characteristics of a biomimetic foil is done by developing an unsteady linearly-varying strength vortex method. A biomimetic foil is represented as a deforming foil with a tail fin. Present method is verified by comparing the simulated results with results using finite element and finite volume methods. A new boundary condition is imposed by considering the relative rotational velocity, which has not been included in the previous published literature. It is found that the undulation amplitude increases the thrust while maximum thickness is stepping down the thrust. It is also shown that there exists an optimal frequency for maximum thrust generation. It is believed that present results can be used in the investigation of the propulsive characteristics of the biomimetic deforming foil.