• Journal of applied mathematics & informatics
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• 제10권1_2호
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• pp.309-323
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• 2002

This paper studies the parameter estimation problem for a steady state flow in an inhomogeneous medium. Our approximation scheme could be used when the diffusion coefficient is singular. The function space parameter estimation convergence(FSPEC) is considered and numerical simulations are performed.

• 한국자동차공학회논문집
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• 제7권7호
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• pp.24-31
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• 1999

The MPI engine becomes increasingly popular because it meets two requirements of stringent pollutant emission and the lower fuel consumption. Even though supplies the same amount of fuel to each cylinder , it is hard to precisely control the air-duel ration due to the different amount of air flowing into each cylinder. The uniformity of air-fuel ration in each cylinder is considerably affected by the plenum chamber configuration . This study is focused on experimentally analyzing the flow characteristics within the plenum chamber In the present experiment , steady and valve dynamic state flow tests are performed and the flow field inside the plenum chamber is visualized and measured by utilizing a laser sheet visualization technique and a PTV method. These measured results indicate that the flow structure in the plenum chamber is highly influenced by the plenum chamber configurations, suction flow rates, crank speeds and so on.

• Bulletin of the Korean Chemical Society
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• 제27권10호
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• pp.1618-1622
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• 2006

Bacteriophage T7 gp4A' is a ring-shaped hexameric DNA helicase that catalyzes duplex DNA unwinding using dTTP hydrolysis as an energy source. To investigate the effect of single-stranded DNA (ssDNA) on the kinetic pathway of dTTP hydrolysis by the T7 DNA helicase complexed with ssDNA, we have first determined optimal concentration of long circular M13 single-stranded DNA and pre-incubation time in the absence of $Mg^{2+}$ which is necessary for the helicase-ssDNA complex formation. Steady state dTTP hydrolysis in the absence of $Mg^{2+}$ by the helicase-ssDNA complex provided $k_{cat}$ of $8.5\;{\times}\;10^{-3}\;sec^{-1}$. Pre-steady state kinetics of the dTTP hydrolysis by the pre-assembled hexameric helicase was monitored by using the rapid chemical quench-flow technique both in the presence and absence of M13 ssDNA. Pre-steady state dTTP hydrolysis showed distinct burst kinetics in both cases, indicating that product release step is slower than dTTP hydrolysis step. Pre-steady state burst rates were similar both in the presence and absence of ssDNA, while steady state dTTP hydrolysis rate in the presence of ssDNA was much faster than in the absence of ssDNA. These results suggest that single-stranded DNA stimulates dTTP hydrolysis reaction by T7 helicase by enhancing the rate of product release step.

• 한국수의병리학회지
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• 제2권2호
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• pp.127-138
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• 1998

Transmissible venereal tumor(TVT) is a naturally occurring contagious neoplasm which can be transmitted by mechanical contact during mating in dogs and transplanted as intact viable cells to dogs and other members of canine family such as coyotes, jackals, wolves, and foxes. The incidence of this tumors tends to increase in Korean native Jindo dogs. This is probably due to the high density and unrestrained management system. With time, TVT reaches the maximum size and then tends to regress spontaneously unless individuals are immunologically compromised. It consists of different types of cells depending on the stage. In this study, 10 tumors were selected from Jindo dogs. These were histologically calssified into three stages; progressive, steady-state, and regressive. Mitotic figures were counted, and their histological appearance at each stage is compared with their DNA ploidy. Histologically, 5 tumor cases were calssed as the progressors, 3 cases as the steady-state tumors, and 2 cases as regressors. Progressors were composed of round cells with large nuclei containing conspicuous nucleoli and frequent mitotic figures. A few spindle-shaped cells and inflammatory cells including mainly lymphocytes, a few neutrophils and macrophages were also seen. In the steady-state tumors, there was an increased number of spindle shaped cells and mitotic figures were rare. Six tumors were diploid and four were aneuploid with the variation coefficient of 7.02. Two of five progressive tumors were aneuploid. Two of three steady-state tumors were aneuploid while both tumors at the regressive stage were diploid. Progressive and steady-state tumors had a much larger S/G2M fraction and a higher mitotic index than regressive tumors. Two tumors which persisted for more than one year were aneuploid. These results suggest that the progressive and steady-state tumors had more active cell division than the regressive neoplasms.

• Management Science and Financial Engineering
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• 제15권2호
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• pp.53-68
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• 2009

In this paper, we address a problem for minimizing the number of items inspected in a back-light-unit (BLU) inspection system, which includes a K-stage inspection system, a source inspection shop, and a re-inspection shop. In order to formulate our objective, we make a steady-state flow analysis between nodes (or shops), and derive the steady-state amount of flows between nodes and defective rates by solving a nonlinear balance equation. We provide an enumeration method for determining an optimal value of K which minimizes the number of items inspected. Our methodology could be applied and extended to similar situations with slight modification.

• 대한설비공학회:학술대회논문집
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• 대한설비공학회 2005년도 동계학술발표대회 논문집
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• pp.439-444
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• 2005

Steady state simulation and dynamic simulation were performed to analyze the operational characteristics of a multi-type refrigeration system, Fully distributed model was adopted to simulate the steady state and transient responses of the system. The main aim was to see the effect of one indoor unit on the other unit. Numerical simulations were carried out for various operation conditions of an indoor unit - secondary fluid inlet temperature, mass flow rate and expansion valve opening. The results showed that the inlet temperature and mass flow rate of the secondary fluid of one indoor unit had minor effect on the operation of the other unit. However, the opening of the expansion valve had significant effect on the performance of the other unit.

• 한국자동차공학회논문집
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• 제8권2호
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• pp.41-49
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• 2000

To understand the signal fluctuation of a wide-range oxygen sensor installed at the exhaust confluence point, when a misfiring is triggered in a cylinder, the steady state and the transient response characteristics of the sensor to the flow of the misfired gas were investigated quantitatively. It was recognized that the steady state output voltage of the sensor increased higher when it contacted the misfired gas even though the fueling condition was the same as the normal combustion case and this characteristic enabled the application of the wide-range oxygen sensor for the misfire detection. The transient response was compared at different engine speeds and it was found that the response speed increased with the engine speed. The signal fluctuation was also estimated quantitatively, using these steady state and transient response of the sensor, and the estimated signal showed satisfactory correlation with the measurements.

• 한국추진공학회지
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• 제4권1호
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• pp.93-101
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• 2000

엔진 운용 중에 유로(flow Path)에 놓여 있는 팬 블레이드(blade)들은 많은 외부하중에 노출되어 있어서 고주기 피로(high cycle fatigue)에 의한 피로 파괴의 위험성이 크다. 그 중 가장 중요하게 평가되는 것이 주기적인 가진력에 의한 공진 현상과 그에 따른 피로파괴 가능성이다. 본 논문에서는 유동장 (flow field)이 지주(struts)에 의해 영향을 받게 되고, 이러한 유동장의 분포가 지주 후방에서 주기함수 형태로 팬 블레이드를 가진 할 때, 팬 블레이드에서의 진동 응답 특성과 구조적인 안정성을 평가하였다. 팬 블레이드의 피로강도를 시험적으로 평가하고, 팬 블레이드 전방 지주에 의한 공기 가진력을 가정하여 유한 요소 해석을 통한 구조적 안정성을 평가하였다. 그리고 엔진 시험에서 측정된 서지 압력 하중을 팬 블레이드의 유한요소 모델에 적용하여 구조적 영향을 평가함으로써 팬 블레이드의 구조적인 안정성을 확인하였다.

• International Journal of Aeronautical and Space Sciences
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• 제3권1호
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• pp.95-104
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• 2002

Numerical solution of the full Navier-Stokes equation as well as the energy equation has been obtained for the unsteady natural convection in a rectangular enclosure. One side wall was maintained at very high temperature simulating fires. Especially the effect of surface radiation was taken into account. While the enclosed air was assumed to be transparent, the internal walls directly interacted one another through the surface radiation. Due to a significant temperature difference in the flow field, the equation of state was used instead of the Boussinesq approximation. It was found that the rapid heating of the adiabatic ceiling and floor by the incoming radiation from the hot wall made the evolution at thermo-fluid field highly unstable in the initial period. Therefore, the secondary cells brought about at the floor region greatly affected the heat transfer mechanism inside the enclosure. The heat transfer rate was augmented by the radiation, resulting in requiring less time for the flow to reach the steady state. At the steady state neglecting radiation two internal hydraulic jumps were clearly observed in upper/left as well as in lower/right comer. However, the hydraulic jump in the lower/right comer could not be observed for the case including radiation due to its high momentum flow over the bottom wall. Radiation resulted in a faster establishment of the steady state phenomena.

• Archives of Pharmacal Research
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• 제28권1호
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• pp.115-119
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• 2005

The clearance of ICG, a known hepatic blood flow marker was investigated in rats in order to examine whether DDB-S influences hepatic blood flow. The effect of DDB-S on the protein binding and blood-to-plasma partition of ICG was measured. The steady-state plasma concentration of ICG was monitored before and after co-administration of various concentration of DDB-S, and ICG clearance was estimated from the steady-state concentration and the infusion rate of ICG. There was no significant difference in protein binding and blood-to-plasma partition of ICG with and without addition of DDB-S (10, 20, and 40 ${\mu}g/mL)$. When ICG was infused into DDB-S pretreated rats, the steady-state concentrations of ICG decreased and the calculated ICG clearance increased. However, no dose-dependency of ICG Css on DDB-S Css was observed. Since DDB-S did not affect the protein binding and blood-to-plasma partition of ICG, the increased clearance of ICG with co-administration of DDB-S seems to be due to the increased hepatic blood flow by DDB-S.