• 청정기술
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• 제18권4호
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• pp.440-445
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• 2012

2007년 영국 Carbon Trust의 Carbon Reduction Label을 시작으로 하여 일본의 CFP (Carbon Footprint Product), 한국 탄소성적표지 인증제도 등 국내외 약 15개 국가 또는 기관에서 제품에 대한 탄소라벨링 제도를 시행중에 있다. 탄소라벨링은 기업이 제품 및 서비스에 대한 전과정에서 발생하는 탄소배출량을 정량화하고 해당 제품에 대한 라벨링을 부착함으로써 제품에 대한 온실가스 배출량을 저감하기 위한 제도로 정의할 수 있다. 본 연구에서는 한국, 영국, 일본의 탄소라벨링 제도 운영 현황과 국가별 제도에 대상 세부 산정 기준에 대한 분석을 실시하기 위해 국내기업 중 청소기, 세제, 포장재료를 대상으로 한국, 영국, 일본 탄소라벨링 기준에 따라 제품의 온실가스 배출량을 산출하였다. 제품별 평가결과 온실가스 배출량 산정기준, 배출계수 등의 차이로 동일한 제품의 경우에도 제품의 온실가스 배출량 차이를 보이고 있다. 그러므로 기업이 국가별로 제품 탄소라벨링을 대응하는데 많은 어려움이 발생할 것으로 보이며 특히 국제표준뿐만 아니라 제품군별 가이드라인 개발이 필요할 것으로 보인다.

• 한국산학기술학회논문지
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• 제22권3호
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• pp.446-452
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• 2021

우리나라 생활수준의 향상과 더불어 식품소비의 양적인 요구가 충족되면서, 세분화된 식품의 기호 성향을 충족시킬 수 있는 닭고기 소비가 증가하고 있다. 2003년 3월 축산물 품질평가원에서 고시(농림부 고시 제2003-14호)한 닭 도체 품질판정세부기준은 닭 도체 부위별 이물질 부착, 피·멍의 크기 및 중량에 따라 품질 등급을 기준을 제시하였다. 그러나 현실적으로 검사관 개개인의 주관적인 평가 기준으로 적용된 고시로 수천 마리의 닭 도체 등급판정을 유지하기가 어려운 문제점을 가지고 있다. 본 논문에서는 닭 도체 품질 세부기준에 따라 닭 도체 부위 분할하기 위해 비접촉/비파괴방식인 컴퓨터 시각 기술 알고리즘을 제안한다. 제안된 알고리즘은 실시간으로 빠르게 움직이는 닭 도체를 부위 분할하기 위하여 조명 외란에 강인하도록 보정하는 과정과 닭 도체와 배경을 구분하기 위한 EM(Expectation maximization), Erosion 및 Labeling 알고리즘, 그리고 닭 도체의 기하학적 형태를 분석하여 부위별 특징점을 찾고 점들의 위치를 계산하여 부위를 분할 할 수 있는 알고리즘을 사용하였다. 총 78마리의 닭 도체 샘플에 대하여 제안한 영상처리 알고리즘을 적용한 결과 닭 도체 부위 분할 알고리즘이 효과적임을 알 수 있었다.

• Korean Journal of Radiology
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• 제25권2호
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• pp.179-188
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• 2024

Objective: ¹⁷⁷Lutetium [Lu] Ludotadipep is a novel prostate-specific membrane antigen targeting therapeutic agent with an albumin motif added to increase uptake in the tumors. We assessed the biodistribution and dosimetry of [¹⁷⁷Lu]Ludotadipep in patients with metastatic castration-resistant prostate cancer (mCRPC). Materials and Methods: Data from 25 patients (median age, 73 years; range, 60-90) with mCRPC from a phase I study with activity escalation design of single administration of [¹⁷⁷Lu]Ludotadipep (1.85, 2.78, 3.70, 4.63, and 5.55 GBq) were assessed. Activity in the salivary glands, lungs, liver, kidneys, and spleen was estimated from whole-body scan and abdominal SPECT/CT images acquired at 2, 24, 48, 72, and 168 h after administration of [¹⁷⁷Lu]Ludotadipep. Red marrow activity was calculated from blood samples obtained at 3, 10, 30, 60, and 180 min, and at 24, 48, and 72 h after administration. Organand tumor-based absorbed dose calculations were performed using IDAC-Dose 2.1. Results: Absorbed dose coefficient (mean ± standard deviation) of normal organs was 1.17 ± 0.81 Gy/GBq for salivary glands, 0.05 ± 0.02 Gy/GBq for lungs, 0.14 ± 0.06 Gy/GBq for liver, 0.77 ± 0.28 Gy/GBq for kidneys, 0.12 ± 0.06 Gy/GBq for spleen, and 0.07 ± 0.02 Gy/GBq for red marrow. The absorbed dose coefficient of the tumors was 10.43 ± 7.77 Gy/GBq. Conclusion: [¹⁷⁷Lu]Ludotadipep is expected to be safe at the dose of 3.7 GBq times 6 cycles planned for a phase II clinical trial with kidneys and bone marrow being the critical organs, and shows a high tumor absorbed dose.

• Journal of Chest Surgery
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• 제46권6호
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• pp.413-425
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• 2013

Background: Graft vessel preservation solution in coronary artery bypass surgery is used to maintain the graft conduit in optimal condition during the perioperative period. Nafamostat mesilate (NM) has anticoagulation and anti-inflammatory properties. Therefore, we investigated NM as a conduit preservative agent and compared it to papaverine. Methods: Sprague-Dawley (SD) rat thoracic aortas were examined for their contraction-relaxation ability using phenylephrine (PE) and acetylcholine (ACh) following preincubation with papaverine and NM in standard classical organ baths. Human umbilical vein endothelial cells (HUVECs) were cultured to check for the endothelial cell viability. Histopathological examination and terminal deoxynucleotidyl transferase dUTP nick end labeling assay were performed on the thoracic aortas of SD rats. Results: The anti-contraction effects of papaverine were superior to those of NM at PE (p<0.05). The relaxation effect of NM on ACh-induced vasodilatation was not statistically different from that of papaverine. Viability assays using HUVECs showed endothelial cell survival rates of >90% in various concentrations of both NM and papaverine. A histopathological study showed a protective effect against necrosis and apoptosis (p<0.05) in the NM group. Conclusion: NM exhibited good vascular relaxation and a reasonable anti-vasocontraction effect with a better cell protecting effect than papaverine; therefore, we concluded that NM is a good potential conduit preserving agent.

• Clinical and Experimental Reproductive Medicine
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• 제44권4호
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• pp.224-231
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• 2017

Objective: We studied the association between sperm DNA fragmentation (SDF) and several clinical in vitro fertilization outcomes. Methods: We retrospectively analyzed 169 consecutive fresh IVF cycles. Semen was collected on the day of oocyte retrieval, and we assessed standard semen parameters and the SDF level (by terminal deoxynucleotidyl transferase dUTP nick-end labeling). Poor ovarian response (POR) was defined as the collection of three or fewer mature oocytes. Oocytes were inseminated by the conventional method or intracytoplasmic sperm injection. Results: SDF did not affect the fertilization or pregnancy rate, but did have a significant effect on the miscarriage rate. In the miscarriage group (n = 10), the SDF level was significantly higher (23.9% vs. 14.1%) and number of mature oocytes was significantly lower (4.3 vs. 7.6) than in the live birth group (n = 45). Multiple regression analysis showed that SDF was an independent predictor of miscarriage (odds ratio, 1.051; 95% confidence interval, 1.001-1.104). The cutoffs for the SDF level and number of mature oocytes that could predict miscarriage were > 13% and ${\leq}3$, respectively. In the low-SDF group (${\leq}13%$), the miscarriage rate was similar in POR patients and those with a normal ovarian response (NOR; 14.2% vs. 4.3%). In the high-SDF group ( > 13%), the miscarriage rate was significantly higher in the POR group than in the NOR group (60.0% vs. 13.3%, p= 0.045). Conclusion: Our study demonstrated that a high SDF level ( > 13%) was associated with a high miscarriage rate, and that it mainly contributed to miscarriage in the POR group. The results suggest that SDF measurements should be considered in couples with POR in order to predict the prognosis of the pregnancy.

• 한국콘텐츠학회논문지
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• 제13권8호
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• pp.450-457
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• 2013

본 연구는 시판 중인 가공식품 라벨 표시정보를 수집하여 표시사항에 대한 정보를 소비자 개인의 용도에 따라 활용할 수 있도록 데이터베이스로 구축하고, 모바일 기반 서비스 시스템을 개발하기 위한 것이다. 시판중인 가공식품 라벨의 표시사항을 분석한 결과 원재료 영양정보 첨가물정보 함량 기준 등이 매우 난해하게 혼재되어 소비자가 라벨 정보의 내용을 파악하여 활용하기 어려운 실정이었다. 따라서 소비자 지향적인 식품표시 정보를 제공하기 위하여 현행 식품위생법의 식품표시기준에 따른 원재료, 첨가물, 영양성분 등 카테고리별로 정보를 재분류하여 데이터베이스화하였다. 이렇게 재가공한 정보를 토대로 소비자들이 가공식품 라벨표시 정보를 보다 과학적이고 명확하게 활용할 수 있도록 알고리즘을 개발하여 모바일기반 서비스 시스템에 활용하였다.

• 대한소아치과학회지
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• 제24권3호
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• pp.688-703
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• 1997

The effect of glossopharyngeal nerve transection on the taste buds of the rat vallate papilla was examined by using the method of DNA nick-end labeling (TUNEL) and standard electron microscopic technique at 1, 3, 5, 7, 9 days after denervation. In general, the number and size of taste buds decreased as more days passed after denervation. They started decreasing on day 3 post denervation and virtually all taste buds were disappeared on day 9 post denervation. In studies using TUNEL method, TUNEL postive cells markedly increased in their numbers one day post denervation, as compared with controls. The number of apoptotic taste bud cells per taste bud profile was averaged to be 0.64 and 0.44 for day 1 and 3 post denervation, respectively, whereas it was 0.10 in controls. In electron microscopy, apoptotic cells were identified by the presence of condensed and fragmentary nuclei in a cytoplasm, which resulted in increased density. In control rats, only few apoptotic cells were found. On days 1 and 3 post denervation, nerve fibers almost disappeared from the taste buds and some apoptotic cells were apparent. On days 7 and 9 post denervation, a few taste bud cells were still present in the epithelium of the bottom of the trench wall of the vallate papilla and most of them showed apoptotic changes. The results indicate that the death of taste bud cells in normal conditions is controlled by apoptosis and the decrease and disappearance of taste buds after denervation is also caused by apoptosis of taste bud cells.

• Nuclear Engineering and Technology
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• 제9권4호
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• pp.203-210
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• 1977

디메틸썰폭사이드를 표지보조제로 사용하여 방사면역측정용 $^{125}$/I 표지인슈린을 효과적으로 만들 수 있었다. 디메틸썰폭사이드 조금을 통상의 표지반응 혼합물에 첨가하여 반응시간을 조절하여 보았더니 표지반응속도는 약간 느렸으나 이렇게 하여 얻은 표지인슈린은 항체와의 결합능이 좋았으며 표준곡선을 점시했을 때 큰 구배를 보였다. 표지반응수율도 반응시간을 1분으로 늘림에 따라 약 30%로 늘어났다. 평균 항체결합능(B/F)의 증가는 일정항체 희석비율하에서 표지보조제없이 표지한 인슈린을 쓴 때가 1.5인데 반해 표지보조제를 쓴 경우는 2.5로서 약 70%의 향상을 보였다. 핵자기공명분광법으로 표지혼합물에 첨가한 디메틸썰폭사이드는 클로라민티에 의해 디메틸썰폰으로 산화된다는 것을 확인하였다. Stagg등의 결과와 대략 같은 이 실험결과를 디메틸썰폭사이드와 인슈린분자 중의 유황결합이 클로라민티에 의해 경쟁적 산화를 받는 것으로 보고 이를 토의하였다.

• 한국임상약학회지
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• 제16권1호
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• pp.9-13
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• 2006

Patient counseling is emerging as one of the most important roles of community pharmacists because the information on the standard labeling for the prescription drug is not sufficient to ensure the correct use of the drug. However, excessive workload of the community pharmacists in Korea discourages the provision of the effective patient counseling. The use of auxiliary label may be an efficient tool to help patients correctly use the prescription drug in this situation. As a preliminary study to encourage the use of auxiliary label, we have performed a survey analysis of familiarity and willingness of community pharmacists to use the auxiliary label. About three quarters of the participating community pharmacists have heard of the auxiliary label, however, there was not a single pharmacist who uses the label. Furthermore, only one fifth of the participating pharmacists were willing to use the label if they have to purchase. Therefore, it is recommended that governmental and non-profit organizations such as Korean Pharmaceutical Association educate community pharmacists regarding usefulness of the auxiliary label with focus on enhancing patient compliance and constrainment of healthcare expense.

• Asian-Australasian Journal of Animal Sciences
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• 제28권6호
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• pp.788-795
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• 2015

Two dimensional-fluorescence difference gel electrophoresis (2D DIGE) is an emerging technique for comparative proteomics, which improves the reproducibility and reliability of differential protein expression analysis between samples. The purpose of this study was to investigate bovine pregnancy-specific proteins in the proteome between bovine pregnant and non-pregnant serum using DIGE technique. Serums of 2 pregnant Holstein dairy cattle at day 21 after artificial insemination and those of 2 non-pregnant were used in this study. The pre-electrophoretic labeling of pregnant and non-pregnant serum proteins were mixed with Cy3 and Cy5 fluorescent dyes, respectively, and an internal standard was labeled with Cy2. Labeled proteins with Cy2, Cy3, and Cy5 were separated together in a single gel, and then were detected by fluorescence image analyzer. The 2D DIGE method using fluorescence CyDye DIGE flour had higher sensitivity than conventional 2D gel electrophoresis, and showed reproducible results. Approximately 1,500 protein spots were detected by 2D DIGE. Several proteins showed a more than 1.5-fold up and down regulation between non-pregnant and pregnant serum proteins. The differentially expressed proteins were identified by MALDI-TOF mass spectrometer. A total 16 protein spots were detected to regulate differentially in the pregnant serum, among which 7 spots were up-regulated proteins such as conglutinin precursor, modified bovine fibrinogen and IgG1, and 6 spots were down-regulated proteins such as hemoglobin, complement component 3, bovine fibrinogen and IgG2a three spots were not identified. The identified proteins demonstrate that early pregnant bovine serum may have several pregnancy-specific proteins, and these could be a valuable information for the development of pregnancy-diagnostic markers in early pregnancy bovine serum.