• Molecules and Cells
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• 제43권6호
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• pp.581-589
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• 2020

Neurons have multiple dendrites and single axon. This neuronal polarity is gradually established during early processes of neuronal differentiation: generation of multiple neurites (stages 1-2); differentiation (stage 3) and maturation (stages 4-5) of an axon and dendrites. In this study, we demonstrated that the neuron-specific n-glycosylated protein NELL2 is important for neuronal polarization and axon growth using cultured rat embryonic hippocampal neurons. Endogenous NELL2 expression was gradually increased in parallel with the progression of developmental stages of hippocampal neurons, and overexpression of NELL2 stimulated neuronal polarization and axon growth. In line with these results, knockdown of NELL2 expression resulted in deterioration of neuronal development, including inhibition of neuronal development progression, decreased axon growth and increased axon branching. Inhibitor against extracellular signal-regulated kinase (ERK) dramatically inhibited NELL2-induced progression of neuronal development and axon growth. These results suggest that NELL2 is an important regulator for the morphological development for neuronal polarization and axon growth.

• Asian-Australasian Journal of Animal Sciences
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• 제24권8호
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• pp.1041-1047
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• 2011

Data on 2,365 Mecheri sheep (1,201 males and 1,164 females), maintained at the Mecheri Sheep Research Station, Pottaneri, India, and recorded between 1979 and 2006, were analysed to study the growth related traits and their genetic control. The body weights at different ages (i.e. at birth, weaning (3 months), 6, 9 and 12 months) were recorded and collected from the birth and growth registers maintained in the farm. The average weights of Mecheri sheep at birth, and at 12 months of age were $2.24{\pm}0.01$ and $16.81{\pm}0.15$ kg respectively. The pre- and post-weaning average daily weight gains were $63.84{\pm}0.75$ and $29.52{\pm}0.43$ g respectively. Study revealed a significant difference with the period of lambing on body weight, weight gain and efficiency in weight gain at different stages of growth. Males were heavier and had a higher weight gain than females at almost all stages of growth and the differences tended to increase with age. The direct heritability estimates increased from birth to six months of age and then decreased. The direct heritabilities of all body weights at different stages of growth were low to moderate in magnitude and the values at birth, weaning, six, nine and 12 months of age were 0.08, 0.17, 0.21, 0.13 and 0.10 respectively. For the estimation of heritability at birth and three months body weights, the direct additive genetic and maternal additive genetic effects have to be taken into account and for the estimation of six months weight, the direct additive genetic and maternal permanent environmental effects have to be included in the model. The estimates of heritability, phenotypic and genetic correlations among the different body weights indicated that the selection for improving the body weights at different traits should be done on the basis of three or six months weight because of higher heritability estimates and having higher genetic correlations with other traits.

• 한국약용작물학회지
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• 제20권3호
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• pp.184-189
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• 2012

This study was carried out to have the basic and applied informations relating to increase the productivity and quality of ginseng. 2 years-old ginseng was cultivated under hydroponic culture with the controlled environment conditions in a greenhouse. Major growth characters and yields were investigated with two different temperatures and several growth stages. The plant height and stem diameter were higher at low temperature than those at high temperature. They were not clearly different with six different growth stages. The root length was not clearly different between two temperatures; however it was continuously grown from June until August. The root diameter was higher at low temperature than that at high temperature. It was rapidly increased from June until August. The length, width, and area of leaf were higher at low temperature than those at high temperature. The fresh and dry weights of different plant tissues were also heavier at low temperature than those at high temperature. The moisture content of ginseng root was continuously decreased from June until August. The yield of ginseng was higher at low temperature compared to that at high temperature. The cultivating conditions in hydroponic culture of ginseng, especially temperature, would be an important factor to have better growth and production.

• 한국작물학회지
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• 제45권2호
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• pp.88-92
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• 2000

Excessive soil water in paddy field induces growth losses during the vegetative stages of soybean plants. Our objectives were to know growth responses of soybean as affected by the level of ridge heights. A field experiment was conducted at the Research Farm of Korea University near Seoul in 1996. Ten cultivars of soybean (Glycine max (L.) Merrill) were planted at the ridge heights of 10, 30, and 50cm in paddy soil on 27 June. Total dry matter accumulation at the 10cm ridge height was severely decreased until the growth stage of R5 as compared to the ridge heights of 30 and 50cm, and this decrement was mainly due to both reduced leaf and stem dry weights. However, seed dry weight was not significantly decreased at the lower ridge height with the increment of harvest index. Cultivar differences were found on seed dry weight, crop growth rate from R1 to R5, and leaf/stem ratio of R5. From the above results, soybean growth responses to excessive soil water in paddy field were different between seed filling stage and late vegetative to early reproductive growth stages.

• 한국연초학회지
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• 제4권1호
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• pp.1-5
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• 1982

The metabolic enzymes, nitrate reductase, amylase and peroxidase and the Photorespiratory enzyme, Slycolate oxidise in Nicotiana tabacum varieties were studied at various growth stages. The enzyme activities of young leaves with rapid growth were different from those of old ones with stationary growth. In young leaves, activity of nitrate reductase was higher than that in mature ones and amylase activity was fairly constant in all stages. Activities of glycolate oxidise and peroxidase were found to be significantly lower in young leaves than in mature ones. Activity of glycolate oxidase in mature middle leaves was 2.45 times higher than that of young ones and inhibited by 36% when the enzyme was treated with 0.16 mM isonicotinic hydrazide.

• 디지털산업정보학회논문지
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• 제15권4호
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• pp.197-212
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• 2019

The purpose of this study is to identify the maturity stages of venture firms through classification analysis, which is widely used as a big data technique. Venture companies should develop a competitive advantage in the market. And the maturity stage of a company can be classified into five stages. I will analyze a difference in the growth stage of venture firms between the survey response and the statistical classification methods. The firm growth level distinguished five stages and was divided into the period of start-up and declines. A classification method of big data uses popularly k-mean cluster analysis, hierarchical cluster analysis, artificial neural network, and decision tree analysis. I used variables that asset increase, capital increase, sales increase, operating profit increase, R&D investment increase, operation period and retirement number. The research results, each big data analysis technique showed a large difference of samples sized in the group. In particular, the decision tree and neural networks' methods were classified as three groups rather than five groups. The groups size of all classification analysis was all different by the big data analysis methods. Furthermore, according to the variables' selection and the sample size may be dissimilar results. Also, each classed group showed a number of competitive differences. The research implication is that an analysts need to interpret statistics through management theory in order to interpret classification of big data results correctly. In addition, the choice of classification analysis should be determined by considering not only management theory but also practical experience. Finally, the growth of venture firms needs to be examined by time-series analysis and closely monitored by individual firms. And, future research will need to include significant variables of the company's maturity stages.

• 산업공학
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• 제20권3호
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• pp.418-426
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• 2007

This study is to suggest the government's support direction for the small and medium sized enterprises (SMEs) by examining the relations among technology level, innovation factors, entrepreneur's characteristics, and start-up reasons. The management bottlenecks and the necessary fields of government's support are also investigated across the company's growth stages. Empirical analysis was conducted based on the 318 Korean SMEs' data receiving the Venture and/or Inno-biz certification. Results show that managing difficulties of the company have typical pattern according to the stage of growth. The characteristics of an entrepreneur such as age, education background and past experience affect the early stage of starting business. We also found that the technology level is closely connected with operational innovation activities and circumstances, entrepreneur's characteristics, start-up motives, and technological innovation activities.

• 한국작물학회지
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• 제28권4호
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• pp.451-457
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• 1983

영업생장말기, 수잉기, 출수개화기, 그리고 등숙초기의 네가지 주요한 생육기에 처리한 수분부족이 상위 3엽의 엽록소, 단백질유리 Proline과 상대팽압도의 변화와 몇가지 수량구성요소에 미치는 영향을 구명하기 위하여 과맥품종인 백동을 공시 수행하여 얻어진 결과를 요약하면 다음과 같다. 1. 수분부족처리에서 엽위별로 보면 지엽하위 1엽이 가장 높은 상대팽압도를 유지하여 엽록소와 단백질이 함량이 많았고, 유리Proline의 축적은 가장 적었다. 또한 생육기별로 보면 엽록소는 출수개화기에, 단백질은 수일기의 처리에서 가장 높았으며, 유리Proline은 수잉기의 처리에서 그 축적이 가장 낮았다. 2. 간장, 수장, 수당입수는 수잉기의 수분부족처리에서 감소영향이 가장 컸으며 천립중은 등숙초기에서, 그리고 종실의 크기는 수잉기와 그 이후 처리에서 가장 많이 감소되었다. 3. 종실의 단백질함량은 수분부족에 의해서 유의한 변화를 나타내지 않았으나 등숙초기에서 약간 감소한 경향이었다. 4. 불임율은 또한 수잉기와 출수개화기의 수분부족에서 심한 증가현상을 나타냈다. 5. 전반적으로 볼 때 생육단계별로는 수잉기에서, 그리고 엽위별로는 지엽 > 지엽하위 1엽 > 지엽하위 2엽의 순으로 수분부족의 영향이 컸다.

• Asian-Australasian Journal of Animal Sciences
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• 제20권10호
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• pp.1612-1617
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• 2007

In this study, we have compared the skeletal muscle proteome at various stages of porcine postnatal development. Korean native pigs were divided into five postnatal stages of 30, 70, 130, 170 and 300 d and their loin muscles were analyzed for muscle proteome by using two-dimensional electrophoresis and mass spectrometry. We found 5 proteins showing a consistent pattern during skeletal muscle growth. Four proteins were identified as myosin light chain 1 slow-twitch (MLC1sa) isoform, troponin T, triosephosphate isomerase (TIP) and DJ-1 protein. The remaining protein was not identified. Two muscle fiber proteins of MLC1sa isoform and troponin T showed a high expression level at an early postnatal stage and then their levels were decreased markedly during growth stages. On the other hand, the expression of TIP and DJ-1 protein, which are well known as catalysis enzyme and antioxidant-related protein, respectively, were linearly increased during growth stages. Thus, the stage-related muscle proteins may be useful as parameters for understanding the developmental characteristics of biochemical and physiological properties in Korean native pig skeletal muscle.

• Preventive Nutrition and Food Science
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• 제8권4호
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• pp.306-314
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• 2003

Volatile flavor components, produced during the young (P-1), immature (P-2), mature (P-3) and old (P-4) growth stages, of shiitake mushrooms (Lentinus edodes), were extracted by simultaneous steam distillation and extraction (SDE), using a mixture of n-pentane and diethyl ether (1:1, v/v) as the extraction solvent. Analyses of the concentrates, by capillary gas chromatography (GC) and gas chromatography-mass spectrometry (GC/MS), led to the identification of 129, 129, 111 and 120 components in the P-1, 2, 3 and 4 stages, respectively. The major volatile compounds were l-octen-3-o1, 3-octanol, 3-octanone and 4-octen-3-one. Ethanol and ethyl acetate were also detected in large amounts. The characteristic volatile compounds found in shiitake mushrooms, such as dimethyl disulfide, dimethyl trisulfide and 1, 2, 4-thiolane, were at low concentrations in all samples. The amount of l-octen-3-o1 decreased as growth progressed, but concentrations of 3-octanone increased. The amount of 4-octen-3-ol decreased from P-1 to P-3, but was at a high concentrations in P-4. The concentration of 3-octanol gradually increased and reached its highest concentration in P-3, but decreased in P-4. The C8-compounds comprised 70.91, 64.09, 64.29 and 60.01 % in the P-1, 2, 3 and 4 stages, respectively, so decreased gradually with growth. The S-compounds were found in the highest concentrations in P-3.