• Radiation Oncology Journal
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• 제27권1호
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• pp.10-14
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• 2009

목적: 식도암에서 수술 후 방사선치료 및 방사선 단독 치료의 효과를 검증하고 예후 인자를 알아보고자 하였다. 대상 및 방법: 1989년부터 2006년까지 방사선치료를 받은 132명의 환자를 후향적으로 분석하였다. 35명은 제2병기 88명은 제3병기 9명은 제4병기 환자였다. 상부 식도암이 18명, 하부 식도암이 33명이었으며 중등부 식도암이 81명이었다. 60명에서는 방사선 단독 치료를 시행하였고 72명은 수술 후 방사선치료를 받았다. 8명에서는 40 Gy 이하를 조사하였으며 78명에서는 40내지 50 Gy를 조사하였다. 나머지 46명은 50내지 60 Gy를 조사 받았으며 수술 후 방사선치료를 받은 대부분의 환자는 45 Gy를 조사받았다. 결과: 전체 환자의 2년 및 5년 생존율은 24% 및 5%이었고 중앙 생존기간은 11개월이었다. 수술 후 방사선치료군의 2년 및 5년 생존율은 19% 및 8%, 방사선 단독치료군의 2년 및 5년 생존율은 18% 및 2%이었다. 제2병기, 제3 병기 및 제4병기 환자의 2년 및 5년 생존율은 각각 43% 및 15, 22% 및 2, 0% 및 0% 이었으며 이는 통계적으로 유의하였다. 상부, 중등부, 하부 식도암의 2년 생존율은 각각 19, 29, 22%이었으며 통계적으로 유의한 차이는 나타나지 않았다. 방사선 단독치료군에서 13명(22%)은 완전관해를, 40명(67%)은 부분관해를 보였고 7명(12%)은 반응을 보이지 않았다. 완전관해를 보인 환자군이 부분관해를 보인 환자군보다 더 나은 2년 생존율을 나타내었다(31% vs 17%). 결론: 식도암에서 방사선치료는 효과적이고 유용한 치료 방법이었으며 병기 및 방사선치료에의 반응 정도가 유의한 예후인자이었다. 그러나 식도암의 장기 생존율 및 예후가 만족스럽지 못하므로 더욱 효과적인 치료 방법의 개발이 향후 필요하리라 사료된다.

• Tuberculosis and Respiratory Diseases
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• 제79권3호
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• pp.121-126
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• 2016

Lung function reportedly declines with age and that this decline is accelerated during disease progression. However, a recent study showed that the decline might peak in the mild and moderate stage. The prognosis of chronic obstructive pulmonary disease (COPD) can be improved if the disease is diagnosed in its early stages, prior to the peak of decline in lung function. This article reviews recent studies on early COPD and the possibility of applying the U.S. Preventive Services Task Force recommendation 2008 and 2015 for early detection of COPD in Korea.

• Asian Pacific Journal of Cancer Prevention
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• 제14권7호
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• pp.4157-4160
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• 2013

Objectives: Understanding the situation of cancer awareness which doctors give to patients might lead to prognostic prediction in cases of of colorectal cancer (CRC). Methods: Subsets of 10,779 CRC patients were used to screen the risk factors from the Cancer Registry in Pudong New Area in cancer awareness, age, TNM stage, and gender. Survival of the patients was calculated by the Kaplan-Meier method and assessed by Cox regression analysis. The views of cancer awareness in doctors and patients were surveyed by telephone or household. Results: After a median observation time of 1,616 days (ranging from 0 to 4,083 days) of 10,779 available patients, 2,596 of the 4,561 patients with cancer awareness survived, whereas 2,258 of the 5,469 patients without cancer awareness and 406 of the 749 patients without information on cancer awareness died of the disease. All-cause and cancer-specific survival were poorer for the patients without cancer awareness than those with (P < 0.001 for each, log-rank test). Cox multivariate regression analysis showed that cancer concealment cases had significantly lower cancer-specific survival (hazard ratio (HR) = 1.299; 95 % confidence interval (CI): 1.200-1.407)and all-cause survival (HR = 1.324; 95 % CI: 1.227-1.428). Furthermore, attitudes of cancer awareness between doctors and patients were significantly different (P < 0.001). Conclusion: Cancer concealment, not only late-stage tumor and age, is associated with a poor survival of CRC patients.

• 대한족부족관절학회지
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• 제13권2호
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• pp.223-226
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• 2009

Freiberg disease is a osteochondrosis of the lesser metatarsal heads. Various surgical treatment have been recommanded including joint debridement and metatarsal head reshaping, metatarsal dorsal wedge osteotomy, metatarsal head excision and joint arthroplasty. Autogenous osteochondral graft for the treatment of Freiberg disease is an effective restorative procedure that provides early range of motion exercise, weight bearing, and reduces other morbidity. We report a case of late stage Freiberg disease treated with arthrotomy, removal of loose body and autogenous osteochondral graft.

• Biomolecules & Therapeutics
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• 제32권3호
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• pp.291-300
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• 2024

Autosomal dominant polycystic kidney disease (ADPKD), a congenital genetic disorder, is a notable contributor to the prevalence of chronic kidney disease worldwide. Despite the absence of a complete cure, ongoing research aims for early diagnosis and treatment. Although agents such as tolvaptan and mTOR inhibitors have been utilized, their effectiveness in managing the disease during its initial phase has certain limitations. This review aimed to explore new targets for the early diagnosis and treatment of ADPKD, considering ongoing developments. We particularly focus on cell polarity, which is a key factor that influences the process and pace of cyst formation. In addition, we aimed to identify agents or treatments that can prevent or impede the progression of renal fibrosis, ultimately slowing its trajectory toward end-stage renal disease. Recent advances in slowing ADPKD progression have been examined, and potential therapeutic approaches targeting multiple pathways have been introduced. This comprehensive review discusses innovative strategies to address the challenges of ADPKD and provides valuable insights into potential avenues for its prevention and treatment.

• 혜화의학회지
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• 제13권1호
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• pp.197-210
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• 2004

Objective : This study was designed to investigate causes, symptoms and treatments for the Chronic rhinorrhea of children with oriental medical literatures. Methods : We surveyed the oriental and western medical books from to recent published books that have articles on Chronic rhinorrhea. Results and Conclusions : The Chronic rhinorrhea are classified to Bigu and Biruan(鼻淵). Bigu is similar to Allergic Rhinitis and Biyan(鼻淵) is similar to Chronic Sinusitis. The external cause of disease is the invasion of Poong han(風寒) etc a wrong air and the internal causes of disease are the deficiency of the spleen, lung and kidney and inner heat caused by stress. Treatment in Oriental medicine consists of herbal-therapy, acupuncture and moxa. The methods of treatment are expelling of Poong han(風寒) in the early stage and helping the vital energy in the late stage.

• 대한두경부종양학회지
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• 제3권1호
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• pp.5-13
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• 1987

Cancer of the head and neck is an uncommon disease accounting for 5 % of all cancers. In an anatomic area so readily visible and palpable for examination without special and expensive diagnositic tools, it is unfortunate that many patients still present with advanced diseases. Since the prognosis is so intimately related to stage of disease, it is very important to detect the earliest stage of cancer with a complete head and neck examination. In the evaluation of cancer at any anatomic site, the description of the extent of the lesion is important. Not only does proper staging of the tumor lead to make decision of the most appropriate treatment, it also serves as a guide for the results of treatment. Proper staging demands a careful clinical assesment of the extent of the cancer. The current staging system for head and neck cancer uses the TNM system devised by American Joint Committee for Cancer Staging and End Result Reporting. T represent the primary tumor, N, regional nodal metastases, and M, distant metastases. The detection, diagnosis, and appropriate treatment of eary cancer will result in improved survival.

• 대한간호학회지
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• 제37권4호
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• pp.459-466
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• 2007

Purpose: This study was to identify predictors of quality of life in breast cancer patients. Physical and pscyhological factors like stress, mood, and fatigue with sociodemographic factors like education, income, job and stage of disease were used to predict quality of life. Methods: One hundred eleven patients with breast cancer participated in this study? The functional Assessment of Cancer Therapy-Breast(FACT-B) was used to assess quality of life. Results: The mean age of the patients was 46.7 years. The FACT-B mean score was 89.89(SD:17.31) Education, income, job and stage of disease were significantly associated with QOL. In a regression analysis, mood, income, and fatigue were significant predictors for QOL where as, stress was not significant. Among the subscales of QOL, physical well-being, functional well-being, emotional well-being, and the breast cancer subscale were included as predictors of QOL Conclusion: Physical and psychological factors were strong predictors of QOL. These results demonstrate the need for interventions to improve QOL in breast cancer survivors.

• 한국통신학회논문지
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• 제37C권12호
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• pp.1263-1270
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• 2012

가축 질병은 축산농가에 생산성 및 소득 감소로 인한 경제적 손실을 가져올 뿐만 아니라 전염병 확산으로 인한 국가적 손실로 이어진다. 본 논문에서는 가축의 활동량 정보 및 체온 정보를 기반으로 가축 질병상태를 조기에 진단할 수 있는 가축 질병예찰 시스템을 제안하고자 한다. 제안하는 시스템은 가속도센서 및 열화상 카메라 장비로부터 수집된 데이터와 가축의 질병별 활동량 및 체온 정보 데이터를 비교함으로써 가축 질병상태를 조기에 진단할 수 있는 가축 질병예찰 시스템이다. 본 시스템을 통해 가축 질병을 미연에 정확히 판단하고 질병으로 인한 피해를 최소화함으로써 축산농가의 생산성 향상 및 수익률을 높일 수 있을 것으로 기대된다.

• Perspectives in Nursing Science
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• 제10권1호
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• pp.52-64
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• 2013

Purpose: The purpose of this study was to explore the utilization of health care of patients with lung cancer in Korea and identify determinants of these patients' health care utilization. Methods: This was a descriptive analytical study. The national medical fees claims data of patients with lung cancer were used. Using SPSS Statistics 20, the ${\chi}^2$-test and logistic regression were performed to determine the factors influencing health care utilization. Results: There were significant differences by sex, age, disease type, stage, comorbidity index, region of institutions, and type of institutions in the utilization of surgical procedures; by age, disease type, stage, comorbidity index, region of institutions, and type of institutions in the utilization of chemotherapy; and by age, stage, comorbidity index, region of institutions, and type of institutions in the utilization of radiotherapy. Conclusion: The findings of this study suggest that democratic and clinical characteristics of patients as well as institutional characteristics affect health care utilization of patients with lung cancer. Additional research is needed to determine the factors influencing health care utilization of patients with lung cancer.