• 대한두경부종양학회지
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• 제7권1호
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• pp.40-44
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• 1991

Cystic metastasis in the neck from pharyngeal cancer has often been mistaken for either primary squamous cell carcinoma of branchiogenic origin or branchial cleft cyst. The distinctive histological and clinical features of cystic metastasis reviewed after its correct indentification can lead to the discovery of an unsuspected primary lesion and result in specific treatment options. Recendy, the authors experienced three cases of cystic metastasis in the neck from pharyngeal cancer ; one was from nasopharyngeal squamous cell carcinoma and the other two were from tonsillar squamous cell carcinomas. This report summarizes our experiences and review of the literatures.

• 대한두경부종양학회지
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• 제21권2호
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• pp.139-145
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• 2005

Background and Objectives: Because of squamous cell carcinoma of the head and neck undergoes a generally poor hospital course, the prognostic significance of the squamous cell carcinomas in head and neck have been evaluated to identify those features associated with aggressive biologic behavior according to the immunologic and histopathologic characteristics. Materials and Method: To assess the significance of EGFR, c-erbB-2, p21 and p53 protein in head and neck tumors and their correlation with prognostic factors, samples from 74 patients with squamous cell carcinomas of larynx, pharynx, and oral cavity were studied immunohistochemically. Results: EGFR, c-erbB-2, p21, and p53 protein were expressed 94.6%, 24.3%, 85.1%, and 55.4% in 74 cases of head and neck squamous cell carcinoma, respectively. The positive expression of EGFR was associated significantly with clinical stage and the negative expressions of p21 was associated significantly with histopathologic differentiation. There were no significant relationships between the reactivity of EGFR, c-erbB-2, p21, and p53 protein. Conclusion: The expression of EGFR, c-erbB-2, p21 and p53 protein could be related to oncogenesis, and the expression of p21 and EGFR protein can be used as a prognosticator in head and neck squamous cell carcinoma under certain limitations, but c-erbB-2 and p53 protein expression alone is not enough for evaluating prognosis of the carcinoma.

• Genomics & Informatics
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• 제19권1호
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• pp.5.1-5.11
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• 2021

Head and neck squamous cell carcinoma (HNSCC) is the most frequent type of head and neck cancer that usually arises from the mucosal surfaces of several organs including nasal cavity, paranasal sinuses, oral cavity, tongue, pharynx, and larynx. The Wnt signaling pathway is a crucial mechanism for cellular maintenance and development. It regulates cell cycle progression, apoptosis, proliferation, migration, and differentiation. Dysregulation of this pathway correlates with oncogenesis in various tissues including breast, colon, pancreatic as well as head and neck cancers. The present study aims to assess the gene alterations in the Wnt family of genes so as to derive an association with HNSCC. Computational approaches have been utilized for the identification of gene alterations in the Wnt family of genes. Several databases such as cBioportal, STRING, and UALCAN were used for the purpose. The frequency of alteration was high in case of Wnt family member 11 (5%). Gene amplification, deep deletions, missense and truncating mutations were observed in HNSCC patients. There was a marked difference in the gene expression profile of WNT11 between grades as well as normal samples. The survival probability measured using the Kaplan-Meier curve also presented with a significant difference among male and female subjects experiencing a low/medium level expression. The female patients showed less survival probability when compared to the male subjects. This provides the prognostic significance of the WNT11 gene in HNSCC. Taken together, the present study provides clues on the possible association of WNT11 gene alterations with HNSCC, which has to be further validated using experimental approaches.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제32권1호
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• pp.69-75
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• 2006

Head and neck squamous cell carcinoma(HNSCC) is the sixth most common cancer among men in the developed world affecting the tongue, pharynx, larynx and oral cavity. HNSCC is thought to represent a multistep process whereby carcinogen exposure leads to genetic instability in the tissue and accumulation of specific genetic events, which result in dysregulation of proliferation, differentiation, and cell loss and the acquisition of invasive capacity. Despite therapeutic and diagnostic progress in oncology during the past decades, the prognosis of HNSCC remains poor. Thus it seems that finding a biological tumor markers which will increase the early diagnosis and treatment monitoring rates, is of paramount importance in respect to improving prognosis. In an effort to identify gene expression signatures that may serve as biomarkers, this study several genes were selected, such as H3,3A, S100A7, UCHL1, GSTP1, PAI-2, PLK, TGF${\beta}$1 and bFGF, and used 7 HNSCC cell lines that were established various anatomical sites, and also 17 other cancer cell lines were used for control group using real-time quantitative RT-PCR and immunocytochemical analysis with a monoclonal antibody. In this study, S100A7 showed a clearly restricted occurrence in tongue originated cell line, and GSTP1 expression level in the pharynx originated cell line was very increased, relative to corresponding other cell lines. These results suggest that S100A7 and GSTP1 genes' expression can occur during tongue and pharynx originated head and neck tumorigenesis and that genetic change is an important driving force in the carcinogenesis process. This data indicate that S100A7 and GSTP1 expression pattern in HNSCC reflect both diagnostic clue and biological marker. And this is provides a foundation for the development of site-specific diagnostic strategies and treatments for HNSCC.

• Journal of Chest Surgery
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• 제24권8호
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• pp.807-813
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• 1991

Between October 1987 and October 1990, 6 patients underwent pharyngolaryngoesophagectomy with transhiatal gastric transposition and pharyngogastrostomy for hypopharyngeal and recurred laryngeal cancer. All patients had squamous cell carcinoma and were male, with age range from 54 to 67 years. Two patients had been treated initially by chemotherapy, but the tumor had persisted. One patient had been treated by radiotherapy and operation, but tumor had recurred in hypopharynx. There was no operative death. Major complications were anastomotic leakage in three cases, wound disruption in four cases and one postoperative bleeding. Anastomotic leakage was recovered in two cases with conservative management. The average hospital day was 33 days postoperatively. We conclude that reconstruction of the pharynx and cervical esophagus with gastric transposition is one of the recommendable procedures for extensive resection of pharynx or cervical esophagus with acceptable morbidity and functional recovery.

• 대한치과보철학회지
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• 제54권2호
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• pp.167-171
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• 2016

상악골 부분 절제술을 시행한 환자들은 저작, 발음, 연하 기능에 문제가 발생하고 안모의 변화로 인해 사회적, 심리적인 어려움을 겪게 된다. 따라서 악안면 보철적 치료를 통한 기능적, 심미적 회복이 매우 중요하다. 적절한 폐쇄 장치는 구개의 외형을 회복시키고 구강과 비강, 상악동, 비인두를 분리시킴으로써 연하와 발음 기능을 회복시키는데 목적이 있다. 본 증례는 편평상피암으로 인해 우측 상악 구치부에서 비인두에 이르기까지 상악골 부분 절제술을 시행한 환자에서 폐쇄장치를 제작하였다. 이를 통해 발음 및 연하 기능을 회복하고 저작 기능의 향상을 도모하였으며 심미적인 부분에서 개선이 이루어졌다. 1년간의 임상적 관찰기간 동안 만족스러운 결과를 얻었기에 이를 보고하고자 한다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권2호
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• pp.585-589
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• 2012

Background: Israeli Arabs are considered as a developing society characterized by poverty and high levels of smoking among men. The purpose of this study was to describe their incidence, mortality and survival rates for oral and pharyngeal cancer between the years 1970-2006. Studies such as this in the Arab world, where the population is almost the same as the Arab population in Israel, are rare. Methods: The incidence and survival data were derived from all relevant registered data at the National Cancer Registry. The group of lesions included cancer of the lips, tongue, buccal mucosa, floor of the mouth, salivary glands, gums, palate and pharynx. Morphological description was according to WHO classification. Results: Most diagnosed patients were male. The mean age was 54.4 years, and mean years of survival were 3.83. The oropharynx was the most common site (28.3%) while the palate was the least frequent (3.12%). Squamous cell carcinoma (SCC) was the most common histological feature (66.3%), while basal cell carcinoma (BCC) was the least (3.9%). The overall 5 years survival rate was 59.4%, this being highest for BCC (82.1%), while SCC was significantly lower (56.2%) (p<0.001). Lip cancers survived better than other sites. Conclusions: Data from this society are similar to other developing societies in the majority of the results. The incidence of oral and pharyngeal cancer is lower among the Arab population, in comparison to the Jewish population in Israel.

• Radiation Oncology Journal
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• 제22권4호
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• pp.254-264
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• 2004

목적: 하인두암의 치료에서 수술 후 방사선치료에 대한 치료결과 분석을 통하여 그 임상적 의의와 한계를 알아보고, 방사선치료와 관련된 예후인자들을 확인하여 향후 새로운 치료방침을 세우는데 기본 자료를 마련하고자 연구를 시행하였다. 대상 및 방법: 1988년부터 1999년까지 부산대학교병원에서 원발성 하인두 편평상피세포암으로 진단되어 수술 후 방사선치료를 시행받은 64명을 대상으로 후향적 분석을 실시하였다. 모든 환자들은 근치적 목적의 종양절제술을 시행한 뒤에 통상적인 분할조사법을 이용하여 원발 부위와 경부 림프절 부위에 수술 후 방사선치료를 실시하였다. 결과: 5년간의 전체 생존율과 질병 관련 생존율은 각각 42.2%42.2%와 51.6%였고, 병기별 5년간 질병 관련 생존율은 Stage I, II, III, IV에서 각각 100%, 80%, 62.5%, 41.5%였다. 예후인자에 대한 단변랑 분석에서 전체 병기, T 병기 및 N 병기, 2차성 원발암 발생 유무, 절제연 침범 여부, 림프절의 외막 침범 여부, 총 방사선량 등이 의미가 있었으며, 다변량 분석에서는 T 병기 및 N 병기, 절제연 침범 여부, 림프절 외막 침범 여부 등이 유의한 예후인자로 판명 되었다. 결론: 절제 가능한 하인두암 환자에서 수술 및 보조적 방사선치료는 후두나 인두의 기능장애 가능성에도 불구하고 생존율이나 국소 제어율 면에서 좋은 치료 결과를 보였다 그러나 상당히 진행된 하인두암의 치료에서는 국소제어나 환자의 삶의 질과 관련하여 기존의 수술 및 방사선 병합치료의 한계를 확인할 수 있었는데, 최근 연구되고 있는 화학-방사선 병합요법이나 세기조절 방사선치료 등과의 비교 연구가 예후인자 관련 연구와 동반해서 진행되어야 할 것이다.