• 생물정신의학
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• 제19권4호
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• pp.164-171
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• 2012

The placebo effect, a response observed during the placebo arm of a clinical trial, is produced by the psychobiological action of the placebo as well as by other potential contributors to symptom amelioration such as spontaneous improvement, regression to the mean, biases, concurrent treatments, and study design. From a psychological viewpoint, there are many mechanisms that contribute to placebo effects, including expectations, conditioning, learning, and anxiety reduction. Placebo responses are also mediated by opioid and non-opioid mechanisms including dopamine, serotonin, cholecystokinin, and immune mediators. During recent years, a trend towards increased placebo effects in clinical trials of neuropsychiatric drugs has been noted. Indeed, the placebo effects observed in clinical trials constitute an increasing problem and interfere with signal-detection analyses of potential treatments. Several potential factors including protocol/study design and conduct related factors may account for the placebo effect observed in clinical trials. This paper reviews key issues related to this problem and aims to identify potential solutions.

• 디지털산업정보학회논문지
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• 제12권3호
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• pp.33-54
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• 2016

In the modern society based on information and communication, which is exposed to the risks of a lot of information security breaches, corporate information assets may be an economical scale in a country. Most of damages derived from corporate technological information leak often occur in small and medium corporations. Although many information security managers in corporations have focused on certification systems such as information security management system, small and medium corporations are poorly aware of the information security, and their environments surrounding it should be also improved. In addition, it is difficult to expect spontaneous participations in it, since the sustainable information security management systems are often not forced to be certified. Thus, the purpose of this study is to examine plans to improve small and medium corporations' technological protections by using some component of the information security management system. On the basis of this examination, it also attempts to discuss some methods for effective and efficient information security in the small and medium corporations' technological protections.

• 한국신재생에너지학회:학술대회논문집
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• 한국신재생에너지학회 2007년도 추계학술대회 논문집
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• pp.143-146
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• 2007

Birnessite-type manganese dioxide($MnO_2$) was coated uniformly onto carbon nanotubes (CNTs) through a spontaneous direct redox reaction between CNTs and permanganate ions($MnO_4\;^-$). The initial specific capacitance of the $MnO_2/CNT$ nanocomposite in an organic electrolyte at a large current density of 1 A/g was 250 F/g, which is equivalent to 139 mAh/g based on the total weight of the electrode material including the electroactive material, conducting agent and binder. The specific capacitance of the $MnO_2$ in the $MnO_2/CNT$ nanocomposite was as high as 580 F/g (320 mAh/g), indicating excellent electrochemical utilization of the $MnO_2$. The addition of CNTs as a conducting agent can improve the high rate capability of $MnO_2/CNT$ nanocomposite considerably. An analysis of the in-situ X-ray absorption near-edge structure (XANES) showed an improvement in the structural and electrochemical reversibility of the $MnO_2/CNT$ nanocomposite by heat-treatment.

• 융합보안논문지
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• 제15권4호
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• pp.149-154
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• 2015

본 연구는 지적장애아동들이 가상현실을 기반으로 한 기능성 게임에 참여하는 과정에서 행동 및 운동수행능력에 어떠한 변화가 보이는지 분석하는데 그 목적이 있다. 본 연구는 지적장애아동 5명을 대상으로 주 2회, 16주간 프로그램을 진행하였다. 그 결과 가상현실을 기반으로 한 기능성 게임에 참여한 지적장애아동은 주의집중, 안정된 움직임, 자신감있는 동작 등과 같은 행동의 변화를 보였으며, 운동수행능력의 경우 하위영역 - 정적 협응, 손동작 협응, 일반동작 협응, 운동속도, 동시적 자발동작, 단일 동작 수행능력- 모두에서 긍정적 변화를 나타냈다. 이와 같은 연구 결과를 바탕으로 가상현실을 기반으로 한 기능성 게임을 체계적이고 규칙적으로 적용하게 되면 지적장애인의 행동변화와 운동수행능력에 긍정적 효과를 가져올 수 있을 것이다.

• 의학교육논단
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• 제22권1호
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• pp.32-45
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• 2020

This narrative review introduces global trends in pharmacovigilance (PV) education for healthcare professionals and the status of PV education in Korea. Proactive participation of healthcare professionals, including physicians, pharmacists, and nurses in reporting suspected adverse events is the main driving force for effective operation of the spontaneous adverse event reporting system database, which in turn facilitates early safety signal detection of otherwise unknown suspected adverse events. The World Health Organization recognizes PV education curriculum as a key aspect in promoting awareness of PV and adverse event reporting among healthcare professionals, and multiple studies have demonstrated that PV educational interventions for healthcare professionals have increased overall adverse event reporting. Considering the global trends in PV education, the curriculum in Korean universities still has room for improvement in promoting PV obligation among future healthcare professionals. Further research is needed to develop PV education curriculum. We suggest a three-step project for innovating PV education in Korea to meet the global PV educational standards: a survey to gauge current PV competencies among healthcare professionals, reform of current PV academic curriculum, and evaluation and fine-tuning of the reformed curriculum.

• 대한치과교정학회지
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• 제50권1호
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• pp.63-71
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• 2020

Odontogenic keratocysts (OKCs) are one of the most aggressive cysts in the oral and maxillofacial area because of their high recurrence rate and infiltrative behavior. In growing patients with OKCs, a radical treatment approach might cause numerous complications, including the disturbance of jaw growth and loss of the involved tooth. This case report describes successful comprehensive orthodontic treatment combined with marsupialization of the cyst in a young girl who exhibited an OKC with impacted teeth. The 10-year-old girl presented with an OKC extending from the mandibular symphysis through the left mandibular body, with ectopic impaction of the mandibular left canine and first premolar, as well as congenitally missing bilateral mandibular second premolars. Interestingly, spontaneous improvement of the positions of the ectopic impacted teeth, along with a reduction in the size of the cyst, occurred during marsupialization. The sequential use of removable and fixed appliances enabled orthodontic traction of the impacted teeth. The treatment outcome was stable at 2.5 years after the end of the treatment. We speculate that comprehensive orthodontic treatment combined with marsupialization can be an effective treatment strategy for patients with OKCs, especially when they are encountered in young, growing patients with impacted teeth.

• Journal of Yeungnam Medical Science
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• 제2권1호
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• pp.299-306
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• 1985

저자들은 3개월 된 남아에서 생긴 선천성 담관낭종으로 인해 vitamin K 흡수 장애로 출혈성 경향이 생기면서 두강내 혈종을 동반한 1예를 치험하였기에 문헌고찰과 함께 보고하는 바이다. vitamin K를 주사하여 출혈성 경향을 교정하고 두강내혈종을 제거한 뒤 담관낭종 절제 및 담관공장 문합술을 시행하였으며, 술후 경과는 양호 했다.

• 한국광학회지
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• 제11권5호
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• pp.340-346
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• 2000

최근 모드변환기가 집적된 진행파형 반도체 광증폭기(SSC-TW-SOA)가 광섬유와의 광결합 효율 향상 및 저가격화를 위해 활발히 연구되고 있다. 본 연구에서는 모드변환기의 구조가 단면 반사율에 미치는 영향을 실험 및 이론적으로 조사하였다. SSC-TW-SOA의 유효단면반사율을 낮추기 위해서는 수직 및 수평방향으로 충분히 모드변환을 행하고 동시에 기운단면 구조를 채용하는 것이 매우 효과적임을 이론적 및 실험적으로 확인하였다. 수직 및 수평방향의 모드변환기가 집적된 TW-SOA에 $20\mu\textrm{m}$ 길이의 창구조, $7^{\circ}$기운단면, 1% 무반사 코팅을 도입함으로써 0.1dB 이하의 작은 ASE ripple를 얻을 수 있었다.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2009년도 제38회 동계학술대회 초록집
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• pp.51-51
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• 2010

Group III-nitride semiconductors have been widely studied as the materials for growth of light emitting devices. Currently, GaN devices are predominantly grown in the (0001) c-plane orientation. However, in case of using polar substrate, an important physical problem of nitride semiconductors with the wurtzite crystal structure is their spontaneous electrical polarization. An alternative method of reducing polarization effects is to grow on non-polar planes or semi-polar planes. However, non-polar and semipolar GaN grown onto r-plane and m-plane sapphire, respectively, basically have numerous defects density compared with c-plane GaN. The purpose of our work is to reduce these defects in non-polar and semi-polar GaN and to fabricate high efficiency LED on non/semi-polar substrate. Non-polar and semi-polar GaN layers were grown onto patterned sapphire substrates (PSS) and nano-porous GaN/sapphire substrates, respectively. Using PSS with the hemispherical patterns, we could achieve high luminous intensity. In case of semi-polar GaN, photo-enhanced electrochemical etching (PEC) was applied to make porous GaN substrates, and semi-polar GaN was grown onto nano-porous substrates. Our results showed the improvement of device characteristics as well as micro-structural and optical properties of non-polar and semi-polar GaN. Patterning and nano-porous etching technologies will be promising for the fabrication of high efficiency non-polar and semi-polar InGaN LED on sapphire substrate.

• Journal of Genetic Medicine
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• 제17권1호
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• pp.47-50
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• 2020

In Turner syndrome (TS), 45,X/47,XXX mosaicism is a rare genotype. Due to its low frequency, the clinical features and prognosis are not clearly known. A 10-year-old girl was diagnosed with 45,X/47,XXX mosaicism TS and presented with short stature. She did not show any other TS phenotypic features, except for short stature, and developed spontaneous puberty and menarche, although she had unilateral ovarian agenesis. She achieved a significant growth improvement following growth hormone treatment. Since 45,X/47,XXX mosaic TS shows different gonadal function from that of classic TS, it is necessary to conduct surveillance for premature ovarian insufficiency.