• 대한핵의학회지
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• 제32권6호
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• pp.482-489
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• 1998

목적: 방사성 동위원소 뇌조조영술은 자발성 두 개 내 저압환자의 체위성 두통과 저뇌척수압의 병태생리를 이해하는데 도움을 줄 수 있다. 저자들은 이 질환의 방사성 동위원소 뇌조조영술의 특징적인 소견을 알아보고자 하였다. 대상 및 방법: 자발성 두개내 저압으로 진단되어 방사성 동위원소 뇌조조영술을 시행한 15명을 대상으로 하였다. 뇌조조영술은 Tc-99m DTPA 111-222 MBq를 요추천자를 통해 지주막하강에 투여한 후 감마카메라로 30분부터 2시간 이내에 방광을 포함한 요추부와 경흉추부의 전면상과 측면상을 얻었고, 4, 6, 24시간에 두부와 경흉추부의 전면상과 측면상을 얻었다. 방광 내 방사성 추적자의 조기 배설유무, 척수강 내 방사성의 이동속도, 연조직 섭취정도, 그리고 대뇌궁융부로의 이동 지연 등을 분석하였다. 결과: 방사성 동위원소 뇌조조영술 소견은 대뇌궁융부로의 방사성 추적자의 이동지연(14/15), 연조직의 섭취증가(11/15), 방광 내 방사성 추적자의 조기 출현(13/13) 등이 있었고 뇌척수액의 누출을 시사하는 척수경막강 주위의 방사성 추적자의 국소 집적도 4예에서 있었다. 결론: 방사성 추적자의 이동 지연과 연조직의 섭취증가 및 방광 내 방사성 추적자의 조기 출현 등이 특징적으로 관찰되었고, 이러한 뇌조조영술 소견은 자발성 두개 내 저압의 주된 병태생리가 뇌척수액의 누출임을 시사하는 것으로 판단되었으며, 방사성 추적자 이동의 역동적 측면을 잘 평가하기 위해서는 방광과 연조직을 포함한 30분 영상과 다발적인 연속영상을 획득하는 것이 필요하다고 생각된다.

• Biomolecules & Therapeutics
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• 제10권2호
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• pp.89-98
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• 2002

In this study general pharmacological profiles of KI-60606 on the central nervous system, the cardiovascular system and the other organs were investigated. The dosages given were 0,5, 10 and 25 mg/kg and drugs were administered intravenously. The animals used for this study were mice, rats, cats and guinea pigs. KI-60606 showed no effects on general behavior, motor coordination, spontaneous locomotor activity, hexobarbital-induced hypnosis time, body temperature, analgesic activity, anticonvulsant activity and contraction of nictitating membrane in cats. Furthermore KI-60606 showed no effects on blood pressure, heart rate, LVP (left ventricular peak systolic pressure), LVEDP (left ventricular end diastolic pressure), LVDP (left ventricular developing pressure), DP(double product), CFR(coronary flow rate), smooth muscle contraction using guinea pig ileum and gastric secretion at all dosage tested except the increase of gastrointestinal transport and urinary $K^+$ excretion.

• Biomolecules & Therapeutics
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• 제7권2호
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• pp.170-177
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• 1999

PEG-hemoglobin SB1 (SB1), which is a hemoglobin-based oxygen carrier, is intended to use as a safe blood substitute against brain ischemia and stroke. The general pharmacological profiles of SB1 were studied. The doses given were 0, 5, 10, 20 ml/kg and drugs were administered intravenously. The animals used for this study were mouse, rat and guinea pig. SB1 showed no effects on general behavior, motor coordination, spontaneous locomotor activity, hexobarbital sleeping time, anticonvulsant activity, analgesic activity, blood pressure and heart rate, left ventricular peak systolic pressure, left ventricular end diastolic pressure, left ventricular developing pressure, double product, heart rate, coronary flow rate, smooth muscle contraction using guinea pig ileum, gastrointestinal transport, gastric secretion, urinary volume and electrolyte excretion at all doses tested except the decrease of body temperature. These findings demonstrated that SB1 possesses no general pharmacological effects at all doses tested.

• Biomolecules & Therapeutics
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• 제6권3호
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• pp.232-241
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• 1998

This study was done to investigate whether cholic acid derivatives have anti-stress activity in various stress models. Two cholic acid derivatives, ursodeoxycholic acid (UDCA) and tauroursodeoxycholic acid (WDCA), were used. physical, psychological, chemical and environmental stress models were performed. Adrenal weight, serum glucose levels and ALP activity were elevated in restraint stress model, but this elevation was prevented by UDCA treatment. Moreover, UDCA and TUDCA inhibited exploratory and spontaneous movements in oscillation stress model. In alcohol-induced stress model, TUDCA improved rotarod performance. UDCA and TUDCA significantly reduced the involution of lymphoid organs and the increment of WBC counts in cold stress model. These findings suggest that choric acid derivatives have antistress effects in various stress models.

• Advances in Traditional Medicine
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• 제4권1호
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• pp.9-17
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• 2004

The present investigation was under taken to study whether the tumor-associated macrophages (TAM) of Daltons lymphoma (DL), a spontaneous transplantable murine T cell lymphoma can be activated to tumoricidal state by crude thymus extract. Intraperitoneal administration of thymus extract to DL-bearing mice resulted in activation of TAM with an enhanced IL-1, TNF and antigen presenting ability. It was found that treatment with thymus extract could also enhance the phagocytic and cytotoxic activity of TAM. However, only a marginal increase in arginase activity was observed. Till date to the best of our knowledge the effect of crude thymus extract on the activation of tumor associated macrophages has not been investigated, this study provides a new piece of information in the area of thymus therapy.

• The Korean Journal of Physiology
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• 제30권1호
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• pp.117-124
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• 1996

This study evaluated the hypothesis that motoneuron collaterals modulate the excitability of ventral spinocerebellar tract neurons. In acute cats, 128 ventral cerebellar tract cells were studied extracellularly to determine the effects of ventral root stimuli. The majority of the cells responded to ventral root stimulation with either short or long latency increases in spike discharge. In many cells with sufficient spontaneous activity ventral root stimulation also evoked a long lasting reduction in activity. In preparations with the dorsal root ganglion removed VSCT neurons had similar response properties. In some cells contralateral ventral root stimulation also evoked excitatory responses. These findings indicate the VSCT can provide the cerebellum with information regarding activity in the final output neurons of the motor system, the alpha motoneurons.

• Biomolecules & Therapeutics
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• 제10권4호
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• pp.258-267
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• 2002

In this study the general pharmacological profiles of AS6 on the central nervous system, cardiovascular and the other organs were investigated. The dosages given were 0, 250, 500 and 1000 mg/kg and drugs were orally administered. The animals used for this study were mice, rats and guinea pigs. Significant increases (p<0.01) in the charcoal transport capacity were observed at the high dose of 1000 mg/kg and significant increases in retardation of pain threshold were observed in the test using acetic acid in all dosed animals. However, AS6 showed no noticeable effects on general behavior, motor coordination, spontaneous locomotor activity, hexobarbital-induced sleep time, body temperature, analgesic activity in the test using hot plate method and anticonvulsant activity. Furthermore no noticeable effects were observed in cardiovascular functions in the isolated rat heart, contraction and relaxation of the smooth muscle in the isolated guinea ileum, gastric secretion and renal function.

• 생약학회지
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• 제24권3호
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• pp.231-234
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• 1993

Neuropharmacological profile of Humulus lupulus (hop) extract was studied in mice. At doses above 100 mg/kg(i.p.), it decreased spontaneous locomotor activity and raised the nociceptive threshold in the hot-plate test. At doses above 250 mg/kg (i.p.), it increased pentobarbital-induced sleeping time and produced muscle relaxant effect. At the dose of 500 mg/kg, anticonvulsive effect against pentylenetetrazole-induced convulsion and hypothermic effect was observed.

• Clinical and Experimental Reproductive Medicine
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• 제11권1호
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• pp.9-16
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• 1984

This study was conducted to determine whether patients could engage in sexual activity following total cystectomy with ileal conduit. Sixteen male bladder cancer patients treated by total cystectomy with or without preoperative irradiation. Patients ranged in age from 48 to 70 years (mean 59.6 years). The interval from therapy ranged from 7 to 82 months (mean 33.8 months).Prior to therapy 11 /16 patients (68.8 %) reported they were engaging some form of sexual activity at least once per month. All were able to achieve an erection and were orgasmic. Following total cystectomy, 6 patients (37.5%) continued to engage in sexual activity at least once per month and were experiencing orgasm. 3 patients (18.8%) reported they were able to achieve an erection. The spontaneous resumptiom of sexual activity by almost one third of the patients in this study refutes the assumption that sexual activity would be impossible following total cystectomy.

• Journal of Nutrition and Health
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• 제30권6호
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• pp.634-648
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• 1997

To examine the effect of Artemisia princeps var orientalis on cardiovascular system, cadiovascular response from its water extracts were studied in the atria and aortae of normal rats. The extracts diminished spontaneous beat and contractile force in the left and right atria, and caused the relaxation of thoraic aortae. As for the blood pressure, the mugwort extract had a descending effect.