• Proceedings of the PSK Conference
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• 2003.10b
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• pp.144.1-144.1
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• 2003

We previously reported that the activation of p$21^{WAFl/Cip1}$ transcription by histone deacetylase inhibitor apicidin was mediated through Spl sites and pointed to the possible participation of protein kinase C (PKC). In this study, we investigated the role and identity of the specific isoforms of PKC involved and identified phosphatidylinositol 3-kinase (PI 3-kinase) as an upstream effector in HeLa cells. Using an isoform-specific pharmacological inhibitor of PKC, a PKC$\varepsilon$ dominant-negative mutant, and antisense oligonucleotide to inhibit PKC$\varepsilon$ specifically, (omitted)

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.150.1-150.1
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• 2003

Gelsolin, a actin binding protein, has been demonstrated to be involved in controlling cell morphology, motility, signaling, and apoptosis. It's expression is frequently downregulated in cervix cancer and several types of different human cancers indicating the role of gesolin in suppression of tumorigenicity. Apicidin, a novel histone deacetylase inhibitor, has been shown to cause growth arrest and morphological change of cancer cells, resulting from the alternation of protein expression, such as p21^${WAF1/Cip1}$ and gelsolin. (omitted)

• Journal of KIISE:Software and Applications
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• v.36 no.6
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• pp.431-442
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• 2009

The Software Product Line (SPL) engineering is one of the most promising software development paradigms. With Feature-Oriented Reuse Method (FORM), reusable and flexible components can be built to aid the delivery of various software products such as mobile phone and digital TV applications based on commonalities and variabilities identified during Feature modeling. Model Driven Architecture (MDA) is also an emerging technology which supports developing software products to work on different platforms with platform independent models (PIM). Combining advantages of these two approaches is helpful to build a group of software products which share common Features while working on various platforms. As first step to combine FORM with MDA, we extend UML2.0 with profiles by which FORM architectures and parameterized Statecharts can be modeled. Secondly, we provide rules to examine whether Features are allocated at positions of elements of Statecharts consistently between a Feature model and a parameterized Statechart. Some rules are designed to check the consistency between FORM architectures and parameterized Statecharts. A case study on an elevator control system is provided to demonstrate the feasibility of our modeling approach and consistency checking rules.

• Journal of Life Science
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• v.27 no.1
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• pp.67-71
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• 2017

Foulbrood disease is infected by Paenibacillus larvae on larval stage of honeybee, and is lethal disease to result in population death. This disease was manifested in 2008 in Korea, is still suffered by the secondary damages. In this study, we are to examine diagnostic PCR approaches to manage the Foulbrood disease. PCR amplification of 16S rRNA is generally using for microbial infection, but the specificity is little poor for the correct diagnosis. Therefore, we are to identify specific genes expressed in Paenibacillus larvae, and perform PCR analysis. We selected five distinct genes from literature references. Those genes are commonly known as toxic genes for host infection, and include Toxin1, Toxin2A & 2B, SplA, CBP49, and SevA&SevB. PCR amplification for these genes is difficult to detect at the first time. So, we performed the second PCR using the first PCR product as a template. This approach using the nested PCR was very useful for detecting large marker genes. When Paenibacillus larvae was cultured in the medium containing plant extracts, PCR amplification of the identified genes is correlated with the microbial growth inhibition. Therefore, these results suggest that the identified genes might be useful to study diagnostic PCR markers for honeybee Foulbrood disease.

• Journal of Korea Port Economic Association
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• v.29 no.2
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• pp.173-194
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• 2013

This paper aims at drawing policy schemes to establish marine clusters so as to enhance Korea's global port competitiveness and applying them to its national management for the advancement of national economy through policy suggestions. The research method is an integrated approach(IA) that comprises SWOT Method with strategic approaches, HFP Model enhanced by KJ Method and descriptive deductions. Strategic schemes established for the SPLC are followed by the group of geographical proximity, integration of ICT, expansion of the interchange of ICT & opportunities of ET, integration of ICT services with marine technologies, supply of integrated services in the SPLC and implementation of organizational policies. In order to make a specific implementation of strategic establishment schemes of the SPLC, we need to select a promotion entity. It is advised to establish the joint organization of the public sector and the private sector, which is considered most desirable. In practice, it is to be followed by promoting support schemes of the organizational policy on the level of national management. In order to reinforce this study, further compensative and proactive researches on the offshore sector with marine clusters are required in terms of the development of the high value added 'blue' ocean.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.41 no.2
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• pp.87-94
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• 2017

Because the cavitation flow driven by an underwater propeller corrodes the materials around it and generates a high level of noise, it has become an important topic in engineering research. In this study, computational fluid dynamics techniques are applied to simulate cavitation flow, and the noise in the flow is predicted by applying the acoustic analogy to the predicted flow. The predicted results are compared with measurement results and other predictions in terms of surface pressure distribution and the temporal variation in liquid volume fraction. The predicted results are found to be in good agreement with the measured results. The source of the noise attributed to the time rate of change in the liquid volume fraction around the hydrofoil is modeled as a monopole source, and the source of the noise due to unsteady pressure perturbations on the hydrofoil surface is modeled as a dipole source. Then the predicted noise results are analyzed in terms of directivity and SPL spectrum. The noise caused by unsteady pressure perturbations was dominant in the entire frequency range considered in the study.

• Journal of the Korean Society for Railway
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• v.19 no.1
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• pp.20-28
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• 2016

Curved squeal noise may result when railway vehicles run on curved tracks. Contact between the wheels and the rails causes a stick-slip phenomenon, which generates squeal noise. In order to identify the mechanism of the squeal noise systematically, a scaled test rig has been fabricated. Knowledge of the contact forces between the wheels and the rail rollers is essential for investigating the squeal noise characteristics; however, it is difficult to measure there contact force. In this study, contact forces have been calculated indirectly according to the modal behavior of the subframe that supports the rail roller and the responses at specific positions of that subframe. In order to verify the estimated contact forces, the displacements at the contact points between the wheels and rail rollers have been calculated from the estimated forces; the resulting values have been compared with the measured displacement values. The SPL at the specific location has been calculated using the estimated contact forces and this also has been compared with the SPL, measured in a semi-anechoic chamber. The comparisons in displacements and SPLs show good correlation.

• Journal of Biomedical Engineering Research
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• v.32 no.3
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• pp.218-229
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• 2011

Companding algorithms have been used to enhance speech recognition in noise for cochlea implant users. The efficiency of using companding for digital hearing aid users is not yet validated. The purpose of this study is to evaluate the performance of the companding for digital hearing aid users in the various hearing loss cases. Using HeLPS, a hearing loss simulator, two different sensorinerual hearing loss conditions were simulated; mild gently sloping hearing loss(HL1) and moderate to steeply sloping hearing loss(HL2). In addition, a non-linear compression was simulated to compensate for hearing loss using national acoustic laboratories-non-linear version 1(NAL-NL1) in HeLPS. In companding, the following four different companding strategies were used changing Q values(q1, q2) of pre-filter(F filter) and post filter(G filter). Firstly, five IEEE sentences which were presented with speech-shaped noise at different SNRs(0, 5, 10, 15 dB) were processed by the companding. Secondly, the processed signals were applied to HeLPS. For comparison, signals which were not processed by companding were also applied to HeLPS. For the processed signals, log-likelihood ratio(LLR) and cepstral distance(CEP) were measured for evaluation of speech quality. Also, fourteen normal hearing listeners performed speech reception threshold(SRT) test for evaluation of speech intelligibility. As a result of this study, the processed signals with the companding and NAL-NL1 have performed better than that with only NAL-NL1 in the sensorineural hearing loss conditions. Moreover, the higher ratio of Q values showed better scores in LLR and CEP. In the SRT test, the processed signals with companding(SRT = -13.33 dB SPL) showed significantly better speech perception in noise than those processed using only NAL-NL1(SRT = -11.56 dB SPL).

• The Korean Journal of Zoology
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• v.39 no.4
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• pp.378-386
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• 1996

We have developed a couple of new luciferase reporter plasmida with very low background reporter actlvltlea. One can be used to measure the promoter strength, after insertion of some promoter fragment into the reporter plasmid, and the other, with very low basal promoter actlvltlea, allis In studying eukaryotic transcriptional regulators. The latter reporter plasmid contains such cli elements as a 17 nucleotide long inftlator, Spl.blndIng sftes, GAL4 binding sltea, and bInding sitea for a certain Drosophila homeodomain proteins. In an attempt to construct an improved reporter plaimid by fadlltating transcriptional termination and minimizing any interference by cryptic promoters which may be preaent in the reporter pleamld DNA, we have inserted transsrlptional termination-related signals, a three tandem repeat of SV4O polyadenylatlon signal (AAA) and the putative transcrtptional termination signal (UMS) of the mouse c-mos gene, Into just upstream of the initIator, and the promoter actlvitiea were measured by a transIent expression assay employing the Drosophila Schneider line 2 cells. As expected, the basal promoter activitIes decreased maximally when both transcription termination related elements were inserted. Moreover, the reporter plasmld with the two elements allowed more sensitive measurement of transcriptional activation than the reporter piasmid without them. Theae reporter plasmids can be used for studying transcriptional regulators of higher organisms Including mammals as well as Droiophlla melanogaiter.

• The Journal of the Acoustical Society of Korea
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• v.40 no.1
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• pp.46-54
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• 2021

In this paper, active noise control was performed to reduce radiated noise in the low frequency band of dishwashers. First, through an analysis of the noise environment of the dishwasher, it was confirmed that the pump noise contributed the most to the radiated noise in the low frequency band, From the result of the noise environment analysis, the reference signal was selected to be the vibration signal of the pump body. The reference signal was obtained by using the accelerometer on the pump body, which can prevent acoustic feedback. The error signal sensor was selected as a microphone located at 1 m in front of the dishwasher and 0.5 m in height. And to design the controller, the error signal and the reference signal were measured at the operational rpms of the dishwasher at 2,500 rpm, 2,600 rpm and 2,800 rpm, and the secondary path transfer function was measured. The designed controller was mounted on Digital Signal Processor (DSP) equipment, and the control performance was verified experimentally. As a result of the measurement at the 3 operational rpms, the 7th multiple component of pump operating frequency decreased by 1.93 dB, 4.43 dB, 5.15 dB per rpm, and the 12th multiple component decreased by 6.67 dB, 2.34 dB, 4.28 dB per rpm. And overall Sound Pressure Level (SPL) decreased by 0.84 dB, 2.58 dB, 1.48 dB by rpm.