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A Feasibility Study of a SiPM Based Intraoperative Beta Imaging/Gamma Probe using the Depth of Interaction Measurement (실리콘 광증폭기와 반응깊이 측정방법을 이용한 수술용 베타 영상/감마 프로브 가능성 연구)

  • Kwak, In-Suk;Kang, Han Gyu;Son, Jeong-Whan;Lee, Jae Sung;Hong, Seong Jong
    • Journal of Biomedical Engineering Research
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    • v.37 no.1
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    • pp.7-14
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    • 2016
  • Radiopharmaceutical agents for positron emission tomography (PET), such as $^{18}F$-FDG and $^{68}Ga$, have been used not only for whole-body PET imaging but also for intraoperative radionuclide-guided surgery due to their quantitative and sensitive imaging characteristics. Current intraoperative probes detect gamma or beta particles, but not both of them. Gamma probes have low sensitivities since a collimator has to be used to reduce backgrounds. Positron probes have a high tumor-to-background ratio, but they have a 1-2 mm depth limitation from the body surface. Most of current intraoperative probes produce only audible sounds proportional to count rates without providing tumor images. This research aims to detect both positrons and annihilation photons from $^{18}F$ using plastic scintillators and a GAGG scintillation crystal attached to silicon photomultiplier (SiPM). The depth-of-interaction (DOI) along the plastic scintillator can be used to obtain the 2-D images of tumors near the body surface. The front and rear part of the intraoperative probe consists of $4{\times}1$ plastic scintillators ($2.9{\times}2.0{\times}12.0mm^3$) for positron detection and a Ce:GAGG scintillation crystal ($12.0{\times}12.0{\times}9.0mm^3$) for annihilation photon detection, respectively. The DOI resolution of $4.4{\pm}1.6mm$ along the plastic scintillator was obtained by using the 3M enhanced specular reflector (ESR) with rectangular holes between the plastic scintillators, which showed the feasibility of a 2-D image pixel size of $2.9{\times}4.4mm^2$ (X-direction ${\times}$ Y-direction).

Plasma-Assisted Molecular Beam Epitaxy of InXGa1-XN Films on C-plane Sapphire Substrates (플라즈마분자선에피탁시법을 이용한 C-면 사파이어 기판 위질화인듐갈륨박막의 에피탁시 성장)

  • Shin, Eun-Jung;Lim, Dong-Seok;Lim, Se-Hwan;Han, Seok-Kyu;Lee, Hyo-Sung;Hong, Soon-Ku;Joeng, Myoung-Ho;Lee, Jeong-Yong;Yao, Takafumi
    • Korean Journal of Materials Research
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    • v.22 no.4
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    • pp.185-189
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    • 2012
  • We report plasma-assisted molecular beam epitaxy of $In_XGa_{1-X}N$ films on c-plane sapphire substrates. Prior to the growth of $In_XGa_{1-X}N$ films, GaN film was grown on the nitride c-plane sapphire substrate by two-dimensional (2D) growth mode. For the growth of GaN, Ga flux of $3.7{\times}10^{-8}$ torr as a beam equivalent pressure (BEP) and a plasma power of 150 W with a nitrogen flow rate of 0.76 sccm were fixed. The growth of 2D GaN growth was confirmed by $in-situ$ reflection high-energy electron diffraction (RHEED) by observing a streaky RHEED pattern with a strong specular spot. InN films showed lower growth rates even with the same growth conditions (same growth temperature, same plasma condition, and same BEP value of III element) than those of GaN films. It was observed that the growth rate of GaN is 1.7 times higher than that of InN, which is probably caused by the higher vapor pressure of In. For the growth of $In_xGa_{1-x}N$ films with different In compositions, total III-element flux (Ga plus In BEPs) was set to $3.7{\times}10^{-8}$ torr, which was the BEP value for the 2D growth of GaN. The In compositions of the $In_xGa_{1-x}N$ films were determined to be 28, 41, 45, and 53% based on the peak position of (0002) reflection in x-ray ${\theta}-2{\theta}$ measurements. The growth of $In_xGa_{1-x}N$ films did not show a streaky RHEED pattern but showed spotty patterns with weak streaky lines. This means that the net sticking coefficients of In and Ga, considered based on the growth rates of GaN and InN, are not the only factor governing the growth mode; another factor such as migration velocity should be considered. The sample with an In composition of 41% showed the lowest full width at half maximum value of 0.20 degree from the x-ray (0002) omega rocking curve measurements and the lowest root mean square roughness value of 0.71 nm.

Color Restoration Method Using the Dichromatic Reflection Model for Low-light-level Environments (저조도 환경에 적합한 이색도 반사 모델을 이용한 색 복원 기법)

  • Lee, Woo-Ram;Jun, WooKyoung;Jun, Byoung-Min
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.15 no.12
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    • pp.7324-7330
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    • 2014
  • Color distortion of the dark images acquired under a low-light-level environment with a weak light source can be cause of the performance decreation of various vision systems. Therefore, recovering the original color of the images is an important process for enhancing the performance of the system. For this, this study proposes a color restoration method using a dichromatic reflection model. This paper assumes that the dark images can be classified into two parts affected by specular or diffuse reflection. Two different color constancy methods were then applied to the images to remove the effects of each reflection and two images were created as a result. The resulting images produced a one color-corrected image by combining with different weights according to the position in the images. For the performance evaluation, this paper used a synthesized image, and considered the Euclidean distance and angular error as an evaluation factor. In addition, a performance comparison was performed with the existing various color constancy method to achieve the objectivity of evaluation. The experimental results showed that the proposed method can be a more suitable solution for color restoration than the existing method.

Clinical Application of Endoscopic Inguinal Lymph Node Resection after Lipolysis and Liposuction for Vulvar Cancer

  • Wu, Qiang;Zhao, Yi-Bing;Sun, Zhi-Hua;Ni, Jing;Wu, Yu-Zhong;Shao, Heng-Hua;Qu, Jun-Wei;Huang, Xin-En
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.12
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    • pp.7121-7126
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    • 2013
  • Aim: To examine lymph nodes obtained after lipolysis and liposuction of subcutaneous fat of the inguinal region of female vulvar cancer patients to explore the feasibility of clinical application. Methods: The field of operation was on the basis of the range of the conventional resection of inguinal lymph nodes. We injected lipolysis liquid fanwise, started liposuction after 15-20 minutes; then the subcutaneous fatty tissue was sucked out clearly by suction tube. We selected the first puncture holes located on 2-3 cm part below anterior superior spine, the others respectively being located 3cm and 6cm below the first for puncturing into the skin, imbedding a trocar to intorduce $CO_2$ gas and the specular body, and excise the lymph nodes by ultrasonic scalpel. The surgical field chamber was set with negative pressure drainage and was pressured with a soft saline bag after surgery. Results: A lacuna emerged from subcutaneous of the inguinal region after lipolysis and liposuction, with a wide fascia easily exposed at the bottom where lymph nodes could be readily excised. The number of lymph nodes of ten patients excised within the inguinal region on each side was 4-18. The excised average number of lymph nodes was 11 when we had mature technology. Conclusion: Most of adipose tissue was removed after lipolysis and liposuction of subcutaneous tissue of inguinal region, so that the included lymph nodes were exposed and easy to excise by endoscope. This surgery avoided the large incision of regular surgery of inguinal region, the results indicating that this approach is feasible and safe for used as an alternative technology.

Images of Decomposition of Hydrogen Peroxide Demonstration Represented in New Media Contents: Focusing on Simulacra and Simulation (뉴미디어 콘텐츠에서 재현되는 과산화수소 분해 실험의 이미지 -시뮬라크르와 시뮬라시옹을 중심으로-)

  • Shin, Sein;Ha, Minsu;Lee, Jun-Ki
    • Journal of The Korean Association For Science Education
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    • v.40 no.1
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    • pp.13-28
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    • 2020
  • This study attempted to understand the characteristics of images of scientific experiments represented and consumed on YouTube, a representative of today's new media. In particular, this paper analyzes the case studies of YouTube's hydrogen peroxide decomposition experiment based on Baudrillard's theory of Simulation and Simulacra, which discusses the strong status of images and the ambiguity of the boundary between virtual and reality. A total of 14 YouTube videos related to hydrogen peroxide decomposition experiments were analyzed. In those videos, hydrogen peroxide decomposition experiments were typically conducted with several signs representing scientific experiments, but the most important sign in the videos were bubbles produced through experiments. For more public consumption of the content, the bubbles resulted from hydrogen peroxide decomposition reproduced in YouTube have been transformed into a more spectacular image as 'super-huge' and 'explosive' bubble. Considering the influence of new media that can be accessed by students anytime and anywhere, it is positive that science experiments in new media enhance students' intimacy and access to science. At the same time, however, it is also important to note the danger that the purpose of scientific experiments will be limited to only 'showing specular images', due to the nature of new media, which mainly deals with immediate and superficial images. Furthermore, this study argues that improving students' science media literacy is required to critically examine the science-related images represented in the new media based on understanding the characteristics and limitations of new media that deeply affect daily life.

Performance of a Hybrid DS/SFH Spread Spectrum System over Nakagami Fading Channel in the Presence of Multiple Tone Jamming (다중 톤 방해신호가 존재하는 나카가미 페이딩 전송로에서 DS/SFH 복합 확산대역 시스템의 성능분석)

  • Byun, Woo-Sub;Sung, Koeng-Mo
    • Journal of the Korean Institute of Telematics and Electronics S
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    • v.36S no.8
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    • pp.8-16
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    • 1999
  • In this paper, the performance of a hybrid DS/SFH-SS(direct-sequence/slow-frequency-hopped spread-spectrum) system with coherent BPSK modulation over Nakagami fading channel in the presence of multiple tone jamming is analyzed. Because the Nakagami m-distribution can describe not only Rayleigh fading but also more general fluctuations involving a specular component by adjusting the value of the fading index m. It is known that for m=1 corresponds to Rayleigh fading, for $1/2{\le}m{\le}1$ corresponds to the worst case fading condition, for m>1 corresponds to Rician fading, and for $m{\to}{\infty}$ corresponds to the nonfading condition. The bit error probability is derived over Nakagami model and numerical evaluations are presented for some combinations of system parameters. The results show that as m increases, the bit error probability is better. Also, at a low JSR(jamming-to-signal power ratio), a pure DS-SS system can achieve lower bit error probability than a hybrid DS/SFH-SS system. But at a high JSR, a hybrid DS/SFH-SS system is shown to be superior to a pure DS-SS system. Therefore, it is demonstrated that without increasing the total system bandwidth, the performance of a hybrid DS/SFH-SS is superior to that of a pure DS-SS system in the presence of multiple tone jamming.

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Developing a Portable Intelligent Projection System (휴대형 지능형 프로젝션 시스템 개발)

  • Park, Han-Hoon;Seo, Byung-Kuk;Jin, Yoon-Jong;Oh, Ji-Hyun;Park, Jong-Il
    • Journal of the Institute of Electronics Engineers of Korea SP
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    • v.44 no.4 s.316
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    • pp.26-34
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    • 2007
  • Intelligent projection system indicates a system that displays desired images on an arbitrary screen in an arbitrary environment using projector without noticeable image distortion. In recent years, projectors have become widespread and ubiquitous due to their increasing capabilities and declining cost. Moreover, the size of projectors is getting smaller and handhold projectors are emerging. Thanks to these advances, the demand for intelligent projection system has been significantly increased and the demand has led to remarkable progress of the related techniques or technologies to intelligent projection system However, there are still some environments (or conditions, mainly dynamic ones) that intelligent projections systems cannot handle and they have limited the application area of intelligent projection systems. This paper exemplifies such environments (e.g. specular screen, dynamic screen) and propose effective solutions (i.e. multiple overlapping projectors, complementary pattern embedding) for thor And the usefulness of the solutions is verified through experimental results and user evaluation. Notice that the environments are considered not simultaneously but independently because it is impossible to consider them simultaneously by simply combining the solutions for each. Acually, a totally different solution would be necessary to consider them simultaneously. Therefore, we expect that the proposed methods would largely extend the application area of intelligent projection systems except for severely arbitrary environment.

Fabrication of Microwire Arrays for Enhanced Light Trapping Efficiency Using Deep Reactive Ion Etching

  • Hwang, In-Chan;Seo, Gwan-Yong
    • Proceedings of the Korean Vacuum Society Conference
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    • 2014.02a
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    • pp.454-454
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    • 2014
  • Silicon microwire array is one of the promising platforms as a means for developing highly efficient solar cells thanks to the enhanced light trapping efficiency. Among the various fabrication methods of microstructures, deep reactive ion etching (DRIE) process has been extensively used in fabrication of high aspect ratio microwire arrays. In this presentation, we show precisely controlled Si microwire arrays by tuning the DRIE process conditions. A periodic microdisk arrays were patterned on 4-inch Si wafer (p-type, $1{\sim}10{\Omega}cm$) using photolithography. After developing the pattern, 150-nm-thick Al was deposited and lifted-off to leave Al microdisk arrays on the starting Si wafer. Periodic Al microdisk arrays (diameter of $2{\mu}m$ and periodic distance of $2{\mu}m$) were used as an etch mask. A DRIE process (Tegal 200) is used for anisotropic deep silicon etching at room temperature. During the process, $SF_6$ and $C_4F_8$ gases were used for the etching and surface passivation, respectively. The length and shape of microwire arrays were controlled by etching time and $SF_6/C_4F_8$ ratio. By adjusting $SF_6/C_4F_8$ gas ratio, the shape of Si microwire can be controlled, resulting in the formation of tapered or vertical microwires. After DRIE process, the residual polymer and etching damage on the surface of the microwires were removed using piranha solution ($H_2SO_4:H_2O_2=4:1$) followed by thermal oxidation ($900^{\circ}C$, 40 min). The oxide layer formed through the thermal oxidation was etched by diluted hydrofluoric acid (1 wt% HF). The surface morphology of a Si microwire arrays was characterized by field-emission scanning electron microscopy (FE-SEM, Hitachi S-4800). Optical reflection measurements were performed over 300~1100 nm wavelengths using a UV-Vis/NIR spectrophotometer (Cary 5000, Agilent) in which a 60 mm integrating sphere (Labsphere) is equipped to account for total light (diffuse and specular) reflected from the samples. The total reflection by the microwire arrays sample was reduced from 20 % to 10 % of the incident light over the visible region when the length of the microwire was increased from $10{\mu}m$ to $30{\mu}m$.

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Three-dimensional Machine Vision System based on moire Interferometry for the Ball Shape Inspection of Micro BGA Packages (마이크로 BGA 패키지의 볼 형상 시각검사를 위한 모아레 간섭계 기반 3차원 머신 비젼 시스템)

  • Kim, Min-Young
    • Journal of the Microelectronics and Packaging Society
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    • v.19 no.1
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    • pp.81-87
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    • 2012
  • This paper focuses on three-dimensional measurement system of micro balls on micro Ball-Grid-Array(BGA) packages in-line. Most of visual inspection system still suffers from sophisticate reflection characteristics of micro balls. For accurate shape measurement of them, a specially designed visual sensor system is proposed under the sensing principle of phase shifting moire interferometry. The system consists of a pattern projection system with four projection subsystems and an imaging system. In the projection system, four subsystems have spatially different projection directions to make target objects experience the pattern illuminations with different incident directions. For the phase shifting, each grating pattern of subsystem is regularly moved by PZT actuator. To remove specular noise and shadow area of BGA balls efficiently, a compact multiple-pattern projection and imaging system is implemented and tested. Especially, a sensor fusion algorithm to integrate four information sets, acquired from multiple projections, into one is proposed with the basis of Bayesian sensor fusion theory. To see how the proposed system works, a series of experiments is performed and the results are analyzed in detail.

Simulating the Availability of Integrated GNSS Positioning in Dense Urban Areas (통합 GNSS 환경에서 도시공간 위성측위의 가용성 평가 시뮬레이션)

  • Suh, Yong-Cheol;Lee, Yang-Won
    • Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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    • v.25 no.3
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    • pp.231-238
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    • 2007
  • This paper describes the availability of the forthcoming integrated GNSS(Global Navigation Positioning System) positioning that includes GPS(Global Positioning System), Galileo, and QZSS(Quasi-Zenith Satellites System). We built a signal propagation model that identifies direct, multipath, and diffraction signals, using the principles of specular reflection and ray tracing technique. The signal propagation model was combined with 3D GIS(three-dimensional geographic information system) in order to measure the satellite visibility and positioning error factors, such as the number of visible satellites, average elevation of visible satellites, optimized DOP(dilution of position) values, and the portion of multipath-producing satellites. Since Galileo and QZSS will not be fully operational until 2010, we used a simulation in comparing GPS and GNSS positioning for a $1km{\times}1km$ developed area in Shinjuku, Tokyo. To account for local terrain variation. we divided the target area into 40,000 $5m{\times}5m$ grid cells. The number of visible satellites and that of multipath-free satellites will be greatly increased in the integrated GNSS environment while the average elevation of visible satellites will be higher in the GPS positioning. Much decreased PDOP(position dilution of precision) values indicate the appropriate satellite/user geometry of the integrated GNSS; however, in dense urban areas, multipath mitigation will be more important than the satellite/user geometry. Thus, the efforts for applying current technologies of multipath mitigation to the future GNSS environment will be necessary.