• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• 제26권3호
• /
• pp.135-145
• /
• 2023

Antibiotics are frequently administered during pregnancy. Although necessary to address acute infections, their use facilitates antibiotic resistance. Other associations have also been found with the use of antibiotics, such as perturbations of gut bacteria, delays in microbial maturation, and increased risks of allergic and inflammatory diseases. Little is known about how the prenatal and perinatal administration of antibiotics to mothers affects the clinical outcomes of their offspring. A literature search was conducted of the Cochrane, Embase, and PubMed engines. The retrieved articles were reviewed by two authors and verified for relevance. The primary outcome was the effect of pre- and perinatal maternal antibiotic use on clinical outcomes. Thirty-one relevant studies were included in the meta-analysis. Various aspects are discussed, including infections, allergies, obesity, and psychosocial factors. In animal studies, antibiotic intake during pregnancy has been suggested to cause long-term alterations in immune regulation. In humans, associations have been found between antibiotic intake during pregnancy and different types of infections and an increased risk of pediatric infection-related hospitalization. A dose-dependent positive association between pre- and perinatal antibiotic use and asthma severity has been reported in animal and human studies, while positive associations with atopic dermatitis and eczema were reported by human studies. Multiple associations were identified between antibiotic intake and psychological problems in animal studies; however, relevant data from human studies are limited. However, one study reported a positive association with autism spectrum disorders. Multiple animal and human studies reported a positive association between pre- and perinatal antibiotic use by mothers and diseases in their offspring. Our findings have potentially significant clinical relevance, particularly considering the implications for health during infancy and later in life as well as the related economic burden.

• 천문학회보
• /
• 제46권2호
• /
• pp.38.1-38.1
• /
• 2021

Dust polarization depends on the physical and mechanical properties of dust, as well as the properties of local environments. To understand how dust polarization varies with grain mechanical properties and the local environment, in this paper, we model the wavelength-dependence polarization of starlight and polarized dust emission by aligned grains by simultaneously taking into account grain alignment and rotational disruption by radiative torques (RATs). We explore a wide range of the local radiation field and grain mechanical properties characterized by tensile strength. We find that the maximum polarization and the peak wavelength shift to shorter wavelengths as the radiation strength U increases due to the enhanced alignment of small grains. Grain rotational disruption by RATs tends to decrease the optical-near infrared polarization but increases the ultraviolet polarization of starlight due to the conversion of large grains into smaller ones. In particular, we find that the submillimeter (submm) polarization degree at 850㎛(P850) does not increase monotonically with the radiation strength or grain temperature (Td), but it depends on the tensile strength of grain materials. Our physical model of dust polarization can be tested with observations toward star-forming regions or molecular clouds irradiated by a nearby star, which have higher radiation intensity than the average interstellar radiation field. Finally, we compare our predictions of the P850-Td relationship with Planck data and find that the observed decrease of P850 with Td can be explained when grain disruption by RATs is accounted for, suggesting that interstellar grains unlikely to have a compact structure but perhaps a composite one. The variation of the submm polarization with U (or Td)can provide a valuable constraint on the internal structures of cosmic dust

• 천문학회보
• /
• 제46권2호
• /
• pp.49.1-49.1
• /
• 2021

We carried out simultaneous monitoring observations of five maser lines, H₂O (22 GHz), SiO 𝝊 =1, 2, J =1-0 (43.1, 42.8 GHz), and SiO 𝝊 =1, J=2-1, J =3-2 (86.2, 129.3 GHz), toward the Mira variable star WX Serpentis with the 21-m antennas of the Korean VLBI Network (KVN) in 2009-2021 (~12 years). Most spectra of the H₂O maser are well separated into two parts of two blue- and one redshifted features within ± 10 km s-1 of the stellar velocity. All detected SiO masers are generally concentrated within ± 5 km s-1 of the stellar velocity, and sometimes appear split into two components. Overall, the profiles of SiO and H₂O masers detected in WX Serpentis illustrate typical characteristics of the Mira variable. In addition, flux variations of both SiO and H₂O masers are well correlated with the optical light curve of the central star, showing a phase lag of ~ 0.1 for SiO masers and ~ 0.2 for H₂O maser. This phenomenon is considered to be the direct effect of propagating shock waves generated by the stellar pulsation, because SiO and H₂O masers are sequentially distributed at different positions with respect to the central star. In addition, we analyzed long-term trends and characteristics of maser velocities, maser ratio, and the velocity extents (the full width at zero power; FWZP). We also investigated a spectral energy distribution (SED) ranging from 1.2 to 240 ㎛ obtained using several infrared data: 2MASS, WISE, IRAS, ISO, COBE DIBRE, RAFGL, and AKARI (IRC and FIS). From the IRAS LRS and ISO SWS spectra of this star, we identified 9.7 and 12 ㎛ silicate emission features consistent with the SE6 spectrum model, corresponding to the typical AGB phase.

• 천문학회보
• /
• 제46권2호
• /
• pp.37.2-37.2
• /
• 2021

Turbulence produces the density and velocity fluctuations in molecular clouds, and dense regions within the density fluctuation are the birthplace of stars. Also, turbulence can produce non-thermal pressure against gravity. Thus, turbulence plays a crucial roles in controlling star formation. However, despite many years of study, the detailed relation between turbulence and star formation remain poorly understood. As part of the Taeduk Radio Astronomy Observatory (TRAO) Key Science Program (KSP), "mapping Turbulent properties In star-forming MolEcular clouds down to the Sonic scale (TIMES; PI: Jeong-Eun Lee)", we mapped two star-forming molecular clouds, the Orion A and the ρ Ophiuchus molecular clouds, in six molecular lines (¹³CO 1-0/C¹⁸O 1-0, HCN 1-0/HCO⁺ 1-0, and CS 2-1/N₂H⁺ 1-0) using the TRAO 14-m telescope. We applied the Principal Component Analysis (PCA) to the observed data in two different ways. The first method is analyzing the variation of line intensities in velocity space to evaluate the velocity power spectrum of underlying turbulence. We investigated the relation between the star formation activities and properties of turbulence. The other method is analyzing the variation of the integrated intensities between the molecular lines to find the characteristic correlation between them. We found that the HCN, HCO⁺, and CS lines well correlate with each other in the integral shaped filament in the Orion A cloud, while the HCO⁺ line is anti-correlate with the HCN and CS lines in L1688 of the Ophiuchus cloud.

• 한국과학예술포럼
• /
• 제26권
• /
• pp.339-351
• /
• 2016

본 연구의 목적은 전 세계의 주요 국제 컨벤션 도시를 중심으로 컨벤션 관광 목적지 브랜드 슬로건을 분석하는 것이다. 자료 수집은 2013년 10개 이상의 국제회의를 개최한 190개 도시의 공식 관광 웹사이트를 통해 이루어졌다. 이중에서 확인된 106개 목적지 브랜드 슬로건의 언어적 표현과 시각적 표현에 대한 내용분석을 실시하였다. 분석 결과, 슬로건의 구조면에서 단어형과 구형이 다수로 간결성을 추구하고 있으며, 스펙트럼 유형에 있어서는 지역 특성과 혜택을 드러내지 못하는 보편형 슬로건이 절반을 차지하였으며, 핵심 용어에 있어서는 'visit, city'를 가장 많이 사용하였다. 한편, 시각적 관점에서 슬로건의 글자체는 명시성이 있는 타이포그래피가 약 70%였으며, 슬로건의 60%가 인문과 자연자원을 이미지화 대상으로 선정하여 차별적 이미지 구축을 도모하는 것으로 나타났다. 또한 본 연구결과에 대한 전문가 회의를 통해 향후 효과적인 컨벤션 관광 목적지 브랜드 슬로건 개발에 대한 시사점을 도출하였다.

• Advances in Energy Research
• /
• 제8권1호
• /
• pp.73-93
• /
• 2022

Focus on climate change and extreme weather conditions has received considerable attention in recent years. Civil engineers are now focusing on designing buildings that are more eco-friendly in the face of climate change. This paper describes the research conducted to assess the impact of future climate change on energy usage and carbon emissions in a typical supermarket at multiple locations across the UK. Locations that were included in the study were London, Manchester, and Southampton. These three cities were compared against their building performance based on their respective climatic conditions. Based on the UK Climatic Projections (UKCP09), a series of energy modelling simulations which were provided by the Chartered Institute of Building Service Engineers (CIBSE) were conducted on future weather years for this investigation. This investigation ascertains and quantifies the annual energy consumption, carbon emissions, cooling, and heating demand of the selected supermarkets at the three locations under various climatic projections and emission scenarios, which further validates annual temperature rise as a result of climatic variation. The data showed a trend of increasing variations across the UK as one moves southwards, with London and Southampton at the higher side of the spectrum followed by Manchester which has the least variability amongst these three cities. This is the first study which investigates impact of the climate change on the UK supermarkets across different regions by using the real case scenarios.

• 대한토목학회논문집
• /
• 제30권4D호
• /
• pp.387-393
• /
• 2010

본 논문에서는 아스팔트 포장의 균열 성장을 분석하기 위해서 확장유한요소법을 사용하였다. 또한 아스팔트의 점탄성 효과를 고려하기 위하여 맥스웰 체인을 이용한 점탄성 구성방정식을 사용하였으며, 균열 모델로는 선형점성균열 모델을 사용하였다. 특히 점탄성 구성방정식을 구성할 때 측정을 통해 얻어지는 온도별 변형계수와 지연시간을 Prony 급수를 이용해 재구성한 크리프 곡선을 직접 사용하지 않고 연속적인 미분이 가능한 멱승 로그 식으로 대체하여 사용하였다. 멱승 로그 식으로 완화시간 스펙트럼(relaxation spectrum)을 계산하여 맥스웰 체인의 부분탄성계수(partial moduli)를 도출하였다. 멱승 로그 적정 식을 통해 구한 맥스웰 체인의 부분 탄성계수는 크리프 곡선을 직접 이용하는 방법으로 구한 부분 탄성계수 보다 안정적인 형태의 곡선을 나타내어 해석을 용이하게 해준다. 개발된 정적균열 해석 모듈을 이용하여 아스팔트 시편의 온도별 정적균열 성장 실험 결과를 성공적으로 모사할 수 있었다.

• 한국환경농학회지
• /
• 제42권4호
• /
• pp.269-278
• /
• 2023

Antibiotics either kill or inhibit the growth of bacteria. However, antibiotic-resistant bacteria are difficult to treat with antibiotics. Infections caused by such bacteria often lead to severe diseases. Antibiotic resistance genes (ARG) can be horizontally transmitted across different bacterial species, necessitating a comprehensive understanding of how ARGs spread across various environments. In this study, we analyzed the plasmid sequences of 33 extended-spectrum beta-lactamases (ESBL) producing Escherichia coli isolated from pigs, farms, and their owners. We conducted an antibiotic susceptibility test (AST) with aztreonam and seven other antibiotics, as well as whole genome sequencing (WGS) of the strains using MinION. Our results demonstrated that the plasmids that did not harbor ARGs were mostly non-conjugative, whereas the plasmids that harbored ARGs were conjugative. The arrangement of these ARGs exhibited a pattern of organization featuring a series of ARG cassettes, some of which were identical across the isolates collected from different sources. Therefore, this study suggests that the sets of ARG cassettes on plasmids were mostly shared between pigs and their owners. Hence, enhanced surveillance of ARG should be implemented in farm environments to proactively mitigate the risk of antibiotic-resistant bacterial infections.

• 한국건축시공학회지
• /
• 제23권5호
• /
• pp.595-605
• /
• 2023

모듈러 건축 사례가 많아지면서 모듈러 건축에 관한 관심이 높아지고 적용 대상 범위가 확대되고 있다. 모듈러 건축의 장점 중 하나는 공장제작을 통한 우수한 품질의 건축물을 안정적으로 공급할 수 있는 것이다. 이를 위해, 현장 양중 및 설치 단계까지 품질관리를 위한 노력과 방법 적용이 필수적이다. 본 연구는 현재 현장 양중 및 설치 단계에서 품질유지 및 관리에 적용하고 있는 방안들의 중요도와 예방효과를 프로젝트 참여자들을 대상으로 설문조사를 실시하고, 이를 IPA 방법으로 분석하였다. 그 결과, 대부분의 품질 유지 및 관리 방법이 잘 적용되고 있으나, 프로젝트 참여자들간 일부 항목들에 대한 인식 차이가 있음을 확인하였고, 이에 대한 개선방안을 제시하였다. 본 연구 결과는 추후 프로제트 참여자들의 현장설치단계 품질관리 인식개선을 위한 연구에 활용할 수 있다.

• Korean Journal of Radiology
• /
• 제20권1호
• /
• pp.126-133
• /
• 2019

Objective: To compare the lumbar vertebral bone marrow fat-signal fractions obtained from six-echo modified Dixon sequence (6-echo m-Dixon) with those from single-voxel magnetic resonance spectroscopy (MRS) in patients with low back pain. Materials and Methods: Vertebral bone marrow fat-signal fractions were quantified by 6-echo m-Dixon (repetition time [TR] = 7.2 ms, echo time (TE) = 1.21 ms, echo spacing = 1.1 ms, total imaging time = 50 seconds) and single-voxel MRS measurements in 25 targets (23 normal bone marrows, two focal lesions) from 24 patients. The point-resolved spectroscopy sequence was used for localized single-voxel MRS (TR = 3000 ms, TE = 35 ms, total scan time = 1 minute 42 seconds). A 2 × 2 × 1.5 cm³ voxel was placed within the normal L2 or L3 vertebral body, or other lesions including a compression fracture or metastasis. The bone marrow fat spectrum was characterized on the basis of the magnitude of measurable fat peaks and a priori knowledge of the chemical structure of triglycerides. The imaging-based fat-signal fraction results were then compared to the MRS-based results. Results: There was a strong correlation between m-Dixon and MRS-based fat-signal fractions (slope = 0.86, R² = 0.88, p < 0.001). In Bland-Altman analysis, 92.0% (23/25) of the data points were within the limits of agreement. Bland-Altman plots revealed a slight but systematic error in the m-Dixon based fat-signal fraction, which showed a prevailing overestimation of small fat-signal fractions (< 20%) and underestimation of high fat-signal fractions (> 20%). Conclusion: Given its excellent agreement with single-voxel-MRS, 6-echo m-Dixon can be used for visual and quantitative evaluation of vertebral bone marrow fat in daily practice.