• Journal of Ginseng Research
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• v.16 no.3
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• pp.235-260
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• 1992

• Journal of Microbiology and Biotechnology
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• v.26 no.12
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• pp.2214-2223
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• 2016

Toll-like receptors (TLRs) can recognize conserved molecular patterns and initiate a wide range of innate and adaptive immune responses against invading infectious agents. The aim of this study was to assess the transcript profile of mink TLRs (mTLRs) in mink peripheral blood mononuclear cells (PBMCs) and a range of tissues, and to explore the potential role of mTLRs in the antiviral immune response process. The results indicated that the mTLR partial nucleotide sequences had a high degree of nucleotide identity with ferret sequences (95-98%). Phylogenetic analysis showed that mammalian TLRs grouped into five TLR families, with a closer relationship of the mTLRs with those of ferret than the other mammalian sequences. Moreover, all the mTLRs were ubiquitously expressed in lymphoid organs (spleen and lymph nodes) and PBMCs. Interestingly, the mTLR expression patterns in lung, uterus, and heart showed quite a lot of similarity. Another remarkable observation was the wide expression of mTLR1-3 mRNAs in all tissues. Among the analyzed tissues, skeletal muscle was revealed to being the lowest repertoire of mTLR expression. Additionally, mink PBMCs exposed to the canine distemper virus revealed significant upregulation of mTLR2, mTLR4, mTLR7, and mTLR8 mRNAs, indicating that mTLRs have a role in innate immunity in the mink. Collectively, our results are the first to establish the basic expression patterns of mTLRs and the relationship between mTLRs and a virus, which will contribute to better understanding of the evolution and the functions of mTLRs in the innate immune system in minks.

• Proceedings of the Ginseng society Conference
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• 1990.06a
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• pp.190-195
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• 1990

• Journal of Ginseng Research
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• v.14 no.2
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• pp.332-337
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• 1990

• Journal of Plant Biology
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• v.18 no.2
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• pp.45-52
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• 1975

Effects of air pollutants on vegetation were reviewed and discussed with special reference to sulfur dioxide. Main contents were on the sources, meteorological factors, injury symptoms, relative sensitivity, growth/yield, indicator/diagnosis, combined effects, injury mechanism and effects on plant metabolism, injury diminishing measures, and future research needs.

• Korean Journal Plant Pathology
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• v.3 no.4
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• pp.304-312
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• 1987

• 연구논문집
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• s.24
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• pp.119-128
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• 1994

A special steels have been developed for the possible applications of turbine blade in nuclear power plant. The compositions of developed alloy were selected by the reference of imported alloy. The various properties such as tensile property, impact energy, hardness, and microstructures were investigated. All the properties of optimum heat treated materials were satisfied with the present specifications of turbine blade materials in unclear power plant. Furthermore, FATT(Fracture appearance transition temperature), high temperature tensile properties, and transformation temperatures of developed alloy also have been studied.

• Journal of Ginseng Research
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• v.42 no.3
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• pp.343-351
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• 2018

Background: Red ginseng is a popularly used traditional medicine with antiaging effects in Asian countries. The present study aimed to explore the changes in protein expression underlying the mechanisms of life span extension and antiaging caused by red ginseng extract (RGE) in Drosophila melanogaster. Methods: A proteomic approach of two-dimensional polyacrylamide gel electrophoresis (2-DE) was used to identify the differential abundance of possible target proteins of RGE in D. melanogaster. The reliability of the 2-DE results was confirmed via Western blotting to measure the expression levels of selected proteins. Proteins altered at the expression level after RGE treatment (1 mg/mL) were identified by matrix-assisted laser desorption/ionization-time of flight tandem mass spectrometry and by searching against the National Center for Biotechnology nonredundant and Uniprot protein databases. The differentially expressed proteins were analyzed using bioinformatics methods. Results: The average survival life span of D. melanogaster was significantly extended by 12.60% with RGE treatment (1 mg/mL) compared to untreated flies. This followed increased superoxide dismutase level and decreased methane dicarboxylic aldehyde content. Based on the searching strategy, 23 differentially expressed proteins were identified (16 up-regulated and 7 down-regulated) in the RGE-treated D. melanogaster. Transduction pathways were identified using the Kyoto Encyclopedia of Genes and Genomes database, and included the hippo and oxidative phosphorylation pathways that play important roles in life span extension and antiaging process of D. melanogaster. Conclusion: Treatment with RGE in D. melanogaster demonstrated that mechanisms of life span extension and antiaging are regulated by multiple factors and complicated signal pathways.

• Journal of Ecology and Environment
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• v.46 no.3
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• pp.273-275
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• 2022

• Journal of the Korean Society of Systems Engineering
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• v.14 no.1
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• pp.1-12
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• 2018

In the energy-guzzling industries such as steel making and cement, power plants utilizing waste heat have been attracting attention to increase energy efficiency. However, the existing economic analysis system doesn't consider the special working fluids and the cost models of the main equipment used in the waste heat recovery power plant. So it is difficult to estimate the plant economics accurately. Therefore, It is required to develop a economic analysis module that can more accurately evaluate for the power plant. In this study, the systems engineering approach was used to design and develop the module that systematically reflects the characteristics of the power plant and various requirements. Specifically, first, the special working fluids and main equipment applied to the power plant were investigated. Next, the cost models for each equipment were developed. Finally, the economic analysis module based on this was developed.