• Journal of Ginseng Research
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• 제42권3호
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• pp.343-351
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• 2018

Background: Red ginseng is a popularly used traditional medicine with antiaging effects in Asian countries. The present study aimed to explore the changes in protein expression underlying the mechanisms of life span extension and antiaging caused by red ginseng extract (RGE) in Drosophila melanogaster. Methods: A proteomic approach of two-dimensional polyacrylamide gel electrophoresis (2-DE) was used to identify the differential abundance of possible target proteins of RGE in D. melanogaster. The reliability of the 2-DE results was confirmed via Western blotting to measure the expression levels of selected proteins. Proteins altered at the expression level after RGE treatment (1 mg/mL) were identified by matrix-assisted laser desorption/ionization-time of flight tandem mass spectrometry and by searching against the National Center for Biotechnology nonredundant and Uniprot protein databases. The differentially expressed proteins were analyzed using bioinformatics methods. Results: The average survival life span of D. melanogaster was significantly extended by 12.60% with RGE treatment (1 mg/mL) compared to untreated flies. This followed increased superoxide dismutase level and decreased methane dicarboxylic aldehyde content. Based on the searching strategy, 23 differentially expressed proteins were identified (16 up-regulated and 7 down-regulated) in the RGE-treated D. melanogaster. Transduction pathways were identified using the Kyoto Encyclopedia of Genes and Genomes database, and included the hippo and oxidative phosphorylation pathways that play important roles in life span extension and antiaging process of D. melanogaster. Conclusion: Treatment with RGE in D. melanogaster demonstrated that mechanisms of life span extension and antiaging are regulated by multiple factors and complicated signal pathways.

• Steel and Composite Structures
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• 제25권3호
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• pp.327-335
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• 2017

To gain more knowledge of aluminum foam sandwich structure and promote the engineering application, aluminum foam sandwich consisting of 7050 matrix aluminum foam core and 304 stainless steel face-sheets was studied under three-point bending by WDW-T100 electronic universal tensile testing machine in this work. Results showed that when aluminum foam core was reinforced by 304 steel face-sheets, its load carrying capacity improved dramatically. The maximum load of AFS in three-point bending increased with the foam core density or face-sheet thickness monotonically. And also when foam core was reinforced by 304 steel panels, the energy absorption ability of foam came into play effectively. There was a clear plastic platform in the load-displacement curve of AFS in three-point bending. No crack of 304 steel happened in the present tests. Two collapse modes appeared, mode A comprised plastic hinge formation at the mid-span of the sandwich beam, with shear yielding of the core. Mode B consisted of plastic hinge formation both at mid-span and at the outer supports.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2003년도 추계학술대회
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• pp.1625-1630
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• 2003

An iterative modal analysis approach is developed to determine the effect of the transverse open cracks and the moving mass on the dynamic behavior of simply supported pipe conveying fluid. The equation of motion is derived by using Lagrange's equation. The influences of the velocity of moving mass, the velocity of fluid flow and a crack have been studied on the dynamic behavior of a simply supported pipe system by numerical method. The crack section is represented by a local flexibility matrix connecting two undamaged beam segments. that is, the crack is modelled as a rotational spring. Totally, as the velocity of fluid flow is increased, the mid-span deflection of simply supported pipe conveying fluid is increased. The position of the crack is middle point of the pipe, the mid-span deflection of simply supported pipe presents maximum deflection.

• Wind and Structures
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• 제10권3호
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• pp.215-232
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• 2007

This paper presents an aeroelastic analysis procedure to highlight the influence of wind velocity on the structural damping and frequency of a long span cable-stayed bridge. Frequency dependent self-excited forces in terms of flutter derivatives are expressed as continuous functions using rational function approximation technique. The aeroelastically modified structural equation of motion is expressed in terms of frequency independent modal state-space parameters. The modal logarithmic dampings and frequencies corresponding to a particular wind speed are then determined from the eigen solution of the state matrix.

• 대한기계학회논문집A
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• 제28권4호
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• pp.419-426
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• 2004

In this paper, studied about the effect of open crack and the moving mass on the dynamic behavior of simply supported pipe conveying fluid. The equation of motion is derived by using Lagrange's equation. The influences of the velocity of moving mass, the velocity of fluid flow and a crack have been studied on the dynamic behavior of a simply supported pipe system by numerical method. The crack section is represented by a local flexibility matrix connecting two undamaged beam segments. Therefore, the crack is modelled as a rotational spring. Totally, as the velocity of fluid flow is increased, the mid-span deflection of simply supported pipe conveying fluid is increased. The position of the crack is located in the middle point of the pipe, the mid-span deflection of simply supported pipe presents maximum deflection.

• 한국경영과학회지
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• 제6권1호
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• pp.25-32
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• 1981

The optimum design problem of a proposed oil pipeline network has been formulated as a zero-one programming model to determine the optimum sizes of pipe and pump which minimize the sum of material costs and operating costs during the 20 years of life span. Applying to a real situation, the problem constitutes an assignment type zero-one programming with 372 zero-one variables and 13 constraints. A heuristic algorithm has been developed based on the modified Petersen algorithm utilizing the special form of the activity matrix. The results showed impressive cost savings of 37 percent of the total cost from the original proposal.

• 호남수학학술지
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• 제29권3호
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• pp.427-443
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• 2007

The spanning column rank of an $m{\times}n$ integer matrix A is the minimum number of the columns of A that span its column space. We compare the spanning column rank with column rank of matrices over the ring of integers. We also characterize the linear operators that preserve the spanning column rank of integer matrices.

• Structural Engineering and Mechanics
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• 제62권1호
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• pp.85-95
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• 2017

This paper presents an explicit analytical iteration method for form-finding analysis of suspension bridges. By extending the conventional analytical form-finding method predicated on the elastic catenary theory, two nonlinear governing equations are derived for calculating the accurate unstrained lengths of the entire cable systems both the main cable and the hangers. And for the gradient-based iteration method, the derivation of explicit calculation for the Jacobian matrix while solving the nonlinear governing equation enhances the computational efficiency. The results from sensitivity analysis show well performance of the explicit Jacobian matrix compared with the traditional finite difference method. According to two numerical examples of long span suspension bridges studied, the proposed method is also compared with those reported approaches or the fundamental criterions in suspension bridge structural analysis, which eventually confirms the accuracy and efficiency of the proposed approach.

• Journal of Pharmaceutical Investigation
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• 제35권3호
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• pp.173-177
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• 2005

Addition of 30% propylene glycol was required to maintain sink condition in the evaluation of percutaneous absorption of estradiol and norethindrone acetate. The permeability of estradiol was higher in silicone and SIS adhesives. However, estradiol was crystallized in silicone, SIS, and SBS adhesive matrix. The permeability ratio of estradiol or norethindrone acetate from acrylic pressure sensitive adhesives varied widely depending on the functional group of the acrylic adhesives. PEO grafting to acrylic adhesive seemed to change physicochemical property of acrylic adhesive and increased the permeability of estradiol and norethindrone acetate significantly. On the contrary, highly cross-linked enhancer compatible acrylic adhesive decreased the permeability of both estradiol and norethindrone acetate. $Span^{\circledR}$ 20 provided the highest enhancing effect on the permeability of both estradiol and norethindrone acetate followed by oleic acid and $Crovol^{\circledR}$ EP40. The permeability of the drugs from the developed system was comparable to that from commercial $Combitran^{\circledR}$, although significantly lower amount of estradiol and norethindrone acetate were loaded in the developed system.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2014년도 춘계 학술논문 발표대회
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• pp.236-237
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• 2014

Recently, it changes to the frame construction in the wall type structure for the life span improvement of the apartment house of our country. The execution of the light panel increased while the execution of the frame construction increased. Therefore, the density and absorption ratio of the magnesium oxide matrix according to the wood flour amount of addition ratio property try to be analyze for the lightweight of the surface material of the light panel. The test result, the density has been declined as the addition ratio increase of the wood flour. In the case of the water absorption ratio, water absorption ratio has been increased as addition ratio increase of wood flour. However, wood flour addition ratio 15% determined the most appropriate when considering the density and water absorption ratio.