• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.5
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• pp.1159-1165
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• 2006

This study was done to investigate the effects of Gamisojaganggi-tang(GSGT) on immunopathologic changes in OVA-induced asthma model of mice. Pathologic indicators associated with this immune disease, which include cytokines, the number of immune-cells, immunoglobin E (IgE), were examined, and histological changes of bronchial tissues were also examined. The administration of GSGT significantly reduced the lung weight compared with control mice of OVA-induced asthma model. The administration of GSGT significantly reduced the number of total cells in BALF compared with control mice of OVA-induced asthma model. The administration of GSGT significantly reduced the number of eosinophil in BALF compared with control mice of OVA-induced asthma model. The administration of GSGT insignificantly increased the number of monocyte in BALF compared with control mice of OVA-induced asthma model. The administration of GSGT significantly reduced the number of lymphocyte in BAL compared with control mice of OVA-induced asthma model. The administration of GSGT significantly reduced the gene expression of eotaxin in lung tissue compared with control mice of OVA-induced asthma model. The administration of GSGT insignificantly reduced the IL-4 and IL-5 production in BALF compared with control mice of OVA-induced asthma model. The administration of GSGT insignificantly reduced the levels of total IgE and ovalbumin-specific IgE in BALF. The administration of GSGT significantly reduced the levels of ovalbumin-specific IgE whereas the serum levels of total IgE were insignificantly reduced compared with control mice of OVA-induced asthma model. The administration of GSGT moderately reduced bronchial alveolar narrowing, bronchiovascular edema and increase in the size of alveolar space, which shown in control mice of OVA-induced asthma model, in a dose dependent manner. Furthermore, GSGT reduced invasion of inflammatory cells, and proliferation of smooth muscle cells in bronchial tissue. These results suggested that GSGT has suppressive effects on pathologic changes associated with disease progression in asthma through the modulation of immune system. GSGT has potential to use as an anti-asthmatic agents.

• Parasites, Hosts and Diseases
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• v.25 no.2
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• pp.99-109
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• 1987

The present study was carried out to examine the effect of a calcinogen, aflatoxin B1 on the ultrastructural changes of ciliary epithelial cells in mice infected with Clonerchis sinensis. A total of 93 male albino mice(BALB/c strain) was divided into 3 groups; group I, treated with 1.0 ppm aflatoxin Bl for 12 weeks; group II, given 50 C. sinensis n;etacercariae, and group III, given 50 metacercariae and treated with 1.0 ppm aflatoxin Bl for 12 weeks. Three mice served for untreated-uninfected controls. From 4 weeks after the treatsment and/or in(ection, three mice from each group were sacrificed at 4 week intervals up to the 40th week, and their hepatobiliary tissues were prepared for transmission electron microscopy. The most prominent ultrastructural changes in group I were remarkable enlargement of nuclear size, separation of nucleolus, dispersed chromatin granules in nuclei and increased dense granules along the inner membrane of nuclei. In the cytoplasm there was slight proliferation of mitochondria and endoplasmic reticulum (ER) at earlier stage. At the 12th week separation of fibrillar and granular components of the nucleolus was a characteristic finding. As the time elapsed, epithelial cells showed fiattened-cuboidal form and a tendency of atrophy. Most of the nuclei were elongated and polygonal in shape. In group II the appearance of elaborate interwoven folds of lateral cytoplasm forming a labyrinth of interconnected intercellular space and variety in nuclear shape were the prominent fadings at earlier stage. The cytoplasm showed slight proliferation and dilatation of mitochondria and ER, and a small number of mucin droplets. In the basement membrane scanty fibrous cells were seen. With time, variety in nuclear shape, marked proliferation and dilatation of rough ER and some collagen fibrils were demonstrated. Other features of intracellular organelles and mucin droplets persisted. In group III cuboidal epithelial cells showed their remarkably enlarged and irregular nuclei, increased chromatin granules in the nuclei, separated nucleoli, proliferated and dilated rough ER. With time, sequestered mitochondria showed blob-like evaginations which lacked cristae and dense matrix, and were limited by a single membrane. Since the 20th week, microvilli were relatively scanty and poorly developed. Organelles and inclusions in the cytoplasm of metaplastic cells were poor. Nuclei were variable in shape. The nlost prominent changes at later stage were separation of nuclei from the cytoplasm, and appearance of numerous and irregularly angled electron dense granules in the nuclei.

• The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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• v.21 no.3
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• pp.103-111
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• 2016

Seasonal dynamics of kelp forest-forming algae, Ecklonia cava population formed following the large-scale disturbance by Typhoon 'Bolaven' in August 2012 were investigated in Jeju Island, Korea. Morphological characteristics, recruits density, mortality rate, total density and biomass were monitored bimonthly from June 2013 to June 2015. Total and longest blade lengths, and individual weight of E. cava showed distinct seasonal trends. Stipe length increased from winter to spring, but did not show increase or reduced from summer to autumn. This indicates that morphological characteristics of E. cava are mainly affected by the change of blades. The optimal temperature for E. cava growth was about $15-18^{\circ}C$ during winter to spring while the growths were inhibited at the water temperature above $20^{\circ}C$ during summer. E. cava exhibited very low recruitment during spring-summer. However, high recruitment was observed on April 2015 when canopy cover was very low due to low density. This indicates that recruitment of E. cava was controlled not by seasonal effects but by physical factors such as canopy and space. The mortality rate of juvenile plants was highest due to their unstable settlement. By June 2015, 34 months after the disturbances, E. cava was almost recovered to the pre-disturbance population size structure. These results suggest that recovery of kelp forest following the large-scale disturbance requires a considerable period of time (more than three years). This study should provide valuable ecological information on management, restoration and protection of kelp species.

• Journal of Korea Multimedia Society
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• v.5 no.4
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• pp.372-385
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• 2002

In this paper, we propose an efficient buffer replacement method for the real-time multimedia data. The proposed method has multi level priority to consider the real-time characteristics. Each priority level is divided into a cold data set that is likely to be referenced for the first time and a hot data set that is likely to be re-referenced. An operation to select the victim data is sequentially executed from the cold set with the minimum priority level to the hot set with the maximum Priority level. It is chosen only at the lower level than or equal to the priority of the transaction that requests a buffer allocation. In the cold set, our method selects a media that has the maximum size in the level for a target of victim first of all. And in the hot set, our method selects a medium that has the maximum interval of the reference first of all. Since it maintains many popular media in the limited buffer space, the buffer hit ratio is increased. It also manages many service requests. As a result, our method improves the overall performance of the system. We compare the proposed method with the Priority-Hints method in terms of the buffer hit ratio and the deadline missing ratio of transactions. It is shown through the performance evaluation that our method outperforms the existing methods.

• Journal of Navigation and Port Research
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• v.32 no.6
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• pp.499-503
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• 2008

As the conference result of MEPC in IMO, development of ballast water management system corresponding to newly established ballast water management standard (D2 regulation) of shipping is being made an active progress over the whole world. The ballast water management system should treat particular material of more than $10{\mu}m$ in high capacity of more than 500t per hour in the event of filtration process. Also, it is very difficult to develop a practical management system since a limited element which a narrow space of the ship should be designed in the minimal volume is assumed. Therefore, the study promoted a study on the next generation auto back wash media filter to overcome such a limited element. Also, the study performed pressure and flux measurement test followed by thickness of each filter medium for filtration by each size to grasp a relation between absorption and pressure at the time of vacuum filtration and mechanical analysis and turbidity change observation of filtered water after vacuum filtration.

• Journal of dental hygiene science
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• v.12 no.6
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• pp.566-571
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• 2012

Marginal and internal fit are very important factor for the clinical long-term success of fixed dental prostheses (FDPs). A variety of methods have been applied to the measuring marginal and internal fit of FDPs. The purpose of this study was to compare the marginal and internal fit of 2 different measuring methods silicone replica technique [SRT] and die cutting technique (DCT). SRT, the space between die and FDPs were filled with light-body silicone, then stabilized by medium-body silicone. DCT, the FDPs were cemented on definitive dies and embedded into epoxy. The silicone replicas and epoxies were sectioned mesio-distal and measured 4 locations (margin, rounded chamfer, axial, occlusal) and using a digital microscope at a magnification $\times$160. For the SRT the mean${\pm}$SDs fit (${\mu}m$) recorded were: margin $88.7{\pm}22.2$, rounded chamfer $90.6{\pm}25.0$, axial wall $61.5{\pm}21.8$, occlusal $134.9{\pm}30.8$. For the DCT the mean${\pm}$SDs fit (${\mu}m$) recorded were: margin $85.3{\pm}18.0$, rounded chamfer $85.4{\pm}24.7$, axial wall $62.0{\pm}21.3$, occlusal $131.7{\pm}30.5$. The mean${\pm}$SDs size (${\mu}m$) of SRT margin was $88.7{\pm}22.2$ and of DCT margin was $85.3{\pm}18.0$. There were no statistically significant difference (p<0.05) of the four parts between SRT and DCT. It is considered an appropriate case to use SRT at fit of FDPs.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.12 no.11
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• pp.2083-2090
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• 2008

In this paper, we propose a method for control of temperature and the direction of wind in an air-cooler using thermal images and fuzzy inference rules in order to achieve energy saving. In a simulation for controlling temperature, a thermal image is transformed to a color distribution image of $300{\times}400$ size to analyze the thermal image. A color distribution image is composed of R, G and B values haying temperature values of Red, Magenta, Yellow, Green, Cyan and Blue. Each color has a temperature value from $24.0^{\circ}C$ to $27.0^{\circ}C$ and a color distribution image is classified into height hierarchies from level 1 to level 10. The classified hierarchies have their peculiar color distributions and temperature values are assigned to each level by temperature values of the peculiar colors. The process for controlling overall balance of temperature and the direction of wind in an indoor space is as follows. Fuzzy membership functions are designed by the direction of wind, duration time, and temperature and height values of a color distribution image to calculate the strength of wind. After then, the strength of wind is calculated by membership values of membership functions.

• Journal of The Korea Institute of Healthcare Architecture
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• v.27 no.3
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• pp.71-78
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• 2021

Purpose: It is important to plan the ward module at a time when the size of beds, the floor area, and the construction budget are all set prior to the hospital design. In this context this study aims (1) to derive various factors affecting the ward module, and (2) to analyze the appropriate room module according to the type. Methods: Design factors related to hospital modules are derived through precedential studies, and the types of ward elevation are classified by reviewing the drawings of 18 case hospitals. And the detailed dimensions and area of the derived elements are analyzed. Results: The X-axis modules of the ward are switched to long span structural columns of 9.9 m, 12.6 m and 13.2 m, but the ward modules still represent 6.6 m. The Y-axis module of the ward shows a dimension of 9 to 9.9m in the process of changing a multi-person room into a four-person room. Type A of curtain wall with columns located on the wall of the room and type B of curtain wall located in the center of the room are analyzed due to their variations. The square window type, which forms the elevation of the square window by exposing the columns to the elevation, and the outframe type, which protrudes from the structural columns and beams, have elevation designs limited. There are, however, no obstacles to the interior space of the hospital room, so the wall composition and furniture arrangement are expected to be free. The ward area of Curtain Wall Type A, which can secure an effective area of 5.9m*5.0m, are 52.1m². The Curtain Wall Type A, Square window type, and the outframe type are 49.8m². Implications: As part of the hospital standard module plan for economical and reasonable hospital building planning, a type was proposed in this study in conjunction with the external design. It is hoped that it be a base for standard module research linked together to the Central Treatment department, Outpatient department and underground parking lot.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.24 no.2
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• pp.39-56
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• 2021

The seed zone is a map that describes the areas where plant material can be transferred with little risk for properly adapting to a new location. The seed zone study is largely divided into studies based on genetic data and studies based on climatic data. Can be. This study was conducted to establish a temporary domestic seed zone applicable to the entire Korean Peninsula and evaluate its possibility based on the US climate-based seed zone establishment methodology. The temporary seed zone was constructed in the same way as the US case by superimposing the data obtained by dividing the winter minimum temperature into 12 grades and the data obtained by dividing the annual heat: moisture index into 6 grades. As a result of the analysis, 65 temporary seed zones were formed throughout the Korean Peninsula, and the areas of the seed zones representing the smallest and largest areas were 3.0km² and 29,423.0km², respectively, and it was confirmed that they had an average size of about 5,064.9km². Temporary seed zones applied in Korea show a pattern of changes in temperature according to the relatively horizontal forest zone, and it was confirmed that the area where the Baekdu-daegan ecological axis is located has a tendency to show lower dryness than other areas. This study applied the US climate-based seed zone methodology in Korea as a pilot, and confirmed the climatic similarity across the Korean Peninsula. Furthermore, it is expected to provide an optimal seed map that improves the success rate of restoration in the future by revising the seed zone grade suitable for the domestic environment in consideration of the results of this study and the possibility of seed adaptation to the field survey and environmental space.

• Journal of Korea Water Resources Association
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• v.51 no.12
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• pp.1181-1194
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• 2018

This study suggests a novel approach of estimating stream flow discharge using the Synthetic Aperture Radar (SAR) images taken from 2015 to 2017 by European Space Agency Sentinel-1 satellite. Fifteen small to medium sized rivers in the Han River basin were selected as study area, and the SAR satellite images and flow data from water level and flow observation system operated by the Korea Institute of Hydrological Survey were used for model construction. First, we apply the histogram matching technique to 12 SAR images that have undergone various preprocessing processes for error correction to make the brightness distribution of the images the same. Then, the flow estimation model was constructed by deriving the relationship between the area of the stream water body extracted using the threshold classification method and the in-situ flow data. As a result, we could construct a power function type flow estimation model at the fourteen study areas except for one station. The minimum, the mean, and the maximum coefficient of determination ($R^2$) of the models of at fourteen study areas were 0.30, 0.80, and 0.99, respectively.