• 사상체질의학회지
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• 제19권3호
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• pp.62-74
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• 2007

1. Objectives This study is a pilot study to investigate the Mongolian's morphologic characteristics of face according to Sasang Constitution. 2. Methods We had collected 100 cases of Mongolian and took pictures their frontal view, lateral view of face and measured height, breaths and projected length of face with Face Features Measurement Program(FFMP) and analyzed shape differences of face according to Sasang constitution. 3. Results and Conclusions (1) In the frontal view of female, there were 11 items(total 322 items) significantly different among three constitutions, and in lateral view 13 items(total 191 items). (2) In the frontal view of male, there were 88 items(total 322 items) significantly different among three constitutions, and in lateral view 46 items(total 191 items).

• 천문학논총
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• 제30권3호
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• pp.811-819
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• 2015

The e-CALLISTO is a network of CALLISTO (Compact Astronomical Low-frequency, Low-cost Instrument for Spectroscopy in Transportable Observatories) spectrometers which detect solar radio bursts 24 hours a day in frequency range 45-870 MHz. The number of channels per spectrum is 200 and the time resolution of whole spectrum is 0.25 second. The Korean e-CALLISTO station was developed by Korea Astronomy and Space Science Institute (KASI) collaborating with Swiss Federal Institute of Technology Zurich (ETH Zurich) since 2007. In this paper, we report replacement of the tracking mount and development of the control program using Visual C++/MFC. The program can make the tracking mount track the Sun and schedule CALLISTO to start and to finish its observation automatically using the Solar Position Algorithm (SPA). Daily tracking errors (RMSE) are 0.0028 degree in azimuthal axis and 0.0019 degree in elevational axis between 2014 January and 2015 July. We expect that the program can save time and labor to make the observations of solar activity for space weather monitoring, and improve CALLISTO data quality due to the stable and precise tracking methods.

• International Journal of Oral Biology
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• 제41권4호
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• pp.253-262
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• 2016

Streptococcus mutans (S. mutans) is one of the most important bacteria in the formation of dental plaque and dental caries. S. mutans adheres to an acquired pellicle formed on the tooth surface, and aggregates with many oral bacteria. It initiates plaque formation by synthesizing glucan from sucrose, which is catalyzed by glucosyltransferases. Propolis is a resinous mixture produced by honeybees, by mixing saliva and beeswax with secretions gathered from wood sap and flower pollen. Bees prevent pathogenic invasions by coating the propolis to the outer and inner surface of the honeycomb. Propolis has traditionally been used for the treatment of allergic rhinitis, asthma and dermatitis. We investigated the inhibitory effects of propolis ethanol extract on biofilm formation and gene expression of S. mutans. The biofilm formation of S. mutans was determined by scanning electron microscopy (SEM) and safranin staining. We observed that the extract of propolis had an inhibitory effect on the formation of S. mutans biofilms at concentrations higher than 0.2 mg/ml. Real-time PCR analysis showed that the gene expression of biofilm formation, such as gbpB, spaP, brpA, relA and vicR of S. mutans, was significantly decreased in a dose dependent manner. The ethanol extract of propolis showed concentration dependent growth inhibition of S. mutans, and significant inhibition of acid production at concentrations of 0.025, 0.05, 0.1 and 0.2 mg/ml, compared to the control group. These results suggest that the ethanol extract of propolis inhibits gene expression related to biofilm formation in S. mutans.

• 대한한방소아과학회지
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• 제25권3호
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• pp.77-84
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• 2011

Objectives: This study was performed to investigate the effect of hot spring therapy on children weight, body composition and heart rate variability. Methods: The study was carried out from 30 children who visited the spa from August 1, 2011 to August 31, 2011. We measured the change of weight, body composition, and heart rate variability after hot spring therapy for an hour per day. Results: The subject was consisted of 13 boys and 17 girls. This study revealed that their weight got lost from a hot spring therapy, which was statistically significant. Their body mass index(BMI) was decreased in from a hot spring therapy, which was not statistically significant. Total body water, muscle, protein, and mineral were decreased from a hot spring therapy, which was statistically significant. We measured HRV(heart rate variability) before and after the hot spring therapy. The mean HRT was increased, which was statistically insignificant. SDNN(standard deviation of the NN interval) and RMSSD(square root of the mean of the sum of the square of differences) were not different before and after the hot spring therapy. ln TP was decreased insignificantly. ln VLF was not affected before and after hot spring therapy. ln LF and ln HF was decreased, LF norm was increased, and HF norm was decreased, which were not statistically significant. Also, LF/HF ratio was increased insignificantly. Conclusions: From these results, we concluded that the weight, total body water, muscle, protein, and mineral got lost from the hot spring therapy. However, the HRV was not affected from the hot spring therapy.

• Bulletin of the Korean Chemical Society
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• 제26권2호
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• pp.285-291
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• 2005

The nonstructural protein 5B (NS5B) of hepatitis C virus (HCV) is the viral RNA-dependent RNA polymerase (RdRp), which is the essential catalytic enzyme for the viral replication and is an appealing target for the development of new therapeutic agents against HCV infection. A small amount of serum from a single patient with hepatitis C was used to get the genome of a Korean HCV isolate. Sequence analysis of NS5B 1701 nucleotides showed the genotype of a Korean isolate to be subtype 1b. The soluble recombinant HCV NS5B polymerase lacking the C-terminal 24 amino acids was expressed and purified to homogeneity. With the highly purified NS5B protein, we established in vitro systems for RdRp activity to identify potential polymerase inhibitors. The rhodanine family compounds were found to be potent and specific inhibitors of NS5B from high throughput screening (HTS) assay utilizing the scintillation proximity assay (SPA) system. The binding mode of an inhibitor was analyzed by measuring various kinetic parameters. Lineweaver-Burk plots of the inhibitor suggested it binds not to the active site of NS5B polymerase, but to an allosteric site of the enzyme. The activity of NS5B in in vitro polymerase reactions with homopolymeric RNA requires interaction with multiple substrates that include a template/primer and ribonucleotide triphosphate. Steady-state kinetic parameter, such as Km, was determined for the ribonucleotide triphosphate. One of compounds found interacts directly with the viral polymerase and inhibits RNA synthesis in a manner noncompetitively with respect to UTP. Furthermore, we also investigated the ability of the compound to inhibit NS5B-directed viral RNA replication using the Huh7 cell-based HCV replicon system. The investigation is potentially very useful for the utility of such compounds as anti-hepatitic agents.

• 한국실내디자인학회논문집
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• 제6호
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• pp.45-52
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• 1995

The presentation of the method by which the furniture and the architecture can be unified in one category, and the study and the verification on the mutual relation in the shape and the function are having been consistently made till the late twenties. The change of the social structure such as increasing the unit dwelling space with the small scale comes to need the efficiency in using space and the open dwelling space by the systematic spa-cial formation. Therefore, the understanding of the mean-ing and the characteristics of system furnitures as the design method which can meet such needs will be made here in this study. The application of the systematic consideration as the method of interior design means the formation of the firm image on the spacial environment through the mix-ture and link of the heterogeneous factors, the organic connection of each surface, the establishment of the natu-ral relation by linking the heterogeneous materials mutu-ally. and the easiness of the entire plan in the end. This study aims at analyzing and studying the typical charac-teristics by understanding the historical background and methodical principle which enabled the appearance of this kind of thought, and the adapted cases of the wood and metal material system furniture. There may be difference between the structural sub-stance and formative consideration. Transformative furni-ture which consists of the factors is the concept for the encrease of the multi purpose value by mixing the unit cabinets. One system can be separated horizontally, verti-cally, and to the drawers, and it gives us the disengage-ment from the artificial environment, since all the heights and width can be transformed as per each situa-tion of the space. The factors which can not be found in the other existing furniture are as follows. 1. disengagement from the artificial environment. 2. establishing the new productiosn trend as freed from the customers' fashion trend. 3. presenting the producing condition which leads the exact technology. 4. flexibility of the furniture which enables the reduction and enlargement in each situation.

• 한국실내디자인학회논문집
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• 제6호
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• pp.21-27
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• 1995

After the rapid growth of economics in South Korea 1960'1, the number of workers in the whole land in-creased day after day along with the growth of industry. As the growth of the third industry occurred quite rapid-ly, the rate of office workers went up high. Accordingly the business office has been changed the primary work-ing space and recognized the main space as much as the living space. As a result of conceptual change about working place, the business office has an important ef-fect on worker's liberal and psychological environment. In order to provide the office workers with the office work-ers with the suitable and convenient working environ-ment, Socio-psychological factors were first considered at the first stage of construction planning. In this paper, I would understand both how office workers take up their attitudes of Socio-psychological point according to the office type and what they claim for their office environment. This understanding offers us fundamental data in office plan. This paper starting from this purpose got the following conclusions. *Office workers are violated their hearing privacies rather than their visual privacies. They are dissatisfied with ensuring their own spaces and satisfied with their nature of domain. *In the feeling of satisfaction by office type, they are on the whole satisfied with their hearing privacies, their visual privacies, their own space, and the nature of do-main in the closed type and mixed type offices. In open type offices, their visual privacy is often violated. *In the property by individual, men feel more violated their hearing privacies than women. In the personal spa-se and domain, women are less stabilized psycholo-gically than men. *The analysis of the attitude by position, a man of po-sition is more violated his hearing privacy and does not understand each other. The common run of workers are violated their visual privacies and the nature of separa-tion.

• Asian Pacific Journal of Cancer Prevention
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• 제16권4호
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• pp.1443-1448
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• 2015

To investigate the significance of FOXO3a and Ki67 in human lung adenocarcinomas. Envision immunohistochemical staining and Western blotting were used to examine the protein expression of FOXO3a in 127 cases of human lung adenocarcinoma specimens. The positive rate in lung adenocarcinoma (55.9%) was lower than that in normal tissues (80%). We found that the expression of FOXO3a was closely related with the degree of differentiation, TNM staging, lymph node metastasis and survival. In addition, significant differences in the different pathological types of lung adenocarcinoma cases (P<0.01). The FOXO3a positive rate of the acini as the main type (APA) (86.7%) and the lepidic as the main type (LPA) (82.4%) was higher than the solid as the main type (SPA) (50.0%), the papilla as the main type (PPA) (42.9%) and the micropapilla as the main type (MPA) (9.4%). Moreover, the expression of FOXO3a was negatively related with Ki67 expression. Our results suggested that the expression of FOXO3a is closely correlated with the aggressiveness of lung adenocarcinoma. It was indicated that disregulation of FOXO3a might play key roles in the occurrence and development of lung a denocarcinoma and joint detection of the two markers might play an important role in diagnosing tumors.

• Clinical and Experimental Pediatrics
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• 제58권5호
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• pp.183-189
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• 2015

Purpose: Catheter urine (CATH-U) and suprapubic aspiration (SPA) are reliable urine collection methods for confirming urinary tract infections (UTI) in infants. However, noninvasive and easily accessible collecting bag urine (CBU) is widely used, despite its high contamination rate. This study investigated the validity of CBU cultures for diagnosing UTIs, using CATH-U culture results as the gold standard. Methods: We retrospectively analyzed 210 infants, 2- to 24-month-old, who presented to a tertiary care hospital's pediatrics department between September 2008 and August 2013. We reviewed the results of CBU and CATH-U cultures from the same infants. Results: CBU results, relative to CATH-U culture results (${\geq}10^4$ colony-forming units [CFU]/mL) were widely variable, ranging from no growth to ${\geq}10^5CFU/mL$. A CBU cutoff value of ${\geq}10^5CFU/mL$ resulted in false-positive and false-negative rates of 18% and 24%, respectively. The probability of a UTI increased when the CBU bacterial count was ${\geq}10^5/mL$ for all infants, both uncircumcised male infants and female infants (likelihood ratios [LRs], 4.16, 4.11, and 4.11, respectively). UTIs could not be excluded for female infants with a CBU bacterial density of $10^4-10^5$ (LR, 1.40). The LRs for predicting UTIs based on a positive dipstick test and a positive urinalysis were 4.19 and 3.11, respectively. Conclusion: The validity of obtaining urine sample from a sterile bag remains questionable. Inconclusive culture results from CBU should be confirmed with a more reliable method.

• 스마트미디어저널
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• 제5권4호
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• pp.131-137
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• 2016

스마트폰을 휴대하기 어려운 공간에서 스마트폰의 착신정보를 알지 못해 중요한 통화를 놓치는 상황을 겪게 되는 현상이 빈번이 발생하기 때문에 이를 해결할 수 있는 기술 개발이 시급하고 취미/여가 생활 중의 스마트폰 도난/분실에 대한 사례가 갈수록 증가하고 있으며 특히 해수욕장, 수영장, 찜질방, 사우나, 스파 등 실내 장소에서 도난 행위가 많이 발생하고 있기 때문에 취미/여가 생활 중 핸드폰을 보호할 수 있는 방안이 필요하다. 기존의 웨어러블 디바이스 '스마트 워치'의 경우 고가의 기기일뿐더러 운동, 취미, 여가 활동 시 기기의 파손과 고장에 따른 A/S비용에 대한 부담감으로 인하여 사용에 대한 부담감이 높기 때문에 부담감을 줄일 수 있고 활용성을 강조할 수 있는 제품의 개발이 시급하다. 본 논문에서는 이러한 문제들을 해결하기 위해 저전력 기반의 스마트폰 착신정보 시스템을 제안하고자 한다.