• Asian Pacific Journal of Cancer Prevention
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• v.16 no.9
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• pp.4115-4121
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• 2015

Background: Colorectal cancer is the second most common cause of cancer death with half a million deaths per year. Incidence and mortality rates have demonstrated notable changes in Asian and African countries during the last few decades. In this study, we first aimed to determine the trend of colorectal cancer mortality rate in each Institute for Health Metrics and Evaluation (IHME) region, and then re-classify them to find more homogenous classes. Materials and Methods: Our study population consisted of 52 countries of Asia and North Africa in six IHME pre-defined regions for both genders and age-standardized groups from 1990 to 2010.We first applied simple growth models for pre-defined IHME regions to estimate the intercepts and slopes of mortality rate trends. Then, we clustered the 52 described countries using the latent growth mixture modeling approach for classifying them based on their colorectal mortality rates over time. Results: Statistical analysis revealed that males and people in high income Asia pacific and East Asia countries were at greater risk of death from colon and rectum cancer. In addition, South Asia region had the lowest rates of mortality due to this cancer. Simple growth modeling showed that majority of IHME regions had decreasing trend in mortality rate of colorectal cancer. However, re-classification these countries based on their mortality trend using the latent growth mixture model resulted in more homogeneous classes according to colorectal mortality trend. Conclusions: In general, our statistical analyses showed that most Asian and North African countries had upward trend in their colorectal cancer mortality. We therefore urge the health policy makers in these countries to evaluate the causes of growing mortality and study the interventional programs of successful countries in managing the consequences of this cancer.

• Atmosphere
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• v.26 no.1
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• pp.85-95
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• 2016

In this study, we investigated the variabilities of wind speed of 850 hPa and precipitable water over the East Asia region using the NCEP Final Analysis data from December 2001 to November 2011. A large variance of wind speed was observed in northern and eastern China during the winter period. During summer, the regions of the East China Sea, the South Sea of Japan and the East Sea show large variances in the wind speed caused by an extended North Pacific High and typhoon activities. The large variances in the wind speed in the regions are shown to be correlated with the inter-annual variability of precipitable water over the inland region of windward side of the Korean Peninsula. Based on the investigation, sensitivity tests to the domain size were performed using the WRF model version 3.6 for heavy precipitation events over the Korean Peninsula for 26 and 27 July 2011. Numerical experiments of different domain sizes were set up with 5 km horizontal and 50 levels vertical resolutions for the control and the first experimental run, and 9 km horizontal for the second experimental run. We found that the major rainfalls correspond to shortwave troughs with baroclinic structure over Northeast China and extended North Pacific High. The correlation analysis between the observation and experiments for 1-h precipitation indicated that the second experiment with the largest domain had the best performance with the correlation coefficient of 0.79 due to the synoptic-scale systems such as short-wave troughs and North Pacific High.

• Journal of Environmental Science International
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• v.12 no.5
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• pp.521-527
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• 2003

To study the intruded phenomena of North Pacific Ocean around Boso peninsular, water property distribution in the adjacent seas to Japan is studied using the hydrographic data obtained by Japan Maritime Agency and Japan Fisheries Agency from 1973 to 1996, The scattering of water type in T-5 diagram is relatively small in the Kuroshio Region. Both the envelopes of saline side and of fresh side of the scattered data points shifts gradually from saline side to fresh side as the observation Line moves from southwest to northeast. In mixed water region, the scattering of water type increases rapidly as the observation line moves north; the envelope of fresh cold side moves towards fresh cold side much faster than that of saline side. This suggests that the water does not advect along the salinity minimum layer, but the salinity minimum layer can be understood as a boundary of two different waters aligned vertically, We defined the typical water masses as the Oyashio Water and the Kuroshio Water. The water mass below the salinity minimum layer may be created by isopycnal mixing of these two water masses with a fixed mixing rate. While the water mass above the salinity minimum cannot be created simply by isopycnal mixing. The salinity minimum layer may be eroded from upper side due to active minxing processes in the surface layer, while the water of the salinity minimum layer moves gradually southward. This appears to give an explanation why the thermosteric anomaly value at salinity minimun decereases towards south.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.32 no.1
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• pp.24-32
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• 1996

This paper described on relation between the catches of tuna and the distribution of water temperature of eastern fishing ground of Tropical region in the Pacific Ocean. The data of catches and water temperature used in this paper were based log book which # 27 CHENG RONG(Gross tonnage : 399 ton) had been worked eastern fishing ground(Lat : 09$^{\circ}$N- 14$^{\circ}$S, Long : 115$^{\circ}$- 149$^{\circ}$W)from January to October, 1991. The obtained result are as follows : 1. On the relation between the catches and the geographical distribution, bigeye tuna was higher catches at Lat 4$^{\circ}$- 9$^{\circ}$N, Long 135$^{\circ}$- 139$^{\circ}$W area in the equatorial counter current region where surface water temperature was range of 27.5$^{\circ}C$ to 27.9$^{\circ}C$, yellowfin tuna was higher catches at Lat 4$^{\circ}$- 9$^{\circ}$S, Long 145$^{\circ}$- 149$^{\circ}$W in the south equatorial current region where surface water temperature was range of 28.$0^{\circ}C$ to 28.4$^{\circ}C$ and albacore tuna was higher catches at Lat 10$^{\circ}$- 14$^{\circ}$S, Long 120$^{\circ}$- 124$^{\circ}$W area in the south equatorial current region where surface temperature was range of 26.5$^{\circ}C$ to 26.9$^{\circ}C$ 2. On the relation between catches and distribution of vertical water temperature, bigeye tuna was higher catches at the water temperature of 1$0^{\circ}C$ to 12$^{\circ}C$ on depth layer between 300m and 360m, yellowfin tuna was higher catches at the water temperature of 15$^{\circ}C$ to 19$^{\circ}C$ on depth layer between 180m and 280m and albacore tuna was higher catches at the water temperature of 12$^{\circ}C$ to 14$^{\circ}C$ on depth layer between 280m and 310m. Above the result, it seemed that bigeye tuna distributed deeper layer than yellowfin and albacore tuna.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.8
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• pp.3721-3729
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• 2014

Background: Cancer is becoming the most important public health burden around the globe. As per the GLOBOCAN 2008 estimates, about 12.7 million cancer cases and 7.6 million cancer deaths were estimated to have occurred in 2008. The burden of cancer cases for India in the year 2020 is calculated to be 1,148,757 (male 534,353; female 614,404) compared to 979,786 in 2010. The pattern of cancer incidence is varying among geographical regions, esophageal cancer for example being high in China, lung cancer in USA, and gallbladder cancer in Chile. The question remains why? Is it due to the diversity in genome pool, food habits, risk factor association and role of genetic susceptibility or some other factors associated with it? In India, the North East (NE)-India region is seeing a marked increase in cancer incidence and deaths, with a very different cancer incidence pattern compared to mainland India. The genome pool of the region is also quite distinct from the rest of India. Northeastern tribes are quite distinct from other groups; they are more closely related to East Asians than to other Indians. In this paper an attempt was made to see whether there is any similarity among the pattern of cancer incidence cases for different sites of NE-India region to South or East-Asia. Materials and Methods: Principal Component Analysis (PCA), Hierarchical Cluster Analysis (HCA), Pearson Correlation coefficient test was assessed to evaluate the linkage of North-East India region to other regions. A p value <0.05 was considered as statistically significant. Results: The results clearly shows that there are similarities in occurrence of cancer incidence patterns for various cancer sites of NE-India with South and East-Asian regions, which may lead to the conclusion that there might be a genetic linkage between these regions.

• Journal of mucopolysaccharidosis and rare diseases
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• v.1 no.1
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• pp.2-4
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• 2015

Though the rate of incidence of each rare disease, including mucopolysaccharidosis (MPS), is low, this is not the case if they are taken as a whole. Rare diseases often have genetic causes and vary in type. However, the signs and symptoms vary greatly by disease, making it difficult to make accurate diagnoses and conduct necessary research, which is why we believe it is a field that deserves more attention and research. It is important to establish an infrastructure of experts in each country and promote cooperation within the Asia-Pacific region in order to improve specialist training and communication. Given the need for a system of cooperation, the Asia Pacific MPS Network (APMN) was established by several MPS experts in South Korea, Japan, and Taiwan in January 2013. Thereafter, the Asia Pacific MPS Registry (APMR), an electronic remote data system, was established by the APMN. Then, the Association for Research of MPS & Rare Diseases (ARMRD), an academic society that supports research on MPS and other rare diseases, was established by President Dong-Kyu Jin in April in 2015. The main task of the ARMRD is to support APMN-related work. The ARMRD published a uniform guideline that reflects the characteristics and circumstances of local patients through the Korean MPS Expert Council. Now, the APMN, APMR, and the annual Korean MPS Symposium are supported by ARMRD. Organizations like the APMN and APMR are necessary because international cooperation and collaboration are needed to conduct clinical trials on those diseases. ARMRD members hope to encourage the interest of experts and researchers of MPS & rare diseases as well as active participation in the research and treatment of patients suffering from rare diseases, including MPS, to ultimately improve the quality of life of the patients as well as their families.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.8
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• pp.3541-3546
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• 2014

TEL-AML1 fusion oncogene (t 12; 21) is the most common chromosomal abnormality in childhood acute lymphoblastic leukemia (ALL). This translocation is associated with a good prognosis and rarely shows chemotherapeutic resistance to 3-drug based remission induction phase of treatment as well as overall treatment. Thus, the higher the frequency of this fusion oncogene, the easier to manage childhood ALL in a given region with less intensive chemotherapy. Although global frequency of TEL-AML1 has been reported to be 20-30%, a very low frequency has been found in some geographical regions, including one study from Lahore, Punjab, Pakistan and others from India. The objective of present study was to investigate if this low frequency of TEL-AML1 in pediatric ALL is only in Lahore region or similar situation exists at other representative oncology centers of Pakistan. A total of 167 pediatric ALL patients were recruited from major pediatric oncology centers situated in Lahore, Faisalabad, Peshawar and Islamabad. Patients were tested for TEL-AML1 using nested reverse transcription polymerase chain reaction (RT-PCR). Only 17 out of 167 (10.2%) patients were found to be TEL-AML1 positive. TEL-AML1+ALL patients had favorable prognosis, most of them (82.4%, 14/17) showing early remission and good overall survival. Thus, our findings indicate an overall low frequency of TEL-AML1 in Pakistan pediatric ALL patients, in accordance with lower representation of this prognostically important genetic abnormality in other less developed countries, specifically in south Asia, thus associating it with poor living standards in these ethnic groups. It also indicates ethnic and geographical differences in the distribution of this prognostically important genetic abnormality among childhood ALL patients, which may have a significant bearing on ALL management strategies in different parts of the world.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.20 no.4
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• pp.360-369
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• 1987

The relationship between the catches of tuna and hydrographic conditions in South-East Pacific region (latitude $5^{\circ}N-12^{\circ}S$, longitude $135^{\circ}W-115^{\circ}W$) was investigated by using the catch data of tuna and Digital Bathythermograph (DBT) data from December 9, 1980 to April 2, 1981. The results are as follows : The study area were located in South Eguatorial Current regions including equatorial upwelling regions in $5^{\circ}N\;to\;12^{\circ}S$. The horizontal mean temperature at the depth of 10m on the first quarter months in the study area was about $25^{\circ}C$C and the salinity of those fishing areas ranged from 34.8 to $35.0\%_{\circ}$. Yellowfin tuna and bigeye tuna were mainly caught in SW vertical temperature profile type, which the depth of thermocline ranged from loom to 300m, and temperature difference of thermocline was about $12^{\circ}C$. The deeper the depth of thermocline, the more the catches of tuna. While albacore tuna was caught well in SS vertical temperature profile type which the temperature of thermocline ranged from $9^{\circ}\;to\;26^{\circ}C$ and its gradient was very smooth. The depth of 1 ml/l surface of dissoved oxygen content ranged from loom to 200m in the South-East Pacific between longitude $140^{\circ}W-100^{\circ}W$, but it was shallower than 100 m near the North-South American continent. The catches of bigeye tuna were larger than those of yellowfin tuna in South Equatorial Current region. As approaching to the South and North American continent, the catches of yellowfin tuna and bigeye tuna decreased because the thermocline becomes shallower and steeper and the depth of the 1 m1/1 surface of dissolved oxygen content became shallower.

• Journal of Korean Society for Atmospheric Environment
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• v.22 no.E1
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• pp.9-18
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• 2006

Aerosol hygroscopic properties were measured by a tandem differential mobility analyzer (TDMA) system during the Aerosol Characterization Experiment (ACE)-Asia campaign from 31 March to 1 May 2001. Two high flow differential mobility analyzers (DMAs) were used to maximize the count rate on board the Center for Interdisciplinary Remotely Piloted Aircraft (CIRPAS) Twin Otter aircraft. Hygroscopic growth factor distributions of particles having initial dry nanoparticle diameters of 0.040, 0.059, 0.086, 0.126, 0.186, 0.273, 0.400, and $0.586{\mu}m$ were measured during 19 research flights. Data collected during 12 of those flights were used to investigate aerosol mixing state and the influence of aerosol source region on size-resolved hygroscopicity. The uniformity in size-resolved hygroscopicity was quantified to facilitate comparison between measurements made in different air masses. Hygroscopic growth factors are strongly dependent on source region and sizes. Mean hygroscopic growth factors were observed to be greatest when the air mass origin was from the south. The mean growth factors for continental sources decreased with initial size from 1.47 to 1.27 for $0.040{\mu}m\;and\;0.586{\mu}m$, but increased with initial size from 1.44 to 1.8 for $0.040{\mu}m\;and\;0.400{\mu}m$ dry diameters for marine sources.

• Atmosphere
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• v.29 no.2
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• pp.165-181
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• 2019

In this study, the regional climate model, RegCM4.0 (25 km), with the HadGEM2-AO data as boundary conditions, was used to simulate the mean climate changes in the mid and late 21st century for CORDEX Phase 2 East Asian region. 122 years (1979~2100) of simulation were performed, and RCP 4.5 and RCP 8.5 were used for the simulation of future climate. In the mid-21st century, the temperature is expected to increase by about 0.5 to $3.0^{\circ}C$ in all regions of East Asia, regardless of season and scenario. The increase in temperature is greater in summer and winter, especially in the northern part of simulation domain. Interannual variability (IAV) is expected to decrease by 25% in summer for RCP 8.5, while it is expected to increase by more than 30% in autumn for both scenarios. Regardless of the scenario, the precipitation in South Korea is expected to increase in late June but decrease in mid-July, with an increase in precipitation greater than $100mm\;day^{-1}$. In RCP 4.5 of the late 21st century, relatively uniform temperature increase ($1.0{\sim}2.5^{\circ}C$) is expected throughout the continent, while RCP 8.5 shows a very diverse increase ($3.0{\sim}6.0^{\circ}C$) depending on season and geographical location. In addition, the IAV of temperature is expected to decrease by more than 35% in both scenarios in the summer. In most of the Northwest Pacific region, precipitation is expected to decrease in all seasons except for the summer, but in South Korea, it is projected to increase by about 10% in all seasons except autumn.