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The effects of the novel IDPc inhibitor, DA-11004, on NADPH generation, insulin secretion, and glucose level in zucker rats

  • Shin, Chang-Yell;Jeong, Mi-Young;Sohn, Jin-Bup;Lee, In-Ki;Son, Mi-Won;Bae, Cheol-Jun;Byun, Jong-Soo;Kim, Dong-Sung;Kim, Soon-Hae
    • Proceedings of the PSK Conference
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    • 2003.04a
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    • pp.130.3-131
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    • 2003

  • The biological effects of NADPH-dependent isocitrate dehydrogenase (IDPc) inhibitor. DA-11004, was examined in obese zucker rats or streptozotocin-induced diabetic SD rats. Diabetes was induced by injection of streptozotocin (50mg/kg) dissolved in citrate buffer (pH 4.8) into the tail vein and induction of diabetes was confirmed by the measurement of the tail blood glucose level at 48h. DA-11004 (30mg/kg, po) was injected for successive 7days and significantly reduced the plasma glucose in streptozotocin-induced diabetic rats (P<0.05). (omitted)

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The effects of the novel IDPc inhibitor, DA-11004, on NADPH generation, insulin secretion, and glucose level in obese diabetic (ob/ ob) mice

  • Lee, In-Ki;Yell, Shin-Chang;Bup, Sohn-Jin;Young, Jeong-Mi;Son-Miwon;Jun, Bae-Cheol;Soo, Byun-Jong;Kim, Dong-Sung;Kim, Soon-Hae
    • Proceedings of the PSK Conference
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    • 2003.04a
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    • pp.132.2-133
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    • 2003

  • The biological effects of NADPH-dependent isocitrate dehydrogenase (IDPc) inhibitor, DA-11004, was investigated in obese diabetic (ob/ ob) mice. DA-11004, metformin, and oxalomalate were daily injected (ip) for 8 weeks and after completing an 8-week period of experiment, mice were sacrificed at 1 hr after the last drugs treatment to collect their blood, liver, and adipose tissues(epididymal and retroperitoneal fat). (omitted)

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DA 11004, a synthetic IDPc inhibitor, inhibits the high fat high sucrose diet-induced obesity in C57BL/6 mice.

  • Jeong, Mi-Young;Shin, Chang-Yell;Sohn, Jin-Bup;Lee, In-Ki;Son, Mi-Won;Bae, Cheol-Jun;Byun, Jong-Soo;Kim, Dong-Sung;Kim, Soon-Hae
    • Proceedings of the PSK Conference
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    • 2003.04a
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    • pp.129.2-130
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    • 2003

  • Recently. it has been known that NADPH-dependent isocitrate dehydrogenase (IDPc) involves in the obesity through production of NADPH, an important cofactor. DA-11004 is a synthetic potent IDPc inhibitor that $IC_{50}$ for IDPc is 1.49$\mu\textrm{M}$ (0.9$\mu$g/ml). The purpose of this study was to evaluate the effects of DA-11004 on the high fat high sucrose (HF)-induced obesity in C57BL/6 mice. (omitted)

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Routing and Collision Avoidance of Linear Motor based Transfer Systems using Online Dynamic Programming

  • Kim, Jeong-Tae;Cho, Hyun-Cheol;Lee, Kwon-Soon
    • Proceedings of the Korean Institute of Navigation and Port Research Conference
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    • v.1
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    • pp.393-397
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    • 2006

  • Significant increase of container flows in marine terminals requires more efficient automatic port systems. This paper presents a novel routing and collision avoidance algorithm of linear motor based shuttle cars using dynamic programming (DP). The proposed DP is accomplished online for determining optimal paths for each shuttle car. We apply our algorithm to Agile port terminal in USA.

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A Study about Finding Optimal Path Using RAS Dynamic Programming (RAS Dynamic Programming을 이용한 최적 경로 탐색에 관한 연구)

  • Kim, Jeong-Tae;Lee, John-Tak;Lee, Kwon-Soon
    • Proceedings of the KIEE Conference
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    • 2007.07a
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    • pp.1736-1737
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    • 2007

  • Significant increase of container flows in marine terminals requires more efficient automatic port systems. This paper presents a novel routing and collision avoidance algorithm of linear motor based shuttle cars using random access sequence dynamic programming (RAS DP). The proposed RAS DP is accomplished online for determining optimal paths for each shuttle car.

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