• Title/Summary/Keyword: Solvent-free Michael addition

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Solvent-Free Michael Addition Between EMME and Secondary Amine under Focused Microwave Irradiation

  • Kim, Ki-Won;Lee, Hee-Jung;Jo, Jeong-Im;Kwon, Tae-Woo
    • Bulletin of the Korean Chemical Society
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    • v.31 no.5
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    • pp.1155-1158
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    • 2010
  • Microwave-assisted Michael reaction between EMME and various amines such as diphenylamine, 4-methyl-N-phenylbenzenamine, N-phenylnaphthalen-1-amine, dihexylamine, diisopropylamine, and 4-nitrobenzenamine were described. Solvent-free conditions on alumina as solid support in the presence of $K_2CO_3$ catalysts gave moderate to good yields (55 - 93%) of diethylmalonate analogues having enamine moieties under focused microwave irradiation.

Indium(III) Chloride Mediated Michael Addition of Indoles to Ketene S,S-Acetals: Synthesis of Bis- and Tris-indolylketones

  • Singh, Thokchom Prasanta;Khan, Ruhima;Noh, Young Ri;Lee, Sang-Gyeong;Singh, Okram Mukherjee
    • Bulletin of the Korean Chemical Society
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    • v.35 no.10
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    • pp.2950-2954
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    • 2014
  • A series of bis and tris-indolylketones and meridianin alkaloids are prepared by one pot Michael reaction of indole and ketene S,S-acetals under solvent-free condition using mild Lewis acid $InCl_3$.