• 대한기계학회논문집
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• 제6권4호
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• pp.331-340
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• 1982

Numerical analysis is made on the turbulent heat transfer with suspension of solid particles in circular tube with constant heat flux. The mean motion of suspending particles in mixture is treated as the secondary gas flow with virtual density and viscosity. Our modeling of turbulent transport phenomena of suspension flow is based on this assumption and conventional mixing length theory. This paper gives the evidence that the mixing length models can be extended to close the governing equations for two phase turbulent flow with solid boundary at a first order level. Results on Nusselt numbers obtained by analytical treatments are compared with available experimental data and discussed. They suggest that the most important parameters of two phase turbulent heat transfer phenomena are relative particle diameter to pipe diameter, gas-solid loading ratio, and specific heat of suspending material.

• Near Infrared Analysis
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• 제1권1호
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• pp.23-26
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• 2000

The objectives of this study were to examine the ability to predict soluble solid and firmness in intact apple based on the visible/near-infrared spectroscopic technique. Two cultivars of apples, Delicious and Gala, were handled, tested and analyzed. Reflectance spectra, Magness-Taylor (MT) Firmness, and soluble solids in apples were measured sequentially. Maximum and minimum diameters, height, and weight of apples were recorded before the MT firmness tests. Apple samples were divided in to a calibration set and a validation set. The method of partial least squares (PLS) analysis was used. a unique set of PLS loading vectors (factors) was development for soluble solid and firmness. The PLS model showed good relationship between predicted and measured soluble solids in intact apples in the wavelength range of 860∼1078 nm. However, the PLS analysis was not good enough to predict the apple firmness.

• Journal of Pharmaceutical Investigation
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• 제26권2호
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• pp.125-135
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• 1996

Solid lipid nanoparticles(SLN) are particulate systems for parenteral drug administration and suitable for controlled release. SLN were prepared by homogenization process. Dispersion at increased temperature (molten lipid) was performed to yield SLN loaded with lipophilic drugs. Tetracaine base, lidocaine base, prednisolone, methyltestosterone and ethinylestradiol were used as model drugs to access the loading capacity and to study the release behavior. To investigate production parameters(lipids, surfactant concentration, homogenizing rpm) in the formation of SLN, particle size was performed by laser diffraction analysis. The mean particle size of SLN with stearic acid or trilaurin was below 1 micron. By decreasing the particle size and increasing the surfactant concentration, the release rate was increased especially in the case of highly lipophilic drug loaded SLN. Methyltestosterone or ethinylestradiol loaded SLN showed a distinctly prolonged release over a few days.

• Journal of Pharmaceutical Investigation
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• 제41권2호
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• pp.75-82
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• 2011

LB71350 is an HIV protease inhibitor with poor aqueous solubility and extensive first pass effect. The purpose of the present study was to test the feasibility of solid dosage form of LB71350 with improved bioavailability utilizing solid dispersion. Three different compositions with varying ratio of (LB71350: Gelucire 44/14: Tween 20) were studied. Capsule filling of these solid dispersion compositions was tested using a semi-automatic capsule filling system. Oral bioavailability in dog was tested. Chemical and physical stability at 4, 25 and $40^{\circ}C$ was monitored by HPLC assay, dissolution test, powder XRD and microscopy. The capsule filling system yielded uniform products of drug loading up to 10%. Oral bioavailability in dog was improved compared to the aqueous suspension of crystalline LB71350. Capsules were chemically stable for up to 6 months at $40^{\circ}C$. However, there were temperature and composition dependent physical changes. Decrease in dissolution rates after storage at $40^{\circ}C$ was due to the polymorphic change. In conclusion, manufacturing process, bioavailability, and physico-chemical stability have been considered to propose a solid dispersion capsule formulation for the HIV protease inhibitor with poor physico-chemical properties. A new less soluble crystalline form identified during the physical stability test warrants further study.

• Bulletin of the Korean Chemical Society
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• 제28권2호
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• pp.276-280
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• 2007

In this work, caffeine and some catechin compounds + C, EC, EGC, and EGCG were extracted from green tea by using molecular imprinted polymers (MIP) as sorbent materials in a solid-phase extraction (SPE) process known as MISPE (molecular imprinted solid-phase extraction). For synthesis of MIP, caffeine was employed as the template, MAA as the monomer, EGDMA as the crosslinker, and AIBN as the initiator. A solution of caffeine (0.2 mg/mL in methanol) was utilized in the solid extraction cartridges following loading, washing, and elution procedures with acetonitrile, methanol, and methanol-acetic acid (90/10, %v/v) as the solvents, respectively. This solid-phase extraction protocol was applied for the extraction of caffeine and some catechin compounds from green tea. A comparison was made between the results obtained with the MIP cartridges and a traditional C18 reversed-phase cartridge. It was thereupon found that the recovery of caffeine by the MIPbased sorbent used in this work was almost two and four times greater than that by a commercially available C18 material. A quantitative analysis was conducted by high performance liquid chromatography (HPLC) using a C18 column (5 μm, 250 × 4.6 mm) with methanol/water (40/60, %v/v) as the mobile phase at a flow rate of 0.5 mL/min.

• Advances in concrete construction
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• 제5권5호
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• pp.451-468
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• 2017

The problem of reducing the self-weight of reinforced concrete structures is very important issue. There are two approaches which may be used to reduced member weight. The first is tackled through reducing the cross sectional area by using voids and the second through using light weight materials. Reducing the weight of slabs is very important as it constitutes the effective portion of dead loads in the structural building. Eleven slab specimens was casted in this research. The slabs are made one way though using two simple supports. The tested specimens comprised three reference solid slabs and eight styropor block slabs having (23% and 29%) reduction in weight. The voids in slabs were made using styropor at the ineffective concrete zones in resisting the tensile stresses. All slab specimens have the dimensions ($1100{\times}600{\times}120mm$) except one solid specimens has depth 85 mm (to give reduction in weight of 29% which is equal to the styropor block slab reduction). Two loading positions or cases (A and B) (as two-line monotonic loads) with shear span to effective depth ratio of (a/d=3, 2) respectively, were used to trace the structural behavior of styropor block slab. The best results are obtained for styropor block slab strengthened by minimum shear reinforcement with weight reduction of (29%). The increase in the strength capacity was (8.6% and 5.7%) compared to the solid slabs under loading cases A and B respectively. Despite the appearance of cracks in styropor block slab with loads lesser than those in the solid slab, the development and width of cracks in styropor block slab is significantly restricted as a result of presence a mesh of reinforcement in upper concrete portion.

• 한국지반공학회논문집
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• 제24권7호
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• pp.37-42
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• 2008

인천시 소재 OO지역 비위생 매립지를 대상으로 선행하중(pre-loading) 공법에 의한 성토시 폐기물층의 침하 계측을 바탕으로 기존에 제시된 경험적 침하 모델을 적용하여 침하 모델의 적용성과 타당성을 분석하였다. 매립 연한이 20년이 지난 비위생 매립에서의 1년간의 성토기간 동안에 9개 지점의 지표면 침하판, 2개의 층별 침하계를 설치하고 약 300일간의 계측을 통해 비위생 매립지의 침하량을 측정하였다. 초기 침하 부분에서 기존의 침하 예측 모델과 본 현장의 침하량을 비교 분석한 결과 PCL(Power Creep Law)모델의 경우 실측 범위내에서 근접한 결과를 보였으나 쌍곡선(hyperbolic) 모델과 Bjarngard와 Edgers 모델의 경우 초기 실측 범위인 약 $50{\sim}70$일부터 300일까지 실측치와 근접하게 예측되었다.

• Computers and Concrete
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• 제13권3호
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• pp.343-359
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• 2014

In this work a numerical method to simulate the response of reinforced concrete structures subject to cyclically imposed displacements is proposed. The method consists of a combination of a displacement and load controlled version of the Newton-Raphson iterative technique, used for the loading and the unloading part of the cycles respectively. The whole procedure is combined with a relatively simple concrete model whose only material parameter is its uniaxial compressive strength. The proposed methodology may realistically simulate, in an easy way, the physical process of any experimentally tested RC structure under imposed displacements cycles. The efficiency of the approach is demonstrated through a series of analyses of experimentally tested specimens reported in the literature.

• Structural Engineering and Mechanics
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• 제4권3호
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• pp.330-344
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• 1996

A model of a cable comprising interacting wires with dry friction forces at the interfaces is subjected to a quasi-static cyclic loading. The first cycle of this process, comprising of axial loading, unloading and reloading is investigated analytically. Explicit load-elongation relationships are obtained for all of the above phases of the cycle. An expression for the hysteretic losses is also obtained in an explicit form. It is shown that losses are proportional to the third power of the amplitude of the oscillating axial force, and are in inverse proportion to the interwire friction forces. The results obtained are used to introduce a model of a cable as a solid rod with an equivalent stiffness and damping properties of the rod material. It is shown that the stiffness of the equivalent rod is weakly nonlinear, whereas the viscous damping coefficient is proportional to the amplitude of the oscillation. Some numerical results illustrating the effect of cable parameters on the losses are given.

• Structural Engineering and Mechanics
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• 제26권3호
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• pp.231-250
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• 2007

The influence of masonry infills with eccentric openings on the seismic performance of reinforced concrete (r/c) frames that were designed in accordance with current code provisions are investigated. Eight 1/3-scale, single-story, single-bay frame specimens were tested under cyclic horizontal loading up to a drift level of 4%. In all examined cases the shear strength of columns was higher than the cracking shear strength of solid infill. The parameters investigated include the shape and the location of the opening. Assessment of the behavior of the frames is also attempted, based on the observed failure modes, strength, stiffness, ductility, energy dissipation capacity and degradation from cycling loading. Based on these results there can be deduced that masonry infills with eccentrically located openings has been proven to be beneficial to the seismic capacity of the bare r/c frames in terms of strength, stiffness, ductility and energy dissipation. The location of the opening must be as near to the edge of the infill as possible in order to provide an improvement in the performance of the infilled frame.