• 대한한의학방제학회지
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• 제13권2호
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• pp.17-40
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• 2005

A/J mice injected with urethane(1mg/ g of body weight) develop tumors with distinct histological patterns, which are classified as solid and papillary. I divided the mice into 3 groups; control group treatment with saline, BA group treatment with herbal formula, Soeuminbojungikgitang 0.4g/kg and BA group treatment with herbal formula 2.0g/kg. The administration of herbal medicine was done every day for 8 weeks. The experimental results from herbal medicine treatment were compared to those from a saline-treated control group. Serial sections of the whole lung(150 to 200 sections per mouse) showed solid and papillary tumors arose from the pulmonary acinus, invading the bronchioles only as the tumors grew. The number of tumor, in the 8 weeks group, are decreased in the experimental groups compared to control group. COX-2 protein and IGF- I protein expression was more increased in lung tumors of the control group compared to BA and BB groups. These results suggest that Soeuminbojungikgitang extract suppress the carcinogenesis of lung in the A/J mouse.

• Archives of Pharmacal Research
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• 제19권1호
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• pp.6-11
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• 1996

The trichothecenes are sesquiterpenoid mycotoxins characterized by the 12,13-epoxytrichothec-9-ene ring system. We have tested cytotoxicity of several naturally-occurring or synthesized trichothecenes against human solid tumor cell lines. Among them, trichothecin(I) and $4-\beta$-Acetoxy-12,13-epoxytrichothec-9-ene (trichodermin, II) exhibited highly cytotoxic activities. 4-.betha.-Hydroxy-12,13-epoxytrichothec-9-ene (trichodermol, III) and $4-\beta$-Methoxy-12,13-epoxytrichothec-9-ene (IV) had mild cytotoxicities. But 12,13-Epoxytrichothec-9-ene-4-one (V) and $4-\beta$-Hydroxy-12,13-epoxytrichothec-9-ene(VI) had no cytotoxicities up to 10 $\mug/ml$. And in the tested cell lines, HCT15 colon cancer cell line was the most sensitive to all tested trichothecenes.

• Journal of Korean Neurosurgical Society
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• 제43권2호
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• pp.105-108
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• 2008

Cystic glioblastoma multiforme (GBM) is a rare disease. Its exact prevalence has not yet been reported. Also, the mechanism of cyst formation remains to be elucidated. We report a case of GBM with a large peripheral cyst. A 43-year-old woman visited our clinic with a 3-month history of severe headache, memory impairment and general weakness. T1-weighted gadolinium-enhanced magnetic resonance (MR) image revealed a midline enhanced solid mass and bilateral symmetric banana-shaped peripheral cysts. A centrally enhanced mass was measured $2{\times}4$ cm in size and both mass and cysts as $7{\times}7$ cm. Both the frontal lobe and the frontal horn were severely compressed inferiorly and posteriorly. We resected a midline solid tumor and cysts via the bilateral interhemispheric transcortical approach. Histopathologic examination revealed GBM. The patient was subsequently treated with fractionated conventional brain radiation therapy, followed by temozolomide chemotherapy. Eighteen months later, there was no tumor recurrence and no neurological deficits were noted. Our patient showed no tumor recurrence and a long survival at a long follow-up.

• 센서학회지
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• 제32권6호
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• pp.418-424
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• 2023

Natural killer (NK) cells play a crucial role in combating infections and tumors. However, their therapeutic application in solid tumors is hindered by challenges, such as limited lifespan, tumor penetration, and delivery precision. Our research introduces a novel ultrasonic actuation technique to navigate NK cells more effectively in the vascular system, particularly at vessel bifurcations where targeted delivery is most problematic. We use a hemispherical ultrasonic transducer array that generates phase-modulated traveling waves, focusing on an ultrasound beam to steer NK cells using blood-flow dynamics and a focused acoustic field. This method enables the precise obstruction of non-target vessels and efficiently directs NK cells toward the tumor site. The simulation results offer insights into the behavior of NK cells under various conditions of cell size, radiation pressure, and fluid velocity, which inform the optimization of their trajectories and increase targeting efficiency. The experimental results demonstrate the feasibility of this ultrasonic approach for enhancing NK cell targeting, suggesting a potential leap forward in solid tumor immunotherapy. This study represents a significant step in NK cell therapeutic strategies, offering a viable solution to the existing limitations and promising enhancement of the efficacy of cancer treatments.

• 한국의학물리학회지:의학물리
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• 제18권3호
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• pp.161-166
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• 2007

공모양의 단단한 종양안에서 수동조준된 약물의 전달에 관한 모델이론이 적절한 경계조건과 초기조건하에서 픽의 확산법칙으로부터 유도된다. 종양안의 농도는 초기값이 일정하면 시간과 지름의 함수로 나타난다. 생각실험(사고실험)으로부터 예측되는 바와 같이, 농도는 시간이 경과함에 따라 평형값에 접근한다. 시간에 따른 농도의 변화는 조직안의 약물의 확산계수, 종양의 크기, 주입된 약물의 양, 경계면에서의 농도의 물매(gradient)에 의해 결정된다.

• Journal of Pharmaceutical Investigation
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• 제36권4호
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• pp.231-237
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• 2006

Hypoxia in solid tumors is known to contribute to intrinsic chemoresistance. Histocultures are in vitro 3 dimensional cultures of tumor tissues and maintain the characteristic microenvironment of human solid tumors in vivo including hypoxia and multicellular structure. In this study, we evaluated the pharmacodynamics of tirapazamine(TPZ), a hypoxia-selective cytotoxin, in human non small cell lung cancer(NSCLC) cells grown as monolayers and histocultures. Antiproliferative activity of TPZ was determined after various conditions of drug exposure, and cell cycle arrest and apoptosis were also measured using flow cytometry. In monolayers, hypoxia selectivity measured by hypoxic/normoxic cytotoxicity ratio was increased with longer exposure. Lower cytotoxicity of TPZ was observed in histocultures compared to monolayers, however, a similar level of cytotoxicity was obtained with longer exposure of 96 hr. TPZ induced $G_2/M$ arrest and apoptosis in both culture conditions, which were greatly enhanced under hypoxic condition. Our data clearly showed the different pharmacodynamics of TPZ in monolayers and histocultures. Antiproliferative activity of TPZ against human solid tumors can be improved with longer drug exposure by exploiting drug delivery systems or by combining angiogenesis inhibitors to maintain drug concentration in tumor tissues.

• Korean Journal of Otorhinolaryngology-Head and Neck Surgery
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• 제61권12호
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• pp.637-643
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• 2018

Radioimmunotherapy (RIT) is a therapy that takes advantage of the "cross-fire" effect of emitted radiation by radionuclides conjugated to tumor-directed monoclonal antibodies (mAb) (including those fragments) or peptides. While RIT has been successfully employed for the treatment of lymphoma, mostly with radiolabeled antibodies against CD20 [$^{90}yttrium$ ($^{90}Y$)-ibritumomab tiuxetan; $Zevalin^{(R)}$ and $^{131}iodine$ ($^{131}I)-tositumomab$; $Bexxar^{(R)}$], its use in solid tumors is more challenging, so far. Immuno-PET, a tool for tracking and quantification of mAbs with PET in vivo, is an exciting novel option to improve diagnostic imaging and guide mAb-based therapy. RIT in solid tumors including head and neck cancer may be an alternative treatment with advances in various biological, chemical, and treatment procedures, and it may help to reduce unnecessary exposure and enhance the therapeutic efficacy. Also, immuno-PET based on RIT might play an important role in cancer staging, in patients or targets selection of targeted therapeutics and in monitoring the response of targeted therapeutics as precision medicine. In this review, fundamentals of RIT/immune-PET and current knowledge of the preclinical/clinical trials in RIT for solid tumor including head and neck cancer are reviewed.

• 한국의학물리학회지:의학물리
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• 제16권2호
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• pp.104-109
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• 2005

암치료에 사용되고 있는 광역학 치료는 환자에게 광민감제를 투여하고 다이오드 레이저(630 nm)를 조사하여 생성되는 단일상태 산소와 자유 라디칼에 의해 암조직을 괴사시키는 치료방법이다. 현재 광역학 치료의 문제점은 부피가 큰 종양이나 고형암에서는 빛이 종양전체를 투과할 수 없으므로 광역학 치료의 효과가 떨어지는 것이다. 따라서 이 문제를 해결하기 위하여 간질성 광역학 치료법을 개발하고자 한다. 생체조직내의 정확한 광선량 측정이 간질성광역학치료의 효과에 매우 중요한 영향을 주므로, 실험 연구에 사용된 계수는 실제 생체조직의 광학 계수이다. 생체조직 대부분은 가시광선영역에서 큰 산란계수를 가지며, 투과 깊이에 많은 영향을 미치는 것으로 확인되었다. 가시영역에서의 인체조직의 투과깊이는 약 $15\~20mm$이었다. 몬테칼로 시뮬레이션(Monte Carlo simulation)을 이용하여 생체조직내의 광전파, 광선량, 에너지율, 투과깊이를 잘 측정할 수 있음을 알았다. 그리고 이 시뮬레이션 결과를 가지고 고형암에 간질성 광역학 치료를 하여 치료효과를 확인하였다.

• Journal of Yeungnam Medical Science
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• 제37권2호
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• pp.147-147
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• 2020

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.224.2-224.2
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• 2002