• 한국컴퓨터정보학회논문지
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• 제15권8호
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• pp.157-161
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• 2010

대도시 대기오염의 대부분이 자동차 배출가스에 의해서 이루어지고 있으며, 세계적으로 환경오염에 대한 규제수준이 점차 강화되고 있어 저공해의 환경 친화적인 자동차의 개발과 보급이 요구되고 있으며, 고유가 시대에서 이미 국내 외에서 개발 양산중인 하이브리드 자동차의 급속한 시장 확대가 예상된다. 하이브리드 자동차에서 전기에너지를 저장하는 배터리는 가장 중요한 구성요소 중 하나이며, 하이브리드 자동차용 배터리(전기에너지를 저장하는 2차 전지)는 순간적으로 에너지를 방출하는 특성 즉 고출력 특성이 일차적으로 요구되며, 자동차 부품으로서의 신뢰성과 내구성이 확보되어야 한다. 따라서 본 논문에서는 하이브리드 자동차에 장착되는 2차 전지의 충 방전 상태를 안정적으로 모니터링 하는 시스템과 전지의 충 방전 성능을 극대화할 수 있고 충 방전 제어가 가능한 실시간 충 방전 모니터링 시스템을 제안하였다. 논문에서 새롭게 제안한 감지부와 제어부로 구성되는 충 방전 시스템은 하드웨어 및 소프트웨어 모듈과 실시간으로 셀 배터리의 충 방전 상태를 효율적으로 제어할 수 있으며 데이터베이스와 통신모듈을 기반으로 원격제어가 가능한 시스템이다.

• Clinical and Experimental Reproductive Medicine
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• 제38권2호
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• pp.68-74
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• 2011

Objective: Previously, we found that oocyte specific homeobox (Obox) 4 plays significant role in completion of meiosis specifically at meiosis I-meiosis II (MI-MII) transition. The purpose of this study was to determine the mechanism of action of $Obox4$ in oocyte maturation by evaluating downstream signal networking. Methods: The $Obox4$ dsRNA was prepared by $in$ $vitro$ transcription and microinjected into the cytoplasm of germinal vesicle oocytes followed by $in$ $vitro$ maturation in the presence or absence of 0.2 mM 3-isobutyl-1-metyl-xanthine. Total RNA was extracted from 200 oocytes of each group using a PicoPure RNA isolation kit then amplified two-rounds. The probe hybridization and data analysis were used by Affymetrix Gene-Chip$^{(R)}$ Mouse Genome 430 2.0 array and GenPlex 3.0 (ISTECH, Korea) software, respectively. Results: Total 424 genes were up (n=80) and down (n=344) regulated after $Obox4$ RNA interference (RNAi). Genes mainly related to metabolic pathways and mitogen-activated protein kinase (MAPK) signaling pathway was changed. Among the protein kinase C (PKC) isoforms, PKC-alpha, beta, gamma were down-regulated and especially the MAPK signaling pathway PKC-gamma was dramatically decreased by $Obox4$ RNAi. In the cell cycle pathway, we evaluated the expression of genes involved in regulation of chromosome separation, and found that these genes were down-regulated. It may cause the aberrant chromosome segregation during MI-MII transition. Conclusion: From the results of this study, it is concluded that $Obox4$ is important upstream regulator of the PKC and anaphase-promoting complex action for maintaining intact germinal vesicle.

• 정보처리학회논문지D
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• 제12D권5호
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• pp.781-788
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• 2005

MTF 메시지는 C4I 체계와 같은 국방 메시지 시스템에서 필요한 정보를 상호 교환하거나 다른 시스템으로 정보를 전달하고자 할 때 사용되는 정형화되고 표준화된 메시지 포맷이며, XML은 다양한 검색 지원 및 하드웨어나 소프트웨어에 종속되지 않는 장점을 바탕으로 인터넷 기반에서 전자정보의 효율적 표현과 교환에 최적의 수단으로 평가 받고 있다. 미군은 MTF에 이러한 XML 기반 기술과 결합한 XML-MTF를 도입하여 지속적인 개량과 발전을 도모하고 있으나, 우리 군은 자체 MTF 체계를 보유하지 않고 있으며 또한, 여러 C4I 체계가 Web 기반으로 이동함에 따라 한$\cdot$미간 효율적인 연합작전 수행을 위해 MTF의 필요성이 증가하고 있다. 본 논문에서는 MTF 메시지의 기본구조 및 본문 구성, 작성규칙을 분석하며, 이러한 결과를 바탕으로 XML 변환을 위한 엘리먼트 명칭과 기본적인 매핑(Mapping) 규칙을 제안한다 또한, 제안된 매핑 규칙을 적용하여 MTF 메시지 샘플을 XML 문서로 직접 변환해 봄으로써 MTF 메시지가 XML 문서로 변환이 가능함을 보이고, 이를 기반으로 MTF 메시지를 생성하고 이를 자동으로 XML 문서로 변환하는 XML-MTF 변환 프로그램을 구현한다.

• Asian-Australasian Journal of Animal Sciences
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• 제32권5호
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• pp.607-613
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• 2019

Objective: Intramuscular fat (IMF) content plays an important role in meat quality. Identification of single nucleotide polymorphisms (SNPs) and genes related to pig IMF, especially using pig populations with high IMF content variation, can help to establish novel molecular breeding tools for optimizing IMF in pork and unveil the mechanisms that underlie fat metabolism. Methods: We collected muscle samples of 453 Chinese Lulai black pigs, measured IMF content by Soxhlet petroleum-ether extraction method, and genotyped genome-wide SNPs using GeneSeek Genomic Profiler Porcine HD BeadChip. Then a genome-wide association study was performed using a linear mixed model implemented in the GEMMA software. Results: A total of 43 SNPs were identified to be significantly associated with IMF content by the cutoff p<0.001. Among these significant SNPs, the greatest number of SNPs (n = 19) were detected on Chr.9, and two linkage disequilibrium blocks were formed among them. Additionally, 17 significant SNPs are mapped to previously reported quantitative trait loci (QTLs) of IMF and confirmed previous QTLs studies. Forty-two annotated genes centering these significant SNPs were obtained from Ensembl database. Overrepresentation test of pathways and gene ontology (GO) terms revealed some enriched reactome pathways and GO terms, which mainly involved regulation of basic material transport, energy metabolic process and signaling pathway. Conclusion: These findings improve our understanding of the genetic architecture of IMF content in pork and facilitate the follow-up study of fine-mapping genes that influence fat deposition in muscle.

• Tissue Engineering and Regenerative Medicine
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• 제15권6호
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• pp.711-719
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• 2018

BACKGROUND: Collagen organization within tissues has a critical role in wound regeneration. Collagen fibril diameter, arrangements and maturity between connective tissue growth factor (CTGF) small interfering RNA (siRNA) and mismatch scrambled siRNA-treated wound were compared to evaluate the efficacy of CTGF siRNA as a future implement for scar preventive medicine. METHODS: Nanocomplexes of CTGF small interfering RNA (CTGF siRNA) with cell penetrating peptides (KALA and $MPG^{{\Delta}NLS}$) were formulated and their effects on CTGF downregulation, collagen fibril diameter and arrangement were investigated. Various ratios of CTGF siRNA and peptide complexes were prepared and down-regulation were evaluated by immunoblot analysis. Control and CTGF siRNA modified cells-populated collagen lattices were prepared and rates of contraction measured. Collagen organization in rabbit ear 8 mm biopsy punch wound at 1 day to 8 wks post injury time were investigated by transmission electron microscopy and histology was investigated with Olympus System and TS-Auto software. CONCLUSION: CTGF expression was down-regulated to 40% of control by CTGF siRNA/KALA (1:24) complexes (p<0.01) and collagen lattice contraction was inhibited. However, down-regulated of CTGF by CTGF $siRNA/MPG^{{\Delta}NLS}$ complexes was not statistically significant. CTGF KALA-treated wound appeared with well formed-basket weave pattern of collagen fibrils with mean diameter of $128{\pm}22nm$ (n = 821). Mismatch siRNA/KALA-treated wound showed a high frequency of parallel small diameter fibrils (mean $90{\pm}20nm$, n = 563). CONCLUSION: Controlling over-expression of CTGF by peptide-mediated siRNA delivery could improve the collagen orientation and tissue remodeling in full thickness rabbit ear wound.

• International Journal of Computer Science & Network Security
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• 제21권2호
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• pp.54-65
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• 2021

The movement control order and shutting down educational institution in Saudi Arabia has jeopardized the teaching and learning process. Education was shifted to distance learning in order to avoid any academic loss. In the middle of the Covid-19 crisis, there is a need to assess the full image of e-learning in Saudi Arabia. To investigate student and teachers' perception and acceptance, parents' attitudes and believes about distance education are the main goals of the study. The mix-method research design was employed to collect data. Three surveys were distributed to 100 students and 50 teachers and 50 parents from different educational institutions in Saudi Arabia, while semi-structured interviews were conducted with 10 parents. Random stratified and convenient sampling methods were adopted. Both descriptive and content analysis was conducted using SPSS25.0 and NVIVO software for quantitative and qualitative data accordingly. The findings showed that students are comfortable with remote education and are receiving enough support from schools and instructors but they think online education can't replace conventional face-to-face learning. Moreover, the results showed that teachers are having challenges in preparing online classes because of the development of conducting online classes and the lack of training. However, parents showed negative attitudes regarding the benefits and values of remote education and preferred conventional learning styles in elementary schools. Parents tended to reject and resist distance learning for several reasons: professional knowledge and lack of time to support their young kids in online classes, the shortcomings of e-learning, young children's inadequate self-regulation. Saudi parents are neither trained nor ready to use e-learning. The study provided suggestion and implications for teacher education and policymakers.

• 한국안전학회지
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• 제35권6호
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• pp.25-31
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• 2020

Boiling Liquid Expanding Vapor Explosion(BLEVE) can cause not only economic damage to the plant but also serious casualties. LPG accidents account for 89.6 percent of all accidents caused by gas leaks in Korea over the past nine years, while casualties from accidents also account for 73 percent of all accidents, according to statistics from the Korea Gas Safety Corporation. In addition, a potential explosion and a fire accident from one LPG storage tank may affect the nearby storage tanks, causing secondary and tertiary damage (domino effect). The safety distance standards for LPG used by LPG workplaces, charging stations, and homes in Korea have become stricter following the explosion of LPG charging stations in Bucheon. The safety distance regulation is divided into regulations based on the distance damage and the risk including frequency. This study suggests two approaches to optimizing the safety distance based on the just consequence and risk including frequencies. Using the Phast 7.2 Risk Assessment software by DNV GL, the explosion overpressure and heat radiation were derived according to the distance caused by BLEVE in the worst-case scenario, and accident and damage probability were derived by considering the probit function and domino effect. In addition, the safety distance between LPG tanks or LPG charging stations was derived to minimize damage effects by utilizing these measures.

• International Journal of Computer Science & Network Security
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• 제22권2호
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• pp.424-435
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• 2022

When the owners of the intellectual property rights of digital content have lost control over it in the digital environment, there emerged fears that the intellectual property laws, especially copyright law, would not be effective as in the material (Offline ) world. The reason is that the digital environment helps to reproduce copies in high quality and at almost no cost, while copyright law protection has been limited to programs embedded in CDs. According to copyright laws, the owner of the program did not have the right to prevent buyers of the initial physical copy of the program from copying and reselling it to more than one individual without the permission of the original owner. As a result, business owners have invented the idea of licensing digital content and programs instead of selling them. They set out terms that serve their commercial interests regardless of their abuse to intellectual property laws or even the rules of the traditional contract to sell a material property. The abuse has resulted from the way those terms are concluded and the heavy rules that are unfair to consumer rights. Therefore, business owners insisted on dealing with the website and its programs and digital content as material property. Here raises the question of whether the website and its digital content are subject to the protection of copyright law or the rules of the traditional contract or licensing contracts. As the answer to this question affects the protection of consumer rights, is it possible to find a balance between it and the protection of the owners of digital programs' rights.That is what we will discuss in this paper.

• 대한간호학회지
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• 제52권5호
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• pp.535-549
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• 2022

Purpose: The study aimed to design and develop an automated personalized self-care (APSC) program for patients with type 2 diabetes mellitus. The secondary aim was to present a clinical protocol as a mixed-method research to test the program effects. Methods: The APSC program was developed in the order of analysis, design, implementation, and evaluation according to the software development life cycle, and was guided by the self-regulatory theory. The content validity, heuristics, and usability of the program were verified by experts and patients with type 2 diabetes mellitus. Results: The APSC program was developed based on goal setting, education, monitoring, and feedback components corresponding to the phases of forethought, performance/volitional control, and self-reflection of self-regulatory theory. Using the mobile application, the participants are able to learn from educational materials, monitor their health behaviors, receive weekly-automated personalized goals and feedback messages, and use an automated conversation system to solve the problems related to self-care. The ongoing two-year study utilizes a mixed method design, with 180 patients having type 2 diabetes mellitus randomized to receive either the intervention or usual care. The participants will be reviewed for self-care self-efficacy, health behaviors, and health outcomes at 6, 12, 18, and 24 months. Participants in the intervention group will be interviewed about their experiences. Conclusion: The APSC program can serve as an effective tool for facilitating diabetes health behaviors by improving patients' self-care self-efficacy and self-regulation for self-care. However, the clinical effectiveness of this program requires further investigation.

• Journal of Korean Neurosurgical Society
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• 제65권5호
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• pp.697-709
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• 2022

Objective : The present study aimed to identify the function of ischemic stroke (IS) patients' peripheral blood and its role in IS, explore the pathogenesis, and provide direction for clinical research progress by comprehensive bioinformatics analysis. Methods : Two datasets, including GSE58294 and GSE22255, were downloaded from Gene Expression Omnibus database. GEO2R was utilized to obtain differentially expressed genes (DEGs). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of DEGs were performed using the database annotation, visualization and integrated discovery database. The protein-protein interaction (PPI) network of DEGs was constructed by search tool of searching interactive gene and visualized by Cytoscape software, and then the Hub gene was identified by degree analysis. The microRNA (miRNA) and miRNA target genes closely related to the onset of stroke were obtained through the miRNA gene regulatory network. Results : In total, 36 DEGs, containing 27 up-regulated and nine down-regulated DEGs, were identified. GO functional analysis showed that these DEGs were involved in regulation of apoptotic process, cytoplasm, protein binding and other biological processes. KEGG enrichment analysis showed that these DEGs mediated signaling pathways, including human T-cell lymphotropic virus (HTLV)-I infection and microRNAs in cancer. The results of PPI network and cytohubba showed that there was a relationship between DEGs, and five hub genes related to stroke were obtained : SOCS3, KRAS, PTGS2, EGR1, and DUSP1. Combined with the visualization of DEG-miRNAs, hsa-mir-16-5p, hsa-mir-181a-5p and hsa-mir-124-3p were predicted to be the key miRNAs in stroke, and three miRNAs were related to hub gene. Conclusion : Thirty-six DEGs, five Hub genes, and three miRNA were obtained from bioinformatics analysis of IS microarray data, which might provide potential targets for diagnosis and treatment of IS.