• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.39 no.9
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• pp.896-903
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• 2011

In this paper, a co-design method for JPEG2000 video compression system using DSP and FPGA is presented. By profiling the complexity of JPEG2000 algorithm, it is noticed that a MQ-coder is the most complex part. Thus, we implement the MQ-coder on FPGA for the parallel processing using VHDL to reduce the complexity. In order to verify the performance of the MQ-coder, JBIG2 standard test vector and images are used. The experimental results show that the proposed MQ-coder enhances the processing time approximately 3 times compared with the previous software MQ-coder.

• Journal of Software Engineering Society
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• v.28 no.1
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• pp.1-6
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• 2019

Google released an initial version of Android that runs Dex(Dalvik Executable) through the Dalvik Runtime. Since Dalvik Runtime is based on interpreter, JIT(Just-in-time) compilation has been applied to improve performance. After Lollipop(Android 5.0) Dalvik Runtime has replaced with ART Runtime which support AOT (Ahead-of-time) compilation of Dex into Native Code. The late st Android has a problem that the application execution speed is slow until the AOT compilation is completed according to the actual usage record after the installation of the app. To improve the problem we have investigate the characteristics of profile that can improve the execution speed of the application and generate the profile automatically. Finally we propose a method that can optimize the application at install time. With the proposed method we can optimize selectively at install time and can help improving the execution speed of the app from the initial execution.

• Bulletin of the Korean Chemical Society
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• v.31 no.2
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• pp.379-383
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• 2010

Metabolites of colorectal cancer tissues from 12 patients were analyzed and compared with those of the normal tissues by two-dimensional NMR spectroscopy. NMR data were analyzed with the help of the metabolome database and the statistics software. Cancerous tissues showed significantly altered metabolic profiles as compared to the normal tissues. Among such metabolites, the concentrations of taurine, glutamate, choline were notably increased in the cancerous tissues of most patients, and those of glucose, malate, and glycerol were decreased. Changes in individual metabolites varied significantly from patient to patient, but the combination of such changes could be used to distinguish cancerous tissues from normal ones, which could be done by PCA analysis. The traditional chemometric analysis was also performed using AMIX software. By comparing those two results, the analysis via $^1H-^{13}C$ HSQC spectra proved to be more robust and effective in assessing and classifying global metabolic profiles of the colorectal tissues.

• Journal of Gastric Cancer
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• v.17 no.1
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• pp.43-51
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• 2017

Purpose: This study aimed to analyze G3BP1 and VEZT expression profiles in patients with gastric cancer, and examine the possible relationship between the expressions of each gene and clinicopathological factors. Materials and Methods: Expression of these genes in formalin-fixed paraffin embedded (FFPE) tissues, collected from 40 patients with gastric cancer and 40 healthy controls, was analyzed. Differences in gene expression among patient and normal samples were identified using the GraphPad Prism 5 software. For the analysis of real-time polymerase chain reaction products, GelQuantNET software was used. Results: Our findings demonstrated that both VEZT and G3BP1 mRNA expression levels were downregulated in gastric cancer samples compared with those in the normal controls. No significant relationship was found between the expression of these genes and gender (P-value, 0.4835 vs. 0.6350), but there were significant changes associated with age (P-value, 0.0004 vs. 0.0001) and stage of disease (P-value, 0.0019 vs. 0.0001). In addition, there was a direct relationship between VEZT gene expression and metastasis (P-value, 0.0462), in contrast to G3BP1 that did not demonstrate any significant correlation (P-value, 0.1833). Conclusions: The results suggest that expression profiling of VEZT and G3BP1 can be used for diagnosis of gastric cancer, and specifically, VEZT gene could be considered as a biomarker for the detection of gastric cancer progression.

• Genomics & Informatics
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• v.6 no.3
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• pp.126-129
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• 2008

The robust identification and comprehensive profiling of copy number alterations (CNAs) is highly challenging. The amount of data obtained from high-throughput technologies such as array-based comparative genomic hybridization is often too large and it is required to develop a comprehensive and versatile tool for the detection and visualization of CNAs in a genome-wide scale. With this respective, we introduce a software framework, CGHscape that was originally developed to explore the CNAs for the study of copy number variation (CNV) or tumor biology. As a standalone program, CGHscape can be easily installed and run in Microsoft Windows platform. With a user-friendly interface, CGHscape provides a method for data smoothing to cope with the intrinsic noise of array data and CNA detection based on SW-ARRAY algorithm. The analysis results can be demonstrated as log2 plots for individual chromosomes or genomic distribution of identified CNAs. With extended applicability, CGHscape can be used for the initial screening and visualization of CNAs facilitating the cataloguing and characterizing chromosomal alterations of a cohort of samples.

• Journal of KIISE:Software and Applications
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• v.36 no.6
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• pp.431-442
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• 2009

The Software Product Line (SPL) engineering is one of the most promising software development paradigms. With Feature-Oriented Reuse Method (FORM), reusable and flexible components can be built to aid the delivery of various software products such as mobile phone and digital TV applications based on commonalities and variabilities identified during Feature modeling. Model Driven Architecture (MDA) is also an emerging technology which supports developing software products to work on different platforms with platform independent models (PIM). Combining advantages of these two approaches is helpful to build a group of software products which share common Features while working on various platforms. As first step to combine FORM with MDA, we extend UML2.0 with profiles by which FORM architectures and parameterized Statecharts can be modeled. Secondly, we provide rules to examine whether Features are allocated at positions of elements of Statecharts consistently between a Feature model and a parameterized Statechart. Some rules are designed to check the consistency between FORM architectures and parameterized Statecharts. A case study on an elevator control system is provided to demonstrate the feasibility of our modeling approach and consistency checking rules.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.7
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• pp.3145-3149
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• 2014

Gene expression profiling facilitates the understanding of biological characteristics of gliomas. Previous studies mainly used regression/variance analysis without considering various background biological and environmental factors. The aim of this study was to investigate gene expression differences between grade III and IV gliomas through partial least squares (PLS) based analysis. The expression data set was from the Gene Expression Omnibus database. PLS based analysis was performed with the R statistical software. A total of 1,378 differentially expressed genes were identified. Survival analysis identified four pathways, including Prion diseases, colorectal cancer, CAMs, and PI3K-Akt signaling, which may be related with the prognosis of the patients. Network analysis identified two hub genes, ELAVL1 and FN1, which have been reported to be related with glioma previously. Our results provide new understanding of glioma pathogenesis and prognosis with the hope to offer theoretical support for future therapeutic studies.

• Proceedings of the Korea Information Processing Society Conference
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• 2004.11a
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• pp.661-664
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• 2004

임베디드 소프트웨어는 제한된 자원을 이용해 빠르고 정확한 기능 수행이 가능하도록 설계 되어야한다. 본 논문은 임베디드 기반 소프트웨어의 효율적인 개발을 위해 개발 소프트웨어의 실행 성능을 분석할 수 있는 프로파일(profile) 도구를 제안한다. 제안하는 시스템은 교차환경(cross-platform environment)에서의 테스트 코드 및 결과 전송을 위한 에이젼트 모듈과 프로파일링을 위한 테스팅 엔진 그리고 내장형 소프트웨어의 프로그램 실행 최적화를 위해 개선되어야 할 함수 정보를 GUI 형태로 출력하는 레포팅 모듈로 구성된다. 본 시스템은 효율성과 신뢰성 있는 임베디드 기반 소프트웨어 개발에 기여할 것으로 기대된다.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.10 no.9
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• pp.1527-1537
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• 2006

The server system of digital contents has to how the context information about client devices to provide the appropriate contents for each device effectively. CC/PP standard specification is an agreement for describing and transmission of the information related with a client device. In this case, the information on device hardware and software, networks and user's preference is included here. In the mean time, WAP forum defined W-HTTP protocol to transmit the CC/PP profile information of a client device to a server system. However, the client devices which use existing HTTP protocol to transmit their information cannot provide the CC/PP profile information to a server. In this paper, we propose an effective method to create and provide the CC/PP profile in the clients which use not only HTTP protocol but also W-HTTP protocol to transmit device information.

• Proceedings of the Korean Society of Crop Science Conference
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• 2017.06a
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• pp.131-131
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• 2017

Though the Platycodon grandiflorum, has a broad range of pharmacologic properties, but the mechanisms underlying these effects remain unclear. In order to profile proteins from the nodal segment, callus, root and shoot, high throughput proteome approach was executed in the present study. Two-dimensional gels stained with CBB, a total of 84 differential expressed proteins were confirmed out of 839 protein spots using image analysis by Progenesis SameSpot software. Out of total differential expressed spots, 58 differential expressed protein spots (${\geq}2-fold$) were analyzed using MASCOT search engine according to the similarity of sequences with previously characterized proteins along with the UniProt database. Out of 58 differential expressed protein, 32 protein spots were up-regulated such as ribulose-1,5-bisphosphate carboxylase, endoplasmic oxidoreductin-1, heat stress transcription factor A3, RNA pseudourine synthase 4, cysteine proteinase, GntR family transcriptional regulator, E3 xyloglucan 6-xylosyltransferase, while 26 differential protein spots were down-regulated such as L-ascorbate oxidase precursor, late embryogenesis abundant protein D-34, putative SCO1 protein, oxygen-evolving enhancer protein 3. However, the frequency distribution of identified proteins using iProClass databases, and assignment by function based on gene ontology revealed that the identified proteins from the explants were mainly associated with the nucleic acid binding (17%), transferase activity (14%) and ion binding (12%). Taken together, the protein profile may provide insight clues for better understanding the characteristics of proteins and its metabolic activities in various explants of this essential medicinal plant P. grandiflorum.