• Genomics & Informatics
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• 제7권1호
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• pp.20-25
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• 2009

Rheumatoid arthritis (RA) is a chronic autoimmune disorder that is characterized by inflammation of the synovial tissue and deterioration of the joint and bone. A recent study reported a potential gene-environment interaction between HLA-DR and smoking. The present study investigated whether a specific gene was related to the association between smoking and the severity of RA (rheumatoid factor levels > 20 IU/ml). We used the resources of the NARAC family collection of GAW 15 databases, and 1139 subjects with RF>20 IU/ml were included in the current analysis. The linkage panel contained 5858 SNP markers, and 5744 SNPs passed quality control criteria. Linear regression analyses, using PLINK software and generalized estimating equation regression models, were used to test for associations between the SNPs and the severity of RA according to smoking groups. Two major findings were established. First, the severity of RA in smokers was associated with rs703618 (p=$6{\times}10^{-5}$), which lies in the intronic region of the stabilin 2 (STAB2) gene on chromosome 12. Second, there were significant differences in the levels of RF between 'ever smokers' and 'never smokers' according to the rs703618 genotype (G/G, A/G, A/A). We investigated whether a specific gene acts as a mediator between smoking and the severity of RA and found that the STAB2 gene could affect this relationship. Our finding indicates that smoking may mediate RA severity by affecting the expression level of a specific gene.

• 한국정보시스템학회지:정보시스템연구
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• 제8권1호
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• pp.149-176
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• 1999

Regional information infrastructure(RII) plays an increasingly important role in determining the competitiveness of companies operating within the region. The purposes of this research are (1) to identify the types of RII demanded by the companies operating within Pusan and KyungNam areas in Republic of Korea, (2) to explain the levels of RII demand using variables including organizational environment, organizational strategy, and the importance of information systems for the organization, and (3) to examine whether the types of RII demand are different depending on the competition strategies that companies are pursuing. The most important type of RII that region companies demand is information systems personnel having knowledge in systems control, systems planning, communication network, database administration, and system construction. In addition, demanded are TSDN, satellite communication network, and shareable software and hardware. The levels of RII demand are different depending on the importance of information systems(IS) roles for the businesses. The more important IS role is for a company, the more sharable computing equipments and facilities are demanded. The importance of IS role is affected by the organizational environment and organizational strategy. The levels of RII demand are different also depending on the competitive advantages that companies are pursuing. Companies focusing on achieving short-term and direct benefits using information technology tend to have higher demands on sharable computing equipments and facilities as well as on information communication services. This research is explorative in nature One major limitation of this research, therefore, is that the plausibility of the postulated hypotheses was not examined simultaneously. This research is meaningful in that it first attempted to measure the demands of regional companies for RII.

• International Journal of Advanced Culture Technology
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• 제7권4호
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• pp.208-221
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• 2019

The inference for this research was concentrated on client's data protection in cloud computing i.e. data storages protection problems and how to limit unauthenticated access to info by developing access control model then accessible preparations were introduce after that an access control model was recommend. Cloud computing might refer as technology base on internet, having share, adaptable authority that might be utilized as organization by clients. Compositely cloud computing is software's and hardware's are conveying by internet as a service. It is a remarkable technology get well known because of minimal efforts, adaptability and versatility according to client's necessity. Regardless its prevalence large administration, propositions are reluctant to proceed onward cloud computing because of protection problems, particularly client's info protection. Management have communicated worries overs info protection as their classified and delicate info should be put away by specialist management at any areas all around. Several access models were accessible, yet those models do not satisfy the protection obligations as per services producers and cloud is always under assaults of hackers and data integrity, accessibility and protection were traded off. This research presented a model keep in aspect the requirement of services producers that upgrading the info protection in items of integrity, accessibility and security. The developed model helped the reluctant clients to effectively choosing to move on cloud while considerate the uncertainty related with cloud computing.

• 한국전자거래학회:학술대회논문집
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• 한국전자거래학회 1999년도 학술대회지 vol.1
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• pp.215-231
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• 1999

CALS, Enterprise Integration, Virtual Enterprise 등을 구현하는데 있어서 BPR (business process re-engineering), ISP (Information Strategy Planning), Analysis/Design 등은 필수 적이다. 이러한 BPR, ISP, A/D 추진하는데 있어서 각 단계의 산출물은 유연하게 연계되지 못한다. 그 이유는 각 단계가 접근하는 초점이 다르고, 산출물의 성격이 다르며, 무엇보다도 각 단계의 전문가가 다르기 때문에 발생한다. 현재 기업이 각 단계를 추진할 때에는 반복적인 피드백을 통하여 정보를 공유하거나, 각 단계의 정보 연계가 제대로 이루어지지 않는다. 이러한 문제를 해결하기 위하여 BPR-ISP-A/D의 정보 연계를 유연하게 하기 위하여 PPO (Product-Process-Organization) 객체 진화에 의한 통합 방법론을 제안 하고자 한다. 그 과정은 1) Real world 정보를 PPO 객체로 정의하고, 2) PPO 객체를 기반으로 BPR을 수행하여 TO-BE model 을 만드는 동시에, 3) PPO TO-BE model과 함께 IT Architecture를 정의하며, 4) PPO 객체를 기반으로 Analysis and Design 과정을 통하여 Application system 객체 및 Data 객체를 정의한다. 이때 PPO 객체는 Real-world 객체에서 Application system 객체 및 Data 객체로 진화하게 되고 BPR-ISP-A/D의 seamless 통합이 이루어진다. 여기서, 단계 1) 과 2)는 System Engineering을 통하여 이루어진다. ARIS(Architecture of Integrated Information System, Dr. A-W. Scheer, 1998)개념을 도입하여 실세계를 정해진 규약에 따라 Model로 Mapping하고, 생성된 Model을 바탕으로 BPR을 수행하여 개선된 Model을 산출해 낸다. 단계 3)은, IE (Information Engineering, James Martine, 1990) 의 ISP가 도입되어, 설계업무를 지원하기위한 기본적인 시스템 구조를 구상하게 된다. 이와 함께 IT Model을 구성하게 되는데, 객체지향적 접근 방법으로 Model을 생성하고 UML(Unified Modeling Language)을 Tool로 사용한다. 단계 4)는 Software Engineering 관점으로 접근한다. 이는 최종산물이라고 볼 수 있는 설계업무 지원 시스템을 Design하는 과정으로, 시스템에 사용될 데이터를 Design하는 과정과, 데이터를 기반으로 한 기능을 Design하는 과정으로 나눈다. 이를 통해 생성된 Model에 따라 최종적으로 Coding을 통하여 실제 시스템을 구축하게 된다.

• 한국건설관리학회논문집
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• 제5권2호
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• pp.106-114
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• 2004

건축공사의 규모가 대형화, 복잡화, 다양화 되면서 개별 현장에서 공사수행에 따른 많은 정보가 발생하여 본사로 보고 되고있다. 이러한 정보들 중에서 개별 현장 및 다중 현장을 동시에 관리하기 위해서는 필요정보만을 추출하여 경영진이 의사결정을 할 수 있는 지원체계의 필요성이 증가하고 있다. 하지만 중견건설업체의 경우 대형건설업체와 비교할 때 본사 조직의 미비 및 관리업무 시스템이 취약하여 다중현장관리가 어려운 실정이다. 특히 이러한 현장관리에 있어서 자원관리의 대부분을 차지하는 자재관리는 프로젝트 관리자의 중요한 관리대상이다. 그러나 자재조달계획을 일정정보와의 연계가 없이 주로 담당자의 경험과 판단에 근거하여 수립하기 때문에 일정이 변경될 때마다 계획을 수작업으로 수정해야하는 실정이며, 이로 인한 불필요한 공기지연이나 재고비용이 발생하고 있다. 본 연구에서는 중견건설업체가 다수 현장을 동시에 관리할 수 있도록 현장의 작업 일보와 공정관리 소프트웨어의 연계를 가정한 자재조달계획 지원모델을 제시한다.

• 한국실내디자인학회논문집
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• 제16권4호
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• pp.110-118
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• 2007

Technology has been viewed at various stages of civilization as leading to future progress. The building, its services systems and management of the work process all contribute to the well-being of people within an organization. Productivity relies on there being a general sense of high morale and satisfaction with the workplace. Now buildings are considered as providing a milieu for human creativity. Flexibility, adaptability, service integration and high standards of finishes offer an intelligence threshold. Building Automation System(BAS) - controlled lighting systems may offer incremental energy saving. Conventional Lighting control systems often control equipment in a single room or over the limited area, because they are centralized control systems, which means that all the controlled circuits must be wired to a single control panel. The computers used by these systems are typically dedicated microprocess that perform only lighting control functions. By comparison, modern Building automation systems are distributed control system, which means that their computing hardware and software are distributed as a network that microprocessor-based control modules and standard PC. PLC(Programmable Logic controller) is extensible virtually without limits, so that all the lighting in a facility can be controlled by single, unified system - the same system that also can control and monitor the building's HVAC, security, and manufacturing processed, elevators, and more. A Building automation system can control light using schedules, manual controls, occupancy sensors, and photosensors, either singly or in combination. Building Lighting control and monitoring system will be for a energy saving and efficient building management system.

• 한국정보통신학회논문지
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• 제4권1호
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• pp.35-43
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• 2000

본 연구는 장애인이 일반인과 똑같이 정보사회에 적응시키기 위해 장애인복지를 위한 정보통신의 발전방향을 연구하였다. 연구의 방법으로는 델파이기법을 도입하였으며, 조사방법으로는 문헌적조사방법과 면담조사방법을 병행하여 연구분석의 틀에 의해 분석하였다. 정보통신에 대한 장애인의 문제점을 살펴보면, 정보통신 접근의 불편, 보편적 서비스 저하, 장애인의 PC 통신 이용 저조, 장애인복지의 낙후, 정보통신요금의 부담, 정보화교육의 부족, 장애인정보의 부족, 장애인복지 정책결정에 장애인 미참여 등으로 분석되었다. 장애인에 필요한 정보통신기술을 살펴보면, 지체장애인에게는 음성인식기술ㆍ화상인식기술ㆍ호흡압력감지기술, 시각장애인에게는 표시기술ㆍ음성인식기술ㆍ문자인식기술ㆍ지적변환처리기술ㆍ화상인식음성합성기술, 청각ㆍ언어장애인에게는 음성신호처리기술ㆍ음성인식기술ㆍ기적변환처리기술ㆍ문자인식기술ㆍ화상인식기술ㆍ음성합성기술이 필요하다. 장애인복지를 위한 정보통신을 발전시키기 위해서는 장애인정보통신위원회의 구성, 보편적 서비스의 제공, 정보화교육의 실시, 연구개발의 지원, 중소정보통신기업의 지원 육성, 소프트웨어산업의 육성, 장애인용 표준화 작업 추진이 요구된다.

• 한국항해항만학회:학술대회논문집
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• 한국항해항만학회 2006년도 International Symposium on GPS/GNSS Vol.2
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• pp.33-37
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• 2006

Since 1993, the civil aviation community through RTCA (Radio Technical Commission for Aeronautics) and the ICAO (International Civil Air Navigation Organization) have been working on the definition of GNSS augmentation systems that will provide improved levels of accuracy and integrity. These augmentation systems have been classified into three distinct groups: Aircraft Based Augmentation Systems (ABAS), Space Based Augmentation Systems (SBAS) and Ground Based Augmentation Systems (GBAS). The last one is an implemented system to support Air Navigation in CAT-I approaching operation. It consists of three primary subsystems: the GNSS Satellite subsystem that produces the ranging signals and navigation messages; the GBAS ground subsystem, which uses two or more GNSS receivers. It collects pseudo ranges for all GNSS satellites in view and computes and broadcasts differential corrections and integrity-related information; the Aircraft subsystem. Within the area of coverage of the ground station, aircraft subsystems may use the broadcast corrections to compute their own measurements in line with the differential principle. After selection of the desired FAS for the landing runway, the differentially corrected position is used to generate navigation guidance signals. Those are lateral and vertical deviations as well as distance to the threshold crossing point of the selected FAS and integrity flags. The Department of Applied Science in Naples has create for its study a virtual GBAS Ground station. Starting from three GPS double frequency receivers, we collect data of 24h measures session and in post processing we generate the GC (GBAS Correction). For this goal we use the software Pegasus V4.1 developed from EUROCONTROL. Generating the GC we have the possibility to study and monitor GBAS performance and integrity starting from a virtual functional architecture. The latter allows us to collect data without the necessity to found us authorization for the access to restricted area in airport where there is one GBAS installation.

• 정보학연구
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• 제1권1호
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• pp.173-188
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• 1998

최근 인터넷을 이용한 전자상거래가 점차 발전됨에 따라 고객의 서비스 구매에 따르는 전자 결제의 이용이 점차 늘어가고 있는 추세이다. 그러나 전자결제는 온라인상에서 이루어지는 활동이라는 점에서 많은 문제를 내포하고 있다. 온라인 신용카드와 전자화폐 그리고 전자수표로 대변되는 전자결제의 수단들은 흔히 해커라 불리어지는 전자상거래의 비주체들에 의하여 오용되어지고 그로 인해 많은 피해가 발생할 우려가 있다. 본 고에서는 전자상거래시의 대금결제 수단인 전자결제의 종류와 문제점에 대하여 알아보고 그러한 문제점을 극복할 수 있는 방법들에 대하여 제시해 본다.

• Genomics & Informatics
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• 제8권3호
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• pp.131-137
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• 2010

Genome-wide association studies (GWASs) have greatly contributed to the identification of common variants responsible for numerous complex traits. There are, however, unavoidable limitations in detecting causal and/or rare variants for traits in this approach, which depends on an LD-based tagging SNP microarray chip. In an effort to detect potential casual and/or rare variants for complex traits, such as type 2 diabetes (T2D) and triglycerides (TGs), we conducted a targeted resequencing of loci identified by the Korea Association REsource (KARE) GWAS. The target regions for resequencing comprised whole exons, exon-intron boundaries, and regulatory regions of genes that appeared within 1 Mb of the GWA signal boundary. From 124 individuals selected in population-based cohorts, a total of 0.7 Mb target regions were captured by the NimbleGen sequence capture 385K array. Subsequent sequencing, carried out by the Roche 454 Genome Sequencer FLX, generated about 110,000 sequence reads per individual. Mapping of sequence reads to the human reference genome was performed using the SSAHA2 program. An average of 62.2% of total reads was mapped to targets with an average 22X-fold coverage. A total of 5,983 SNPs (average 846 SNPs per individual) were called and annotated by GATK software, with 96.5% accuracy that was estimated by comparison with Affymetrix 5.0 genotyped data in identical individuals. About 51% of total SNPs were singletons that can be considered possible rare variants in the population. Among SNPs that appeared in exons, which occupies about 20% of total SNPs, 304 nonsynonymous singletons were tested with Polyphen to predict the protein damage caused by mutation. In total, we were able to detect 9 and 6 potentially functional rare SNPs for T2D and triglycerides, respectively, evoking a further step of replication genotyping in independent populations to prove their bona fide relevance to traits.