• 한국응용과학기술학회지
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• 제15권1호
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• pp.99-108
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• 1998

Novel type surfactants containing two long-chain hydrophobic alkyl groups and two hydrophilic sulfonate groups were successfully synthesized by reactions of ethylene glycol diglycidyl ether with long-chain fatty alcohols, after then by reactions with 1,3-propane sultone and sodium hydride under THF solvent. All these compounds, so called Gemini surfactants, were purified by thin layer chromatography and column chromatography. Their structures were identified by FT-IR and $^{1}H$-NMR.

• Archives of Pharmacal Research
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• 제15권2호
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• pp.142-145
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• 1992

A novel preparative method for hexaprofen, which is a potent antiinflammatory agent, is described. Friedel-Crafts reaction of cyclohexylbenzene with ethyl $\alpha$-chloro-$\alpha$-(methylthio) acetate 1 and $\alpha$-chloro-$\alpha$-(methylthio) acetonitrile 2 afforded ethyl 2-(methylthio)-2-(4-cyclohexylphenyl) acetate 7 and 2-methylthio-2-(4-cyclohexylphenyl) acetonitrile 8, respectively. Compounds 7 and 8 were converted into the corresponding ethyl 2-methylthio-2-(4-cyclohexylphenyl) propionate 9 and 2-methylthio-2-(4-cyclohexylphenyl) propionitrile 10 by methylation with sodium hydride and methyl iodide. Hexaprofen 13 was prepard by hydrolysis of ethyl 2-(4-cyclohexylphenyl) propionate 11 and of 2-(4-cyclohexylphenyl) propionitrile 12 followed by desulfurization of compounds 9 and 10.

• Bulletin of the Korean Chemical Society
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• 제16권7호
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• pp.625-630
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• 1995

α-Linked D-altropyranosidic derivatives were obtained by configurational change at C-3 of α-D-mannopyranosides as the key step in preparation of allyl and methyl α-D-glycopyranosides of 6-deoxy-D-altro-heptose. The manno-altro conversion was effected by sequential reactions of Swern oxidation and stereoselective borohydride reduction. Allyl 4,6-O-benzylidene-2-O-p-methoxybenzyl-α-D-mannopyranoside was transformed to the corresponding altropyranoside via 3-oxo-arabino-hexopyranoside. Allyl 7-O-benzyl-6-deoxy-3,4-O-isopropylidene-α-D-altro-heptopyranoside has been prepared as a glycosyl acceptor to be coupled with β-D-GlcpNAc-(1→3)-α-D-Galp glycosyl donor for the synthesis of an O-antigen repeating unit of Campylobacter jejuni serotypes O:23 and O:36. Stereoselective borohydride reduction also succeeded in yielding methyl 2,4,7-tri-O-benzyl-6-deoxy-α-D-altro-heptopyranoside from the corresponding 3-oxo-α-D-arabino-heptopyranoside. C-6 Homologation was achieved by sequential reactions of cyanide displacement of 6-sulphonates, reduction of the resulting heptopyranosidurononitrile with diisobutylaluminum hydride, hydrolysis of the imine, and further reduction with sodium borohydride.

• 한국수소및신에너지학회논문집
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• 제20권4호
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• pp.300-308
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• 2009

In a pursuit of the development of alternative mobile power sources with a high energy density, a planar and air-breathing PEMFCs with a new type of hydrogen cartridge which uses onsite $H_2$ generated from sodium borohydride ($NaBH_4$) hydrolysis have been investigated for use in advanced power systems. Two types of $H_2$ generation through $NaBH_4$ hydrolysis are available: (1) using organic acids such as sulphuric acid, malic acid, and sodium hydrogen carbonate in aqueous solution with solid $NaBH_4$ and (2) using solid selected catalysts such as Pt, Ru, CoB into the stabilized alkaline $NaBH_4$ solution. It might therefore be relevant at this stage to evaluate the relative competitiveness of the two methods mentioned above. The effects of flow rate of stabilized $NaBH_4$ solution, MEA (Membrane Electrode Assembly) improvement, and type and flow control of the catalytic acidic solution have been studied and the cell performances of the planar, air-breathing PEMFCs using $NaBH_4$ has been measured from aspects of power density, fuel efficiency, energy density, and fast response of cell. In our experiments, planar, air-breathing PEMFCs using $NaBH_4$ achieved to maximum power density of 128mW/$cm^2$ at 0.7V and energy efficiency of 46% and has many advantages such as low operating temperature, sustained operation at a high power density, compactness, the potential for low cost and volume, long stack life, fast star-up and suitability for discontinuous operation.

• 대한기계학회논문집B
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• 제38권2호
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• pp.139-146
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• 2014

수소화붕소나트륨은 수소 에너지를 저장 및 공급할 수 있는 안정된 금속 물질이다. 본 논문에서는 탈수소 화학반응기 유로 설계를 위해 수력학적 직경 $461{\mu}m$를 가지는 마이크로채널에서 수소화붕소나트륨 수용액의 탈수소 화학반응이 일어날 때 수용액과 수소 기체 간의 이상유동 계면마찰에 대하여 실험연구를 수행하였다. 화학반응기 마이크로채널은 직사각 단면으로 높이 $300{\mu}m$, 너비 1 mm, 길이 50 mm 로 실리콘 웨이퍼에 공정되었으며, 가수분해 촉진을 위해 루테늄을 촉매로서 100 nm 두께로 채널 표면에 증착하였다. 가시화 결과 Re 수 30 이하에서 기포유동 양상이 관측되었다. 이상마찰승수는 기포율에 선형적으로 비례하며, 탈수소 화학반응기를 설계할 때 계면마찰에 영향을 미치는 수용액의 초기농도, 촉매 화학반응률, 체류시간을 고려해야 된다.

• 한국응용과학기술학회지
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• 제13권3호
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• pp.61-71
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• 1996

In acid-catalyzed acetal cyclization of long aliphatic aldehydes($R=n-C_7H_{15}$ ; $n-C_9H_{19}$ ; $n-C_{11}H_{23}$) with 1,1,1-tris(hydroxymethyl)propane, 2-alkyl-5-hydroxymethyl-5-ethyl-1,3-dioxanes were obtained. The final products, sodium 2-alkyl-5-(sulfonatedpropylethermethyl)-5-ethyl-1,3-propanesultion in the presence of sodium hydride. These compounds were a new group of destructible surfactants which were readily hydrolyzed and oxidized in natural water reservoirs. Physical properties of these new compounds involved some surface properties such as Krafft point(Kp), critical micelle concentration(cmc), surface tension of aqueous solutions near cmc(${\gamma}_{min}$), foaming power, emulsion power and hydrolysis properties were determined. The destructible surfactants containing 1,3-dioxane ring were synthesized to about $85{\pm}5.5%$ yield. The cmc values of the compounds by ring method were assumed to $0.5{\sim}5.0{\times}10^{-3}mol/L$ range and surface tensions at cmc were $29.5{\sim}33.0dyne/cm$ respectively at $25^{\circ}C$. The foaming power and foam stability were $170{\sim}230mm$ and $52{\sim}135mm$ respectively at $1{\times}10^{-2}mol/L$, foam was occurred rarely below $1{\times}10^{-3}mol/L$. The emulsion property of liquid paraffin was better than that of soybean oil. For hydrolysis property with ph and time, these compounds were decomposed within about 200minutes at $ph1{\sim}2$. Hopefully these compounds are expected to be a good O/W emulsifier that have decomposability in acid and may be used in the process which do not need foaming.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1997년도 춘계학술대회
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• pp.73-73
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• 1997

A series of 4-phenyl-1-(indoline-5-sulfonyl)-2-imidazolone derivatives has been synthesized starting from 2-bromoacetophenone. Reaction of 2-aminoacetophenone obtained from 2-bromoacetophenon by Delepin synthesis and potassium cyanate affords 1,3-dihydro-4-phenyl-2-imidazolone. This key intermediate was treated with sodium hydride and N-trifluoroacetyl-indoline-5-sulfonylchloride, and trifluoroacetyl group was deprotected to give 4-Phenyl-1-(indoline-5-sulfonyl)-2-imidazolone. Various substituents were introduced on the nitrogen of indoline. Antitumor activity of this series of compound was evaluated by MTT method. Nearly all of the compounds showed broad-spectrum activity.

• 대한화학회지
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• 제57권5호
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• pp.612-617
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• 2013

The versatile, hitherto unreported 3-(4-(2-phenyldiazenyl)-2-oxo-2H-chromen-3-yl)-3-oxopropanenitrile 3 was prepared by two convenient routes: either by the reaction of ethyl 4-(2-phenyldiazenyl)-2-oxo-2H-chromen-3-carboxylate 2 with acetonitrile in the presence of sodium hydride or by treatment of 4-(2-phenyldiazenyl)-3-(2-bromoacetyl)-2H-chromen-2- one 5 with potassium cyanide. Reaction of 3 with heterocyclic diazonium salts 6, 7, 14 and 17 furnished the corresponding hydrazones 8, 9, 15 and 18. The latter hydrazones underwent intramolecular cyclization into the corresponding pyrazolo[5,1- c]-1,2,4-triazine 10, 1,2,4-triazolo[5,1-c]-1,2,4-triazine 11, 1,2,4-triazino[4,3-b]indazole 16 and imidazo[2,1-c]-1,2,4-triazine 19 derivatives, respectively upon refluxing in pyridine.

• 한국항공우주학회지
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• 제41권3호
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• pp.226-232
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• 2013

소형 무인항공기의 동력장치로 연료전지 시스템을 적용하기 위해 화학수소화합물 수소 저장방법을 이용한 소형 수소 발생 제어장치를 설계하였다. 효율이 높은 소형/경량 수소 발생 제어장치를 설계하기 위하여 $NaBH_4$ 수용액 공급 유량에 따른 Co-B 촉매의 수소 전환율을 확인하였고, 100W 스택의 최대 수소 발생량에 적합한 Co-B 촉매양을 제안하였다. 효율적인 연료 소모를 위해 Dead-end 방식의 스택을 선택하였고, 수소 발생 제어장치 내부 압력을 이용한 펌프 on/off 제어로 수소 생성량을 제어하였다. 소형 수소 발생 제어장치를 이용한 연료전지 시스템의 각 작동구간에서 안정된 운전을 확인하였다. 장시간 운전 실험을 통하여 최대 7시간 운전이 가능하며, 임의의 비행 프로화일에 요구되는 추력 프로화일은 최소 4시간 이상 조정 가능함을 확인하였다.

• 공업화학
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• 제8권4호
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• pp.568-574
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• 1997

Ni/MH전지에서 Cu 도금이 MH(metal hydride)음극의 전극 특성에 미치는 영향을 실험적으로 조사하였다. $LaNi_5$와 Cu도금된 $LaNi_5$를 활물질로 사용하여 냉간압착법과 페이스트법의 혼용법으로 전극을 제조하였다. 그 결과 소량의 CMC(carboxymethylcellulose sodium salt)를 첨가하고 열처리를 행하지 않은 전극이 높은 방전용량을 보였다. $LaNi_5$보다는 Cu 도금된 $LaNi_5$를 활물질로 사용하여 제조한 전극의 방전용량이 증가하였으며, 이는 $LaNi_5$표면에 도금된 구리에 의해 전극의 전자 전도도가 증가되었기 때문이며 도금된 구리의 양이 증가할 수록 그 효과는 현저하였다. 또한 전극의 방전용량은 산성 무전해도금의 경우가 알칼리성 무전해도금을 행한 전극보다 우수한 용량을 나타내었다. Al이 첨가된 $LaNi_{4.5}Al_{0.5}$ 전극이 $LaNi_5$전극보다 우수한 방전용량을 보였다. 구리 도금이 $LaNi_5$의 피독특성에 미치는 영향을 CO기체의 피독실험으로 조사하였다.