• BMB Reports
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• v.55 no.5
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• pp.238-243
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• 2022

Autism or autism spectrum disorder (ASD) is a behavioral syndrome characterized by persistent deficits in social interaction, and repetitive patterns of behavior, interests, or activities. The gene encoding Methyl-CpG binding protein 2 (MeCP2) is one of a few exceptional genes of established causal effect in ASD. Although genetically engineered mice studies may shed light on how MeCP2 loss affects synaptic activity patterns across the whole brain, such studies are not considered practical in ASD patients due to the overall level of impairment, and are technically challenging in mice. For the first time, we show that hippocampal MeCP2 knockdown produces behavioral abnormalities associated with autism-like traits in rats, providing a new strategy to investigate the efficacy of therapeutics in ASD. Ketamine, an N-Methyl-D-aspartate (NMDA) blocker, has been proposed as a possible treatment for autism. Using the MeCP2 knockdown rats in conjunction with a rat model of valproic acid (VPA)-induced ASD, we examined gene expression and ASD behaviors upon ketamine treatment. We report that the core symptoms of autism in MeCP2 knockdown rats with social impairment recovered dramatically following a single treatment with ketamine.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.13 no.8
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• pp.3842-3861
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• 2019

In cut throat competition, organizations all over the world try to utilize the immense opportunities the Internet has to offer in almost all of their operations. Today, Social networking sites (SNSs) provide utilities designed to help companies to recruit right personnel. Considering the implication of social media for recruitment at infancy stage in Pakistan and lack of studies related to it, this study aims to investigate the role of different SNSs qualities (Easily navigate, Secure process, Eminence Proficiency, Candidate's Attraction and Network Expedition) in effective E-recruitment (EER). Data were collected through structured questionnaire from employees and managers of major telecom companies of Pakistan. Finally, the result of 355 returned and valid questionnaire with 55% response rate show that the relationship between SNSs qualities and EER is significant. Moreover, results also prove that EER is better than the tradition recruitment and a SNSs comparison show that Facebook is more effective than LinkedIn for EER. The results of this study will help Pakistani companies to develop a successful e-HRM and EER strategy in the current scenario.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.17 no.10
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• pp.2732-2749
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• 2023

Device-to-Device (D2D) communication has received increasing attention and been studied extensively thanks to its advantages in improving spectral efficiency and energy efficiency of cellular networks. This paper proposes a novel relay selection algorithm for multi-hop full-duplex D2D communications underlaying cellular networks. By selecting the relay of each hop in a reverse manner, the proposed algorithm reduces the heavy signaling overhead that traditional relay selection algorithms introduce. In addition, the social domain information of mobile terminals is taken into consideration and its influence on the performance of D2D communications studied, which is found significant enough not to be overlooked. Moreover, simulations show that the proposed algorithm, in absence of social relationship information, improves data throughput by around 70% and 7% and energy efficiency by 64% and 6%, compared with two benchmark algorithms, when D2D distance is 260 meters. In a more practical implementation considering social relationship information, although the proposed algorithm naturally achieves less throughput, it substantially increases the energy efficiency than the benchmarks.

• Journal of Korean Institute of Industrial Engineers
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• v.39 no.3
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• pp.156-162
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• 2013

Social manufacturing architecture is based on information delivery through social media and SNS, PLM and social platform, crowd source and knowledge base on whole phase of product life cycle. Although advanced social manufacturing issues are rising globally, its technology emerging into domestic industry is likely to be slow. We focused to review technological changes and R&D trend, patent issues, and then suggest assignments and advices to be practiced for social manufacturing modeling.

• Journal of Engineering Education Research
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• v.14 no.2
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• pp.60-67
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• 2011

This study is to analyze employment stress and career decision efficacy of undergraduates from engineering and social science department. Research object is 310 undergraduates(engineering department: 164 and social science department: 146) from three colleges in Seoul and Cheju. As a result of testing employment stress and career decision efficacy undergraduates had significant difference according to major and grade. Employment stress of undergraduates from engineering department was more serious than undergraduates from social science department. As a result of analyzing on the basis of grade employment stress of sophomores was more serious than freshmen. Career decision efficacy of undergraduates from social science department was higher than other group. Career decision efficacy of freshmen was higher than sophomore. Employment stress and career decision efficacy showed negative corelation in corelation analysis. This study implies that course educating program should be specialized according to major and grade. This study suggests that we should develop course educating curriculum connecting with major education.

• Journal of Korean Society of Disaster and Security
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• v.9 no.2
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• pp.15-21
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• 2016

According to the disaster statistics issued by the Ministry of Public Safety and Security, traffic accidents, fire, collapses and others are classified into twenty-three (23) categories. In the past, disasters were mainly caused by the influence of nature, such as typhoon or drought. On the other hand, as society has become city-centered, social disasters' types, frequencies and scales are becoming more diversified and ever-increasing. However, there are no specific criteria and assessment methods that can measure degrees of social disasters-related risks objectively. Therefore, this study targeted traffic accidents, fire and collapses from major social disasters, utilized data that are related to occurrence rate, scale of casualties and scale of property loss in past eight years, and calculated the disaster risk index using the distance (Euclidean distance) between two points on the 3D spatial coordinates, in order to make the objective assessment by social disaster type possible. These results will enable the objective evaluation of risk index of major social disaster to be used as the foundational data when building the national disaster management system.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.24 no.5
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• pp.567-575
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• 2020

As online social networks are used as a critical medium for modern people's information sharing and relationship, their users are increasing rapidly every year. This not only increases usage but also surpasses the existing media in terms of information credibility. Therefore, emerging marketing strategies are deliberately attacking social networks. As a result, public opinion, which should be formed naturally, is artificially formed by online attacks, and many people trust it. Therefore, many studies have been conducted to detect agents attacking online social networks. In this paper, we analyze the trends of researches attempting to detect such online social network attackers, focusing on researches using social network graph characteristics. While the existing content-based techniques may represent classification errors due to privacy infringement and changes in attack strategies, the graph-based method proposes a more robust detection method using attacker patterns.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.3
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• pp.1436-1441
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• 2014

Social enterprise has been increasingly recognized for as important economic and social contribution to modern society. Recently, many efforts and academic researches related to social enterprise are now emerging from practitioners and academics. This work focused on the key elements affecting the performance of social enterprises such as specifically social entrepreneurship, relationship-oriented organizational culture and government support policy. In this empirical model, two performance variables such as economic and social performance represent the dependent variables. And the size and age of the social enterprises are the controlled variables. By analyzing survey data of 107 social enterprises interesting and meaningful results are obtained. Social entrepreneurship influenced economic and social performance of social enterprises. And relationship-oriented organizational culture influenced economic and social performance of social enterprises. On the other hand, government support policy influenced economic performance of social enterprises, but did not influence its social performance. The developed empirical model of social entrepreneurship in this study showed that community-oriented organizational culture and government policy are important factors for the efficient and successful management of social enterprises in Korea.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.10 no.4
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• pp.1643-1660
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• 2016

Connectivity and trust in social networks have been exploited to propose applications on top of these networks, including routing, Sybil defenses, and anonymous communication systems. In these networks, and for such applications, connectivity ensures good performance of applications while trust is assumed to always hold, so as collaboration and good behavior are always guaranteed. In this paper, we study the impact of differential behavior of users on performance in typical social network-enabled routing applications. We classify users into either collaborative or rational (probabilistically collaborative) and study the impact of this classification and the associated behavior of users on the performance of such applications, including random walk-based routing, shortest path based routing, breadth-first-search based routing, and Dijkstra routing. By experimenting with real-world social network traces, we make several interesting observations. First, we show that some of the existing social graphs have high routing costs, demonstrating poor structure that prevents their use in such applications. Second, we study the factors that make probabilistically collaborative nodes important for the performance of the routing protocol within the entire network and demonstrate that the importance of these nodes stems from their topological features rather than their percentage of all the nodes within the network.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.17 no.5
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• pp.1168-1173
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• 2013

This paper proposes a new visualization method based on cloud technique which uses internal relationship of user correlation and external relation of social network to visualize user relationship hierarchy. The visualization method of this paper can well represent user-focused relationship hierarchy on social networks by a correlation matrix. The importance of a access node reflects into user relationship hierarchy by exploiting external relation of social network. Users of the method can well understand user relationships on account of representing user relationship hierarchy from social networks. In addition, the method use hadoop and hive for distribution storing and parallel processing which the result of calculation visualizes hierarchy graph using D3.