• 대한불안의학회지
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• 제16권2호
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• pp.106-112
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• 2020

Objective : Social anxiety disorder (SAD) is characterized by fear of social threat and exhibits limbic hyper-reactivity toward social stimuli such as emotional faces. A previous study identified the uncinate fasciculus (UF) sub-tract as particularly related to facial memory. To explore the white matter tract relating to face-specific brain regions, we investigated the UF sub-tract in SAD. Methods : The diffusion tensor images of 22 patients with SAD and 20 healthy controls were analyzed with tractography. The UF sub-tract was delineated using the regions of interest of face patches in the anterior temporal lobe and the orbitofrontal cortex, and fractional anisotrophy (FA) and total number of streamlines (ST) were analyzed. We examined the group comparison of FA and ST of the UF sub-tract and correlations of FA and ST with the social anxiety symptoms such as the Liebowitz Social Anxiety Scale (LSAS), the Social Interaction Anxiety Scale (SIAS), the Social Phobia Scale (SPS) and the Fear of Negative Evaluation scale (FNE) in SAD. Results : There were no group differences in FA and ST of the UF sub-tract. However, negative correlations were observed between ST of the right UF sub-tract and severity of social anxiety symptoms (LSAS, r_s=-0.480, p=0.024; SIAS, r_s=-0.580, p=0.005; SPS, r_s=-0.590, p=0.004; FNE, r_s=-0.675, p=0.001) in patients with SAD. Conclusion : Although patients with SAD did not show quantitative abnormalities in the UF sub-tact connecting face-specific brain regions, this structure seems to play a role in the symptom severity of SAD.

• 생물정신의학
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• 제22권4호
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• pp.216-222
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• 2015

Objectives The principal aim of the present study was to investigate the characteristic depressive symptoms in patients with social anxiety disorder (SAD) and panic disorder in comparison to patients with depressive disorder. Methods This study included 132 patients with SAD, 128 panic disorder and 64 depressive disorder (major depressive disorder, dysthymia etc.) patients without comorbid psychiatric disorders. The Beck Depressive Inventory (BDI) is used to measure depressive symptoms. We divided BDI into three categories originally described by Shafer AB, including negative attitude toward self, performance impairment, and somatic symptoms. We compared the depressive symptoms of SAD, panic disorder and depressive disorder by using ANOVA. Results Negative attitude toward self was noticeable in SAD (SAD $0.54{\pm}0.23$, panic disorder $0.41{\pm}0.17$, depressive disorder $0.46{\pm}0.11$, p < 0.001). Performance impairment and somatic symptoms were remarkable in panic disorder than in SAD and depressive disorder (performance impairment : SAD $0.39{\pm}0.21$, panic disorder $0.44{\pm}0.14$, depressive disorder $0.40{\pm}0.09$, p = 0.009 ; somatic symptoms : SAD $0.07{\pm}0.10$, panic disorder $0.15{\pm}0.12$, depressive disorder $0.14{\pm}0.08$, p < 0.001). Conclusions The results facilitate an approach to optimal treatment for patients with comorbidity of anxiety disorder and depression.

• 대한불안의학회:학술대회논문집
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• 대한불안의학회 2004년도 춘계 회원연수교육
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• pp.46-55
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• 2004

• 우울조울병
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• 제9권1호
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• pp.30-36
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• 2011

Purpose : Anxiety disorder and depressive disorder are often comorbid with each other, and the comorbidity is associated with poorer psychiatric outcome, resistance to treatment, increased risk for suicide, greater chance for recurrence. We aimed to investigate the comorbidity of anxiety disorder in Korea. Method : Subjects were total of 867 depressed patients recruited CRESCEND-K multicenter trial. We used SCID (Structured Clinical Interview for DSM - IV) to find comorbidity of anxiety disorders in depressed patient. Results : Of 867 patients, total 8.2% had anxiety disorder. Proportion of anxiety disorder Not Otherwise Specified was 3.5%, panic disorder was 1.7%, generalized anxiety disorder was 1.1%, post traumatic stress disorder was 0.9%, obsessive compulsive disorder was 0.6%, social phobia was 0.4%. Conclusion : In this study, anxiety disorder in depression were measured at a low comorbidity rate in compare to previous studies. Selection bias, use of antidepressants at registration, severity of depression symptoms, and point of SICD administration seems to have affected these results. It is probable that comorbidity evaluation would be more precise if shorter, structured interviews such as M. I.N.I.-Plus were used during first clinical interview for depression diagnosis.

• Psychiatry investigation
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• 제15권11호
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• pp.1079-1086
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• 2018

Objective The pathophysiology of social anxiety disorder (SAD) is not yet well understood, but previous research has suggested that oxytocin is associated with social behavior and may play a role in human anxiety states and anxiety-related traits. The aim of this study was to investigate the possible relationship between social anxiety symptoms and plasma oxytocin levels. Methods Twenty-three male patients with SAD and 28 healthy male controls participated in this study. All participants were assessed using the Mini International Neuropsychiatric Interview (MINI) and the Liebowitz Social Anxiety Scale (LSAS). Multivariate regression analysis was performed to identify associations between plasma oxytocin levels and SAD. Results In multiple regression models, after controlling for age and years of education, we found that higher oxytocin levels were significantly associated with higher total LSAS scores ($R^2=0.157$, coefficient=0.145, 95% CI=-0.0005-0.291, p=0.051) and fear subscale scores ($R^2=0.134$, coefficient=0.083, 95% CI=0.007-0.159, p=0.034) in the SAD group. Conclusion In this study, increased plasma oxytocin levels were associated with higher social anxiety symptoms among SAD patients, but not among controls. This might be because among SAD patients, higher oxytocin (OT) secretion is an insufficient compensatory attempt to reduce social anxiety symptoms.

• 한국융합학회논문지
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• 제8권4호
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• pp.111-122
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• 2017

본 연구에서는 컴퓨터 기반의 인지편향수정 프로그램(Cognitive Bias Modification Program - Interpretation, CBM-I)을 이용하여 사회불안 경향이 있는 대학생들을 위한 해석편향 수정 프로그램을 개발하고, 이 프로그램이 사회불안증상 및 해석편향 변화에 미치는 효과를 검증하고자 하였다. 40명의 사회불안 경향성자들을 긍정해석 훈련집단((n=21)과 비처치대기집단((n=19)에 배정하였고 치료 전후 해석 편향과 사회불안증상 수준(e.g. 부정적 평가에 대한 두려움 척도, 레보위츠 사회불안 척도)을 비교하였다. CBM-I 훈련은 참가자들이 긍정적인 방식으로 모호한 상황을 해석하면 긍정적 피드백을 제공하고, 부정적인 방식으로 해석하면 부정적 피드백을 제공하는 방식으로 진행되었으며, 긍정해석 훈련집단의 경우 3주간 3번의 회기에 참가하였다. 사후분석에서 긍정훈련 조건에 참가한 내담자들의 자기 보고식 사회불안 증상이 감소하였다(t=2.35, p<.05; t=4.70, p<.001). 이러한 결과는 다중회기로 실시된 해석 편향의 수정이 임상적으로 유용할 수 있음을 시사한다.

• 정신신체의학
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• 제28권1호
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• pp.1-7
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• 2020

연구목적 본 연구는 불안장애, 우울장애, 불안장애와 우울장애를 공병으로 지닌 환자군의 심리적 특성을 탐색하기 위해 시행되었다. 방 법 2017년 1월부터 2019년 5월까지 한양대학교 구리병원 정신건강의학과에 내원 및 입원하여 심리평가를 진행한 환자들 중 정신건강의학과 전문의 혹은 임상심리사에 의해 DSM-5에 근거하여 불안장애, 우울장애, 불안장애와 우울장애를 공병으로 진단받은 환자를 대상으로 이루어졌다. 참가자들이 실시한 MMPI-2를 연구자들이 RF로 변환한 뒤 SPSS를 활용하여 집단 간 차이에 대하여 검증하였다. 결 과 MMPI-2-RF의 결과 EID, RC2, HLP, SAV, INTR-r가 공병 집단에서 가장 높았다. 또한 BXD, RC4, JCP, AGGR-r가 우울 집단에서 가장 높았다. 결 론 공병 집단은 단일 집단에 비하여 낮은 긍정 정서와 무력감 등과 같은 우울 증상, 사회적 회피 및 불편감과 같은 내면화 증상이 더 심각한 수준으로 나타났다. 또한 우울 집단은 불안 집단과 공병 집단에 비해 분노감과 공격성과 같은 외현화 증상이 더 많은 것으로 밝혀졌다. 이러한 연구 결과를 토대로 본 연구의 의의와 제한점에 대하여 논의하였다.

• 대한불안의학회지
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• 제14권2호
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• pp.99-105
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• 2018

Objective : The purpose of this study was to investigate effects of depression and anxiety on treatment response of social skills training in adolescents with autism spectrum disorders (ASD). Methods : A total of 107 teenagers that participated in the Program for the Education and Enrichment of Relational Skills (PEERS$^{(R)}$) between 2011 and 2015 were analyzed using linear regression. Outcome measures used were the Korean version of Social Responsiveness Scale (SRS), the Test of Adolescent Social Skills Knowledge-Revised (TASSK-R), and the Korean version of Autism Diagnostic Observation Schedule (K-ADOS). Depression and anxiety were assessed by the Korean version of Child Depression Inventory (CDI), the Korean version of State and Trait Anxiety Inventory for Children (STAIC), and the Korean version of Child Behavior Checklist (K-CBCL). Results : As a result, depressive symptoms measured by CDI (p<0.05) and anxiety symptoms measured by STAIC (p<0.05) had significant influence on score change of social interaction domain of ADOS. It remained significant even after the baseline score was adjusted as covariates (p<0.05). Conclusion : We observed that pre-treatment anxiety and depressive symptoms of teenagers had significant effects on the treatment outcome of PEERS$^{(R)}$, especially in terms of face-to-face social interaction.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제16권1호
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• pp.124-131
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• 2005

소아, 청소년기에 발생하는 양극성장애는 주의력결핍/과잉행동장애, 행동장애 뿐만 아니라 불안장애도 중복진단 비율이 높다. 불안장애 중 강박장애, 사회공포증, 공황장애, 분리불안장애가 많이 공존한다고 보고 되었지만 불안장애와 양극성장애 발생사이의 시간적 관련성에 관한 전향적이면서 믿을만한 연구는 드물다. 본 저자는 양극성장애에 선행한 불안증상에 대해 항우울제를 투여하였을 때 발생한 조증삽화 2예를 보고하고자 한다. 기분변화의 과거력이나 양극성장애의 가족력이 없어도 선행된 불안증상에 대해 항우울제를 사용할 때는 조증삽화의 가능성을 염두에 두고 조심스럽게 처방해야 될 필요성이 있으며 향후 소아, 청소년 양극성장애와 불안장애 사이의 시간적 연관성과 약물학적 치료 지침에 대해 포괄적이며 전향적인 연구가 필요할 것이다.

• 생물정신의학
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• 제16권1호
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• pp.37-45
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• 2009

Objectives : It is reported that panic disorder is frequently comorbid with other psychiatric illnesses. The aim of this study was to investigate differences of psychiatric comorbidity according to age of onset of panic disorder. Methods : Three hundred-two patients participated in the study. All the patients were evaluated by clinical instruments for the assessment the presence of other comorbid psychiatric disorders and various clinical features; Korean version of Mini International Neuropsychiatric Interview, Self-report questionnaires(Beck Anxiety Inventory, Beck Depression Inventory, Anxiety Sensitivity Index and State-Trait Anxiety Inventory) and clinical rating scale (Hamilton Anxiety Scale, Hamilton Depression Scale and Global Assessment of Functional score). Chi-square test was used to determine the difference between early onset and late onset panic disorder. Results : Forty percent of panic patients were found to have at least one comorbid psychiatric diagnosis. There were no differences among the groups divided by number of comorbidity in sex, agoraphobia comorbidity, duration of panic disorder, except onset age of panic disorder. Early onset group had more comorbidy with social phobia, agoraphobia, PTSD. We also found that Early onset panic disorder patients were more likely to experience derealization, nausea, parethesia than late onset panic disorder patients. Conclusion : The results of our study are in keeping with previous data from other parts of the world. Our finding suggest that earier onset of panic disorder related to more psychiatric comorbidity.