• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1994년도 Proceedings of the Korea Automatic Control Conference, 9th (KACC) ; Taejeon, Korea; 17-20 Oct. 1994
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• pp.593-596
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• 1994

When a force impulse acting on a massive and plex object is measured with a dynamometer, be resonant vibration of the measurement system often leads to serious inaccuracies. A more accurate measurement is obtained when the transfer function ,of the object-dynamometer system is used to compensate for the error in the dynamometer's output signal. The natural frequency and the damping coefficient of the transfer function are estimated by analyzing the waveform of the free damped vibration period after the loading of the force has ended. The residue of the system is determined such that the compensated force spectrum becomes smooth within a neighborhood of the natural frequency. The effectiveness of this signal processing method is experimentally tested on a hammer impulse, under the assumption that the hammer's high resonant frequency accurately models the problems encountered in force impact measurement. The compensation method is used to derive a improved estimate of the hammer impulse.

• 대한수학회지
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• 제61권3호
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• pp.427-444
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• 2024

The matrix completion problem is to predict missing entries of a data matrix using the low-rank approximation of the observed entries. Typical approaches to matrix completion problem often rely on thresholding the singular values of the data matrix. However, these approaches have some limitations. In particular, a discontinuity is present near the thresholding value, and the thresholding value must be manually selected. To overcome these difficulties, we propose a shrinkage and thresholding function that smoothly thresholds the singular values to obtain more accurate and robust estimation of the data matrix. Furthermore, the proposed function is differentiable so that the thresholding values can be adaptively calculated during the iterations using Stein unbiased risk estimate. The experimental results demonstrate that the proposed algorithm yields a more accurate estimation with a faster execution than other matrix completion algorithms in image inpainting problems.

• 한국인터넷방송통신학회논문지
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• 제9권5호
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• pp.155-161
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• 2009

본 논문은 이미지 픽셀의 픽셀값 차이(Pixel-value Differencing: PVD)와 최하위 비트(Least Significant Bit: LSB) 교체 방법을 이용하여 원본 이미지의 픽셀값 성질에 맞게 적용하여 고용량의 데이터를 이미지에 숨길 수 있는 방법을 제시한다. 기존에 LSB와 PVD 방법에 근거하여 비밀 자료를 숨기고, 숨겨진 자료를 감지할 수 없도록 하기 위해 많은 자료 은닉 방법들이 연구되었다. 두 연속된 픽셀값 차이가 적을 경우에는 부드러운 영역(Smooth Area)에 속하게 되고, 두 픽셀값 차이가 클 경우에는 경계 영역(Edge Area)에 속한 픽셀로 구별되는데, 본 논문에서 제시하는 방법은 이미지의 부드러운 영역과 경계 영역을 감지하여 부드러운 영역에는 LSB 교체 방법을 적용하고, 경계 영역에는 픽셀값 차이를 이용한 방법을 적용하였다. 실험 결과에서는 본 논문에서 제시한 방법이 기존의 LSB교체 기법을 이용하거나 픽셀값 차이를 이용한 자료은닉 방법에 비해 숨길 수 있는 자료량과 스테고 이미지(Stego-image)의 품질 측면에서 우수함을 보이고 있다.

• 한국수자원학회논문집
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• 제39권9호
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• pp.737-744
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• 2006

난류의 내부 영역의 유속은 단순한 공식으로 표현하기 매우 어려운 형태를 가지고 있다. 이 속도 분포를 기술하는 여러 가지 공식들이 제안된 바 있지만, 모든 공식들은 많은 항들을 가지거나 적분형 또는 음함수꼴을 가지고 있다. 이것은 이 식들이 적용하기 힘들거나, 매개 변수들을 추정하기 어렵다는 것을 의미한다. 이 연구에서는 매끄러운 바닥 위를 흐르는 난류 내부 영역의 유속 분포를 표현할 수 있는 간단한 형태의 새로운 공식을 제안하였다. 이 공식은 전통적인 대수 법칙에 감쇄 함수를 곱한 형태이다. 단 하나의 추가적인 매개 변수를 도입하여, 전체 내부 영역의 유속 분포를 적절하게 표현할 수 있었다. 이 공식은 벽법칙이 성립하는 바닥 근처의 유속과 대수 법칙이 성립되는 중복 영역의 유속 분포까지를 적절하게 나타낼 수 있다. 또한, 추가된 매개 변수인 감쇄 계수는 쉽게 추정할 수 있다. 이 변수는 Reynolds 수의 변화에 민감하지 않으며, 공식에 의하여 계산된 유속 분포도 또한 이 매개 변수의 변화에 대해서 민감하지 않다.

• 태양에너지
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• 제13권2_3호
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• pp.91-106
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• 1993

유동층을 열교환기에 응용하기 위한 시도로 알루미나 입자를 유동입자로 하는 수직 이중관식 유동층형 열교환기에서 내관으로 평활관과 핀관(종형핀)을 사용하는 경우에 각각의 열전달효과를 비교, 검토하였다. 본 실험에서는 평균직경이 $0.41{\sim}0.77mm$ 범위의 4종의 알루미나 입자를 사용하였으며, 초기충진높이는 50mm($H_o/H=0.083$)에서 250mm($H_o/H=0.417$)의 범위로 하였다. 입자의 크기와 초기 충진높이 및 유동화속도가 열전달계수에 미치는 영향을 검토하고, 단상강제대류형 열교환기와 열전달효과를 비교한 결과, 평활관을 사용하는 경우에는 7.8배, 핀관을 사용하는 경우에는 12.9배의 전열증진효과가 있었다. 또 유동층에서는 유동화속도가 증가함에 따라 열전달계수는 최대값을 보인후 다시 감소하는데, 이때의 Nu수 및 Re수와 Ar수의 무차원 관계식을 구하였다.

• The Journal of Korean Physical Therapy
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• 제20권4호
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• pp.35-42
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• 2008

Purpose: Alterations in the structure and function of vascular smooth muscle cells (VSMCs) are important in cardiovascular disease and maintaining chronic hypertension. Chronic hypertension is associated with changes in vascular smooth muscle tone. The spontaneous or myogenic tone of a blood vessel reflects the ability to adapt smooth muscle tone to changes in transmural pressure. However, the intracellular signaling mechanisms involved in myogenic tone are not fully understood. Methods: Here, we investigated the relationship between mitogen-activated protein kinases (MAPKs) and phosphatidylinositol-3 kinase (PI3K) in isometric contraction and enzymatic activity using muscle strips from rats made hypertensive with aldosterone-analogue deoxycorticosterone acetate (DOCA) salts. Results: Changes in myogenic tone and intracellular $Ca^{2+}$ concentration ($[Ca^{2+}]_i$) were different after physiological salt solution (PSS) in normotensive and hypertensive rats. The myogenic tone and quiescent phosphorylation induced by the PSS treatment were inhibited by 10 ${\mu}$M PD098059, an extracellular-regulated protein kinase 1/2 (ERK1/2) inhibitor, and 10 ${\mu}$M wortmannin, an inhibitor of PI3K, in hypertensive rats. Conclusion: The development of DOCA-induced hypertension is associated with altered isometric contractions and $[Ca^{2+}]_i$ via changes in activation of ERK1/2 and PI3K after DOCA-salt treatment. Therefore, ERK1/2 and PI3K activity affect hypertension and may be suitable targets for physical therapy in cardiovascular disease.

• 대한기계학회논문집B
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• 제26권7호
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• pp.911-918
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• 2002

Evaporation heat transfer coefficients of carbon dioxide($CO_2$), R-22, and R-134a in a horizontal smooth tube were measured and analyzed as a function of heat flux, mass flux, and evaporating temperature. The experiments were carried out by varying heat flux from 10 to 20 $kW/m^2$, mass flux from 170 to 340 $kg/m^2s$, and saturation temperatures of 5 and $10^{\circ}C$. It was found that the heat transfer coefficient of $CO_2$ decreased with a rise of quality due to an earlier liquid-film dryout as compared to R-22 and R-134a. Averaged heat transfer coefficients of $CO_2$ were 22-63% higher than those of R-22 and R-134a at all test conditions. The effects of mass flux and heat flux on averaged heat transfer coefficients were much greater in $CO_2$ than in R-22 and R-134a. When comparing $CO_2$ test results with the correlations in the literature, the existing models yielded large deviations at medium and high qualities. Therefore, a generalized correlation for $CO_2$evaporation heat transfer needs to be developed by including the effects of dryout phenomenon.

• BMB Reports
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• 제53권4호
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• pp.206-211
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• 2020

Vascular smooth muscle cells (VSMCs) are a unique cell type that has unusual plasticity controlled by environmental stimuli. As an abnormal increase of VSMC proliferation is associated with various vascular diseases, tight regulation of VSMC phenotypes is essential for maintaining vascular homeostasis. Hypoxia is one environmental stress that stimulates VSMC proliferation. Emerging evidence has indicated that microRNAs (miRNAs) are critical regulators in the hypoxic responses of VSMCs. Therefore, we previously investigated miRNAs modulated by hypoxia in VSMCs and found that miR-1260b is one of the most upregulated miRNAs under hypoxia. However, the mechanism that underlies the regulation of VSMCs via miR-1260b in response to hypoxia has not been explored. Here we demonstrated that hypoxia-induced miR-1260b promotes VSMC proliferation. We also identified growth differentiation factor 11 (GDF11), a member of the TGF-β superfamily, as a novel target of miR-1260b. miR-1260b directly targets the 3'UTR of GDF11. Downregulation of GDF11 inhibited Smad signaling and consequently enhanced the proliferation of VSMCs. Our findings suggest that miR-1260b-mediated GDF11-Smad-dependent signaling is an essential regulatory mechanism in the proliferation of VSMCs, and this axis is modulated by hypoxia to promote abnormal VSMC proliferation. Therefore, our study unveils a novel function of miR-1260b in the pathological proliferation of VSMCs under hypoxia.

• 생명과학회지
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• 제17권1호
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• pp.45-50
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• 2007

세포 배양액에 tetracycline이 없는 경우 FADD를 발현하면서 사멸하는 평활근세포 (FADD-SMC)에서 분비하는 $TNF-\alpha$의 활성을 조사하였다. 배양액에 tetracycline이 없는 경우 FADD-SMC는 약 1000 pg/ml의 $TNF-\alpha$를 분비하였다. $TNF-\alpha$를 포함하는 배양액을 분리하고, 이 배양액을 정상세포에 처리한 결과 인산화한 p38 MAPK와 nuclear, factor, kappa B (NF-kB)의 활성이 증가하였다. 또한 이 배양액을 L929 세포에 처리하는 경우 세포독성이 발생하였다. NF-kB, p38 MAPK 그리고 L929 세포에 대찬 효과는 배양액에서 suluble TNF receptor를 이용하여 $TNF-\alpha$를 제거하는 경우 감소하였다.

• Toxicological Research
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• 제12권2호
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• pp.195-201
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• 1996

Endotoxic shock causes death in humans and animals via extreme hypoperfusion of peripheral organs. A massive production of nitric oxide (NO) both from the endothelical cells and smooth muscle cells has been proposed as a possible mechanism in this process. Since NO attenuated the contractility to vasoconstricting agents such as norepinephrine (NE) by directly acting on the smooth muscle cells, this mechanism was considered mainly as a postsynaptic mechanism. In this research it was investigated whether NO, thus released, also participates in the presynaptic events for the regulation of vascular tone in endotoxic shock. The role of NO was studied by adding NO donors or NO synthase inhibitor $N^\omega $methyl-L-arginine (NMA) in stimulated sympathetic nerves of the mesenteric vascular bed and the Langendorff heart of rats. Sodium nitroprusside (SNP), an NO donor, reduced the pressor responses of isolated mesenteric artery either to electrical stimulation or exogenously administered phenylephrine (PE). In this mesentery, although neither agent influenced NE release, in the presence of the adrenergic $\alpha_2$-receptor antagonist yohimbine, elecrical stimulation-evoked NE release was augumented by SNP. In the heart SNP facilitated the NE release induced by electrical stimulation, while NMA had no effect. From these results it is proposed that there exists a local reflex phenomenon in the junction between the sympathetic nerve terminals and the smooth muscle of resistance blood vessels; by which sympathetic responses are reduced by NO at the postjunctional level while NO facilitates NE release contributing to augumentation of sympathetic tone. All these facts suggest that NO produced during endotoxic shock has dual effects: whereas NO blunts the vasoconstrictive activity of NE at the postsynaptic level, NO presynaptically facilitates the release of NE from sympathetic nerve terminals.