Brandes, Johann C.;Amin, A.R.M. Ruhul;Khuri, Fadlo;Shin, Dong-Moon
Tuberculosis and Respiratory Diseases
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제69권1호
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pp.1-15
/
2010
Lung cancer remains the most common cause of cancer death in the United States and worldwide. About 80~90% of cases are smoking-related and smoking cessation programs are of great importance in reducing lung cancer risk. However, the lifetime risk for lung cancer remains elevated even in ex-smokers. Chemoprevention holds the promise to further reduce this risk and thus to decrease lung cancer incidence and mortality. Over the last decades, most chemoprevention trials for lung cancer have yielded negative outcomes. Population-based studies suggest that high intake of certain foods such as soy, red wine or green vegetables may be associated with decreased cancer risk. Because of these observations and their general safety, a plethora of natural compounds is currently being studied for the chemoprevention of cancer. In this review we discuss promising in vitro and in vivo data of novel natural compounds, their interference with molecular mechanisms responsible for lung cancer development and potential implications for their further preclinical and clinical investigation.
Purpose: The purpose of the study was to investigate the effect of the environment on adolescent binge drinking. Methods: The study was designed as a cross-sectional study. Using statistics from the 17th (20201) Korea Youth Risk Behavior Web-based Survey, the raw data target population was 2,629,588 people, and the sample group used for analysis as the final data was 54,848 people. A Rao-scott 𝑥2 test and univariate multinomial logistic regression analysis were performed using IBM SPSS 27.0. Results: In the results of univariate logistic regression analysis and multivariate logistic regression analysis, common related variables were gender, school level, academic achievement, sleep satisfaction, current smoking, daily smoking, and alcohol education experience. Conclusion: As a result of confirming the factors influencing binge drinking in Korean adolescents, some variables that increase the possibility of problematic drinking behavior in the socio-environmental areas such as individuals, communities, and national policies were identified. For effective prevention and intervention, it is necessary to develop programs to build a healthy environmental support system with support from national policies, including individuals, peer groups, and communities.
Objectives: This study was conducted in order to prepare fundamental data and assess the short-term effects of applying cerebrovascular disease prevention programs by the Ministry of Employment and Labor and the Korea Occupational Safety and Health Agency (KOSHA) in Korea. Methods: The number of study subjects was 2,676 workers (58.5%) who were able to evaluate the level of incidence risk at pre- and post-applications of the program, among the 4,576 total workers who were enrolled in the cerebrovascular disease prevention program during 2011. The guidelines for this prevention program were adopted from KOSHA GUIDE H-1-2010. To determine the program' effectiveness, the workers'risks for cerebrovascular disease were assessed pre- and post-application of the program. Results: The blood pressure level was significantly reduced by 4.09 mmHg for the mean systolic blood pressures and 5.47 mmHg for diastolic blood pressures, respectively. The mean level of total cholesterol and BMI were also reduced significantly by 2.07 g/dl and 0.1 $0.1kg/m^2$. The rate of smoking was decreased by 4.0% and the percentage of workers engaging in regular exercise was increased by 29.8%. The level of overall cerebrovascular disease risk was reduced among 1,451 (70.7%) of 2,052 workers at low risk and above. The level of cerebrovascular disease risk was lower in the improved group for health behavior than the unimproved group (odds ratio =1.7, p < 0.001). Conclusions: The author considers that the application of the cerebrovascular disease prevention program by the Korea Occupational Safety and Health Agency reduced cerebrovascular diseases risks among workers who were enrolled in the cerebrovascular disease prevention program and it must be accompanied by an improvement in health behavior for prevention of cerebrovascular disease.
Purpose: The objective of this study was to develop a predictive model for the sexual experiences of adolescents using the random forest method and to identify the "variable importance." Methods: The study utilized data from the 2019 to 2021 Korea Youth Risk Behavior Web-based Survey, which included 86,595 man and 80,504 woman participants. The number of independent variables stood at 44. SPSS was used to conduct Rao-Scott χ2 tests and complex sample t-tests. Modeling was performed using the random forest algorithm in Python. Performance evaluation of each model included assessments of precision, recall, F1-score, receiver operating characteristics curve, and area under the curve calculations derived from the confusion matrix. Results: The prevalence of sexual experiences initially decreased during the COVID-19 pandemic, but later increased. "Variable importance" for predicting sexual experiences, ranked in the top six, included week and weekday sedentary time and internet usage time, followed by ease of cigarette purchase, age at first alcohol consumption, smoking initiation, breakfast consumption, and difficulty purchasing alcohol. Conclusion: Education and support programs for promoting adolescent sexual health, based on the top-ranking important variables, should be integrated with health behavior intervention programs addressing internet usage, smoking, and alcohol consumption. We recommend active utilization of the random forest analysis method to develop high-performance predictive models for effective disease prevention, treatment, and nursing care.
This study was conducted to get a resonable set of budget allocation to public health programs. Matrix Delphi technique was used to obtain the logic of study results and eventually to form a human model which could predict opinion of professionals on budget allocation. Thirty-two professionals in academic and governmental area responded to Delphi survey. Questionnaire was developed using matrix formation, and the matrix was formed by 6 decision criteria on budget allocation and 26 public health programs. The decision criteria are as following: size of problem(morbidity), severity of problem, social equity, importance of prevention, technical feasibility and efficiency of programs. Severity of problem dropped out of the model because it had significant correlation with the size of problem. A total score of each program was obtained by weighting the relative importance of each criteria which also were given by survey respondents. These total scores indicate that the most important public health program is vaccination for infants and children in terms of budget allocation. Monitoring communicable diseases, mental health program, and anti-smoking program are the next. In addition, respondents were asked of the desirable budget size of each program. The result was rearranged by multiple regression model using the scores of each decision criteria. In this process, the current budget size of central government was provided to the respondents, and included in the model. h set of desirable budgets modified using tile model was obtained. Considering the current size of budget, tile results of the model is very different from that of the total score. Managing dementia is ranked the first. Health promotion program for the elderly, rehabilitation of the disabled and monitoring communicable diseases are the next. The need to increase the budget of vaccination for the infants and children was not found as so high. The matrix structure in Delphi survey gave us the precise basis to make optimal decision, and made it possible to develop an opinion predicting model. However the plentifulness and diversity of professional opinions were not fully obtained due to the limited number of decision criteria.
Purpose: This study was conducted to investigate factors influencing preventive health behaviors in undergraduates, including knowledge about, and attitudes to cancer. Methods: The participants were 219 undergraduates in H, and C Universities in G City, and K University in S City. Data were collected from April 1 to June 30, 2014, and analyzed using SPSS/WIN 21.0. Results: The mean score for knowledge about cancer was 18.70. The mean score for attitude to cancer was 3.19, and the mean score for preventive health behaviors was 3.12. Knowledge about cancer showed a positive correlation with attitude to cancer and a positive correlation with preventive health behaviors. Attitude to cancer showed a positive correlation with preventive health behaviors. Significant factors that influenced preventive health behaviors for cancer were attitudes to cancer, age, worries about cancer, smoking, and regular exercise. These variables explained 43.5% of preventive health behaviors for cancer. Conclusion: Findings of this study indicate that programs to enhance positive attitudes to cancer prevention should be developed to increase preventive health behaviors in undergraduates and that further study should be done on the effects of such programs.
Purpose: The purpose of this study was to analyze differences in health behaviors among adolescents in order to provide fundamental data to develop an effective body weight control program. Methods: Secondary analysis was done using data from the 9th (2013) Online Survey on Adolescents' Health Behaviors by the Korea Centers for Disease Control and Prevention. The adolescents were divided into low weight, normal weight, overweight, and obesity groups according to body mass index (BMI). Differences in health behaviors were analyzed. Results: Gender, grade, socioeconomic status, perceived-health status, exercise, breakfast, fast food, ramen noodles, snacks, carbonated soft drinks, fruits and vegetables, satisfaction with sleep, stress, smoking, and alcohol consumption were significantly different among the groups. Ingestion of carbonated soft drinks and snacks was significantly higher in the low weight group compared to the normal weight group. Eating fast foods, ramen noodles, and snacks was significantly lower in the overweight and obesity groups compared to the normal weight group. Conclusion: Findings indicate that health behaviors among the groups differ from traditional knowledge about obesity. To develop optimal programs and improve efficacy, prior knowledge should be used to think differently and individualized programs should be based on an understanding health behaviors of adolescents.
Purpose: This study is aimed at showing the effect of work-site health promotion programs for health promoting behavior, cholesterol, and quality of life of middle-aged workers. Method: Thirty-one middle-aged workers were the experimental group and thirty-one were the control group. The 8-week work-site health promotion program was given to the experimental group. After this, health promoting behavior, cholesterol and quality of life were measured by questionnaires for the experimental and control groups. Health promotion theory, flexibility and muscle strength, aerobic exercise, nutrition, stress management, cancer prevention and early detection, smoking and alcohol problems, and summary lecture were all included in the 8-week work-site health promotion program. Health promoting behavior was measured by Park's HPBS, cholesterol was measured by enzyme method, and quality of life was measured by Ro's QOL. Result: The experimental group showed a higher score of health promoting behavior than the control group. There were no differences on cholesterol and quality of life between the experimental and control groups. Conclusion: It is necessary that nurses provide middle-aged workers with work-site health promotion programs to improve health promoting behavior. It's necessary also to re-study this with the pre-post research design.
Purpose: This study was conducted to examine the degree of senile macular degeneration in elders aged 65 or older and identify factors associated with senile macular degeneration in elders within communities. Methods: Participants in this cross-sectional descriptive study were 388 elders without cataract, glaucoma, and diabetic retinopathy. Data were collected through face to face interviews using a questionnaire in an urban area from June 2010 to December 2011. To detect senile macular degeneration, the participants' self-tests were carried out with Amsler grid testing. Stepwise multivariate logistic regression was performed to evaluate the effects of health behavior and knowledge about eye health on senile macular degeneration. Results: The proportion of participants with senile macular degeneration was 11.6%. Factors that significantly increased the risk of senile macular degeneration included eye discomfort and history of ophthalmic examination (p<.05). Factors that significantly decreased the risk of senile macular degeneration included regular change of magnifiers, non-use of magnifiers, and knowledge about preventive effects of non-smoking and antioxidant vitamin intake on senile macular degeneration (p<.05). Conclusion: This study showed that programs for preventing senile macular degeneration were necessary for elders within communities and the results of this study can be used for developing those programs.
Purpose: The purpose of this study was to investigate the effect of physical activity on suicidal ideation according to gender in South Korean adolescents. Methods: This study is designed as a cross-sectional study. Using the statistics from the 12th (2016) Korea Youth Risk Behavior Web-based Survey, hierarchical logistic regression analysis was conducted. The study sample comprised 62,558 middle and high school students aged primarily 12 to 17. Results: The rate of engaging in physical activity more than three times a week was 39.6% for boys and 28.8% for girls and the rate of suicide ideation was 9.35% for boys and 14.9% for girls. Male students were 1.42 times more likely to commit suicide when they did not engage in physical activity than when they do more than three times a week but it was found to have no significant effect on female students. Conclusion: Physical activity should be encouraged in the physical education curriculum and the school health area to reduce suicidal ideation in adolescents. Differentiated interventions are required according to gender. It is suggested that intervention programs involving physical activity be implemented more actively for male students and intervention programs centering on obesity and smoking prevention be implemented for female students.
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