• Health Policy and Management
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• v.30 no.2
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• pp.199-210
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• 2020

Background: Based on the importance of ceasing smoking programs to control the regional disparity of smoking behavior in Korea, this study aims to reveal the variation of smoke rate and determinants of it for 229 provinces. An evaluation of the relative efficiency of the cease smoking program under the consideration of regional characteristics was followed. Methods: The main sources of data are the Korean Statistical Information Service and a national survey on the expenditure of public health centers. Multivariate regression is performed to figure the determinants of regional variation of smoking rate. Based on the result of the regression model, clustering analysis was conducted to group 229 regions by their characteristics. Three clusters were generated. Using data envelopment analysis (DEA), relative efficiency scores are calculated. Results from the pooled model which put 229 provinces in one model to score relative efficiency were compared with the cluster-separated model of each cluster. Results: First, the maximum variation of the smoking rate was 16.9%p. Second, sex ration, the proportion of the elder, and high risk drinking alcohol behavior have a significant role in the regional variation of smoking. Third, the population and proportion of the elder are the main variables for clustering. Fourth, dissimilarity on the results of relative efficiency was found between the pooled model and cluster-separated model, especially for cluster 2. Conclusion: This study figured regional variation of smoking rate and its determinants on the regional level. Unconformity of the DEA results between different models implies the issues on regional features when the regional evaluation performed especially on the programs of public health centers.

• Fire Science and Engineering
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• v.18 no.1
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• pp.42-48
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• 2004

The deterministic modeling techniques like Zone model and Field model are mainly used for thermal distribution and smoke flow at fire case in multi use facilities. While Zone model analyse fire simulation by dividing spaces by 2 section, the Field model dividing many cells. However, the difficultly follows to prove efficiency between the two models when it applys. Therefore new modeling development is required which in closes to real situation by verify number algorithm and related data for fire modeling. The paper analyses the efficiency of two different fire modeling at interior spaces of multiplex cinema theater. It is found that the zone model for average distribution and the field model for detail space phenomenon are relevant to apply. Also, Filed model is useful to the result that fire analysis and position of detector and review for smoke control system.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.11
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• pp.237-243
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• 2018

Performance-oriented design has been introduced in fire protection design, and various efforts have been made to minimize the damage caused by fire in the design stage. We conducted a study to provide information for reasonable design factors using a Fire Dynamic Simulation code provided by the NIST on boundary width and amount of supply. This paper shows that using a living-room air-supply system in a large space and dividing the space by a ventilation boundary are the two factors that are considered to have the greatest influence on the design of the living room ventilation. The results show that for performance-based design, the width of the ventilation boundary is designed to be the maximum limit in the initial design. It is judged that reasonable air volume determination should be made through various methods.

• Tuberculosis and Respiratory Diseases
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• v.82 no.2
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• pp.158-165
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• 2019

Background: A recent study reported that mesenchymal stem cells possess potential cellular therapeutic properties for treating patients with chronic obstructive pulmonary disease, which is characterized by emphysema. We examined the potential therapeutic effect of Wharton's Jelly-derived mesenchymal stem cells (WJMSCs), following pretreatment with pioglitazone, in lung regeneration mouse emphysema models. Methods: We used two mouse emphysema models, an elastase-induced model and a cigarette smoke-induced model. We intravenously injected WJMSCs ($1{\times}10^4/mouse$) to mice, pretreated or not, with pioglitazone for 7 days. We measured the emphysema severity by mean linear intercepts (MLI) analysis using lung histology. Results: Pioglitazone pretreated WJMSCs (pioWJMSCs) were associated with greater lung regeneration than non-augmented WJMSCs in the two mouse emphysema models. In the elastase-induced emphysema model, the MLIs were $59.02{\pm}2.42{\mu}m$ (n=6), $72.80{\pm}2.87{\mu}m$ (n=6), for pioWJMSCs injected mice, and non-augmented WJMSCs injected mice, respectively (p<0.01). Both pioWJMSCs and non-augmented WJMSCs showed regenerative effects in the cigarette smoke emphysema model (MLIs were $41.25{\pm}0.98$ [n=6] for WJMSCs and $38.97{\pm}0.61{\mu}m$ [n=6] for pioWJMSCs) compared to smoking control mice ($51.65{\pm}1.36{\mu}m$, n=6). The mean improvement of MLI appeared numerically better in pioWJMSCs than in non-augmented WJMSCs injected mice, but the difference did not reach the level of statistical significance (p=0.071). Conclusion: PioWJMSCs may produce greater lung regeneration, compared to non-augmented WJMSCs, in a mouse emphysema model.

• Journal of Korean Tunnelling and Underground Space Association
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• v.12 no.4
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• pp.307-319
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• 2010

As we learned in Daegu subway fire accident, fire in the railway tunnel is prone to develop to large disaster due to the limitation of smoke control and smoke exhaust. In railway tunnel, in order to ensure fire safety, fire prevention and fighting systems are installed by quantitative risk assessment results. Therefore, in this research, developed the program to establish quantitative risk assessment and suggested quantitative safety assessment method including fire scenarios in railway tunnel, fire and evacuation analysis model, fatality estimate model and societal risk criteria. Moreover, this method applys to plan preventing disaster for Honam high speed railway tunnel. As results, we presented the proper distance of escape route and societal risk criteria.

• Tuberculosis and Respiratory Diseases
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• v.71 no.2
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• pp.88-96
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• 2011

Background: It is known that cigarette smoke (CS) causes cell death. Apoptotic cell death is involved in the pathogenesis of CS-related lung diseases. Some members of the protein kinase C (PKC) family have roles in cigarette smoke extract (CSE)-induced apoptosis. This study was conducted to investigate the role of PKC epsilon in CSE-induced apoptosis in human lung fibroblast cell line, MRC-5. Methods: Lactate dehydrogenase release was measured using a cytotoxicity detection kit. The MTT assay was used to measure cell viability. Western immunoblot, Hoechst 33342 staining and flow cytometry were used to demonstrate the effect of $PKC{\varepsilon}$. Caspase-3 and caspase-8 activities were determined using a colorimetric assay. To examine $PKC{\varepsilon}$ activation, Western blotting was performed using both fractions of membrane and cytosol. Results: We showed that CSE activated $PKC{\varepsilon}$ by demonstrating increased expression of $PKC{\varepsilon}$ in the plasma membrane fraction. Pre-treatment of $PKC{\varepsilon}$ peptide inhibitor attenuated CSE-induced apoptotic cell death, as demonstrated by the MTT assay (13.03% of control, 85.66% of CSE-treatment, and 53.73% of $PKC{\varepsilon}$ peptide inhibitor-pre-treatment, respectively), Hoechst 33342 staining, and flow cytometry (85.64% of CSE-treatment, 53.73% of $PKC{\varepsilon}$ peptide inhibitor-pre-treatment). Pre-treatment of $PKC{\varepsilon}$ peptide inhibitor reduced caspase-3 expression and attenuated caspase-3, caspase-8 activity compared with CSE treatment alone. Conclusion: $PKC{\varepsilon}$ seem to have pro-apoptotic function and exerts its function through the extrinsic apoptotic pathway in CSE-exposed MRC-5 cells. This study suggests that $PKC{\varepsilon}$ inhibition may be a therapeutic strategy in CS-related lung disease such as chronic obstructive pulmonary disease.

• Journal of Korean Institute of Fire Investigation
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• v.6 no.1
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• pp.49-66
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• 2005

The purpose of this study is to present reference data to be considered in designing fur the fire safety of atrium buildings. This study deals with the characteristics of atrium buildings in the fire safety aspect, analysis of fire examples and foreign fire codes of atrium space. And con-crete factors to be consigning fur the fire facilities of atrium buildings are presented. Recently many atrium spaces have been built in Korea. They provide new experience of space with resident and pedestrians. However, because of the lack of knowledge in design principle and disaster prevention, large loss of lives is expected in an emergency situation. cion. Therefore safety ensuring from the case is urgently needed. The following is the summary on the standard of effective fire facilities for the atrium. 1. The smoke control. inside atrium must use the machine ventilation in the atrium. 2. It is desirable to divide the section between atrium and nearby living room by anti-smoke screen in order to prevent damage by smoke when fire break out. 3. It is desirable to instill an excellent fire detector like infrared light detector as a replacement of old one. 4. It is desirable to transfer from closed operating sprinkler to fire-cycle sprinkler equipment or ablative sprinkler when the height is lower than 20m.

• Korean Journal of Head & Neck Oncology
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• v.18 no.2
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• pp.150-156
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• 2002

Objectives: Most of human cancers may result from exposure to environmental carcinogens, and individual effectiveness in the detoxification of these chemicals will influence susceptibility to malignant disease. Glutathione S-Transferases(GSTs) enzymes are involved in the detoxification of active metabolites of many carcinogens from tobacco smoke and may be important in modulating susceptibility to smoke-related cancer. The purpose of this study is to determine the polymorphism of GSTM1, GSTT1, and GSTP1 in control group and head and neck squamous cell carcinoma group of Korean, and to investigate the effect of GSTs polymorphism on the risk of head and neck cancer. Materials and Methods: A hospital-based case-control study was performed with a group of 133 control individual and 136 head and neck squamous cell carcinoma patients. The polymorphisms of GSTs were analysed using polymerase chain reaction in GSTM1 and GSTTl, and polymerase chain reaction-restriction fragment length polymorphism in GSTP1. Results: The relative risk (odds ratio) of GSTM(-) genotype was 1.14(95% CI, 0.70-1.85) compared to GSTM1(+). The odds ratio of GSTTl(-) genotype was 0.91(95% CI, 0.55-1.50). In old age($65$) group, the odds ratio of GSTT1(-) genotype was 5.2(95% CI, 1.53-17.89). The GSTP1 Val/Val genotype conferred a 1.7-fold risk(95% CI, 0.40-7.34) of head and neck cancer compared with GSTP1 Ile/Ile genotype. Among the combined genotypes of GSTs, GSTM1(-)/GSTT1(+)/GSTP1 Val/Val and GSTM1(-)/GSTTl(-)/GSTP1 Ile/Val genotypes conferred a 2.6-fold and 1.3-fold risk(95% CI, 0.24-14.15 and 0.43-3.14) compared with the GSTM1(+)/GSTTl(+)/GSTP1 Ile/Ile genotype, respectively. Conclusion: Polymorphism of GSTs might modulate susceptibility to head and neck cancer in Korean population. The genotype of GSTP1 Val/Val and combined genotypes of GSTM1(-)/GSTT1(+)/GSTP1 Val/Val, and GSTM1(-)/GSTT1(-)/GSTP1 Ile/Val might be important risk factors to determine the individual susceptibility to head and neck squamous cell carcinoma.

• Journal of Korean Society of Environmental Engineers
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• v.38 no.5
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• pp.269-278
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• 2016

In order to improve air quality in the Seoul Metropolitan Area (SMA), the "Special Act on Seoul Metropolitan Air Quality Improvement" has been enforced since 2005. The strategy has resulted in some reduction of air pollution, but there has not been much research into the quantitative impact analysis of each separate preventive countermeasure. Therefore, we analyzed nitrogen oxide reduction resulting from implementation of the emission control plan for on-road mobile sources. The MM5-SMOKE-CMAQ model system was employed for air quality prediction. Reduced $NO_x$ emissions for SMA was 16,561 ton, 4.7% of reduction rate, in 2007. One countermeasure, tighter acceptable standards for manufacturing vehicles, dominated other countermeasures for effective $NO_x$ emission control. Large spatial differences in reduced emissions, those for Seoul being twice that of Incheon and Gyeonggi, showed greater $NO_x$ emission reduction impact in the heart of the metropolitan complex. The $NO_2$ concentration decreased by 0.60 ppb (2.0%), 0.18 ppb (1.5%), and 0.22 ppb (1.7%) in Seoul, Incheon, and Gyeonggi, respectively. Concentration decreases in spring and winter were larger, 1.5~2.0 times, than summer and fall. However, the $NO_2$ reduction impact did not correspond directly to local $NO_x$ emission controls in the city area because of the natural flow and dispersion, both urban and downwind.

• Fire Science and Engineering
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• v.31 no.2
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• pp.52-60
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• 2017

Numerical simulations were performed to evaluate the habitability of an operator for a cabinet fire in the main control room of a nuclear power plant presented in NUREG-1934. To this end, a Fire Dynamics Simulator (FDS), as a representative fire model, was used. As the criteria for determining the habitability of operator, toxic products, such as CO, were also considered, as well as radiative heat flux, upper layer temperature, smoke layer height, and optical density of smoke. As a result, the probabilities of exceeding the criteria for habitability were evaluated through the sensitivity analysis of the major input parameters and the uncertainty analysis of fire model for various fire scenarios, based on V&V (Verification and Validation). Sensitivity analyses of the maximum heat release rate, CO and soot yields, showed that the habitable time and the limit criterion, which determined the habitability, could be changed. The present methodology will be a realistic alternative to enhancing the reliability for a habitability evaluation in the main control room using uncertain information of cabinet fires.