• Journal of Korean Medical classics
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• v.35 no.3
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• pp.59-69
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• 2022

Objectives : The existence of specialized medical texts on a certain disease is reflective of its prevalence of the time. Smallpox and measles were major pediatric diseases, of which previous studies examined the outbreak of measles in late Joseon and the relationship among various specialized texts, and how records of the two diseases in the general medical literature has changed chronologically. Research on the two diseases recorded in different texts written by the same author has not been conducted before. Methods : Examination of the organization of the smallpox and measles parts in the Yosandangsinjipuibangkeumnangjibo and Bojeoksinbang, followed by comparative analysis was undertaken. Results : While the two texts show great similarity in the general contents of smallpox and measles, there was difference in the way they were written. In the case of the Yosandangsinjipuibangkeumnangjibo the author lists referenced literature, while in the Bojeoksinbang he does not. Also, compared to the Yosandangsinjipuibangkeumnangjibo, the Bojeoksinbang has detailed titles for the contents in both introduction and the detailed parts, while in the Bojeoksinbang there are contents that could not be found in the Yosandangsinjipuibangkeumnangjibo, along with more pattern differentiation in the former. Conclusions : The Yosandangsinjipuibangkeumnangjibo which was published in May of 1806 is a general type of medical text, in which the part on pediatrics is positioned in the first two volumes out of the entire 12 volumes, indicative of the author's emphasis on pediatric disease. The Bojeoksinbang which was published in December of 1806 discusses in-depth theories on smallpox and measles out of all pediatric disease, from which we can glimpse a specialized field of pediatrics in the late Joseon period.

• The Journal of Korean Medical History
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• v.31 no.2
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• pp.41-52
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• 2018

In this study, we research the tendency of medical text publication by examining the period of the great measles outbreak and the period of the publication of specialized smallpox texts. Using the National Institute of Korean History database for the Annals of Joseon Dynasty, the Daily Records of Royal Secretariat of Joseon Dynasty and Bibyeonsadeunglok, we will compare all records of measles occurrence. Measles and smallpox (Majin in Korean) have similar symptoms and treatment methods. In East Asia, when measles occurred it spread to Joseon and Japan, which are verified by records of the Annals of Joseon Dynasty, the Daily Records of Royal Secretariat of Joseon Dynasty and Bibyeonsadeunglok. The medical books related to measles are; Ryuhasinbang, Majinpyeon, Geupyubang, Yimsinyeokbang, Eulmisinjeon, Majingbang, Jinyeokbang, Magwahoetong, Majingibang, Susengsingam, Hongjinsinbang. Measles and Majin are the same disease. During the period of measles occurrence, measles-related medical books were published, and this relation of measles occurrence and measles-related medical text publication is verified by several national records.

• Journal of Microbiology and Biotechnology
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• v.33 no.8
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• pp.981-991
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• 2023

Monkeypox (Mpox) virus, a member of the Poxviridae family, causes a severe illness similar to smallpox, which is characterized by symptoms such as high fever, rash, and pustules. Human-to-human transmission cases have been reported but remained low since the first recorded case of human infection occurred in the Congo in 1970. Recently, Mpox has re-emerged, leading to an alarming surge in infections worldwide since 2022, originating in the United Kingdom. Consequently, the World Health Organization (WHO) officially declared the '2022-23 Mpox outbreak'. Currently, no specific therapy or vaccine is available for Mpox. Therefore, patients infected with Mpox are treated using conventional therapies developed for smallpox. However, the vaccines developed for smallpox have demonstrated only partial efficacy against Mpox, allowing viral transmission among humans. In this review, we discuss the current epidemiology of the ongoing Mpox outbreak and provide an update on the progress made in diagnosis, treatment, and development of vaccines for Mpox.

• Journal of the Korean Society of Safety
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• v.22 no.4
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• pp.102-109
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• 2007

A bioterrorism attack is the deliberate release of viruses, bacteria, or other germs(agents) used to cause illness or death in people, animals, or plant. These agents are found in nature, but it is possible that they could be changed to increase their ability to cause disease, make them resistant to current medicines, or to increase their ability to be spread into the environment. Terrorists may use biological agents because these agents can be extremely difficult to detect and do not cause illness for several days. Some bioterrorism agents, like smallpox virus, can spread from person to person, like anthrax, can not. From these agents, we discussed the characteristics of biological agents and national safety regulation on the weapons of mass destruction including bioterrorism.

• Journal of the korean veterinary medical association
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• v.38 no.9
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• pp.781-800
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• 2002

Recently, biological weapons (BWs) prepared with pathogenic microorganisms, toxins and biological vectors have been used maliciously for biological warfare, bioterrorism and/or agroterrorism by hostile countries and terrorists. In this review, historical background of disease and malicious use of BWs pathogenicity of microorganisms, advanced methodology involved in laboratory diagnosis, and prevention and control of anthrax (Bacillus anthracis), plague (Yersinia pseudotuberculosis subs. pestis), glanders (Burkholderia mallei), and smallpox (Variola virus) which have been abused for biological warfare or bioterrorism were discussed. In addition, the pathogenicity of microorganisms and the methodology needed to diagnose and control 6 diseases identified by WHO/CDC, ie., smallpox, inhalation anthrax, pneumonic plague, botulism, tularemia, and hemorrhagic fevers that would wreak havoc if terrorists successfully disseminated the germs by air were described.

• Journal of Preventive Medicine and Public Health
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• v.41 no.4
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• pp.209-213
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• 2008

Following the Anthrax bioterrorism attacks in the US in 2001, the Korean government established comprehensive countermeasures against bioterrorism. These measures included the government assuming management of all infectious agents that cause diseases, including smallpox, anthrax, plaque, botulism, and the causative agents of viral hemorrhagic fevers (ebola fever, marburg fever, and lassa fever) for national security. In addition, the Korean government is reinforcing the ability to prepare and respond to bioterrorism. Some of the measures being implemented include revising the laws and guidelines that apply to the use of infectious agents, the construction and operation of dual surveillance systems for bioterrorism, stockpiling and managing products necessary to respond to an emergency (smallpox vaccine, antibiotics, etc.) and vigorously training emergency room staff and heath workers to ensure they can respond appropriately. In addition, the government's measures include improved public relations, building and maintaining international cooperation, and developing new vaccines and drugs for treatments of infectious agents used to create bioweapons.

• Journal of applied mathematics & informatics
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• v.41 no.5
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• pp.1017-1035
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• 2023

In this paper, we construct a monkeypox model which is similar to smallpox infection. It is caused by a monkeypox virus which is related to Poxviridae family. It will occur mostly in West African communities and in remote Central. We develop a system of differential equations for an SEIR (Suspected, Exposed, Infected and Recovered) model and analyze the outbreak of monkeypox disease and its effect on United States(US) population. We establish theorems on asymptotical stability conditions for endemic equilibrium and disease-free equilibrium. The basic reproduction number R₀ has been determined using next generation matrix. We expect that this study will be effective at controlling monkeypox spread in United States. Our goal is to see whether monkeypox can be controlled and destroyed by smallpox vaccination. We find that monkeypox is controllable and can be fully destroyed in disease free state by vaccination. However, in the endemic state, monkeypox cannot be destroyed by vaccination alone.

• The Journal of Korean Medical History
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• v.25 no.1
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• pp.11-22
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• 2012

This study is about King Kyung-jong's medical history written on "The Daily Records of Royal Secretariat of Chosun Dynasty". Kyung-jong, the 20th King of Chosun was born in 1688 as a prince and passed away in 1725. When he was prince, his main diseases were some infectious things; for example, smallpox, measles, a sort of malaria, a sort of mumps etc. But the time he was king, his main diseases were related unenergetic(虛證). According to "The Daily Records of Royal Secretariat of Chosun Dynasty" yak-bang(藥房) records, some informations about his health are different from general knowledges. At first, His father's dead is more related his health than his mother's dead. Second, he was fat, not thin(or desiccate). Third, his infertility was not caused his mother when she died. Fourth, he was regarded as one of psychological healthy person. And not exactly related Kyung-jong's health, in "The Daily Records of Royal Secretariat of Chosun Dynasty" at Kyung=jong's era, there are some meaningful informations at medical history. One is a doctor who was smallpox specialist. His name is Yoo-Sang, he treated three of Chosun's King very perfectly and his family worked for the royal family's health for 150 years, especially treating smallpox. the other is prescription Gamijojungtang(加味調中湯), Kyung-jong's favorite prescription. This prescription is considered royal special prescription at Chosun.

• Journal of Microbiology and Biotechnology
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• v.29 no.4
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• pp.651-657
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• 2019

Although smallpox was eradicated in 1980, it is still considered a potential agent of biowarfare and bioterrorism. Smallpox has the potential for high mortality rates along with a major public health impact, eventually causing public panic and social disruption. Passive administration of neutralizing monoclonal antibodies (mAbs) is an effective intervention for various adverse reactions caused by vaccination and the unpredictable nature of emerging and bioterrorist-related infections. Currently, vaccinia immune globulin (VIG) is manufactured from vaccinia vaccine-boosted plasma; however, this production method is not ideal because of its limited availability, low specific activity, and risk of contamination with blood-borne infectious agents. To overcome the limitations of VIG production from human plasma, we isolated two human single-chain variable fragments (scFvs), (SC34 and SC212), bound to vaccinia virus (VACV), from a scFv phage library constructed from the B cells of VACV vaccine-boosted volunteers. The scFvs were converted to human IgG1 (VC34 and VC212). These two anti-VACV mAbs were produced in Chinese Hamster Ovary (CHO) DG44 cells. The binding affinities of VC34 and VC212 were estimated by competition ELISA to $IC_{50}$ values of $2{\mu}g/ml$ (13.33 nM) and $22{\mu}g/ml$ (146.67 nM), respectively. Only the VC212 mAb was proven to neutralize the VACV, as evidenced by the plaque reduction neutralization test (PRNT) result with a $PRNT_{50}$ of ~0.16 mg/ml (${\sim}1.07{\mu}M$). This VC212 could serve as a valuable starting material for further development of VACV-neutralizing human immunoglobulin for a prophylactic measure against post-vaccination complications and for post-exposure treatment against smallpox.

• Korean Journal of Veterinary Research
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• v.29 no.3
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• pp.407-416
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• 1989

The prospect of live vaccines consisting of genetically modified vaccinia virus expressing foreign genes is exciting, but important issues concerning safety and efficacy need to resolved. Vaccinia virus (VV) is an efficient expression vector with broad host range infectivity and large DNA capacity. This vector has been particularly useful for identifying target antigens for humoral and cell-mediated immunity. The WHO smallpox eradication program, involving the extensive use of VV vaccines, resulted in the late 1970s in the elimination of one of the world's most feared diseases. This achievement is a triumph for preventive medicine and for international collaboration in public health. In 1980, WHO recommended that the routine use of smallpox vaccine should be stopped. Against this background, the prospect of li ve vaccines consisting of genetically modified VV expressing foreign antigens arising from the work of Moss, and Paoletti and their colleagues in 1982 has been greeted with enthusiasm. These investigators have shown that genes coding for immunogenic proteins can be inserted into VV DNA without impairing the ability of the virus to grow in cell culture. Moreover experimental animals infected with VV recombinants containing genes coding for a variety of immunizing proteins have been shown to be protected against challenge infection with the corresponding infectious agent. In this communication, I describe current progress in the construction of a novel plasmid vector that facilitate the insertion and expression of foreign genes in VV as well as the selection of recombinants.