• Journal of Pharmaceutical Investigation
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• 제29권4호
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• pp.315-321
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• 1999

Poly (lactide-co-glycolide) (PLGA) microspheres containing ovalbumin (OVA) as a model protein drug were prepared by double emulsification method, and various conditions such as mixing rate, volume of outer phase and isopropyl alcohol concentration in outer phase during secondary emulsification were observed to control the size of microspheres. In addition, entrapment efficiency of OVA and protein denaturation were also evaluated. As the rate of stirring was increased, the size of particles was decreased. But excessive stirring increased the particle size of microspheres. In a preparation condition of small volume of outer phase, the particle size was decreased but the entrapment efficiency was increased. Adding isopropyl alcohol to outer phase decreased the size of particles, but increased the entrapment efficiency. Microparticles should have smaller size than $10\;{\mu}m$ to be uptaked by Peyer's patch in small intestine. High speed of mixing and relatively small volume of outer phase are needed to reduce the size. In addition, appropriate amount of isopropyl alcohol in outer phase also plays an important role in size reduction of PLGA microspheres.

• Journal of Ecology and Environment
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• 제41권8호
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• pp.223-234
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• 2017

Background: Spatial structure of plants in a population reflects complex interactions of ecological and evolutionary processes. For dioecious plants, differences in reproduction cost between sexes and sizes might affect their spatial distribution. Abiotic heterogeneity may also affect adaptation activities, and result in a unique spatial structure of the population. Thus, we examined sex- and size-related spatial distributions of old-growth forest of dioecious tree Torreya nucifera in extremely heterogeneous Gotjawal terrain of Jeju Island, South Korea. Methods: We generated a database of location, sex, and size (DBH) of T. nucifera trees for each quadrat ($160{\times}300m$) in each of the three sites previously defined (quadrat A, B, C in Site I, II, and III, respectively). T. nucifera trees were categorized into eight groups based on sex (males vs. females), size (small vs. large trees), and sex by size (small vs. large males, and small vs. large females) for spatial point pattern analysis. Univariate and bivariate spatial analyses were conducted. Results: Univariate spatial analysis showed that spatial patterns of T. nucifera trees differed among the three quadrats. In quadrat A, individual trees showed random distribution at all scales regardless of sex and size groups. When assessing univariate patterns for sex by size groups in quadrat B, small males and small females were distributed randomly at all scales whereas large males and large females were clumped. All groups in quadrat C were clustered at short distances but the pattern changed as distance was increased. Bivariate spatial analyses testing the association between sex and size groups showed that spatial segregation occurred only in quadrat C. Males and females were spatially independent at all scales. However, after controlling for size, males and females were spatially separated. Conclusions: Diverse spatial patterns of T. nucifera trees across the three sites within the Torreya Forest imply that adaptive explanations are not sufficient for understanding spatial structure in this old-growth forest. If so, the role of Gotjawal terrain in terms of creating extremely diverse microhabitats and subsequently stochastic processes of survival and mortality of trees, both of which ultimately determine spatial patterns, needs to be further examined.

• 한국안전학회지
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• 제32권6호
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• pp.131-136
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• 2017

This study deals with the small-size roundabout accidents. The purpose of this study is to analyze the characteristics of small-size roundabout accidents from developing various types of accident models, and to discuss the improvement countermeasures by vehicle type. The geometric characteristics of 36 roundabouts are surveyed, and the traffic accident data from 2008 to 2014 are collected and classified as those of car, truck and motor cycle. In this study, dependent variable is the number of accident and independent variables are such 15 variables as geometry and traffic volume. The main results are as follows. First, the null hypotheses that the size of roundabout and type of vehicle are not related to traffic accident are rejected. Second, 8 count data models which are all statistically significant are developed. Third, the number of circulatory roadway lane and sidewalk are selected as common variables of roundabout size. Finally, the number of entry and circulatory roadway lane are selected as common variables of vehicle type.

• 아태비즈니스연구
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• 제14권1호
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• pp.341-350
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• 2023

Purpose - How are gains from trade distributed between countries when economic integration is achieved through free trade? The purpose of this paper is to answer this question. Design/methodology/approach - This study attempts to address the issue of distribution of trade gains between participating countries following economic integration in terms of positive economics. The analysis is therefore based on a theoretical methodology. Findings - First, commodity prices fall and consumer surplus increases in both large and small countries. Second, when economic integration into free trade is achieved, gains from trade always exist in small countries. However, the size of trade gains depends on the degree of difference from the market size of the partner country, the large country. However, the size of the gains from trade depends on the extent of difference between the market size of the large country. If the market size of a large country is much larger and there is a large difference, trade gains will be very large, whereas if the market size is similar, profits of domestic firm will decrease. Therefore, in that case, the size of the gains from trade becomes relatively small because only the gains from exchange exists. On the other hand, in a large country with a large market size, there is a possibility of trade gains only when the market size is similar to that of a small country, which is a trading partner. However, if there is a large difference in market size, the decrease in profits of domestic firm is relatively larger than the increase in consumer surplus due to trade, and rather, a trade loss occurs. Research implications or Originality - Our analysis contributes to filling the gaps in the literature regarding the distribution of gains from trade, and from a policy point of view, it is meaningful in examining the impact of market size, an important variable considered in regional economic integration of countries.

• 대한산업공학회지
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• 제37권3호
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• pp.209-215
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• 2011

The objective of this study was to determine whether there are differences in hand muscle activities (APB : abductor pollicis brevis, ED : extensor digitorum, ECU : extensor carpi ulnaris, and EI : extensor indicis) and subjective discomfort according to the three mouse sizes (small, medium, large) and two task types (pointing and scrolling). The mouse size and task type showed significant interaction effects on the total NEMG (p = 0.004) and on the NEMG of the abductor pollicis brevis muscle (p = 0.001). The total NEMG and the NEMG of APB showed the highest value in the 'scrolling' task using the 'small' mouse. However, the NEMG of the EI was different according to the mouse size, and the 'small' mouse showed the lowest value. The subjective discomfort was the lowest in the 'medium' mouse, and all nine subjects preferred the 'medium' size. The hand-size related anthropometric variables showed different correlations according to the task type and mouse size with the NEMGs and subjective discomfort. The results of this study could be used as a basic information for the determination of the proper mouse size according to the hand size.

• 한국지진공학회논문집
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• 제18권4호
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• pp.171-180
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• 2014

Since the execution of structural design by professional structural engineers is not mandatory for small-size buildings in Korea, structural design is conducted by architects or contractors resulting in concern about the seismic safety of the buildings. Therefore, the Korean Structural Engineers Association proposed dedicated structural design criteria in 2012. The criteria were developed based on a deterministic approach in which the structural members are designed only with information of story and span length of the buildings and without structural analyses. However, due to the short time devoted to their development, these criteria miss satisfactory basis and do not deal with structural walls popularly used in Korea. Accordingly, the Ministry of Land, Infrastructure and Transport launched a research on the 'development of structural performance enhancement technologies for small-size buildings against earthquakes and climate changes'.. As part of this research, this paper intends to establish direction for the preparation of deterministic structural design guidelines for seismic safety of domestic small-size reinforced concrete buildings. To that goal, a typical plan of these buildings is selected considering frames only and frames plus walls, and then design is conducted by changing the number of stories and span length. Next, the seismic performance is analyzed by nonlinear static pushover analysis. The results show that the structural design guidelines should be developed by classifying frames only and frames plus walls. The size and reinforcement of structural elements should be provided in the middle level of the current Korean Building Code and criteria for small buildings by considering story and span length for buildings with frames only, and determined by considering the shape and location of walls and the story and span length as well for buildings with frames plus walls. It is recommended that the design of walls should be conducted by reducing the amount of walls along with symmetrically located walls.

• Journal of Radiation Protection and Research
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• 제41권3호
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• pp.222-228
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• 2016

Background: We are developing a small size dosimeter for dose estimation in particle therapies. The developed dosimeter is an optical fiber based dosimeter mounting an radiation induced luminescence material, such as an OSL or a scintillator, at a tip. These materials generally suffer from the quenching effect under high LET particle irradiation. Materials and Methods: We fabricated two types of the small size dosimeters. They used an OSL material Eu:BaFBr and a BGO scintillator. Carbon ions were irradiated into the fabricated dosimeters at Heavy Ion Medical Accelerator in Chiba (HIMAC). The small size dosimeters were set behind the water equivalent acrylic phantom. Bragg peak was observed by changing the phantom thickness. An ion chamber was also placed near the small size dosimeters as a reference. Results and Discussion: Eu:BaFBr and BGO dosimeters showed a Bragg peak at the same thickness as the ion chamber. Under high LET particle irradiation, the response of the luminescence-based small size dosimeters deteriorated compared with that of the ion chamber due to the quenching effect. We confirmed the luminescence efficiency of Eu:BaFBr and BGO decrease with the LET. The reduction coefficient of luminescence efficiency was different between the BGO and the Eu:BaFBr. The LET can be determined from the luminescence ratio between Eu:BaFBr and BGO, and the dosimeter response can be corrected. Conclusion: We evaluated the LET dependence of the luminescence efficiency of the BGO and Eu:BaFBr as the quenching effect. We propose and discuss the correction of the quenching effect using the signal intensity ratio of the both materials. Although the correction precision is not sufficient, feasibility of the proposed correction method is proved through basic experiments.

• 유통과학연구
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• 제13권12호
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• pp.13-21
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• 2015

Purpose - The purpose of this research paper is twofold. First, this paper attempts to grasp the damage caused to small and medium-size retail traders from online wholesalers in the field. Second, this paper engages in a psychological characterization of the enterprise spirit and the management of small and medium-size entrepreneurs in the retail trade business that are harmed by online wholesalers. Research design, data, and methodology - Data on three large Korean wholesalers engaged in ongoing litigation during the first half of 2014, including E-Mart Traders E-Club, and regarding applications for business adjustments from three large wholesalers were used. Results - The results show that small and medium-size distribution merchants seek political support for facility modernization, policy-specific funds, development of the distribution of PB products, advanced distribution techniques, joint logistics systems, establishment of distribution and logistics centers, sharing of parking facilities, and joint ordering systems. Conclusions - This study examined the damage to, and the government's support of policy demands from, small retail traders.

• 대한인간공학회지
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• 제3권1호
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• pp.3-11
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• 1984

This study aims to investigate the effects of the size of operator's hand and the use of foot on the production quantity and product quality. To find out the facts the survey is conducted by measuring the hand size for the worker who is randomly chosen and by grouping them into the large hand size group and small hand size group on the base of the measuring data. The grouped operators are assigned to their job as usual, and their daily production quantities and qualities are measured. The survey shows that the production quantity of the small hand group are higher than the large hand group, and the number of defects of the small hand group are less than the large hand group.

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
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• 제6권10호
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• pp.41-49
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• 2000

Today, medical system faces to two major flows of change. The first one changes to small-to-middle size special hospital from large size general hospital. The another one changes to the patient-focused hospital. In these two flows of change, women's hospital is a typical small-to-middle size special hospital. In Korea, several studies on the architectural planning of delivery-part designed with recent trends in large size general hospital have done with focusing on LDR type or LDR/P type, but few studies on the architectural planning of the recent trends in women's hospitals. Therefore, this study aims to propose improve way after analysis the developing circumstances and problems on the Architectural planning on women's hospital by case studies on Women's hospital builded recently in Korea.