• Journal of Microbiology and Biotechnology
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• v.18 no.5
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• pp.913-917
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• 2008

The cyclic undecapeptide, cyclosporin A (CyA), is one of the most commonly prescribed immunosuppressive drugs. It is generated nonribosomally from a multifunctional cyclosporin synthetase enzyme complex by the filamentous fungus Tolypocladium niveum. In order to maximize the production of CyA by wild-type T. niveum (ATCC 34921), each of three culture stages (sporulation culture, growth culture, and production culture) were sequentially optimized. Among the three potential sporulation media, the SSMA medium generated the highest numbers of T. niveum spores. The SSM and SM media were then selected as the optimal growth and production culture media, respectively. The addition of valine and fructose to the SM production medium was also determined to be crucial for CyA biosynthesis. In this optimized three-stage culture system, 3% of the spore inoculum generated the highest level of CyA productivity in a 15-day T. niveum production culture, thereby implying that the determination of an appropriate size of T. niveum spore inoculum plays a critical role in the maximization of CyA production.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.16 no.10
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• pp.2287-2292
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• 2012

In this study, $Co^{60}$ gamma-ray induced loss on Ge-doped single mode (SM) fiber has been measured. Gamma-ray is irradiated for 4 hours at the dose rate of 0.5 kGy/hr, 2 kGy/hr, 8 kGy/hr. Consequently, gamma-ray induced loss based on radiation effects in Ge-doped SM fiber occur significantly. Furthermore, dose rate effect was observed, that dose rate using the same total dose increased higher, then optical fiber loss increased more. Also annealing effect was observed, that the loss after irradiation, increased higher, then the recovery rate of loss was increased. This results are foreseen to be base data in the future radiation-hardened optical fiber study.

• Journal of the Korean Chemical Society
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• v.31 no.6
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• pp.567-575
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• 1987

Fourty five ancient Korean glass pieces have been determined for 19 elements such as Ag, As, Br, Ce, Co, Cr, Eu, Fe, Hf, K, La, Lu, Na, Ru, Sb, Sc, Sm, Th and Zn, and for one such as Pb by instrumental neutron activation analysis and by atomic absorption spectrometry, respectively. The multivariate data have been analyzed for the relation among elemental contents through the variance-covariance matrix. The data have been further analyzed by a principal component mapping method. As the results training set of 5 class have been chosen, based on the spread of sample points in an eigen vector plot and archaeological data. The 5 training set consisting of 36 species and a test set consisting of 9 species bave finally been analyzed for the assignment to certain classes or outliers through the statistical isolinear multiple component analysis (SIMCA). The results have showed the whole species for 5 training set and 3 species in the test set are assigned appropriately and these are in accord with the results by principal component mapping.

• Journal of Magnetics
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• v.20 no.1
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• pp.31-39
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• 2015

Macroscopic hysteresis loops and microscopic magnetic moment distributions have been determined by a three-dimensional (3D) model for exchange-coupled Sm-Co/${\alpha}-Fe$/Sm-Co trilayers with in-plane collinear easy axes. These results are carefully compared with the popular one-dimensional (1D) micromagnetic models and recent experimental data. It is found that the results obtained from the two methods match very well, especially for the remanence and coercivity, justifying the calculations. Both nucleation and coercive fields decrease monotonically as the soft layer thickness $L^s$ increases while the largest maximum energy product (roughly 50 MGOe) occurs when the thicknesses of hard and soft layers are 5 nm and 15 nm, respectively. Moreover, the calculated angular distributions in the thickness direction for the magnetic moments are similar. Nevertheless, the calculated nucleation and pinning fields as well as the energy products by 3D OOMMF are systematically smaller than those given by the 1D model, due mainly to the stray fields at the corners of the films. These demagnetization fields help the magnetic moments at the corners to deviate from the previous saturation state and facilitate the nucleation. Such an effect enhances as $L^s$ increases. When the thicknesses of hard and soft layers are 10 nm and 20 nm, respectively, the pinning field difference is as large as 30%, while the nucleation fields have opposite signs.

• Journal of Wellbeing Management and Applied Psychology
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• v.5 no.2
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• pp.43-50
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• 2022

Purpose: The small-scale environmental impact assessment conducted during the development project stage has focused on the preservation of the natural environment centered on non-urban areas, due to the nature of urbanization, health problems for citizens of high-density urban areas have a limitation in that they are relatively neglected. In the case of strategic environmental impact assessment and environmental impact assessment in urban areas, there is no basis for evaluation in urban areas because there are exceptions to be excluded from the target projects or there are no target project regulations for buildings. Therefore, in this research, we examined the problems with the target project such as the current environmental impact assessment, and tried to establish a system improvement plan that can solve them. Research design, data and methodology: After reviewing the current environmental impact assessment-related laws (including enforcement ordinances) and national land planning laws (including enforcement ordinances), exceptions such as environmental impact assessment in urban areas were identified and problems were identified. Based on this, an amendment to the Enforcement Decree was proposed to provide institutional support for the expansion of target projects such as environmental impact assessment in urban areas. Results and Conclusions: Through this research, it is expected that the projects subject to environmental impact assessment on development projects in urban areas directly related to the health of the people will be expanded, and the net function of the environmental impact assessment system will be maximized.

• Journal of Wellbeing Management and Applied Psychology
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• v.6 no.3
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• pp.13-18
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• 2023

Purpose: The small-scale environmental impact assessment has been in operation since its implementation in August 2000, and is a system that meets the purpose of sustainable development in consideration of the environment in areas requiring conservation. However, when preparing a small environmental impact assessment report, the contents of the reduction measures are too qualitative, or reports are prepared to simply list the compliance stipulated by individual laws, and the contents of consultations prepared by consultative agencies and review agencies are not much different. In addition, the direction of consultation on development projects for similar locations of the same project type is frequently changed by reflecting the subjective judgment of the consultative officer of the Ministry of Environment (Environment Agency). Therefore, this study attempted to improve the establishment of measures to reduce the existing simple listing of qualitative contents and the inconsistent presentation of review opinions by consultative agencies and review agencies. Research design, data and methodology: The research method extracted absolute evaluation items and relative evaluation items among small environmental impact assessment items, analyzed and presented detailed items, and prepared a distribution table for each section according to the details of the relative evaluation items, and presented them as a table. Results: This study was conducted to derive uniform results with objective indicators in the preparation and consultation process of a small-scale environmental impact assessment. Conclusions: Once a quantitative evaluation is established, the consultant can objectively determine and process the environmental impact.

• Journal of Wellbeing Management and Applied Psychology
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• v.6 no.2
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• pp.39-46
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• 2023

Purpose: The small-scale environmental impact assessment system in Korea was introduced and implemented in August 2000, but it has a problem that it cannot guarantee implementation due to the large proportion of qualitative reduction measures for each evaluation item. Therefore, when preparing a small-scale environmental impact assessment, research was conducted on how to improve the existing simple listing-type reduction measures and qualitative evaluation standards to quantitative reduction measures and evaluation standards reflecting regional characteristics. Research design, data and methodology: The small-scale environmental impact assessment system in Korea was introduced and implemented in August 2000, but it has a problem that it cannot guarantee implementation due to the large proportion of qualitative reduction measures for each evaluation item. Therefore, when preparing a small-scale environmental impact assessment, research was conducted on how to improve the existing simple listing-type reduction measures and qualitative evaluation standards to quantitative reduction measures and evaluation standards reflecting regional characteristics. Results: As a result of the analysis of qualitative and quantitative factors, the arithmetic sum of the qualitative factors of the total six projects is 160, accounting for 80% of the total number of reduction measures, and the quantitative factors are 40, accounting for 20%. Among them, the number of qualitative reduction measures reached 97.4% for animal and plant items, and more than 90% for air quality, noise and vibration, and eco-friendly resource circulation items. Conclusions: Therefore, it is necessary to avoid establishing qualitative reduction measures and set quantitative measures as the basis, but to specify the specifications, size, and installation location related to the reduction measures, and to calculate the numerical reduction efficiency.

• Ocean and Polar Research
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• v.28 no.4
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• pp.395-405
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• 2006

We measured the fugacity of $CO_2$ $(fCO_2)$, temperature, salinity, nutrients and chlorophyll a in the surface water of the western North Pacific $(4^{\circ}30'{\sim}33^{\circ}10'N,\;144^{\circ}20'{\sim}127^{\circ}35'E)$ in September 2002. There were zonally several major currents which have characteristics of specific temperature and salinity (NECC, North Equatorial Counter Current; NEC, North Equatorial Current; Kuroshio etc.). Surface $fCO_2$ distribution was clearly distinguished into two groups, tropical and subtropical areas of which boundary was $20^{\circ}N$. In the tropical Int surface $fCO_2$ was mainly controlled by temperature, while in the subtropical area, surface $fCO_2$ was dependent on total inorganic carbon contents. Air-sea $CO_2$ flux showed a large spatial variation, with a range of $-0.69{\sim}0.79 mmole\;m^{-2}day^{-1}$. In the area of AE (Anticyclonic Eddy), SM(Southern Mixed region) and NM (Northern Mixed region), the ocean acted as a weak source of $CO_2$ $(0.6{\sim}0.79 mmole\; m^{-2}day^{-1})$. In NECC, NEC, Kuroshio and ECS (East China Sea), however, the fluxes were estimated to be $-0.3mmole\; m^{-2}day^{-1})$ for the first three regions and $-1.2mmole\; m^{-2}day^{-1})$ for ECS respectively, indicating that these areas acted as sinks of $CO_2$. The average air-sea flux in the entire study area was $0.15mmole\;m^{-2}day^{-1})$, implying that the western North Pacific was a weak source of $CO_2$ during the study period.

• Proceedings of the Korean Geotechical Society Conference
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• 2005.10a
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• pp.536-549
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• 2005

국내 대부분을 차지하고 있는 NATM의 주요원리는 주변지반의 지보효과를 활용하는 터널굴착공법이다. 따라서 실제 지반조건이 원설계조건 보다 역학적으로 불량한 경우 보강공법의 적용은 필수적이라 할 수 있으나, 합리적인 설계변경은 현실적으로 쉽지 않은 실정이다. 또한 현실적인 이유로 양방향으로 터널을 관통하는 설계법과 달리 종종 1방향 굴진으로 터널을 관통하는 경우가 있다. 그러나 이러한 1방향 굴진은 불가분 굴진 종점부에서 저토피 갱구를 향하게 되므로, 지반이 연약한 경ㅇ우 막장 붕괴의 위험이 매우 높은 것으로 알려져 있다. 본 터널은 설계 시 갱구부 지반을 풍화암과 연암으로 보고 설계 하였으나, 실제 굴착 시 확인된 지층은 핵석을 포함한 실트질모래(SP-SM)로 판명되었다. 더구나 터널굴진 방향에 있어서도 양방향 굴착이 아닌 저토피 갱구를 향한 1방향 굴진을 실시하였으며, 이러한 시공 중에 터널관통을 불과 19m 남겨둔 갱구부에서 막장부괴와 동시에 상부사면 함몰이 발생하였다. 본 연구는 토사터널 갱구부 1방향 굴진 시 발생한 막장붕괴 보강사례로서, 지상보강(시멘트밀크 그라우팅)과 갱내보강(방사상 FRP보강그라우팅) 그리고 인버트폐합을 실시하여 성공적으로 터널시공을 완료한 사례연구이다. 본 사례는 향후 토사터널 갱구부의 설계와 시공에 유용한 참고자료가 될 것이다.

• Proceedings of the KOSOMBE Conference
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• v.1996 no.11
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• pp.22-24
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• 1996

Small size DC motor control method for portable drug delivery system has been developed to be used for the actuator of insulins pump. The control method gives the controllabilities both in high speed(40-50 revolution per second(rps)) DC motor drive and also in low speed(0.5-1rps). In low speed mode DC motor is controlled to act like stepping motor and in high speed to optimize power consumption. To control both mode modified bang bang control is suggested. Using this method small size DC motor(spec.) speed is controlled from 0.2 rps to 50 rps. Experimental setup is developed using micro-processor(PIC16C73, Micro Chips co., USA), motor turns checking circuitry, small size DC motor for pager(SM1012, Samhong co., Korea) and gear box. Results from experiment meet need for vailable load condition which is require for portable drug delivery system.