• Biomedical Science Letters
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• v.29 no.2
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• pp.53-57
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• 2023

The main objective of pathologists is to achieve accurate lesion diagnoses, which has become increasingly challenging due to the growing number of pathological slides that need to be examined. However, using digital technology has made it easier to complete this task compared to older methods. Digital pathology is a specialized field that manages data from digitized specimen slides, utilizing image processing technology to automate and improve analysis. It aims to enhance the precision, reproducibility, and standardization of pathology-based researches, preclinical, and clinical trials through the sophisticated techniques it employs. The advent of whole slide imaging (WSI) technology is revolutionizing the pathology field by replacing glass slides as the primary method of pathology evaluation. Image processing technology that utilizes WSI is being implemented to automate and enhance analysis. Artificial intelligence (AI) algorithms are being developed to assist pathologic diagnosis and detection and segmentation of specific objects. Application of AI-based digital pathology in biomedical researches is classified into four areas: diagnosis and rapid peer review, quantification, prognosis prediction, and education. AI-based digital pathology can result in a higher accuracy rate for lesion diagnosis than using either a pathologist or AI alone. Combining AI with pathologists can enhance and standardize pathology-based investigations, reducing the time and cost required for pathologists to screen tissue slides for abnormalities. And AI-based digital pathology can identify and quantify structures in tissues. Lastly, it can help predict and monitor disease progression and response to therapy, contributing to personalized medicine.

• Korean Journal of Ecology and Environment
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• v.56 no.3
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• pp.196-206
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• 2023

Benthic attached diatoms (BADs), a major primary producer in lotic stream and river ecosystems are micro-sized organisms and require a highly magnified microscopic technique in the observation work. Thus, it is often not easy to ensure accuracy and precision in both qualitative and quantitative analyses. This study proposed a new technique applicable to improve quality control of aquatic ecosystem monitoring and assessment using BADs. In order to meet the purpose of quality control, we developed a permanent mounting slide technique which can be used for both qualitative and quantitative analyses simultaneously. We designed specimens with the combination of grid on both cover and slide glasses and compared their efficiency. As a result of observation and counting of BADs, the slide glass designed with the color-lined grid showed the highest efficiency compared to other test conditions. We expect that the method developed in this study could be effectively used to analyze BADs and contributed to improve the quality control in aquatic ecosystem health monitoring and assessment.

• The Korean Journal of Nuclear Medicine
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• v.4 no.1
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• pp.43-49
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• 1970

In recent years with development of immuno-electrophoresis, more acurate analysis of the serum protein became possible. However, there is few reports in the literature which investigated the changes of the immunoglobulin compared with electrophoretically fractioned serum thyroglobulin in the patients with various thyroid diseases. The purpose of this report is to investigate the changes of thyroglobulin in various thyroid diseases by the method of immuno-electrophoresis and to compare the results with.serum protein fractionated by the method of agar-gel micro-electrophoresis. Materials and Methods: Sera from 9 patients with diffuse toxic goiter, 2 nodular nontoxic goiter, 2 thyroiditis, 3 hypothy, roidism, 1 thyroid cancer, 7 cystic degeneration of the thyroid gland, and 10 normal subject were taken. All cases were confirmed by various laboratory thyroid function tests and thyroid needle biopsy. Immuno-electrophoretic analysis of the serum were performed by Scheidegger's modified micro-immuno-electrophoretic method. The antiserum was obtained from the Travenol Laboratories International, Hyland Products Division and was rabbit anti-human thyroglobulin. Microscope slide agar-gel electrophoresis for serum protein fractionation was performed at $4^{\circ}C$ using veronal buffer, pH 8.6 and ionic strength 0.05, with 54 volts and 2.8 mA for 60 minutes. The fractionated slide was stained with 0.1% thiazine red. The results were as follows: 1) Increase of immune-globulin macroglobulin (IgM), alphaglobulin, and immune-globulin A (IgA) by 95.8%, 100%, 29.2% respectively was found in the serum from various thyroid diseases. 2) Thyroglobulin fraction was found to be increased in 50%, no change in 41.7%, and no line in 8.3% with all of the various goiter patients. On the other hand, 10 normal control group showed only 2 cases of increase, 5 cases of no change and 3 cases of no line.

• Journal of the Institute of Electronics Engineers of Korea CI
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• v.40 no.4
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• pp.232-239
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• 2003

This paper discusses the design and implementation of a human-oriented interface based on computer vision that efficiently controls presentation slides. The user does not have to be confined to a keyboard or mouse any more, and can move around more freely because slides for presentation can be up and down using a general laser pointer that is used for presentation. Regions for virtual buttons are set on the slide so that the user can conveniently point the buttons using the laser pointer. We have proposed a simple and efficient method that computes the button areas in the image without complicated calibration. The proposed method has been implemented based on Microsoft PowerPoint ; moreover it can be applied to other PowerPoint-like presentation softwares. Our method for human-centered slide control enables the user to give audiences a more interactive presentation in a natural way.

• The Journal of the Korean Society for Microbiology
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• v.3 no.1
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• pp.5-14
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• 1968

Prostitutes living in Songdo beach in Pusan, for two years period (from September 4, 1964 to August 28, 1966) were investigated for the present status and Venereal Diseases. The following results were obtained. 1. Age distribution:The youngest was 18 years old and the oldest 29. The group between 22-25 years old was 72.8%, approximately three fourth of all prostitute. 2. Educational background: From illiterate to college graduated. The group of graduated primary school was 80.7%, approximately four fifth of all prostitutes. 3. Distribution of birth places: From all cities and provinces in Korea except Chejudo Island province. Kyongsang Namdo province was highest(24%), Kyongsan Pukdo province 18%, Pusan city 12%, and Seoul city 11%. 4. Monthly and weekly Venereal Diseases examination to prostitutes: Total examined cases were 7757, consisting of 323 monthly, and 75 weekly. Total numbers of disqualified persons were 592(7.63% of total examined), consisting of 25 monthly, and 6 weekly. 5. Clinical and laboratory findings of the rejected prostitutes at the Venereal Disease examination: Among total cases of rejected 592, gonococcal positive cases were 2.89%, staining by gram's method, cervical erosions 3.53%, and numerous pus cells but gonococcal negative 1.53%. 6. Seasonal distribution of prostitutes : Songdo beach is one of the famous sea shore sightseeing resort in Pusan. Therefore, numbers of prostitutes were increasing in hot season, summer and decreasing in cold season, winter. 7. Number of disqualified prostitutes at the Venereal Disease examination by seasonal trend: In autumn 18.04%, winter 8.68%, spring 5.85%, and summer 4.43%, in order as described, the decreasing tendency was observed. 8. Serolgical tests for syphilis: VDRL slide method and Kolmer-Wassermann reaction were performed to the prostitutes. STS were positive by VDRL slide method in 8.33-33.87%, Kolmer-Wassermann reaction in 8.33-27.42% of the prostitutes. The results of sero-positive of syphilis showed tendency toward gradually increase from 1964 to 1966. 9. Authors were observed only 1 case or soft chancer, but neither lymphogranuloma venereum nor granuloma inguinale were detected.

• Journal of the Korea Computer Graphics Society
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• v.29 no.3
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• pp.127-135
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• 2023

Accurate segmentation of histopathology whole slide images (WSIs) is a crucial task for disease diagnosis and treatment planning. However, conventional automated segmentation algorithms may not always be applicable to WSI segmentation due to their large size and variations in tissue appearance, staining, and imaging conditions. Recent advances in interactive segmentation, which combines human expertise with algorithms, have shown promise to improve efficiency and accuracy in WSI segmentation but also presented us with challenging issues. In this paper, we propose a novel interactive segmentation method, ZoomISEG, that leverages multi-resolution WSIs. We demonstrate the efficacy and performance of the proposed method via comparison with conventional single-scale methods and an ablation study. The results confirm that the proposed method can reduce human interaction while achieving accuracy comparable to that of the brute-force approach using the highest-resolution data.

• Bulletin of the Korean Chemical Society
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• v.24 no.4
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• pp.411-412
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• 2003

• Journal of Environmental Science International
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• v.11 no.8
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• pp.765-771
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• 2002

The current study investigated the relationship between image processed data and human visibility data for natural forest scenes from the perspective of color. In particular, the results indicated relatively low Pearson product-moment correlations between the color ratings obtained from the two methods used in the study. The first method measured the color content of slides using a image processing program, while the second used a panel of human judges to rate the color content of each slide.

• Proceedings of the Earthquake Engineering Society of Korea Conference
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• 2003.03a
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• pp.193-199
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• 2003

The most cultural heritages are composed of piled multi-block systems which are vulnerable to earthquakes. The stone of low height tends to slide when the excitation such as earthquake is applied and this sliding motion has effects on the whole response of the structure. In this study, analytical method of sliding motion of the piled multi-block systems considering horizontal rotation is developed and compared with shaking table test results. It is shown that the nonlinear analysis of sliding motion of multi-block system leads to satisfactory results.

• Journal of Advanced Marine Engineering and Technology
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• v.16 no.3
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• pp.51-57
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• 1992

Authors had analyzed the Press machine's vibrational characteristics by Substructure Synthesis Method. This paper discribes the structural Dynamic Optimization for the machine using Sensitive Analysis Method. The substructure synthesis method and sensitive analysis methods are used for the vibration analysis and structural modification. The results obtained are as follows ; 1. The tooling precision of the press machine is ruled by the bending vibration of the slide. 2. The structural Modification Method for minimizing impact responses is proposed, and modal analysis and sensitive analysis method are introduced to solve it. 3. The impact responses of running machine were reduced to 40% of the unmodified machine by using the proposed method.