• 제목/요약/키워드: Skin patch

검색결과 174건 처리시간 0.023초

인공 진피(알로덤®)을 이용한 하지의 골이 노출된 연부 조직 결손의 재건 (Reconstruction of the Bone Exposed Soft Tissue Defects in Lower Extremities using Artificial dermis(AlloDerm®))

  • 전만경;장영철;고장휴;서동국;이종욱;최재구
    • Archives of Plastic Surgery
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    • 제36권5호
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    • pp.578-582
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    • 2009
  • Purpose: In extensive deep burn of the lower limb, due to less amount of soft tissue, bone is easily exposed. When it happens, natural healing or reconstruction with skin graft only is not easy. Local flap is difficult to success, because adjacent skins are burnt or skin grafted tissues. Muscle flap or free flap are also limited and has high failure rate due to deep tissue damage. The authors acquired good outcome by performing one - stage operation on bone exposed soft tissue defect with AlloDerm$^{(R)}$(LifeCell, USA), an acellular dermal matrix producted from cadaveric skin. Methods: We studied 14 bone exposed soft tissue defect patients from March 2002 to March 2009. Average age, sex, cause of burn, location of wound, duration of admission period, and postoperative complications were studied. We removed bony cortex with burring, until conforming pinpoint bone bleeding. Then rehydrated AlloDerm$^{(R)}$(25 / 1000 inches, meshed type) was applicated on wound, and thin split thickness(6 ~ 8 / 1000 inches) skin graft was done at the immediately same operative time. Results: Average age of patients was 53.6 years(25 years ~ 80 years, SD = 16.8), and 13 patients were male(male : female = 13 : 1). Flame burn was the largest number. (Flame burn 6, electric burn 3, contact burn 4, and scalding burn 1). Tibia(8) was the most affected site. (tibia 8, toe 4, malleolus 1, and metatarsal bone 1). Thin STSC with AlloDerm$^{(R)}$ took without additional surgery in 12 of 14 patients. Partial graft loss was shown on four cases. Two cases were small in size under $1{\times}1cm$, easily healed with simple dressing, and other two cases needed additional surgery. But in case of additional surgery, granulation tissue has easily formed, and simple patch graft on AlloDerm$^{(R)}$ was enough. Average duration of admission period of patients without additional surgery was 15 days(13 ~ 19 days). Conclusion: AlloDerm$^{(R)}$ and thin split thickness skin graft give us an advantage in short surgery time and less limitations in donor site than flap surgery. Postoperative scar is less than in conventional skin graft because of more firm restoration of dermal structure with AlloDerm$^{(R)}$. We propose that AlloDerm$^{(R)}$ and thin split thickness skin graft could be a solution to bone exposured soft tissue defects in extensive deep burned patients on lower extremities, especially when adjacent tissue cannot be used for flap due to extensive burn.

교통약자를 고려한 보도의 경사도와 높이 결정을 위한 실험연구 (Experimental Study on the Determination of Slope and Height of Curbs Considering the VRUs)

  • 김현진;임준범;최병호;오철;강인형
    • 한국도로학회논문집
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    • 제20권1호
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    • pp.107-115
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    • 2018
  • PURPOSES : As the population of the mobility handicapped, who are classified as the disabled, the elderly, pregnant women, children, etc., has increased, the voices for guaranteeing their rights have been increasing as well. Thus, the design manuals for roads and sidewalks for the mobility handicapped were developed by the local government, such as the Ministry of Land, Transport, and Tourism, in Seoul City. However, according to the 2013 survey results of the Seoul Metropolitan City, the mobility handicapped still feel uncomfortable with the sidewalks, and particularly request for the improvement of the step and slope of the sidewalk curb. Therefore, in this study, we conducted an empirical experimental study to determine the slope of the sidewalk curb and height of the steps considering the mobility handicapped and analyzed whether there is a statistically significant difference. METHODS : The methodology of this study is an empirical experimental one. In the study, five non-disabled people, 10 wheelchair users, and 10 eye patch and stick users walked about 2-3 min on the sidewalk plates of the sloped type (0%, 5%, 6.3%, 8.3%) and stepped type (0 cm, 1 cm, 3 cm, 6 cm), and their human physiological responses, such as the skin temperature, volume of perspiration on forehead and chest, and heart rate, were measured and recorded. After combining the data, we conducted a nonparametric test, ANOVA, or t-test to determine whether there was a statistically significant difference according to each slope and step type. RESULTS : It was found that for the non-disabled, there was no significant difference in human physiological responses according to the slope and steps of the sidewalk. It can be said that the non-disabled do not feel much physiological discomfort while walking. In the case of the sloped sidewalk plate, the heart rate of the wheel chair users increased when the slope was 6.3%. In the case of the eye patch and stick users, the volume of perspiration on the chest increased at a slope of 5.0%. In general, it is judged that a sidewalk with a slope that is less than 5% does not cause a change in the physiological response. In the case of a stepped sidewalk plate, when 0 cm, 1 cm, and 3 cm were compared for wheelchair users, the amount of forehead perspiration increased from 1 cm. Meanwhile, in the case of the eye patch and stick users, when 0 cm and 6 cm were compared, the amount of perspiration on the forehead and chest as well as the heart rate all increased at 6 cm. Taken together, in the case of wheelchair users, a difference was shown when the height of the step of the sidewalk plate was 1 cm, suggesting that installing it at 0 cm does not cause any physiological discomfort. Moreover, in the case of the eye patch and stick users, when comparing only 0 cm and 6 cm, 0 cm was considered to be suitable, as there was a difference in physiological response at 6 cm. CONCLUSIONS : In this study, we set the human physiological responses such as chest skin temperature, amount of perspiration, and heart rate as evaluation items, and our study was considered to be a meaningful experiment that targeted wheelchair users as well as eye patch and stick users. The validity of the evaluation items was confirmed, as the results of human physiological responses were significant. As for the sidewalk design, according to the experiment result, it is considered that differential application should be implemented according to the type of mobility handicap, rather than uniformly applying a sidewalk step of 2 cm and sidewalk slope of 1/25, which are the current legal standards.

슬관절 인공관절 전치환술 환자에서 부프레노르핀 경피 패치의 적용부위에 따른 수술 후 통증 조절 효과 비교: 후향적 환자-대조군 연구 (Comparison of the Postoperative Pain Control Effects of a Buprenorphine Transdermal Patch on Total Knee Arthroplasty Surgery Patients according to Its Applied Sites: Retrospective Case-Control Study)

  • 김옥걸;이상욱;김현민
    • 대한정형외과학회지
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    • 제55권6호
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    • pp.527-533
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    • 2020
  • 목적: 슬관절 인공관절 전치환술(total knee arthroplasty, TKA) 후 통증 조절을 위한 부프레노르핀 경피 패치(buprenorphine transdermal patch, BTDP)의 흉부 적용 및 무릎 적용 효과를 비교하고자 하였다. 대상 및 방법: 2018년 8월부터 2019년 8월까지 TKA를 시행한 231명 중에서 나이, 성별, 체질량 지수(body mass index) 등을 고려한 환자-대조군 연구를 통해 선별된 200예를 대상으로 후향적으로 분석하였다. BTDP를 적용하기 전후에 Numeric Rating Scale (NRS), 부작용 및 순응도를 측정하였으며 흉부 적용군(A군=100명)과 무릎 적용군(B군=100명) 사이의 모든 측정치를 비교하였다. 결과: 술 후 BTDP 적용군 간의 휴식 시 NRS는 전반적으로 비슷하였으나 B군의 술 후 2, 3일째 오후, 5일, 6일, 7일째 휴식 시 NRS는 A군의 NRS보다 통계적으로 유의하게 낮았다. BTDP 적용 후 중추신경계, 위장관계 부작용은 B군에서 유의하게 낮았다. 심혈 관계, 피부의 부작용은 두 군 간에 유의한 차이가 없는 것으로 나타났다. 통증 조절을 위한 지속적인 BTDP 유지에서도 B군이 A군에 비하여 유의하게 높게 나타났다. 결론: TKA 후 BTDP를 통증이 있는 무릎 관절에 직접 적용하는 것은 술 후 초기 통증 조절에 있어 우수한 결과를 보였으며 기존의 흉부 적용 방법보다 부작용 빈도를 줄여 환자의 순응도를 높일 수 있는 유용한 방법으로 판단된다.

Morphological Analysis of Blind-Side Hypermelanosis of the Starry Flounder, Platichthys stellatus during Early Development

  • Kang, Duk-Young;Byun, Soon-Gyu;Myeong, Jeong-In;Kim, Hyo-Chan;Min, Byoung-Hwa
    • 한국발생생물학회지:발생과생식
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    • 제18권2호
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    • pp.79-87
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    • 2014
  • In Pleuronectiformes, blind-side malpigmentation (hypermelanosis) is common in cultured flatfishes, and is economically important. To understand the mechanism of blind-side hypermelanosis in flatfishes, we examined when the malpigmentation initially occurred, and studied how the symptoms proceeded during early development of the starry flounder, Platichthys stellatus. To assess quantitative pattern changes of blind-side skin, we observed morphological development of the whole body from 22 (total length [TL] $10.0{\pm}0.2$ mm and body weight [BW] $8.8{\pm}0.57$ mg) to 110 days (TL $23.4{\pm}0.7$ mm, BW $193.6{\pm}23.3$ mg) after hatching (DAH), and also examined the malpigmented area rate of blind-side skin and the malpigmented fish ratios. The experimental animals were reared in fiberglass-reinforced plastic (FRP) tanks in water at a temperature of $18.9{\pm}1.9^{\circ}C$ and salinity of $32.6{\pm}0.6$ psu and were fed with rotifer and Artemia nauplii from 22 to 48 DAH, and with A. nauplii and commercial feed from 49 to 110 DAH. As results, the first staining patch seen by the naked eye was observed around the area between the anus and pelvic fin or caudal edge of the trunk at 80 DAH (TL $20.6{\pm}0.5$ mm, BW $112.5{\pm}8.8$ mg). The pigmented area and the pigmented fish ratios were significantly increased from 80 to 110 DAH. These results indicated that malpigmentation on the blind side of starry flounder was initially observed at about 2 cm in length and 100 mg in weight, and the pigmented domain on the blind-side skin was continually broadened by the differentiation of pigmented cells (melanophores and xanthophores) with growth.

3-O-cetyl-L-ascorbic acid의 주름 개선 효과 (Anti-wrinkle effect of 3-O-cetyl-L-ascorbic acid)

  • 박창민;이순영;정민석;최종완
    • 대한화장품학회지
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    • 제34권4호
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    • pp.303-309
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    • 2008
  • 건강한 피부 기능의 악화 원인으로는 콜라겐 섬유 감소, 탄력섬유 변성, 활성산소종의 과다 생성 등이 있다. 이로 인하여 피부 탄력 저하나 주름이 생성된다. 피부 탄력 저하 및 주름 생성과 같은 피부 노화를 개선하기 위해 대표적으로 비타민 A, C 및 그 유도체들이 화장품에 적용되고 있지만 화학적 불안정성의 문제점이 있어 새로운 유도체들의 합성 개발에 노력을 기울이고 있다. 본 연구에서는 피부개선을 위한 화장품 원료로 최근 비타민 C로부터 새롭게 합성된 3-O-cetyl-L-ascorbic acid (VCCE)의 주름 개선과 관련된 효능 효과를 평가하였다. VCCE의 in vitro 실험 결과 procollagen type I의 합성을 0.002%에서 최대 149% 증가시켰다. 또한 인체적용시험에서 일차적으로 폐쇄 첩포 실험 결과 자극이 유발되지 않았으며, 모사판 분석 및 PRIMOS system을 이용한 주름측정결과에서도 주름개선효과를 확인하였다. 결과적으로, VCCE는 주름 개선을 위한 화장품 성분으로서 높은 응용 가치를 제시한다.

도라지 추출물로부터 천연계면활성제의 개발 (Development of a Natural Surfactant from Extracts of Platycodon Grandiflorum)

  • 김희진;박숙경;김보영;홍슬기;조성기;김동욱
    • Korean Chemical Engineering Research
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    • 제46권2호
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    • pp.227-232
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    • 2008
  • 화장품용 천연계면활성제를 개발하기 위해 도라지(platycodon grandiflorum) 껍질에서 유기용매를 이용하여 추출물을 얻었다. 도라지 추출물의 화장품용 계면활성을 측정하기 위해 계면장력, 용해도, 기포력, 분산력, 유화력, 유화활성, 유화안정성을 측정하였고 피부자극을 평가하기위해 첩포시험을 실시하였다. 도라지 사포닌 함량이 0.005 wt%일 때 castor oil에 대한 계면장력은 11.5 dyn/cm로 비교대상인 Tween 40이나 quillaja bark보다 낮은 계면활성을 보여주었다. 도라지 추출물은 화장품에 유상으로 사용되는 olive oil, soybean oil, canola oil에 대해서도 우수한 유화활성과 유화안정성을 나타내었다. 2~5%의 도라지 추출물과 글리세린을 사용한 피부자극 시험에서는 도라지 추출물은 약간의 피부자극을 보여 주었다. 결론적으로 도라지 추출물은 화장품용 계면활성력은 양호하나 다소의 피부자극을 보여주었다.

전통 생약재에서의 항노화와 주름 개선 활성 신소재 탐색 (Screening of Traditional Herbal Medicines to Develop New Materials for Anti-aging and Anti-wrinkle in the Skin)

  • 이상은;손동욱;윤여필;임태형;조자운;김현수
    • 대한화장품학회지
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    • 제31권2호
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    • pp.147-152
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    • 2005
  • 본 연구는 화장품 소재개발에 있어 보다 안전하고 우수한 활성을 나타내는 천연 소재를 개발하고자 하였다 본초학과 식품공전에 수재되어 있는 전통생약재에 대한 연구는 국내 화장품 원료개발의 중요한 부분으로써 우리나라가 경쟁력을 가질 수 있는 부분으로 사료되며, 본 연구에서는 폐와 피부 질환에 사용되는 전통생약재 121종을 선별하였다. 이들 전통생약재 추출물들을 대상으로 DPPH free radical 소거법과 SOD 활성 측정법에 의한 항산화 활성과 주름 생성의 주 기전에 관련된 elastase 효소 억제 활성을 관찰하였다. 항산화 활성을 보이면서도 주름 형성관련 효소인 엘라스타제에 대한 억제 활성을 지니는 전통생약재 9종을 선별하였다. 항주름/피부탄력 활성을 나타내리라 사료되는 9종의 생약재에 대한 각각의 정상 세포에 대한 세포독성을 측정한 결과, 효과를 나타내리라 여겨지는 0.1 g/mL 이하의 농도에서 세포 독성이 없는 것으로 확인되었다. 또한 인체피부 일차 자극 실험을 통해 피부자극 유무를 측정한 결과 피부자극이 없음을 확인하였다 본 연구를 통해 식품공전과 동의보감 자료에 의거, 폐와 피부질환에 관련된 전통생약재 121종 중 9종에 대해 항주름과 피부탄력에 관련한 향장 소재로써의 개발 가능성을 확인하였다.

스킨헬스케어를 위한 증류 죽초액 함유 천연화장품의 여드름 피부 임상 적용 연구 (A Clinical Research of Acne Skin through Natural Cosmetics with Distilled Bamboo Vinegar Contents for Skin Health Care)

  • 박가희;박정연
    • 한국엔터테인먼트산업학회논문지
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    • 제14권7호
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    • pp.589-597
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    • 2020
  • 본 연구는 천연물질인 증류 죽초액이 함유된 천연화장품의 여드름 피부 개선에 대한 효과성을 검증하여 여드름 화장품 소재 개발을 목적으로 하였다. 연구의 대상 10대 남·여 20명을 선정하여 난수표방식에 따라 10명은 천연화장품(폼 클렌징, 토너, 팩)을 사용한 대조군으로 10명은 증류 죽초액이 함유된 천연화장품(폼 클렌징, 토너, 팩) 사용한 실험군으로 배정하였다. 화장품 사용 기간은 12주로 하였고, Mark-·Vu 피부 측정기를 사용하여 사전, 6주 후, 12주 후 피부의 피지, 모공 크기, 붉은기를 측정하였다. 수집된 자료는 SPSS v. 21.0 통계 패키지 프로그램을 활용하여 분석하였으며, 결과는 다음과 같다. 첫째, 천연화장품의 피부 안정성 확인을 위한 인체첩포시험 결과 피부에 안전한 제품으로 확인되었다. 둘째, 대조군과 실험군의 피지, 모공 크기, 붉은기에 대한 동질성 검증 결과 동질성이 확보되었다. 셋째, 증류 죽초액이 함유된 천연화장품의 여드름 피부 개선 효과 검증에서 실험군이 대조군에 비해 이마와 오른 볼 부위의 피지, 모공 크기, 붉은기 변화의 감소율이 더 크게 나타났다. 이에 증류 죽초액이 함유된 천연화장품은 피부에 안전하며, 여드름 피부에서 피부의 피지 감소와 모공 크기 및 붉은기 감소에 효과적인 것으로 확인됨에 따라 화장품 산업에서 증류 죽초액 활용을 기대하는 바이다.

Effect of IceWave® organic nanoscale patches on reduction of musculoskeletal pain

  • Piven, Emily;Dharia, Rupesh;Jones, Karen;Davis, Chuck;Nazeran, Homer
    • 셀메드
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    • 제3권1호
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    • pp.5.1-5.5
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    • 2013
  • In this pilot dual-site study with LifeWave IceWave$^{(R)}$ patches, using subjects as their own controls, data were acquired from a convenience sample of 16 males and 24 females, 50% Caucasian-Americans, 50% Hispanic-Americans, ages 20 - 85 with neuromuscular pain. The hypothesis was: the application of IceWave$^{(R)}$ patches to the skin will reduce one's perception of pain. Subjects were tested at baseline (without any patches), and then at 1 and 3 h on day 1 and at 1 h on days 2 - 5 after patch application. At every time point, the mean change, indicative of one's perception of pain, was highly significantly (p < 0.0001) reduced, with a statistical power of 100% compared to baseline. Based on these findings, the hypothesis was accepted as true.

Lactobiocin의 피부 염증 및 여드름 저해효과에 관한 연구 (Inhibitory activity of Lactobiocin on the skin inflammation and acnes)

  • 김광수;오세종;김기환;홍진천;이승화
    • 대한화장품학회지
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    • 제28권1호
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    • pp.150-165
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    • 2002
  • The purpose of this study was to evaluate bacteriocin activity against human flora. Lactobiocin, a bacteriocin produced by Lactococcus sp. HY 449, inhibited the growth of Starphylococcus epidermidis, Starphylococcus aureus, Streptoccoccus pyogenes and Propionibacterium acnes. When crude bacteriocin was added to indicator cells during logarithmic growth, the optical density(O.D 650nm) of cells without bacteriocin increase after 5h of incubation. Whereas in the presence of bacteriocin, the O.D of cell suspensions decreased. The similar patterns were observed for absorbance readings at 280 nm and 260 nm. The release of cellular components when cell were treated with Lactobiocin suggests some degree of membrane damage or cell lysis. Scanning electron microscopy of cells following treatments with Lactobiocin in PBS buffer revealed disruptures of cell morphology. These results indicate that bacteriocin appears to cause cell lysis of tested strains. In cytotoxicity on human fibroblast, LD$\_$50/ of Lactobiocin was ca. 50 mg/ml and no change was observed cell proliferation at the same concentration. Any irritation and allergic reaction did not observed when evaluated by human patch test for Lactobiocin.