• International journal of thyroidology
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• v.10 no.1
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• pp.50-55
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• 2017

Sweet's syndrome, or acute febrile neutrophilic dermatosis, occurs in association with autoimmune diseases such as Hashimoto's thyroiditis but is rare in Graves' disease, in which all cases are induced by propylthiouracil (PTU). We report a case of Sweet's syndrome in a patient with Graves' disease treated with methimazole (MMI) during three weeks. A 34-year-old man presented with the acute onset of high fever, skin rashes on the whole body, arthralgia, and acroparesthesia. Laboratory results showed leukocytosis and elevated C-reactive protein. MMI first stopped and antibiotics and antihistamine therapy started, but his symptoms dramatically improved after oral prednisolone. Graves' disease has again been treated by MMI because of his aggravated ophthalmopathy. After one year of retreatment with MMI, there has been no recurrence of Sweet's syndrome, supporting that Sweet's syndrome in this case was not related to MMI exposure. To our knowledge, this is the first report of Sweet's syndrome associated with Graves' disease per se but not PTU or MMI use.

• International journal of thyroidology
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• v.11 no.2
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• pp.176-181
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• 2018

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis has been reported in Graves' disease patients treated with antithyroid drugs (ATDs), especially propylthiouracil. ATD-induced ANCA-associated vasculitis usually involved the kidneys followed by the respiratory organs and skin. The treatment of ANCA-associated vasculitis induced by ATDs is to stop ATD therapy immediately, which often leads to an overall good prognosis. We report a case of ANCA-associated vasculitis in the peripheral nerves of the lower extremities in a 66-year-old woman who was treated with methimazole (MMI) for Graves' disease. To our knowledge, this is the third case of peripheral nervous system (PNS) involvement of ATD-induced vasculitis and the first case of PNS vasculitis associated with MMI.

• Medical Lasers
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• v.9 no.2
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• pp.184-186
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• 2020

Lower eyelid blepharoplasty is a popular facial rejuvenation surgery that restores the infraorbital region. The procedure is performed by removing excessive fatty tissues, muscles, and other unnecessary structures. The structure of the eyelid differs from person to person and is quite complex; therefore, numerous side effects are expected. Common lower eyelid blepharoplasty complications are asymmetrical faces, retrobulbar hemorrhage, blurred vision, and ectropion. This paper reports a case of a prominent periorbital vein after lower eyelid blepharoplasty. The prominent periorbital vein after surgery is a rare side effect that has not been reported to the best of the author's knowledge. This case was treated with a long-pulse 1,064-nm neodymium:yttrium-aluminum-garnet laser.

• Korean Journal of Audiology
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• v.24 no.2
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• pp.99-102
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• 2020

Trichofolliculoma (TF) is a follicular hamartoma in which hairs protruding out of single orifice. To the best of my knowledge, only two auricular TF has been reported in the English literature. Moreover, clinically TF have been described to mimic malignancy. I present a case of an adult female with mass at the intertragal notch of the left auricle for several years. The clinical diagnosis was thought to be epidermoid cyst, accessory tragus, and other benign skin adnexal tumor. To prevent recurrence, the wide local excision of the mass was performed. The final diagnosis of TF was made. No recurrence was noted during the follow-up of 1 year. It is important for otologists to be familiar with the clinical and pathologic characterization of TF, to make the correct diagnosis.

• Journal of Audiology & Otology
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• v.24 no.2
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• pp.99-102
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• 2020

Trichofolliculoma (TF) is a follicular hamartoma in which hairs protruding out of single orifice. To the best of my knowledge, only two auricular TF has been reported in the English literature. Moreover, clinically TF have been described to mimic malignancy. I present a case of an adult female with mass at the intertragal notch of the left auricle for several years. The clinical diagnosis was thought to be epidermoid cyst, accessory tragus, and other benign skin adnexal tumor. To prevent recurrence, the wide local excision of the mass was performed. The final diagnosis of TF was made. No recurrence was noted during the follow-up of 1 year. It is important for otologists to be familiar with the clinical and pathologic characterization of TF, to make the correct diagnosis.

• Journal of Genetic Medicine
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• v.19 no.2
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• pp.57-62
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• 2022

Systemic autoinflammatory diseases (SAIDs) are characterized by unprovoked inflammatory episodes such as recurrent/periodic fever, serositis, skin lesions, abdominal symptoms, arthritis/arthralgia, and central nervous system involvement. Genetic diagnosis of SAIDs has been challenging because disease manifestations overlap among themselves and with other immunological disease categories, such as infection and autoimmune diseases. However, the advent of next-generation sequencing (NGS) technologies and expanding knowledge about the innate immunity and inflammation have made the routine genetic diagnosis of SAIDs possible. Here, we review the recurrent/periodic fevers, other recently identified autoinflammatory diseases, and type I interferonopathies, and discuss the clinical usefulness of NGS targeted sequencing for SAIDs, and recent advance of understandings for this heterogeneous disease group as for underlying primary immunodeficiency.

• Archives of Plastic Surgery
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• v.51 no.1
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• pp.27-29
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• 2024

Facial massages are frequently performed to achieve a feeling of freshness, rejuvenation, skin tightening, and delayed onset of wrinkles. However, vigorous massages can induce unexpected symptoms. Here, we present a case of a woman who complained of an asymmetric facial appearance and a mass-like lesion following a long-term facial massage intervention. A facelift incision was performed. Platysma muscle rupture was observed intraoperatively, which was then repaired. To our knowledge, this is the first report of a vigorous facial massage-induced ipsilateral platysma rupture.

• Fisheries and Aquatic Sciences
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• v.23 no.3
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• pp.6.1-6.9
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• 2020

Background: Halophyte plant (HPs), a salt-resistant flora, has been reported to provide several health benefits, but the knowledge of its cosmeceutical potential is still ambiguous. Here, 70% ethanol extracts of 22 HPs collected from along the coast of South Korea were investigated for their potentials of antioxidant, anti-aging, and whitening properties for use as materials in novel cosmeceuticals. Methods: Antioxidant activities were determined by DPPH (1,1-diphenyl-2-pricrylhydrazyl) free radical and hydrogen peroxide scavenging assays, and skin aging-related enzyme activities (anti-elastase, anti-collagenase, anti-hyaluronidase, and anti-tyrosinase) were evaluated by using the spectrophotometric method. Results: Among the 22 HPs, we found that Ischaemum antephoroides f. coreana and Atriplex gmelinii extracts presented the strongest scavenging effects against DPPH free radical and hydrogen peroxide, respectively. Our finding additionally suggested that Salicornia europaea extract might provide a major source of anti-elastase and anti-hyaluronidase; meanwhile, Rosa rugosa extract showed the highest anti-collagenase effect. Furthermore, the highest tyrosinase inhibitory activity was possessed by Spartina anglica extract. Conclusion: These findings may suggest that halophyte plants showing biological activities may be potent inhibitors of tyrosinase, elastase, collagenase, and hyaluronidase and could be useful for application in cosmeceuticals.

• Steel and Composite Structures
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• v.24 no.2
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• pp.213-226
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• 2017

The behavior of building industry metal sheeting under shear forces has been extensively studied and equations have been developed to predict its shear stiffness. Building design engineers can make use of these equations to design a metal deck form bracing system. Bridge metal deck forms differ from building industry forms by both shape and connection detail. These two factors have implications for using these equations to predict the shear stiffness of deck form systems used in the bridge industry. The conventional eccentric connection of bridge metal deck forms reduces their shear stiffness dramatically. However, recent studies have shown that a simple modification to the connection detail can significantly increase the shear stiffness of bridge metal deck form panels. To the best of the author's knowledge currently there is not a design aid that can be used by bridge engineers to estimate the stiffness of bridge metal deck forms. Therefore, bridge engineers rely on previous test results to predict the stiffness of bridge metal deck forms in bracing applications. In an effort to provide a design aid for bridge design engineers to rely on bridge metal deck forms as a bracing source during construction, cantilever shear frame test results of bridge metal deck forms with and without edge stiffened panels have been compared with the SDI Diaphragm Design Manual and ECCS Diaphragm Stressed Skin Design Manual stiffness expressions used for building industry deck forms. The bridge metal deck form systems utilized in the tests consisted of sheets with thicknesses of 0.75 mm to 1.90 mm, heights of 50 mm to 75 mm and lengths of up to 2.7 m; which are representative of bridge metal deck forms frequently employed in steel bridge constructions. The results indicate that expressions provided in these manuals to predict the shear stiffness of building metal deck form panels can be used to estimate the shear stiffness of bridge metal deck form bracing systems with certain limitations. The SDI Diaphragm Design Manual expressions result in reasonable estimates for sheet thicknesses of 0.75 mm, 0.91 mm, and 1.21 mm and underestimate the shear stiffness of 1.52 and 1.90 mm thick bridge metal deck forms. Whereas, the ECCS Diaphragm Stressed Skin Design Manual expressions significantly underestimate the shear stiffness of bridge metal deck form systems for above mentioned deck thicknesses.

• The Journal of Korean Medical History
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• v.30 no.2
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• pp.63-71
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• 2017

Traditional Asian medicine has an extensive evidence base built upon thousands of years of experience within Asia, of curing various diseases. Only recently, within the past two centuries, have modern medical scientists developed interest in traditional Asian medicine. Asian Medicine seems to be regarded only as an adjunctive medicine and viewed as alargely un-proven alternative medicine to complement western medicine, used in some cases to establish a new paradigm of "integrative medicine". This article reviews how Korean herbal cosmetics emerged by applying traditional Asian medicine to the science of cosmetics. The characteristics of Korean herbal cosmetics are examined through examples of history, concepts and traditions. With the advancements in biotechnology, studies are now being conducted on the dermatological effects and processing methods of herbal ingredients, including ginseng. The authors explain the current research on the identification on the active ingredients of herbs, extraction methods, and bio-processing of ingredients to improve the biological efficacies of herbs on the skin. A summary of studies focused on modern reinterpretations of ageing theories, such as 'Seven year aging cycle', are provided. In conclusion, the development of Korean cosmetics products are based on the accumulated knowledge of thousands of years of experience including; 1) practical heritage of traditional Asian medicines such as Donguibogam; 2) excellent medicinal plants, such as ginseng, which are native to Korea; and 3) innovative attempts to modernize materials, processes, and principles.