• 한국전문물리치료학회지
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• 제2권1호
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• pp.14-20
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• 1995

The purpose of this study was to measure and compare the skin temperature over the exercised muscle and corresponding non-exercised muscle after unilateral isokinetic exercise using digital thermography. Thirty-two young healthy volunteers with no history of knee injury were tested. After isokinetic exercise at 60 degree per second angular velocity using the right leg in a climatic chamber at ambient temperature of $23-26^{\circ}C$, skin temperature of the anterior thigh was tested. After exercise, the skin temperature of both the right and left leg had fallen significantly. The skin temperature of the exercised leg fell less than that of the non-exercised leg. The fall in skin temperature after work was not due to increased evaporative cooling, but was the result of segmental vasoconstriction probably caused reflexly in the spinal cord by non-thermal afferents from exercising muscle or moving tissues. The effect of thermoregulatory vasodilation was reduced by reflex vasoconstriction caused by non-thermal factors such as catecholamine.

• Journal of Trauma and Injury
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• 제37권1호
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• pp.86-88
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• 2024

Misinterpreting radiographic findings can lead to unnecessary interventions and potential patient harm. The urgency required when responding to the compromised health of trauma patients can increase the likelihood of misinterpreting chest x-rays in critical situations. We present the case report of a trauma patient whose skin fold artifacts were mistaken for pneumothorax on a follow-up chest x-ray, resulting in unnecessary chest tube insertion. We hope to help others differentiate between skin folds and pneumothorax on the chest x-rays of trauma patients by considering factors such as location, shape, sharpness, and vascular markings.

• Archives of Reconstructive Microsurgery
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• 제21권1호
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• pp.61-67
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• 2012

Purpose: The purpose of this study was to investigate the role of mast cells and their product, histamine and leukotriene in ischemia-reperfusion injury. Methods: Forty Sprague-Dawley rats were divided into four groups. (Group I: Control group without ischemia, Group II: Normal saline with ischemia, Group III: Cimetidine with ischemia, Group IV: Zafirlukast with ischemia) Skin flap was elevated and ischemic insult was given by clamping the artery for 12 hours. Before reperfusion, the rats were treated with saline, cimetidine and zafirlukast. Flap survival was evaluated at 7 days. Neutrophil counts, mast cell counts were evaluated 24 hours after reperfusion. Results: Flap survival rate in the control group was 92.33%, whereas normal saline group had 37.34% survivals. Cimetidine and zafirlukast treated group showed significantly higher survival rates than normal saline group. The neutrophil and mast cell counts in cimetidine and zafirlukast treated group were significantly decreased than normal saline group. Cimetidine treated group showed higher survival rate and lower cell counts than zafirlukast treated group. Conclusion: The administration of cimetidine and zafirlukast can decrease neutrophils and mast cells caused by ischemia-reperfusion and increase flap survivals. It is suggests that antihistamine and leukotriene receptor antagonist have protective effect against ischemia-reperfusion injury to skin flap in rat.

• The Korean Journal of Pain
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• 제21권3호
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• pp.187-196
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• 2008

Background: Upregulation of one type of the pro-inflammatory chemokine (CCL2) and its receptor (CCR2) following peripheral nerve injury contributes to the induction of neuropathic pain. Here, we examined whether another type of chemokine (CCL3) is involved in neuropathic pain. Methods: We measured changes in mechanical and thermal sensitivity in the hind paws of naïve rats or rats with an L5 spinal nerve ligation (SNL) after intra-plantar injection of CCL3 or met-RANTES, an antagonist of the CCL3 receptor, CCR1. We also measured CCL3 levels in the sciatic nerve and the hind paw skin as well as CCR1 expression in dorsal root ganglion (DRG) cells from the lumbar spinal segments. Results: Intra-plantar injection of CCL3 into the hind paw of naive rats mimicked L5 SNL-produced hyperalgesia. Intra-plantar injection of met-RANTES into the hind paw of rats with L5 SNL attenuated hyperalgesia. L5 SNL increased CCL3 levels in the sciatic nerve and the hind paw skin on the affected side. The number of CCR1-positive DRG cells in the lumbar segments was not changed following L5 SNL. Conclusions: Partial peripheral nerve injury increases local CCL3 levels along the degenerating axons during Wallerian degeneration. This CCL3 binds to its receptor, CCR1, located on adjacent uninjured afferents, presumably nociceptors, to induce hyperalgesia in the neuropathic pain state.

• 대한한의학회지
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• 제26권3호
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• pp.13-26
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• 2005

Objectives : Applying herbal-acupuncture using Ursi Fet into Zusanli (UZ) on to the atopic dermatitis (AD) in mice to study changes in external dermal formation, change of leukocytes in vasculature, change of lipid formation in stratum corneum and distribution of ceramide. This study was done through forcing an injury to the mice's back skin which damages the lipid protection formation in the stratum corneum. Methods : The AD which was caused intentionally using the external application on the mice's back skin was treated with VB; the change of leukocytes in the vasculature was identified through optima 5.2 and Student's t-test and the results were made into a dermal formation graph. Results : After dispensing UZ into the AD, the dermal injury decreased. The recovery of the lipid protection formation which includes lipid and ceramide in the stratum comeum (for suppressing acute inflammation due to factors such as PKC, $TNF-\alpha,\;IL-1\beta$, which controlled the secretion of the relating inflammatory cytokine) also went on to show a decrease of both angiogenesis and degranulated mast cells. In addition, the decrease of epithelial injury also caused the growth of cells to decrease in the stratum basale and cytoclasis. In the vasculature, the leukocytes were also decreased na this could relate to a decrease in AD. Conclusions : UZ has an effect on AD by suppressing dermal injury through the recovery of the lipid protection formation in the stratum corneum.

• BMB Reports
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• 제43권1호
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• pp.46-51
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• 2010

Thermal burn injury induces inflammatory cell infiltrates in the dermis and thickening of the epidermis. Following a burn injury, various mediators, including reactive oxygen species (ROS), are produced in macrophages and neutrophils, exposing all tissues to oxidative injury. The anti-oxidant activities of flavonoids have been widely exploited to scavenge ROS. In this study, we observed that several flavonoids-kaempferol, quercetin, fisetin, and chrysin-inhibit LPS-induced IL-8 promoter activation in RAW 264.7 cells. In contrast with quercetin and fisetin, pretreatment of kaempferol and chrysin did not decrease cell viability. Inflammatory cell infiltrates in the dermis and thickening of the epidermis induced by burn injuries in mice was relieved by kaempferol treatment. However, the injury was worsened by fisetin, quercetin, and chrysin. Expression of TNF-a induced by burn injuries was decreased by kaempferol. These findings suggest the potential use of kaempferol as a therapeutic in thermal burn-induced skin injuries.

• 대한한의학회지
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• 제25권3호
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• pp.137-148
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• 2004

Objectives : To study change of external dermal formation, change of leukocytes in vasculature, change of lipid formation in stratum corneum and distribution of ceramide through administering Sihocheonggan-san (SC) extract on to the control (CON). This study was done through forcing injury to mice's back skin which have lipid protection formation in stratum corneum. Materials and Methods : The CON to which damage was caused intentionally using the external application on the mice's back skin used the SC. The change of leukocytes in vasculature were identified through optima 5.2 and Student's t-test and the results were made into a dermal formation graph. Results : After dispensing SC extract into the CON, dermal injury was decreased. Especially, recover of lipid protection formation, which includes lipid and ceramide in stratum corneum suppressing acute inflammation that some factors are PKC, TNF-α, IL-12B which controlled the secretion of relating inflammatory cytokine, also went onto decrease of angiogenesis, and a decrease of degranulated mast cells was noted. In addition, the decrease of epithelial injury also caused the growth of cells to decrease in stratum basale and cytoclasis. In the vasculature, the leukocytes were also decreased and it could relate to decrease in CON. Conclusions : SC has effect on CON suppressing the dermal injury through recovering of lipid protection formation in stratum corneum.

• 재활간호학회지
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• 제2권1호
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• pp.22-28
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• 1999

The development of standards and guidelines of rehabilitation nursing has been the major concerns for providing better nursing to the rehabilitation clients. As the patients with stroke and spinal cord injuries are the most prevalent physical disabilities in Korea, this study focussed on the nursing diagnoses of these two groups of patients. In order to identify the nursing diagnoses frequently used In their practice for the patients with stroke and spinal cord injuries, a survey was done with the questionnaire form developed by the research team. The surveyee were the staff nurses working at rehabilitation wards more than 2 years from 8 general hospitals in Korea, They identified and set the priorities of 13 nursing diagnoses from 79 stroke patients and 10 nursing diagnoses from 35 patients with spinal cord injuries during the periods from March 1 to June 2, 1999. The identified nursing diagnoses for the stroke patients are impaired physical immobility, sensory-perceptual alteration, activity intolerance, self-care deficit, altered defecation, altered urination, risk for injury, unilateral neglect, impaired skin integrity, altered thought processes, pain, altered health maintenance, dysreflexia. The identified nursing diagnoses for spinal cord injuries are altered urination, altered defecation, impaired skin integrity, pain, risk for injury, reflex incontinence, impaired physical immobility, self-care deficit, activity intolerance, knowledge deficit.

• Archives of Reconstructive Microsurgery
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• 제11권2호
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• pp.153-161
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• 2002

Purpose : Plantar surfaces, calcaneal area, and region of Achilles insertion, which are extremely related with weight-bearing area and shoes application, must be reconstructed with glabrous and strong fibrous skin. Numerous methods of reconstructing defects of these regions have been advocated, but the transfer of similar local tissue as a cutaneous flap with preservation of sensory potential would best serve the functional needs of the weight-bearing and non-weight-bearing surfaces of this region. Therefore it is recommended to use the limited skin of medial surface of foot that is similar to plantar region and non-weight-bearing area. In this paper we performed the medial plantar flap transfered as a fasciocutaneous island as one alterative for moderate-sized defects of the plantar forefoot, plantar heel, and area around the ankle in 25 cases and report the result, availability and problem of medial plantar flap. Materials and methods : We performed proximally based medial plantar flap in 22 cases and reverse flow island flap in 3 cases. Average age was $36.5(4{\sim}70)$ years and female was 3 cases. The causes of soft tissue defect were crushing injury on foot 4 cases, small bony exposure at lower leg 1 case, posterior heel defect with exposure of calcaneus 8 cases, severe sore at heel 2 cases, skin necrosis after trauma on posterior foot 4 cases, and defect on insertion area of Achilles tendon 6cases. Average follow up duration was 1.8(7 months-9.5 years) years. Results: Medial plantar flaps was successful in 22 patients. 18 patients preserved cutaneous branches of medial plantar nerve had sensation on transfered flap but diminished sensation or dysesthesia. At the follow up, we found there were no skin ulceration, recurrence of defect or skin breakdown in all 18 patients. But there was one case which occurred skin ulceration postoperatively among another 4 cases not contained medial plantar nerve. At the last follow up, all patients complained diminished sensation and paresthesia at medial plantar area distally to donor site, expecially with 4 patients having severe pain and discomfort during long-time walking. Conclusion : Medial plantar island flap based on medial plantar neurovascualr pedicle have low failure rate with strong fibrous skin and preserve sensibility of flap, so that it is useful method to reconstruct the skin and soft tissue defect of foot. But it should be emphasized that there are some complications such like pain and paresthesia by neuropraxia or injury of medial plantar nerve at more distal area than donor site. We may consider that medial plantar flap have limited flap size and small arc of rotation, and require skin graft closure of the donor defect and must chose this flap deliberately.

• 한국잠사곤충학회지
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• 제46권2호
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• pp.72-76
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• 2004

가잠과 천잠 및 작잠의 실크 단백질 분획물로부터 피부섬유아세포에 대한 증식 효과를 알아본 결과 다음과 같은 결과를 얻을 수 있었다. 1. 가잠 및 천${\cdot}$작잠 단백질로부터 다양한 분자량대의 실크 단백질을 순수 분리 분획화 하여 사람 피부세포(human skin fibroblast; CCD-986sk)에 기계적 상처를 준 후 처리한 결과, 평균분자량(Mw)이 300-500 및 950-1500 분획군이 세포 증식에 뛰어난 효과가 있음을 확인${\cdot}$선발하였다. 2. 가잠의 경우 평균 분자량 590(BM-1), 1400(BM-2)에서, 천잠은 340(AY-1), 940(AY-2), 작잠에서는 300(AP-1), 1440(AP-2)에서 $10\;{\mu}g/ml$의 농도로 처리했을 경우 피부섬유 아세포의 증식이 무처리구에 비하여 40% 이상의 증식 효과를 갖았다. 또한 유효 농도 범위에서 대식세포인 RAW 264.7 세포에 대해서는 세포독성을 지니지 않았다. 3. 아미노산 조성에 있어 저분자량 AY-1 분획의 전아미노산 및 유리아미노산은 Tyr 함량이 매우 높게(25-48 g/100g)나타났으며, 작잠의 저분자 분획인 AP-1에서는 Lys 함량이 높게(5.2 g/100g) 나타남을 확인하였다. 4. 동일한 실크 단백질일 경우 저분자량 분획물에서 피부 세포 증식에 좀 더 효과적이였다.