• Journal of Veterinary Clinics
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• v.25 no.6
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• pp.466-470
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• 2008

The purpose of this study is to investigate whether the effects of topically applied petrolatum and glycerin on the barrier repair of acetone-induced skin damage in 6 beagle dogs. To confirm the effects of petrolatum and glycerin on acetone disrupted skin models, we performed to evaluate the characteristics of transepidermal water loss and SC hydration and scanning electron microscopic observations. TEWL and SC hydration measurements were carried out 3, 6, 12, 24, 48h after applying petrolatum and glycerin during recovery from acute disruption. Our results showed that there were some different effects between petrolatum and glycerin on the acetone damaged skin such as barrier function repair process and SC hydration status. The results indicate that the significant improvement could be observed in glycerin apply more than petrolatum after acetone damages, and further study will be required.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.11 no.9
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• pp.3375-3379
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• 2010

Objective: The purpose of this study was to investigate the characteristics of facial skin parameters (hydration, lipid and pH) on forehead and cheek according to Ayurvedic constitution classification of Vata, Pitta and Kapha. The condition of hydration, lipid and pH in the facial skin was measured using non-invasive diagnostic technique. The collected data was analyzed with the SPSS 16.0 windows statistical program. Design: Eighty-nine Korean female subjects were recruited for this study and the average age of them was $19.9{\pm}0.84$ years. Three groups by the Ayurvedic constitution were classified by questionnaire. Results: There was a significant difference in hydration, lipid and pH according to Ayurvedic constitution. The measurement of hydration on the face depending on the constitution were shown in the order of Pitta, Kapha and Vata (p<0.001). The measurement of lipid on the face depending on the constitution were shown in the order of Kapha, Pitta and Vata (p<0.001, p<0.01). The measurement of pH on the face depending on the constitution were shown in the order of Kapha, Pitta and Vata (p<0.01). Conclusion: Facial skin surface seemed to be dependent on Ayurvedic constitution classification in Korean. These findings indicated that Ayurvedic constitution classification might be a useful esthetic treatment for caring facial skin in the future.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.42 no.4
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• pp.343-349
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• 2016

Many minerals and nutrient salts are abundant in Jeju lava sea water. The objective of this study was to evaluate the skin hydration effects of Jeju lava sea water. The skin barrier serves as a protective barrier that prevents the loss of moisture. The water holding capacity and water transport of the epidermis have been proposed to be important determinants of skin hydration. Jeju lava sea water increased the mRNA expression of filaggrin and caspase-14 which is related to natural moisturizing factor (NMF) formation. Aquaporins 3 (AQP3) are proteins that facilitate the transport of water across cell membranes. Jeju lava sea water increased the mRNA expression and protein expression of AQP3. We employed a skin equivalent model to assess the efficacy of Jeju lava sea water. In a skin equivalent model, Jeju lava sea water increased the CD44 (hyaluronic acid receptor) which is related to skin hydration. From these results, we found out Jeju lava sea water maybe help to skin hydration.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.32 no.2
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• pp.24-58
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• 2019

Objectives : The purpose of this study is to confirm the Efficacy and Safety of "Functional cosmetics containing Humulus japonicus Extract" on dry skin due to mild atopic dermatitis. Methods : A total of 48 patients who visited Semyung Oriental Medical Center from March 20th, 2018 to July 5th, 2018 were included in the study. In this study, the patients were treated with Functional cosmetics containing Humulus japonicus Extract and positive control group. For 6 weeks of gross examination, instrumental assessment were made before and after the study to evaluate how well the products for treatment group with positive control products for control group in recovering the dry skin barriers by mild atopic dermatitis. Results : 1. In the primary endpoint, Skin Hydration showed a statistically significant increase and Transepidermal Water Loss(TEWL) showed a statistically significant decrease in treatment group between Baseline and 6 weeks. 2. In the secondary endpoint, Skin Hydration showed a statistically significant increase in treatment group between Baseline and 3 weeks, but TEWL showed no statistical significance. 3. In the secondary endpoint, Skin Hydration showed a statistically significant increase in treatment group between 3 weeks and 6 weeks, but TEWL showed no statistical significance. 4. In the secondary endpoint, Change of Skin Hydration and TEWL between treatment and control group showed a statistical significance in 6 weeks. 5. In the secondary endpoint, Change of Skin Hydration of 1cm below the medial aspect of the elbow between treatment and control group showed a statistical significance in 3 weeks. 6. In the secondary endpoint, Change of Skin Hydration between treatment and control group showed a statistical significance in 3 weeks and 6 weeks except Center between the medial aspect of the elbow and the wrist in 3 weeks, and Change of TEWL between treatment and control group showed a statistical significance in 6 weeks. 7. To evaluate the safety of the products for the human body, Adverse events, EASI Score, Itching Symptoms Assessment, vital sign check were conducted; There were no severe adverse events during this study. And both experimental group and control group showed no abnormal level. Therefore, it is suggested that products, if used for certain period, should be safe for the human body. Conclusions : According to the above experiments, it is suggested that "Functional cosmetics containing Humulus japonicus Extract" should be effective for dry skin due to mild atopic dermatitis.

• Journal of the Korean Magnetic Resonance Society
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• v.10 no.1
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• pp.105-114
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• 2006

Purpose: We achieved high resolution MR imaging and spectra of human skin in vitro with using a 14.1 T MRI/MRS system, and evaluated the hydration effect of various cosmetic products by measuring the skin's. moisture concentration. Materials and Methods: We used the Bruker 14.1 T MRI/MRS system with a vertical standard bore that was equipped with a DMX spectrometer gradient system (200 G/cm at a maximum 40 A), RF resonators (2, 5 and 10 mm) and Para Vision software. Spin echo and fast spin echo pulse sequences were employed for obtaining the high resolution MR images. The 3D-localized point resolved spectroscopy (PRESS) method was used to acquire the MR spectra. Results: The high resolution MR images and spectra of human skin in vitro were successfully obtained on a 14.1 T system. The water concentration of human skin after applying a moisturizer was higher than that before applying a moisturizer. Conclusions: The present study demonstrated that the high-resolution MR images and spectra of human skin from a high field NMR instrument could be applicable to evaluating the hydration state of the stratum corneum.

• Proceedings of the SCSK Conference
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• 2003.09b
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• pp.424-437
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• 2003

This study was observed the variations in skin color, hydration, sebum content according to age groups at the forehead, both cheeks, and chin in 154 healthy Korean women subjects with aged 30 to 59. We selected four face sites (forehead, right cheek, left cheek, and chin) and measured with chromameter, corneometer, and sebumeter. All statistical analysis was performed on the computer software package SPSS 8.0. There was no significant difference of lightness between facial four regions in age groups but lightness showed to tend to age-related decrease on each regions. Redness and yellowness showed the highest values on chin and forehead respectively but there was no tendency to steady changes according to age variation. Both cheeks showed the highest hydration level and the lowest sebum content compared with forehead and chin in all age groups and there was tendency to age-related changes of sebum content on both cheeks. So we concluded there was decreasing tendency in lightness and sebum content according to the increase of age and there was no age-related change of skin hydration level at least in facial skin.(omitted)

• Journal of the Society of Cosmetic Scientists of Korea
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• v.23 no.3
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• pp.39-47
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• 1997

Retinol as well as RA is well known to have many beneficial effects on aged skin. But the skin irritation potential and unstable condition of the products containing them have been some problems in their cosmetic uses. So, retinol containing gel product was developed for less skin irritancy and more stability in cosmetic products. To examine the clinical effects of retinlo containing product, we used cilnicla non-invasive assessment techniques on 40 volunteers for 6 months maintaining double-blind test conditions. According to our results, the use of retinol containing product improved skin color and hydration level slightly. But there was no statistical differences. There was no erythema reaction compared to the use of RA. Especially, the skin elasticity increased above 20% and skin wrinkles of crows' feet region decreased more than 10%. Besides the instrumental analysis, a large majority of volnteers felt that their skin were improved in the case of wrunkles, elasticity, hydration and color.

• Proceedings of the KAIS Fall Conference
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• 2010.11b
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• pp.878-881
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• 2010

For better diagnosis and prescription in Korean traditional medicine, Lee Je-Ma (1837-1900) created Sasang Constitution classification which was divided into four groups of Taeyangin, Soyangin, Taeumin and Soumin based on both body shape and natural disposition. The purpose of this study was to investigate the characteristics of facial skin parameters (hydration, lipid and pH) on forehead and cheek according to Sasang Constitution classifications of Taeumin, Soyangin and Soumin in Korean. Eighty-nine Korean female subjects were recruited for this study and the average age of them was 19.9${\pm}$0.84 years. The four groups by the Sasang Constitution were classified by questionnaire for the Sasang Constitution classification proposed by Kyung-Hee Oriental Medicine Hospital. Consequently, thirty-eight (42.7%) among the subjects were grouped into Soumin, twenty-nine (32.6%) into Taeumin, twenty (22.5%) into Soyangin and two (2%) into Taeyangin. Taeyangin group was excluded from statistical analysis due to small subjects. Hydration, lipid and pH parameters on forehead and cheek were measured by using non-invasive instruments of Corneometer (CM 825, Schwarzhaup, Germany), Sebumeter (SM 815, Schwarzhaup, Germany) and Skin-pH-meter (pH 905, Schwarzhaup, Germany), respectively. The measurements by the same investigator were performed under standardized condition with a room temperature of $21^{\circ}C$ and a humidity level of 40% to 50%. As a result, hydration (F=25.481, p=.000), lipid (F=5.753, p=.005) and pH (F=5.010, p=.009) of the forehead skin showed significant differences in the order of Taeumin, Soyangin and Soumin. Hydration (F=23.216, p=.000), lipid (F=6.898 p=.002) and pH (F=5.070, p=.008) of the cheek skin showed significant differences in the order of Taeumin, Soyangin and Soumin. In conclusion, facial skin surface seemed to be dependent on Sasang Constitution classification in Korean. These findings indicated that Sasang Constitution classification might be an useful esthetic treatment for caring facial skin in the future.

• Journal of the Korean Applied Science and Technology
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• v.27 no.2
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• pp.175-182
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• 2010

Various research on the surface of the skin and the relationship between epidermis and composition of ion have been performed. Traditionally, bamboo extract was used as an important material for enhancing healthy condition of a skin. Bamboo salt is well known as one of the most famous traditional medical treatments. In this study, we investigated the stability of P/S (Polyol-in-Silicone) emulsions containing a fair amount of bamboo salt in the range of 0.5~5.0 wt%. For improving the stability of emulsions, we varied the quantity of fatty alcohol and wax ester in emulsions and the stability was checked using DSC (Differential Scanning Calorimeter). We also studied the efficacy of treating the P/S emulsions containing bamboo salt. From the experiment, the emulsions show the mitigation of stimuli, enhancing the skin hydration and improving the appearance of the skin.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.21 no.2
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• pp.126-141
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• 2008

Objective : This clinical research was conducted to test patients with Atopic Dermatitis by external application with Yeongyuseungmatang in cosmetics. Methods : We gave scores to 33 patients who visited the Dept. of Oriental Medical Opthalmology & Otolaryngology & Dermatology of Semyung Jecheon Oriental Medical Hospital from April 17th, 2008 to June 12th. Seventeen patients were treated with Yeongyuseungmatang(Experimental group) and sixteen patients were treated with Atopico skin care cream(Control group) for 4weeks. We observed change of total IgE, eosinophil count, Skin Temperature, Transepidermal Water Loss(TEWL), Skin Hydration and Skin pH. Also Clinic Index of Atopic Dermatitis(SCORAD Index) and global assesment of efficacy were used to evaluate the effects of Yeongyuseungmatang. Statistical analysis was performed by using frequency analysis and descriptive analysis. Statistical significance was achieved if the probability was less than 5%(p<0.05). Results : 1. After 4 weeks of external application treatment, SCORAD Index in Yeongyuseungmatang was significant statistically decreased compared with control group. 2. After 4 weeks of external application treatment, eosinophil count in Yeongyuseungmatang was significant statistically decreased compared with control group but total IgE was very increased both Yeongyuseungmatang and control group. 3. Statistically, Yeongyuseungmatang and control group didn't showed significant effect on Skin Temperature was measured by Thermometer SM815. 4. Transepidermal Water Loss(TEWL) in Yeongyuseungmatang was significant statistically decreased compared with control group measured by Tewameter TM300. 5. Skin Hydration in Yeongyuseungmatang was significant statistically increased compared with control group measured by Corneometer CM825. 6. Statistically, Yeongyuseungmatang and control group didn't showed significant effect on Skin pH was measured by Skin-pH-Meter PH905. 7. After 4 weeks of external application treatment, Yeongyuseungmatang showed significant effect on global assesment of efficacy. Conclusion : Considering the above results, we can speculate that cosmetics with Yeongyuseungmatang has some therapeutical effects in mitigating the symptoms of atopic dermatitis.