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http://dx.doi.org/10.6114/jkood.2019.32.2.024

A Clinical Study for the Efficacy and Safety of Functional Cosmetics Containing Humulus japonicus Extract in Patients with Dry Skin due to Mild Atopic Dermatitis  

Park, Hye-Su (Dept. of Korean Medical Ophthalmology & Otolaryngology & Dermatology, College of Korean Medicine, Semyung University)
Kim, Yong-Min (Dept. of Cosmetic Science & Beauty Biotechnology, Semyung University)
Kim, Hee-Tack (Dept. of Korean Medical Ophthalmology & Otolaryngology & Dermatology, College of Korean Medicine, Semyung University)
Publication Information
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology / v.32, no.2, 2019 , pp. 24-58 More about this Journal
Abstract
Objectives : The purpose of this study is to confirm the Efficacy and Safety of "Functional cosmetics containing Humulus japonicus Extract" on dry skin due to mild atopic dermatitis. Methods : A total of 48 patients who visited Semyung Oriental Medical Center from March 20th, 2018 to July 5th, 2018 were included in the study. In this study, the patients were treated with Functional cosmetics containing Humulus japonicus Extract and positive control group. For 6 weeks of gross examination, instrumental assessment were made before and after the study to evaluate how well the products for treatment group with positive control products for control group in recovering the dry skin barriers by mild atopic dermatitis. Results : 1. In the primary endpoint, Skin Hydration showed a statistically significant increase and Transepidermal Water Loss(TEWL) showed a statistically significant decrease in treatment group between Baseline and 6 weeks. 2. In the secondary endpoint, Skin Hydration showed a statistically significant increase in treatment group between Baseline and 3 weeks, but TEWL showed no statistical significance. 3. In the secondary endpoint, Skin Hydration showed a statistically significant increase in treatment group between 3 weeks and 6 weeks, but TEWL showed no statistical significance. 4. In the secondary endpoint, Change of Skin Hydration and TEWL between treatment and control group showed a statistical significance in 6 weeks. 5. In the secondary endpoint, Change of Skin Hydration of 1cm below the medial aspect of the elbow between treatment and control group showed a statistical significance in 3 weeks. 6. In the secondary endpoint, Change of Skin Hydration between treatment and control group showed a statistical significance in 3 weeks and 6 weeks except Center between the medial aspect of the elbow and the wrist in 3 weeks, and Change of TEWL between treatment and control group showed a statistical significance in 6 weeks. 7. To evaluate the safety of the products for the human body, Adverse events, EASI Score, Itching Symptoms Assessment, vital sign check were conducted; There were no severe adverse events during this study. And both experimental group and control group showed no abnormal level. Therefore, it is suggested that products, if used for certain period, should be safe for the human body. Conclusions : According to the above experiments, it is suggested that "Functional cosmetics containing Humulus japonicus Extract" should be effective for dry skin due to mild atopic dermatitis.
Keywords
Atopic dermatitis; Humulus japonicus; Functional Cosmetics; Moisturizing; TEWL;
Citations & Related Records
Times Cited By KSCI : 4  (Citation Analysis)
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1 Kim JC, Hong SU. The Effects of Ionized Maifanite on Skin Damages of Nc/Nga Mice after Atopic Dermatitis Elicitation. J Korean Med Ophthalmol Otolaryngol Dermatol. 2007;30(1):29-42.   DOI
2 Jung HJ, Hwang-Bo M, Do EJ, Suk JM, Kim MR, Kim YH, et al. A Clinical Research about Herbal Cosmetics Containing Phellinus linteus Extracts in Atopic Dermatitis Patients. J Korean Med Ophthalmol Otolaryngol Dermatol. 2010;23(3):154-64.
3 Hwang SY, Jo MJ, Kim SC, Jee SY. Anti-inflammatory effects of the MeOH extract of Humulus japonicus in vivo. J Korean Med Ophthalmol Otolaryngol Dermatol. 2009;22(2):92-103.
4 Sin MK. Clinical Traditional Herbalogy. Seoul:Younglimsa. 1997:449-50.
5 Hur JY, Jeong CH, Shim KH. Chemical Components of Humulus japonicus Leaves and Stalks. J. Agriculture & Life Sciences. 2003;37(1):1-7.
6 Lim DB, Lee YJ. The Effect of Humulus japonicus on Analgesia, Anti-inflammation, and Urination. J. of Herbology. 1993;8(1):69-75.
7 Lee HS. Preventive effect and mechanism of Humulus japonicus extract on obesity. Major in Pharmacology. The Graduate School of Chung-Ang University. 2017.
8 Hong SM. Beneficial effect of Humulus japonicus extract on hyperlipidemia and fatty liver induced by high fat diet obesity. Major in Pharmacology, Department of Medicine. The Graduate school of Chung-Ang University. 2014.
9 Hwang SY. Anti-inflammaory effects of the MeOH extract of Humulus japonicus in vivo and in vitro. Department of Oriental Medicine. Graduate school of Daegu Haany University, Daegu, Korea. 2008.
10 Park SW, Chung SK, Park JC. Active Oxygen Scavenging Activity of Luteolin-7-O-${\beta}$-D-Glucoside Isolated from Humulus japonicus. J. Korean. Soc. Food. Sci, Nutr. 2000;29(1):106-10.
11 KDA Textbook Editing Board. Textbook of Dermatology. 6th edition. Seoul:medbook. 2014:202-13.
12 Lee SH. The Protective Effect of Humulus japonicus Extracts on Ethanol-Induced Chronic Hepatotoxicity in Rats. Major in Health, Social & Clinical Pharmacy Dept. of Pharmacology. The Graduate school Chung-Ang University. 2017.
13 Moon SH. Studies of the effects of Humuli Herba on rats with nephritis induced by LPS. Dept. of Oriental medicine. Graduate School of Kyungwon University. 2008.
14 Lee JH, Lee KC, Ha DH, Son IH, Lee WB, Oh YK, et al. Effect of Herba Humuli on the Cardiotoxicity Mediated by Methotrexate in Clutured Myocardial cells. Korean J. Oriental Medical Physiology & Pathology. 2001;15(4):585-9.
15 Hwang SY, Jung HJ, Jang WS, Jo MJ, Kim SC, Jee SY. Anti-inflammatory effects of the MeOH extract of Humulus japonicus in vitro. J Korean Med Ophthalmol Otolaryngol Dermatol. 2009;22(3):71-9.
16 Gong NM, Jee SY. A Literature study about comparison of Eastern-Western medicine on the Atopic dermatitis. J Korean Med Ophthalmol Otolaryngol Dermatol. 1999;12(1):241-53.
17 Heo J. A new Translation Donguibogam. Seoul:Bubin Publishers Co. 2005:769,3565.
18 Do HK. Myeonguibyeolrok. Bejing: Inminwisaeng Publishing, Inc. 1986:165.
19 Hong MS, Son ES, Lee SJ, Lee SK, Lee YJ, Song SD. Anti-mycobacterial Effects of the Extract of Humulus japonicus. Korean Journal of Food Science and Technology. 2014;46(1):94-9.   DOI
20 Lee YR, Kim KY, Lee SH, Kim MY, Park HJ, Jeong HS. Antioxidant and Antitumor Activities of Methanolic Extracts from Humulus japonicus. Korean Journal of Food and Nutririon. 2012;25(2):357-61.   DOI
21 Kim HJ. Refractory Atopic Dermatitis. 2016 KAAACI Annual Spring Congress: New Paradigms in Allergic Diseases. 2016:255-62.
22 Ahn SK, Jang KH, Kim TH, Jeong J, Cheon SH, Kang YC, et al. Common Skin Disease. 3rd ed. Seoul:Jeong Woo Medical Book. 2015:75-111.
23 Hatakka K, Piirainen L, Pohjavuori S, Poussa T, Savilahti E, Korpela R. Allergy in day care children: prevalence and environmental risk factors. Acta Paediatr. 2009;98(5):817-22.   DOI
24 De Bruin Weller MS, Knulst AC, Meijer Y, Bruijnzeel-Koomen CA, Pasmans SG. Evaluation of the child with atopic dermatitis. Clin Exp Allergy. 2012;42(3):352-62.   DOI
25 Maheswaran D, Zeng Y, Chan-Yeung M, Scott J, Osornio-Vargas A, Becker AB, et al. Exposure to Beta-(1,3)-D-glucan in house dust at age 7-10 is associated with airway hyperresponsiveness and atopic asthma by age 11-14. PLoS One. 2014;9(6):1-11.
26 Kang MS, Kim JB, Kim HT. A Clinical Study for the Effect of External Applications Containing Herbal Extracts on Mild Atopic Dermatitis Patients. J Korean Med Ophthalmol Otolaryngol Dermatol. 2014;27(3):40-55.   DOI
27 Kang MS, Kim YM, Kim HT. A Clinical Study for Moisturizing Effects of Herbal Cosmetics Containing Sinhyotakrisan Extracts. J Korean Med Ophthalmol Otolaryngol Dermatol. 2016;29(1):81-92.   DOI
28 Son KJ, Park JH, Kim YH, Go GY, Kim YJ, Han JY, et al. Anti-atopic Effect of Chamaecyparis Obtusa oil (CHO_O) in DNCB-induced atopic dermatitis-like skin lesions NC/Nga mice. J Korean Med Ophthalmol Otolaryngol Dermatol. 2016;29(1):33-46.   DOI
29 O MJ, Yoo YB, Lim SH, Kim HT. A Clinical study for the effect of ointment contained Takrisodok-Eum on recovering the damaged skin barrier by Atopic dermatitis. J Korean Med Ophthalmol Otolaryngol Dermatol. 2011;24(3):84-107.   DOI
30 Lee JW, Go GY, Jung CH, You SJ, Kim YH, Ahn TW. Effect of DOGO phreatic weter containing germanium on Atopic Dermatitis in NC/Nga mouse. J Korean Med Ophthalmol Otolaryngol Dermatol. 2014;27(4):141-57.   DOI