• Journal of Welding and Joining
• /
• 제33권5호
• /
• pp.26-30
• /
• 2015

Hastelloy X in this study was applied in jet engine F-15 air fighter as shroud to isolate the engine from outer skin. After 15 years operation at elevated temperature the mechanical properties decreased gradually due to the precipitation of continues second phases in the grain boundaries and precipitated inside the grain. The crack happened at the edge of the shroud due to the thermal and mechanical stress from jet engine. Selective TEM analysis found that the grain boundaries consist of $M_{23}C_6$ carbide, $M_6$ Ccarbide and small percentage of sigma(${\sigma}$) phase. Furthermore, it was confirmed the nano size of ${\sigma}$ and miu (${\mu}$) phase inside the grain. In this study, it was investigated the microstructure of the degraded shroud component and HAZ of repair welded shroud. In the HAZ, it was observed the dissolution of the $M_{23}C_6$ carbides and smaller precipitates, the migration of the undissolved larger $M_{23}C_6$ carbide and $M_6$ Ccarbide. It is also observed the liquation due to the simply melt of the segregated precipitates in the grain boundaries. Interestingly, the segregated second phases which simply melt in the grain boundaries more easily happened at higher heat input welding condition. High temperature tensile test was done at $300^{\circ}C$, $700^{\circ}C$ and $900^{\circ}C$. It was obtained that the toughness of welded sample is lower compare to the non-welded sample. The solution heat treatment at $1170^{\circ}C$ for 5 minutes was suggested to obtain a better mechanical properties of the shroud. The high cycle fatigue number of the repair welded shroud shows a much lower compare to the shroud. In addition, the high cycle fatigue number at room temperature after solution heat treatment was almost double compare to the before solution heat treatment under 420-500MPa stress amplitude. However, the high cycle fatigue number of repaired welded sample was shown a much lower compare to the non- welded shroud and solution treated shroud. One of the main reasons to decrease the tensile strength and the high cycle fatigue properties of the repair welded shroud is the formation of the liquid phase in HAZ.

• 대한수의학회지
• /
• 제47권3호
• /
• pp.291-298
• /
• 2007

Olive flounder, Paralichthys olivaceus is one of the most important cultured fish in Korea, its farming has been negatively impacted by viral, bacterial and parasitic diseases. Streptococcal infection was considered as a serious problem because of significant economic losses in olive flounder farm industry. The development and evaluation of vaccine for protection against infection by this agent were required. We evaluated the safety and efficacy of ${\beta}$-hemolytic Streptococcus (S.) iniae vaccine on olive flounder Three hundreds of flounders (weight $119.8{\pm}20.7g$, body length $22.6{\pm}1.4cm$) were reared in 0.5 tons aquaria in land-marine tank system. Seawater was provided from the sea of Inchon in Korea, and water temperature was set to $22^{\circ}C$ and $25^{\circ}C$ in the vaccination and challenge test, respectively. We used the formalin-inactivated ${\beta}$-hemolytic S. iniae (F2K) vaccine (M VAC INIAE; Kyoritsu seiyaku, Japan) originated in Japan. The vaccine was intraperitoneally administered to fish. Both of vaccinated group and control group were challenged with intraperitoneally injection by virulent S. iniae SI-36 isolates with $1.0{\times}10^7CFU/fish$ at 3 weeks after vaccination. Difference on mortality of control and vaccinated group (90.0 and 15.0%, 76.5 and 8.0% respectively) at two trials were found significant (p<0.05), and relative percent survival were 83.4% and 89.5%, respectively. The dead fishes were showed dark pigmentation of skin, abdominal extension, hemorrhagic ascites, and liver necrosis, and isolated the S. iniae strain from ascites, liver and kidney. We confirmed the safety and efficacy of ${\beta}$-hemolytic S. iniae vaccine by determinations of the optimal management condition and artificial challenge test in olive flounder.

• 대한예방한의학회지
• /
• 제17권2호
• /
• pp.29-46
• /
• 2013

A survey conducted on 1,103 patients or caretakers visited Korean medical clinics and hospitals between August 25, 2011 to September 30, 2011 by the Ministry of Health and Welfares and Korea Institute for Health and Social Affairs was analyzed and obtained following results: 1. For sociodemographic distribution, female(813) outnumbered male(290) patients with majority of patients ranging from 30s to 60s. Married patients(793) outnumbered unwed(150) patients and 65.0% with higher than high school education. Statistical significance was seen in gender, age, marital status, and education level but no significant difference for status of employment, income level, and types of insurance between the clinics and hospitals. (P<0.05). 45.1% had less than \2,000,000 in monthly salary and most of coverage was provided by either regional or work insurance. 2. 67.9% of the patients rated health conditions to be better than average and 32.1% listed as poor. People in good health showed tendency to visit Korean medical facilities. Musculo-skeletal conditions such as arthritis, ankle sprain, lumbago, muscular injury, and frozen shoulder were common conditions, followed by gastric disorders, common cold and herbal tonics. No significant difference was observed between the clinics and hospitals for above conditions, but significance was seen in atopic dermatitis, stroke, and sequela from traffic accidents (P<0.05). 3. Ten most common conditions addressed at Korean medical facilities were lumbago, arthritis, muscular injury, back sprain, gastric disorders, ankle sprain, common cold, herbal tonics, frozen shoulder and stroke. Major treatment modalities rendered were herbal medicine, herbal supplements, acupuncture and moxibustion, cupping, tuina, and Korean midical physical therapy. No significant difference existed between the clinics and hospitals. 4. All modalities showed at least 85% effectiveness. No statistical significant difference between the clinics and hospitals except for herbal decoction. (P=0.0452) 5. 88.3% of responses showed treatment satisfaction with significant difference between the clinics and hospitals (P=0.002). The occurrence of side effects was at 2%, mostly corning from treating digestive, skin, kidney disorders and neurological issues. No significant difference was observed between the clinics and hospitals. From the above results, the typical population visiting Korean medical facilities can be summarized as being middle aged female with relatively higher education and moderately low income. The health condition is generally good and the purpose of visit is to receive traditional treatments of acupuncture, herbal medicine, and physical therapy. Treatment efficacy and satisfaction were high with no significant differences between the clinics and hospitals.

• 원예과학기술지
• /
• 제28권4호
• /
• pp.585-592
• /
• 2010

복숭아 '장호원황도'에 있어 저장, 유통 중 품질 향상을 위한 1-MCP 처리 및 에틸렌제거제 처리효과를 검토하였다. 1-MCP를 $1.0{\mu}L{\cdot}L^{-1}$ 농도로 처리하였던 경우 8일간의 상온 유통 중 경도유지 및 착색지연에 효과적인 것으로 나타났는데 완숙과에 비하여 성숙과에서 1-MCP 처리 효과가 크게 나타났다. 그러나 1-MCP를 $0.5{\mu}L{\cdot}L^{-1}$ 농도로 처리하였던 경우에는 품질유지 효과가 나타나지 않았다. 1-MCP를 0.5 및 $1.0{\mu}L{\cdot}L^{-1}$로 처리하였던 경우 과실의 에틸렌 발생을 억제하였는데 호흡률 저하는 $1.0{\mu}L{\cdot}L^{-1}$ 처리구에서만 유의하게 나타났다. 저온저장 중 1-MCP 처리와 에틸렌제거 처리 효과를 비교한 결과, 처리 효과가 저장 5일 후까지만 1-MCP를 처리한 과실의 경도가 높게 유지되었고 에틸렌 제거제 처리의 경우 성숙과의 경우에만 단기적 경도 유지효과를 보여주었다. 저온저장 중 에틸렌제거를 실시하였던 경우 성숙과에서 저장 초기에 경도 감소를 지연하는 효과를 보였으나 완숙과에서는 효과가 떨어지는 것으로 조사되었다. 한편 1-MCP 처리 과실에 대한 박스 내 에틸렌제거제 복합처리는 과실의 경도유지효과를 나타내어 상온유통 5일 후 성숙과의 경우 1-MCP 처리구는 무처리구에 비하여 약 2배 경도가 높아 실용성이 있는 것으로 판단되었다.

• Journal of Pharmaceutical Investigation
• /
• 제27권4호
• /
• pp.303-311
• /
• 1997

Proliposomal patch of clenbuterol, ${\beta}_2-agonist$ bronchodilator, was prepared and its feasibility as a novel transdermal drug delivery system was examined. Proliposomal granules containing clenbuterol was prepared by a standard method using sorbitol and lecithin with (Rx 2) or without cholesterol (Rx 1). The porous structure of sorbitol in the proliposomes was maintained allowing tree flowability of the granules. Following contact with water, the granules were converted probably to liposomes almost completely within several minutes. It indicates that proliposomes may be hydrated, when they are applied on the skin under occlusive condition in vivo, by the sweat to form liposomes. Clenbuterol release from Rx 1 and Rx 2 proliposomes to pH 7.4 isotonic phospate buffer (PBS) across cellulose membrane (mol. wt. cut-off of 12000-14000) was retarded significantly compared with that from the mixture of clenbuterol powder and blank proliposomes. Interestingly, proliposomes prepared with lecithin and cholesterol (i.e., Rx 2 proliposomes) showed much more retarded release of clenbuterol than proliposomes prepared only with lecithin (i.e.. Rx 1 proliposomes), indicating that clenbuterol release from proliposomes can be controlled by the addition of cholesterol to the proliposomes. Proliposomal patches were prepared using PVC film as an occlusive backing sheet, two sides adhesive tape (urethane, 1.45 mm thickness) as a reservoir for proliposome granules and Millipore MF-membrane (0.45 mm pore size) as a drug release-controlling membrane. Rx 1 or Rx 2 proliposomes containing 4.6 mg of clenbuterol were loaded into the reservoir of the patch. Clenbuterol release from the patches to pH 7.4 PBS was determined using USP paddle (50 rpm)-over-disc release method. Clenbuterol release from the proliposomal patches was much more retarded even than from a matrix type clenbuterol patch (Boehringer Ingelheim ltd). Being consistent with clenbuterol release from the proliposomal granules, the release from the patches was highly dependent on the presence of cholesterol in the proliposomes : Patches containing Rx 2 proliposomes showed several fold slower drug release than patches containing Rx 1 proliposomes. When the patch containing Rx 1 proliposomes was applied on to the back of a hair-removed rat, clenbuterol concentration in the rat blood was maintained during 6-72 hrs. Transdermal absorption of clenbuterol from the patch was accelerated when the patch was prehydrated with 50 ml of pH 7.4 PBS before topical application. Above results indicate that sustained transdermal delivery of clenbuterol is feasible using proliposomal patches if the cholesterol content and pore size of the release rate-controlling membrane of patches, for example, are appropriately controlled.

• Fisheries and Aquatic Sciences
• /
• 제19권3호
• /
• pp.14.1-14.10
• /
• 2016

Isoelectric solubilization/precipitation (ISP) processing allows selective, pH-induced water solubility of proteins with concurrent separation of lipids and removal of materials not intended for human consumption such as bone, scales, skin, etc. Recovered proteins retain functional properties and nutritional value. Four roe protein isolates (RPIs) from yellowfin tuna roe were prepared under different solubilization and precipitation condition (pH 11/4.5, pH 11/5.5, pH 12/4.5 and pH 12/5.5). RPIs contained 2.3-5.0 % moisture, 79.1-87.8 % protein, 5.6-7. 4 % lipid and 3.0-3.8 % ash. Protein content of RPI-1 and RPI-2 precipitated at pH 4.5 and 5.5 after alkaline solubilization at pH 11, was higher than those of RPI-3 and RPI-4 after alkaline solubilization at pH 12 (P < 0.05). Lipid content (5.6-7.4 %) of RPIs was lower than that of freeze-dried concentrate (10.6 %). And leucine and lysine of RPIs were the most abundant amino acids (8.8-9.4 and 8.5-8.9 g/100 g protein, respectively). S, Na, P, K as minerals were the major elements in RPIs. SDS-PAGE of RPIs showed bands at 100, 45, 25 and 15 K. Moisture and protein contents of process water as a 2'nd byproduct were 98.9-99.0 and 1.3-1.8 %, respectively. Therefore, yellowfin tuna roe isolate could be a promising source of valuable nutrients for human food and animal feeds.

• 항공우주시스템공학회지
• /
• 제14권1호
• /
• pp.28-35
• /
• 2020

본 논문은 회전익 항공기의 동체에 특정 장비를 장착하기 위한 지지 구조물에서 균열이 발생하여 이를 개선하기 위한 목적으로 수행한 연구이다. 회전익 항공기 동체의 스킨(Skin) 구조물에 추가된 지지 구조물인 더블러(Doubler)는 개발 단계에서의 하중을 기반으로 설계 및 제작 되었으며, 항공기 운용 중 특정 시점에 더블러의 표면에서 균열이 발견되었다. 균열의 원인을 찾기 위해서 장비 장착 시 체결 조건으로 발생할 수 있는 원 구조물의 초기 변형을 고려하고, 항공기 날개 통과 주파수와 해당 구조물의 고유 주파수를 동특성 해석 조건으로 고려 하였다. 이러한 시나리오의 검토 결과로 초기 변형을 유발하는 패스너 체결 부위의 물리적인 틈(Gap) 제거를 위한 심(Shim)구조물을 추가하고, 두께가 보강된 더블러를 장착하였다. 개선된 설계의 구조적 검증을 위한 동특성 해석 결과를 검토하여 구조 강도의 증가를 확인하고, 더블러에 대한 피로 평가 수행을 통해 항공기 요구 수명 조건 또한 충족함을 확인하였다.

• 시큐리티연구
• /
• 제12호
• /
• pp.73-87
• /
• 2006

이 연구는 경호경비직 종사자집단과 경호학과 학생집단의 신체적, 정신적 자각상태 호소를 통해 건강프로그램이 개인의 건강에 미치는 영향과 남${\cdot}$여 간의 차이를 규명하는데 그 목적이 있다. 따라서 본 연구는 2년 이상의 경호경비 경력자 358명과 경호학과 학생 220명을 대상으로 T.H.I.에 의한 설문지 조사를 하였으며, 자료의 분석은 건강프로그램 처치여부, 성별, 경호경력에 따른 심신자각증상 호소점수의 차이를 비교하기 위해 변량분석(Analys of Variance/ANOVA)을 실시하였고, 통계적으로 유의한 차이가 나타났을 경우 사후비교 검정방법으로 Scheffe의 다중비교법을 사용하여 다음과 같은 결론을 얻었다. 1. 전체적으로 경호학과 학생집단이 경호경비원 집단보다 심신자각상태 호소점수의 분포에서 낮은 평균치를 나타내었으며, 특히 정서불안정, 다자각증상, 생활불규칙, 우울성, 호흡기, 눈과 피부, 공격성에서 유의하게 낮게 나타났다. 2. 건강프로그램 처치 후 남${\cdot}$여간 심신자각상태의 비교에서는 모든 항목에서 남성이 여성보다 낮게 나타났으며, 허구성 및 호흡기 항목에서만 통계적으로 유의 하지 않았고, 그 외 항목에서는 유의한 차를 보여주었다. 3. 경호경비 경력에 따른 경호경비원의 심신자각상태 비교에서는 정서불안정, 우울성, 허구성 항목에서 유의한 차이가 나타났는데 정서불안정 및 우울성은 경호경비 경력이 많을수록 낮았고, 허구성은 오히려 경호경비경력이 많을수록 높게 나타났다.

• 멤브레인
• /
• 제15권2호
• /
• pp.147-156
• /
• 2005

폴리이서설폰은 상용화된 엔지니어링 고분자 소재 중에서 이산화탄소/질소 및 이산화탄소/메탄의 분리 능력이 아주 우수하면서 이산화탄소에 대한 가소화에 대한 저항력이 아주 뛰어난 것으로 알려져 있다[1-4]. 본 연구에서는 연소 배가스내 이산화탄소의 분리/회수를 위하여 건-습식 상전이법에 의해 비대칭구조의 폴리이서설폰 중공사막을 제조하였다. 제막용액은 고비점이면서 폴리이서설폰의 용매인 NMP와 저 비점의 폴리이서설폰의 팽윤제인 acetone를 일정한 조성으로 함께 녹여서 제조하였다. 방사용액의 농도, NMP와 acetone의 비, 방사높이, 증발조건, 실리콘 코팅조건을 변화시키면서 중공사를 제조하였으며, 얻어진 중공사막의 이산화탄소와 질소에 대한 기체투과도와 선택도는 순수기체를 통하여 측정하였다. 최적의 PES 중공사막은 PES/Acetone/NMP = 30/35/35 $wt\%$ 방사용액과 실리콘의 코팅조건하에 제조된 것으로 폴리이서설폰 소재 자체의 고유선택도인 $30\~40$의 $CO_2/N_2$ 선택도를 보였으며 $25\~50$ GPU의 이산화탄소 투과플럭스를 보였다. 이러한 선택도와 투과도로부터 계산된 중공사 외표면의 선택층의 두께는 $0.1\;{\mu}m$였다. 제조된 폴리이서설폰중공사막이 향후 연소 배가스내 이산화탄소 분리/회수용 막분리 공정에 적용될 경우 우수한 결과를 보일 것으로 예측된다.

• 대한간호학회지
• /
• 제7권2호
• /
• pp.1-10
• /
• 1977

Personalized Patient centered nursing care is increasingly difficult to achieve despite the fact that it remains one of our consistent goals. So, we must find away to individualized nursing care. One means, to achieve this is by use of the nursing history form, which has been developed to help the nurse make maximum use of her limited time with the patient, by obtaining systematically the information needed to plan his nursing care. The nursing history form can be used to collect data about individual nursing needs but also it lends itself to the collection of epidemiological data relevant to the needs of patient population. So this study was undertaken in an attempt to describe the general characteristics of the population studied, to find out their perceptions and expectations related to their illness and hospitalization, to find out specific basic needs and to examine the relationship between the patients nursing needs and demographic characteristics through the responses to the nursing history questions. The study population defined and selected was all the patients (70) who were admitted to Yonsei University Hospital from October 1 - 15, 1975. The direct interview method was used and the data were categorized by the investigator, according to the nature of responses to each question and were subjected to the percentile and the chi- square tests. The findings can be summarized as follows 11. General characteristics of the study population ; The population was made up mainly of urban patients who were highly educated. The age was equally distributed. 2. Patients, perceptions and expectations related to illness and hospitalization ; 88.6% of the patients knew about the reason for hospitalization but 64. 5% could state symptoms only. 37.5% recognized the cause of illness. Approximately three fourth of the patients expressed on expectation for early recovery. 60.0% of the patient responses indicated, that they expected less than 10 days of hospitalization. Of the total responses regarding hospitalization, 45.7% were negative about the post -hospitalization expectation, 45.7% expected to return to work. As a result of these findings, we can see that there is a great educational need, a psychological need and environmental need for adaptation to the hospital and a socio- economic need for the post - hospitalization period. 3. Specific basic needs : The physical needs include the problem of getting sufficient sleep (50.0%), difficulty in food intake(47.1%), problems with hospital diet (47.0%), abnormal condition of the skin(44.3%), problems with bowel elimination(35.7%), assistance with bathing(35.7%), pain(30.0%), difficulty in walking(30.0%) , difficulty in seeing(30.0%) problems in urinary elimination(20.0%) , and difficulty in hearing(10.0%), 4. Nursing needs and epidemiological characteristics ; Age distribution was related to the rendition of the mouth but no significant differences were observed statistically with the patients responses to the other nursing history questions according to the epidemiological variables of age, sex, education and residence.