• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.12
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• pp.7005-7011
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• 2014

In this study, due to aging, we propose the possible solutions for a variety of skin problems, skin problems of middle-aged women appear. The object of the present invention is to provide the basic data required for use in cosmetic skin care methods and then to find the direction in accordance with the use situation of the subjective skin cosmetics. For this, total 235 the age of 50's women living in Gyeonggi. Found that the correlation between the method by the subjective skin and cosmetics(***p<.001). Found that the correlation between the method of administration and the skin cosmetic and subjective(***p<.001). These results suggest that training and development can be made for a great skin care program to find the exact status of individuals based on a variety of skin problems from the facial skin of middle-aged women.

• The Korean Journal of Community Living Science
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• v.15 no.2
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• pp.55-64
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• 2004

The purpose of this study was to examine the differences in skin temperature and thermal comfort of participants in a $19^\circ{C}$ room (the recommended room temperature in the winter) depending on age, sex and clothing weight. Subjects were divided into four groups (6 young males, 5 young females, 6 old males, 6 old females) and experimental trials consisted of three conditions: wearing underwear in a $19^\circ{C}$ room (19CUW), without underwear in a $19^\circ{C}$ room (19C), and without underwear in a $24^\circ{C}$ room (24C). The results indicated the following: 1) There were no significant differences in mean skin temperature based on age or sex, and the mean skin temperatures of the four groups were in the range of 32.4∼$34.0^\circ{C}$. 2) In the 19C condition, the skin temperatures of the hands and feet of old females were higher than those of the other three groups. 3) In terms of perceived thermal comfort, young females showed a tendency to feel the most uncomfortable. Both old and young groups agreed that the 24C condition was the most comfortable. 4) Relational coefficients between thermal comfort and skin temperatures were higher in the young group than in the old group. Furthermore, the perceived thermal comfort had a stronger relationship with mean skin temperatures than with local skin temperatures. 5) The mean skin temperatures of subjects who indicated they were 'comfortable' were in the range of 31∼$36^\circ{C}$ regardless of age or sex.

• Journal of Korean Physical Therapy Science
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• v.21 no.1
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• pp.37-43
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• 2014

Background : The purpose of this study is to verify the type of influence on the skin color according to the photoaging symptoms depending on the degree of external activities among the factors that influence the skin due to UV exposure and to obtain the basic study data on the physical therapy of the skin. Methods : In this study, in order to investigate the type of influence on the skin color according to the photoaging symptoms when the body is exposed to the UV rays having various effects on our body, a study was conducted using questionnaires and skin color measurement tool targeting 20 male college soccer students with many external activities and the senior high school students who has relatively less external activities due to the preparation for college entrance. The skin color was measured and the results were compared. Result : In the test group having relatively higher external activities, while they had less use of the sunscreen, they had more degree of UV exposure, and for the recognition of ultraviolet hazard, more were aware that it was harmful. In addition, in the skin color measurement test conducted targeting the son and the father in order to investigate the association between the skin color and the genetic factors, the experimental group showed a significant difference(p<.05) but the control group did not show any significant difference(p>.05). Conclusion : Based on such study results, the UV exposure time and the use of sunscreen are thought to be an important factor in the skin care.

• Fashion & Textile Research Journal
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• v.12 no.6
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• pp.830-836
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• 2010

The purpose of this research was to investigate the effects of skin pressure by wearing all-in-one on the rhythm of body temperature such as skin and rectal temperature which play a crucial role in the nocturnal rhythm. Five healthy female were participated in the study as subjects. The experimental clothing was an all-in-one, one of the foundation, which is worn for shaping the body. The total experimental periods were 5 days. On the 1st day, subjects did not wear the all-in-one (None), and they wore it for about 12 hours per day from 2nd to 5th day (Wearing1~4). Skin and rectal temperature were measured during the entire experimental days to figure out the rhythm of body temperature during sleep. When subjects wore the all-in-one, the gradients of the forearm and calf skin temperature at the sleep onset were significantly smaller than "None". It indicated that the rise of extremities' skin temperature was low on the "Wearing1~4". The decline of rectal temperature in "Wearing 1~4" was smaller than "None". Therefore, the skin pressure by all-in-one may cause the temperature of extremities' skin and rectum to change, resulting the fluctuation of the circadian rhythm, finally it could have effects on the rhythm of sleep.

• Journal of the Korean Society of Fashion and Beauty
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• v.2 no.3 s.3
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• pp.1-10
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• 2004

The purpose of this study is to find out the operant factors, or types of skin care, and, more importantly, to propose the intervention for more effective skin care and marketing strategies in this business. That is the main reason that the study employes Q methodology which measures human subjectivity objectively and scientifically. This study finally revealed three distinctive factors : Type I, The Passive Follower, Type II, The Active Needs, and Type III, The Independent Judgment. The first type includes people who show passive recognition. They want to be put in charge of experts in the skin care center and to buy cosmetics recommended by experts, and are deep interest in the reaction of other people. The second type contains people who desire things actively. To live delightfully and fashionably, they think of the necessity of skin and body care as an important thing, and feel that it is necessary to take care of the skin beauty actively and regularly for the aging resistance. The third type includes people who judge independently. In general, they recognize and desire the necessity of the skin care, but they think of the skin care as a part of the health care more widely rather than a special thing. These three types are not fixed, but continuously changed in the accordance with the condition and interaction with the circumstance, the results will be utilized as basic materials for the skin and health care through the application according to the characteristic of each type they belong.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.36 no.1
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• pp.65-69
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• 2010

Collagen is the most abundant animal protein in mammals, accounting for about 30 % of all proteins. It is present in connective tissue and contributes to the structural framework of most organs. The tripeptide (glycineproline-hydroxyproline) with the INCI name Tripeptide-29 is main component of collagen type I. The palmitoyl tripeptide (palmitoyl-glycine-proline-hydroxyproline) with the INCI name Paimitoyi Tripeptide-29 is a synthetic material that was designed as a topical agent to stimulate collagen production. We synthesized the palmitoyl tripeptide as a potential anti-wrinkle compound. This compound has been characterized using HPLC. This compound proved, through in vitro tests, to stimulate collagen production and fibroblast proliferation. These results were very promising, so human studies were subsequently performed. We investigated the skin improvement effect of the palrnitoyl tripeptide on human skin by using non-invasive instruments. We measured physiological effects such as skin wrinkles and elasticity after volunteers applied the cosmetic products for 8 weeks. We observed significant improvement in skin wrinkles and elasticity after use of the cosmetic products for 8 weeks. We concluded that the palmitoyl tripeptide had an anti-aging effect on human facial skin.

• Archives of Plastic Surgery
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• v.37 no.5
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• pp.659-666
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• 2010

Purpose: Blepharoplasty plays a vital role in facial rejuvenation. Aging eyelids are the result of relaxation of lid structures as the skin, the orbicularis muscle, and mainly the septum, with subsequent protrusion or pseudoherniation of intraorbital fat contents. Traditional blepharoplasty has often involved the excision of excessive lax skin and muscle and removal of fat, leaving the eyelid unnatural and even causing the brow ptosis. The authors propose the septal approach through which the amount of skin excision can be decreased and solid fixation can be achieved in the upper blepharoplasty. Methods: From November 2007 to February 2010, total of 15 patients underwent upper blepharoplasty with septal approach. In 9 patients, orbital septum anchored into the orbital periosteum only. But in 6 patients, the attenuated septum was strengthened through shortening and fixing into orbital periosteum with non-absorbable suture. Results: Pleasing results were obtained from most of the patients. But one patient who had septum anchoring procedure complained of slight undercorrection, therefore secondary operation with septum shortening procedure was followed. Conclusion: We found that the method using orbital septum fixation into orbital periosteum has several advantages: less amount of skin excision, less recurrence rate, and more natural appearance. And the results were reliable and satisfactory.

• Biomolecules & Therapeutics
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• v.22 no.1
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• pp.35-40
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• 2014

Resveratrol is a polyphenolic compound found in various natural products such as grapes and berries and possesses anti-cancer, anti-hyperlipidemia, and anti-aging properties. Recently, it has been reported that resveratrol inhibits ${\alpha}$-melanocyte-stimulating hormone signaling, viability, and migration in melanoma cells. However, these effects have not been confirmed in vivo, specifically brownish guinea pigs. To evaluate the potential of resveratrol as a regulator of melanin for hyperpigmentation therapy, the influence of resveratrol on pigmentation was investigated by ultraviolet B-induced hyperpigmentation in brownish guinea pig skin. We found that resveratrol reduced the expression of melanogenesis-related proteins tyrosinase, tyrosinase-related proteins 1 and 2, and microphthalmia-associated transcription factor in melanoma cells. Furthermore, topical application of resveratrol was demonstrated to significantly decrease hyperpigmentation on ultraviolet B-stimulated guinea pig skin in vivo. Based on our histological data, resveratrol inhibits melanin synthesis via a reduction in tyrosinase-related protein 2 among the melanogenic enzymes. This study is the first to provide evidence supporting resveratrol as a depigmentation agent, along with further clinical investigation of resveratrol in ultraviolet B-induced skin disorders such as hyperpigmentation and skin photoaging.

• Journal of Microbiology and Biotechnology
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• v.31 no.4
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• pp.630-636
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• 2021

Glabridin, a compound of the flavonoid, has shown outstanding skin-whitening and anti-aging properties, but its water insolubility limits its wide application. Therefore, glabridin liposome (GL) has been developed to improve its poor bioavailability, while there are few studies to evaluate its amelioration of UVB- induced photoaging. This study is performed to investigate the amelioration of GL against UVB- induced cutaneous photoaging. The prepared GL has a spheroidal morphology with an average diameter of 200 nm. The GL shows lower cytotoxicity than glabridin, but it has a more effective role in inhibition of melanin. Moreover, the application of GL can effectively relieve UV radiation induced erythema and leathery skin, associated with the down-regulated expression of inflammatory cytokines (TNF-α, IL-6 and IL-10). Taken together, these results demonstrate that GL has potentials as topical therapeutic agents against UVB radiation induced skin damage through inhibiting inflammation.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.40 no.3
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• pp.279-287
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• 2014

Estrogen deficiency results in a reduction of skin quality and function in postmenopausal women. Over the past decade, many studies have supported that estrogen provides anti-aging effects as a result of the ability of estrogen to prevent skin collagen decline, restore skin elasticity, and increase skin hydration in postmenopausal women skin. Due to their structural similarity with estrogen, isoflavones have been called phytoestrogens. Photoprotective effects of isoflavones are well established while their estrogenic-like activities are not fully understood in human skin. In this study, we investigated whether daidzein, an effective isoflavone, has phytoestrogenic activity and induces transcriptional change of extracellular matrix components in dermal fibroblasts. We examined the luciferase activity of daidzein and ${\beta}$-estradiol using transiently transfected NIH3T3-ERE cells. The estrogenic receptor-dependent transcriptional activity was increased in a dose-dependent manner when treated with daidzein, with a maximum of 2.5-fold induction at $10{\mu}g/mL$ of daidzein compared with non-treated control. In addition, daidzein significantly in creased the expressions of collagen type I, collagen type IV, elastin, and fibrillin-1 in human dermal fibroblasts. By comparing with the effects of ${\beta}$-estradiol through out all the experiments, we confirmed that daidzein had estrogenic activity and function in fibroblasts. These results suggest that daidzein-based application, having both photoprotective and phytoestrogenic effects, may be a powerful approach for skin anti-aging of postmenopausal women.