• Korean Journal of Agricultural Science
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• v.24 no.2
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• pp.290-297
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• 1997

Danored is considered as the most favorable grape variety for national wine manufacturing in terms of sugar, organic acid contents, annual production amount, as well as quality control convenience after harvest. This study was canied out to know the influence of suspended solid(SS) and skin contact time(SCT) with Danored variety on the white wine quality. The results are summarized as follows; 1. Suspended solid and skin contact time did not greatly influence on the chemical composition of Danored juice. But skin contact time provided slightly increaseness to the content of phenol compounds 2. Suspended solid accelerated fermentation rate of white wine manufacturing. Although the content of suspended solid are less amount than 0.3% in must, wine fermentation was completed to dryness in concentration of sugar. 3. When the content of suspended solid was around 3%, higher alcohol in white wine was increased by the 20%. This result is relatively small increasement compared to the other reported results. 4. Because Danored contained less amount of phenol compounds comparison with other grape varieties, browning capacity in white wine was much favorable to quite low concentration. Especially, phenolic compounds was decreased remarkably as one of fermentation characteristics of Danored variety. 5. As a result of sensory evaluation, wine quality was A-1> B-1> A-2> B-2 in its favorable ranking orders. It was so concluded that A-1 might be the most acceptable one from this study.

• Proceedings of the SCSK Conference
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• 2003.09a
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• pp.765-779
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• 2003

Physiological lipid mixtures comprised of cholesterol, ceramide and free fatty acid better maintain epidermal homeostasis and have been recently used for dermatoses induced by skin barrier damage, for example for atopic dermatitis and xerotic skin. Itching and dry atopic dermatitis of the skin may be related to altered skin barrier function. In a previous study, the use of multi-lamellar emulsion (MLE), which is a lipid mixtures containing cholesterol, pseudoceramide and free fatty acid, has been shown to accelerate the recovery of the epidermal permeability barrier. In this study, we assessed the efficacy of MLE compared with a currently used anti-itch moisturizer (AIM), the active ingredients of which are menthol and camphor, on barrier recovery after barrier disruption. To clarify the effect of MLE and AIM after acute barrier perturbation, we measured the relation between transepidermal water loss (TEWL) and the barrier recovery rate at 3, 6, 24, and 48 hours after tape stripping hairless mice and then observed changes in the stratum corneum (SC), including the intercellular lipid structure and secretion of lamellar bodies, by electron microscopy. MLE treated skin recover skin barrier function more rapidly, and AIM treated skin delayed barrier repair. Morphological changes in the epidermis, of MLE treated skin revealed well-conserved lipid multi-lamellar structures at 24 h after tape stripping, whereas AIM treated skin showed altered lamellar bilayers within the SC interstices at 48 h. In addition, MLE treated skin showed an increase in the number of LBs and in their secretions and a decrease in the number of SC layers versus AIM treated skin. These results suggest that MLE may accelerate the production of an epidermal permeability barrier in hairless mice by increasing the number and secretion of LB and improve the dryness and itch associated with an altered epidermal permeability barrier.

• The Journal of Korean Medicine
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• v.30 no.1
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• pp.83-94
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• 2009

Background and Objectives: The skin barrier protects skin against a harmful environment. Its function includes an antimicrobial barrier as well as a physical barrier. Stress is harmful to the skin barrier and there are many studies on this, but there are few about the effect of stress during pregnancy on the skin barrier of offspring. The aim of this study was to investigate the effect of stress during pregnancy on the skin barrier of offspring by examination with the naked eye, cortisol, weight, TEWL and histologic tests. Materials and Methods: Male hairless mice ten weeks old were coupled with females for three days. After twelve days the females were divided into two groups. We stressed one group and not the other group. The offspring from the non-stressed (N group) and stressed (S group) grew up until four weeks. The S group was exposed to chronic mild stress using the chronic stress model protocol modified method of Wilner and Towell for a week. We made examinations with the naked eye, assessment of cortisol, weight, TEWL, and histologic test to contrast the S group with the N group. Statistical analysis was performed by using Mann-Whitney and Friedman test. Statistical significance was achieved if the probability was less than 5% (p<0.05). Results: 1. By making an examination with the naked eye, S group showed papules, creases and dryness on their skin, but N showed no change compared with normal skin. 2. There was no statistically significant difference between S group and N group in cortisol (p>0.05). 3. There was no statistically significant difference between S group and N group in weight. N group had less weight than S group (p<0.05). 4. There was no statistically significant difference between S group and N group in TEWL (p>0.05). 5. There was no statistically significant difference between S group and N group in TEWL recovery (p>0.05). 6. In TEWL and TEWL recovery, there was statistically significant difference by time between S group and N group (p<0.005). Histologically, S group showed a thicker epidermis and epidermal crest than N group. Conclusions: We found that stress during pregnancy has negative effects on the skin barrier of offspring. Though there were no statistically significant differences between S group and N group in TEWL recovery, we found evidence that the recovery of skin barrier function is interrupted by stress during pregnancy by examination with both the naked eye and histology.

• Journal of Physiology & Pathology in Korean Medicine
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• v.21 no.5
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• pp.1099-1107
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• 2007

This study was investigated the anti-allergic effect of SJSBT on DNCB induced atopic dermatitis in NC/Nga mice. We summerized as the follow. SJSBT significantly decreased the clinical manifestations of atopic dermatitis including itching, dryness, edema, hemorrhage, and lichenification in dose dependent manner. SJSBT markedly suppressed invasion and edema of leukocytes and mast cell in dorsal skin and ear tissue. SJSBT significantly reduced the number of CD11b+/Gr-1 cell compared with positive control, but it had no affect the number of CD3+ and CCR3+/CD3+ cell. SJSBT markedly suppressed the expression of cytokine and chemokine such as IL-6, $TNF-{\alpha}$, eotaxin and CCR3 compared with positive control group. SJSBT significantly decreased the invasion of CD4+ and CCR3+ cell in ear and dorsal skin tissue compared with positive control group by using immunohistochemical staining. Taken together, these findings suggested that SJSBT has an anti-allergic activity and this might be useful for the clinical application to treat allergic diseases such as atopic dermatitis.

• Journal of Physiology & Pathology in Korean Medicine
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• v.32 no.6
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• pp.396-402
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• 2018

Hataedock (HTD) treatment is a traditional preventive therapy for the fetal toxicosis- the acute allergic disease after childbirth, mainly manifested by a variety of skin allergies such as scab, phlegm. The aim of this study was to investigate the efficacy of HTD treatments for the alleviation of inflammation in Dermatophagoides farinae-induced obese NC/Nga mice. 20 mg/kg of Coptidis Rhizoma, Glycyrrhizae Radix (CRGR) extracts as a remedy of HTD treatments were orally administered to NC/Nga mice. We induced obesity in the mice by high-fat diet. To induce skin allergies, the extracts of Dermatophagoides farinae were topically applied on the NC/Nga mice at 4th-6th and 8th-10th weeks. Structural and molecular changes in the skin tissues were measured by immunohistochemical staining. HTD treatment decreased the atopic dermatitis (AD)-like symptoms including hemorrhage, erythema, erosion, edema, and dryness. HTD treatment suppressed the mast cell activation confirmed by reduction of $Fc{\varepsilon}RI$, substance P, and serotonin. The expression of several inflammatory mediators including nuclear factor-kappa B ($NF-{\kappa}B$) p65, inducible nitric oxide synthase (iNOS), vascular endothelial growth factors (VEGFs) was also decreased by HTD treatment. HTD treatment suppressed the allergic, inflammatory responses in the skin tissues of the NC/Nga mice by reducing mast cells and down-regulating several inflammatory mediators.

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 2008.04a
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• pp.359-361
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• 2008

This paper presents the fuzzy minutiae-based matching to improve the accuracy of the difference between template and imput fingerprint image. Minutiae-based matching method is the most well-known and widely used method for fingerprint matching. However, fingerprint pressure, dryness of the skin, skin disease, sweat, dirt, grease, and humidity in the air cause the noisy fingerprint images and the distortion is produced by users moving their fingers on the scanner surface. The input image may be rejected from the Fingerprint Recognition System, because the distorted fingerprint image is very different from the original image. Large tolerence boxes and fuzzy discriminant function is required to improve the accuracy.

• Journal of Ginseng Research
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• v.32 no.1
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• pp.48-56
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• 2008

Chronic ultraviolet (UV) exposure is the major cause of photoaging that causes skin wrinkling, roughness, dryness, laxity, and pigmentation. Recently, increasing efforts are being made to understand the relationship between foods and skin health. Ginsenosides are present in ginseng (Ginseng Radix Rubra) extract, and are known to have biomedical properties, such as, anti-oxidant and anti-inflammatory effects. In this study, we investigated whether KTNG0345 prepared from red ginseng extracts delivered orally reduces skin wrinkling and ultraviolet B (UVB)-induced wrinkle formation in hairless mouse skin. KTNG0345 was administrated orally to the mice (5 times a week) during the period of UVB-irradiation (3 times a week) for 8 weeks at three different doses of 300 mg/kg, 500 mg/kg and 1000 mg/kg (w/v). UV doses were increased weekly by 1 MED (1MED = 75 $mJ/cm^2)$ up to 4 MED and then maintained at this level. After the 8-week administration period, it was found that orally administered KTNG0345 significantly inhibited UVB-induced wrinkle formation in a dose-dependent manner. Increases in skin thickness caused by UVB were prevented by KTNG0345. Moreover, it also significantly inhibited matrix metalloproteinases (MMP) -13 and MMP-9 expressional inductions by UVB. In addition, KTNG0345 was observed to prevent UVB-induced water loss of epidermis in hairless mouse skin. Our results demonstrate that orally administered KTNG0345 has anti-wrinkling effects in hairless mouse skin, and suggest that dietary red ginseng and herbal mixture may be considered a functional beauty food for preventing UVB-induced skin wrinkles.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.4
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• pp.264-274
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• 2019

This study attempted to analyze the effects of cleansing oil on skin by preferred vegetable base oil. For this, a questionnaire survey was performed against 100 people, and their face washing habit and preferred vegetable base oils were examined. Based on the results, 4 different cleansing oils were prepared and experimented. The experiment was conducted against 10 adult women in their 20-30s, and moisture level, sebum level and trans-epidermal water loss (TEWL) before and after the experiment were measured. After the test, satisfaction was measured, and the results found the followings: When asked what cleansing oil is most preferred by vegetable base oil type, 'rose hip oil' was the highest, followed by 'olive oil', 'apricot kernel oil' and 'camellia oil'. According to the clinical trials, both moisture and sebum levels increased before and after cleansing in all four cleansing oil types by the preferred vegetable base oil (p<0.001, p<0.001). In addition, TEWL decreased with a difference by base oil (p<0.01). According to a subjective satisfaction survey which was performed after the experiment, rose hip oil-contained cleansing oil (RHC) was the highest in terms of cleansing effect and satisfaction level. Consequently, it was confirmed that the cleansing oil by vegetable base oil improved skin conditions by protecting a skin barrier with a positive effect on the improvement of sebum and moisture levels and TEWL. Even though a preferred oil type and a satisfaction level may differ by preferred oil and feeling after use, cleansing oil by vegetable base can be helpful as a skin care product which eases skin dryness and protects a skin barrier.

• Journal of Environmental Science International
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• v.4 no.5
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• pp.517-526
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• 1995

The health symptoms assessment and urinary hippuric acid excretions of workers exposed to toluene occupationally in shoes workshops were investigated by the Questionnaire and the field monitoring. Based on the results, the acute health symptoms of workers exposed to toluene by questionnaire were fatigue(58.7%), irritation of the eyes, nose and throat(57.2%), and skin dryness(43.3%). And the complaints about workshop environment are odor, dust and noise. The mean values of urinary hippuric acid excretions in m식e and female were 1.08 $\pm$ 0.50 g/l, 1.59 $\pm$ 1.27 g/l in total workers, espectively.

• Journal of Environmental Science International
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• v.4 no.5
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• pp.131-131
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• 1995

The health symptoms assessment and urinary hippuric acid excretions of workers exposed to toluene occupationally in shoes workshops were investigated by the Questionnaire and the field monitoring. Based on the results, the acute health symptoms of workers exposed to toluene by questionnaire were fatigue(58.7%), irritation of the eyes, nose and throat(57.2%), and skin dryness(43.3%). And the complaints about workshop environment are odor, dust and noise. The mean values of urinary hippuric acid excretions in m식e and female were 1.08 $pm$ 0.50 g/l, 1.59 ± 1.27 g/l in total workers, espectively.