• Journal of The Korean Society of Integrative Medicine
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• v.10 no.3
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• pp.27-36
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• 2022

Purpose : This study was aimed to analyze the effects of cosmetics containing Persicaria perfoliata water extract (PPWE) on the skin moisturizing and improvement of skin condition in clinical trials. Methods : Clinical trial was conducted for five weeks after IRB approval at Dong-Eui University. Out of a total of 64 people, 15 people each were assigned to four groups as follows; control group A, B, C and the experimental group A that using cosmetic containing PPWE. Skin condition was measured two times, before and after clinical trial, by a professional skin analyzer, SDM (skin diagnosis system). Moisture and oil value of participants was analyzed twice, each morning and evening, using a portable device on their cheeks. In addition, the survey was investigated subjective satisfaction on change in skin condition and the satisfaction on the use of cosmetics. Result : The experimental group exhibited subjectively significant changes before and after clinical trials on skin its dryness (p=.039), blush (p=.017), and redness (p<.001). In addition, subjective evaluation was also the highest satisfaction in aspects of number of application (p=.003), amount of application (p=.002), moisture maintenance, and skin scratching frequency. The satisfaction on the use of cosmetics was the highest in the intention to repurchase (p=.045), recommendation willingness to others (p=.020), and intention to use various products (p=.001). Skin moisture of the clinical trial participants using the SDM, moisture level and elasticity of the experimental group increased by 12.94 and 10.28. Moisture level, which was measured by a portable device, was the most potently increased in the experimental group. Conclusion : Consequently, PPWE containg cosmetics exhibited the effects of moisturization and attenuated skin dryness in clinical trials, which might be utilized as a fundamental data to develop numerous lines of cosmetics.

• Korean Journal of Head & Neck Oncology
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• v.19 no.2
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• pp.170-174
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• 2003

Pleomorphic adenoma is the most common benign tumor in the parotid gland and a parotidectomy with preservation of the facial nerve is a widely accepted treatment. We experienced a case of huge pleomorphic adenoma arising in the parotid gland with suspicious skin invasion. This present case was 67-year-old male presenting huge parotid mass $(12{\times}7cm)$ that has been present for 30 years and this tumor showed rapid-growing nature recently. The overlying skin surface was ulcerated with serous discharge and tightly adherent to the mass. The risk of malignant transformation of a pleomorphic adenoma increases with the duration of disease. The preoperative tentative diagnosis was carcinoma ex pleomorphic adenoma in the parotid gland. The initial pathologic diagnosis of fine needle aspiration biopsy was unsatisfactory smear. After parotidectomy, the histologic examination revealed that the parotid tumor was benign pleomorphic adenoma. We present a case of huge pleomorphic adenoma with skin invasion in the parotid gland with review of literatures.

• Tuberculosis and Respiratory Diseases
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• v.78 no.2
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• pp.56-63
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• 2015

A small number of viable tuberculosis bacilli can reside in an individual with latent tuberculosis infection (LTBI) without obvious clinical symptoms or abnormal chest radiographs. Diagnosis and treatment for LTBI are important for tuberculosis (TB) control in public and private health, especially in high-risk populations. The updated 2014 Korean guidelines for TB recommend that tuberculin skin tests, interferon-gamma release assays, or a combination of the two can be used for LTBI diagnosis according to age and immune status of the host as well as TB contact history. The regimens for LTBI treatment include isoniazid, rifampicin, or isoniazid/rifampicin. However, results of drug susceptibility test from the index case must be considered in selecting the appropriate drug for recent contacts. Standardized LTBI diagnosis and treatment based on the new 2014 guidelines will contribute to the effective TB control in Korea as well as to the establishment of updated guidelines.

• Korean Journal of Oriental Medicine
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• v.13 no.2 s.20
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• pp.91-100
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• 2007

In this paper, We tried to analyze the patent trend on constitution diagnosis and treatment related technologies. For this, constitution diagnosis and treatment related technologies divided into 16 sub-technology by the advisory committee. And we analyzed patents applied in Korea, Japan, U.S.A., China, and Europe. The 16 sub-technology consist of pulse analyzer, skin diagnosis, tongue analyzer, face and body detector, face analyzer, voice analyzer, intelligence ontology, meridian diagnosis, infrared thermography, electric stimulation, laser, high and low frequency, physical, magnetic, and ultrasound therapy. As a result we found that patents of constitution diagnosis and treatment in Korea has been growing steadily in both quality and quantity since 1980s. The number of patent the pulse analyzer and low frequency therapy are larger than others. But applied relevant international patents, marketability of the patent and Cites per Patent (CPP) index are shown to be very low. In conclusion, to occupy key original technologies of the Oriental medical device, we need to apply more patent of the whole related technology and international patents.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.56 no.11
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• pp.2051-2057
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• 2007

In Oriental medicine, the status of a tongue is the important indicator to diagnose one's health like physiological and clinicopathological changes of inner parts of the body. The method of tongue diagnosis is not only convenient but also non-invasive and widely used in Oriental medicine. However, tongue diagnosis is affected by examination circumstances a lot like a light source, patient's posture and doctor's condition. To develop an automatic tongue diagnosis system for an objective and standardized diagnosis, segmenting a tongue is inevitable but difficult since the colors of a tongue, lips and skin in a mouth are similar. The proposed method includes preprocessing, graph-based over-segmentation, detecting positions with a local minimum over shading, detecting edge with color difference and estimating edge geometry from the probable structure of a tongue, where preprocessing performs down-sampling to reduce computation time, histogram equalization and edge enhancement. A tongue was segmented from a face image with a tongue from a digital tongue diagnosis system by the proposed method. According to three oriental medical doctors' evaluation, it produced the segmented region to include effective information and exclude a non-tongue region. It can be used to make an objective and standardized diagnosis.

• Archives of Craniofacial Surgery
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• v.21 no.2
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• pp.123-126
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• 2020

Skin cancer, which often occurs as a result of skin exposure to ultraviolet light radiation, usually presents with characteristic abnormal features, such as ulcerative lesions, irregular morphology, bleeding, and excessive growth. Therefore, skin cancer rarely resembles a benign tumor on visual inspection. Nonetheless, squamous cell carcinoma and basal cell carcinoma with nodular or polypoid features can have a similar appearance to that of benign tumors, meaning that they are sometimes misdiagnosed as benign. As benign and malignant tumors have some overlapping features, clinicians sometimes use additional imaging techniques such as ultrasonography to improve the accuracy of the diagnosis because even a malignant tumor that externally resembles a benign tumor generally has internal morphological features characteristic of malignancy, such as invasion and irregular borders. However, these imaging tools also have limitations, and punch or excisional biopsy can be needed if malignancy cannot be completely ruled out. Herein, we report a case of skin malignancy initially misdiagnosed as a benign epidermal cyst based on external visual inspection and ultrasonography.

• Journal of the Korean Medical Association
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• v.61 no.11
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• pp.655-661
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• 2018

Incidence of basal and squamous cell carcinoma is increasing among Korean. With increasing this incidence we need to attend the management and prevention of these cutaneous malignancies. Basal cell carcinoma (BCC) is the most common skin malignancy. Sun exposure is the most important environmental cause of BCC. Daily sun protection especially avoiding sun exposure between 10 a.m. and 4 p.m. provides most effective prevention against chronic ultraviolet-induced skin damage. Hedgehog pathway inhibitors are used locally advanced and metastatic BCC lesions in Korea. Until recently, there are no reports whether it developed resistance of Hedgehog pathway inhibitors with advanced BCC in Korean patients. Among malignant skin tumors, 19.1% were squamous cell carcinoma (SCC). The incidence of SCC was rapidly increased over the past years. However, the incidence rate of SCC in Japan has not been changed from the period 1976-1980 to 1986-1990. Sentinel lymph node biopsy for SCC did not provide diagnostic value. Bowen's disease and Erythroplasia of Queyrat are considered as carcinoma in situ of the skin. Erythroplasia of Queyrat have worse prognosis with a higher rate of malignant degeneration. Dermoscopy may helpful tool in assisting the noninvasive diagnosis of carcinoma in situ of the skin.

• Archives of Craniofacial Surgery
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• v.22 no.6
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• pp.333-336
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• 2021

Verrucous carcinoma (VC) is a rare subtype of squamous cell carcinoma that commonly occurs in the oral cavity. However, VC of the facial skin is relatively rare. We report a case of a 91-year-old woman with VC of the facial skin in the left zygoma area. She was diagnosed with actinic keratosis (4×3 cm) of the same site approximately 12 years previously, but declined further treatment. The mass was excised with a minimum of 0.4 cm from gross margins with the result of free from tumor of all margins by frozen section, allowing for primary closure after skin undermining. Basal resection was performed in the preplatysmal plane. The diagnosis of VC was confirmed by histopathological examination. Postoperatively, the wound healed without incident and with no signs of facial nerve injury. To our knowledge, this is the first reported case of VC of facial skin arising from actinic keratosis.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.27 no.2
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• pp.1-13
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• 2014

Objective : The purpose of this study is to understand conspicuous features of geroderma with visceral manifestation theory(臟象論). Methods : We categorized skin aging into wrinkles, hyperpigmentation, dry skin and face flush. After investigating the reason, histological changes and mechanism of each classification in western medicine, we interpreted them according to the malfunction of five viscera(五臟) in Korean medicine. Result : The results are as follows. 1. Pathologic change of dermis and subcutaneous fat makes wrinkles. We consider wrinkles as the malfunction of the spleen(脾). 2. Irregular synthesis and disproportion of melanin makes hyperpigmentation. We consider hyperpigmentation as the malfunction of the liver(肝). 3. Dry skin is attributed to a subtle disorder of epidermal maturation. We consider dry skin as the malfunction of the lung(肺). 4. Facial flush is detected in rosacea and menopausal hot flush, which are both related with blood vessel abnormality. We consider facial flush as the malfunction of the heart(心) Conclusion : We interpreted the pathologic changes and mechanism of skin aging in western medicine as the decrease of five viscera(五臟) in visceral manifestation theory(臟象論) of Korean medicine. Further studies are needed to apply these hypothesis to clinical diagnosis and treatment.

• The Korea Journal of Herbology
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• v.34 no.3
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• pp.37-44
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• 2019

Objectives : Acne is a common disease that affects more than 70% of adolescents. Acne patients have a poor quality of life compared to patients with other skin diseases. We tried to demonstrate the effectiveness of acne treatment using cleansing soap which is easily used in daily life. Methods : We selected 20 students with acne symptoms on their facial skin. We made herbal Cp (Cold process) soaps using Seosiokyongsan, Kyungohkgo, Hwangryunhaedoktang and Baeksoooh and distributed them to experiment participants. We let them wash their face in the morning and evening for 6 weeks using herbal Cp soap. Prior to the experiment, their skin condition was checked and assessed using A-ONE Smart One-Click Automatic Facial Diagnosis System three times at 3-week intervals. Acne status was classified into 6 stages according to KAGS and acne status was also measured 3 times in total. After the experiment, the changes of skin were analyzed through facial analysis test. Results : Based on the KAGS classification, the condition of acne has improved as a whole. The state of moisture was gradually increased and the state of skin oil was significantly decreased after 6 weeks of using soap compared to before using soap. Conclusions : Cp soaps made from four kinds of herbal medicine are believed to improve the condition of acne by increasing the moisture of the facial skin and decreasing the skin oil content.