• Journal of Environmental Impact Assessment
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• v.24 no.5
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• pp.432-443
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• 2015

Ski industry is sensitive to climate change. Many studies were carried out to learn the impact on climate change to large scale ski resorts around the world and the results are difficult to be applied to small scale ski resorts in general. So, this study targeted small ski resorts composing the ski industry of Korea and forecasted the impact of climate change. As a result, based on the mitigation efforts to minimize climate changes of the future (RCP 4.5), ski industry could be maintained at the same level of today. However, if climate change continues at the current trend (RCP 8.5), ski resorts will face loss of business days. If 100 days are considered as the minimum days to maintain the ski business, among 17 ski resorts in Korea, 3 ski resorts will be driven out of business by 2030s, 12 more ski resorts by 2060s and remaining 2 ski resort by 2090s will end the business. It means that smaller ski resorts has higher chance of facing difficulties in running business just as large scale ski resorts. Therefore, to sustain the ski business, technical and managerial efforts to adapt to the changing environment is needed.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1993.04a
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• pp.74-74
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• 1993

The in vitro cytotoxicity of SKI 2053R was evaluated against human tumor cell lines along with those of cisplatin and carboplatin using MTT assay. The cell lines tested were two human lung cancer cell lines and five human stomach cancer celt lines. The level of cytotoxic effects of SKI 2053R against two human lung cancer cell lines was located between cisplatin and carboplatin. However, the cytotoxic activity of SKI 2053R against five human stomach cancer cell lines was similar to that of cisplatin. SKI 2053R is considered to be selectively cytotoxic toward human stomach cancer cell lines. We carried out pharmacokinetic and ex vivo phrmacodynamic studies of SKI 2053R in beagle dogs to predict the clinical antitumor effect of SKI2053R, comparing with those of cisplatin and carboplatin. In ex vivo pharmacodynamics which used MTT assay as bioassay on the 2 lung and 5 stomach cancer cell, mean antitumor indexes (ATIs) of SKI 2053R were highest among three compounds in both lung and stomach cancer cell lines, especially in stomach cancer cell. Much higher ATI profile and maximal inhibition rates of SKI 2053R appeared in the stomach cancer cells will give desirable advantages to clinical trial s against gastric carcinoma. The anti tumor activity and target organ toxicity of SKI 2053R were compared with those of cisplatin on stomach cancer cell line, KATO III xenografted into nude BALB/c(nu/nu) mice. All groups of cisplatin and SKI 2053R showed active tumor regression. The inhibition rates(IR) of SKI 2053R were higher than that of cisplatin on the basis of mean IR. Though the loss of body weight was observed in all groups from the first week, the SKI 2053R group recovered it soon from the third week after the initiation of treatment, maintaining the most active anti tumor activity among three groups.

• Fashion & Textile Research Journal
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• v.25 no.2
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• pp.199-209
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• 2023

This study identified design elements of the functions required for children's ski pants. Data for this study were collected through questionnaire surveys conducted among children's ski instructors and children's sportswear developers. Five functionalities of children's skiwear were evaluated: mobility, stability, comfort, protection, and convenience. A total of 25 functional design elements related to the patterns, design details, and physical characteristics of fabrics for ski garments, were evaluated. The results of this study are as follows. First, children's sportswear developers evaluated that the pattern elements were important. Most of the pattern design elements highly related to mobility. Children's ski instructors' appraisal was that the height of the back waist was the important feature. Second, regarding the design details, children's ski instructors evaluated the size adjustment function and ventilation system as important elements. Many design detail elements were highly related in respect of stability, comfort, protection, and convenience. Third, the physical characteristics of fabric were strongly associated with mobility, comfort, and protection. As regards the physical characteristics of fabric, children's ski instructors valued anti-fouling highly, but children's sportswear developers attached more importance to the weight of the fabric. The results of this study will be useful in designing functional ski pants for children of elementary and intermediate ski levels. Since there may be limitations related to the ski level and age of children wearing ski pants, it is suggested that follow-up studies according to various groups of the ski pant wearers should be done.

• Journal of the Korean Society of Safety
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• v.24 no.2
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• pp.13-16
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• 2009

A ski lifter for winter sports is one of the necessary and familiar facilities. But recently safety concern about ski lifter has been built. The ski lifter crash in Pocheon happened recently showed an example of safety concern and frigidity for safety awareness. In this report, the cause of the ski lifter crash in Pocheon was reviewed, and some suggestions were made to prevent a similar accident base on this review.

• Toxicological Research
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• v.8 no.2
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• pp.235-253
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• 1992

A subacute toxicity study of cis-Malonato[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane]platinum(II)(SKI 2053R) was carried out to obtain information on its toxicological profiles, and to determine the maximum tolerated dose in beagle dogs. Four groups of beagle dogs (2M and 2F per group, 0,0.5,1.0,2.0mg/kg/day)were given 15 i.v. injections of SKI 2053R. In order to compare the toxic effects of SKI 2053R with those of cisplatin, one group was treated with cisplatin(0.7mg/kg/day)according to the same treatment schedule. The dosing schedule was divided into 3 courses of 5 consecutive days with 23-day dose-free intervals between each course. After completion of the treatments, remaining dogs were necropsied under established guidelines. Three of four dogs in the high dose group and one of four dogs in the middle dose group treated with SKI 2053R died of hypovolemic shock secondary to hemorrhagic and ulcerative enterocolitis. No toxicity-related mortality occurred in the low dose group of SKI 2053R. No survivor was observed in the group of cisplatin. Clinical signs including vomiting, diarrhea, anorexia and loss body weight were apparent in dogs given either cisplatin or high and middle doses of SKI 2053R. Severe thrombocytopenia and leukocytopenia were observed in the high dose group of SKI 2053R and cisplatin-treatment group, while toxicities as bone marrow suppression were reversible. The significant elevation of serum ALP values in group of SKI 2053R(2.0 mg/kg/day and 1.0mg/kg/day) and cisplatin(0.7mg/kg/day)was observed. Slight proteinuria waa observed in high and middle dose level groups of SKI 2053R. In histopathological examinations, pathological alterations of liver, kidney and spleen were noted dose-dependantly in dogs treated with SKI 2053R, and there was no overt sign of toxicity in low dose group of SKI 2053R. Compared to SKI 2053R, more severe durg-related toxicities occurred in dogs treated with cisplatin. It waw estimated that maximum tolerated dose of SKI 2053R in this treatment schedule was 0.5~0.7mg/kg/day. In conclusion, overall toxic potential of SKI 2053R was approximately 3 times lower than that of cisplatin with respect of lethality.

• Journal of Embryo Transfer
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• v.26 no.4
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• pp.237-244
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• 2011

Ski protein is implicated in proliferation/differentiation in a variety of cells. We had previously reported that Ski protein is present in granulosa cells of atretic follicles, but not in preovulatory follicles, suggesting that Ski has a role in apoptosis of granulosa cells. The alternative fate of granulosa cells other than apoptosis is to differentiate to luteal cells, however, it is unknown whether Ski is expressed and has a role in granulosa cells undergoing luteinization. Thus, the aim of the present study was to examine whether the initiation of luteinization with luteinizing hormone (LH) directly regulates expression of Ski in the luteinized granulosa and luteal cells after ovulation by in vitro models. RT-PCR and real time PCR analysis respectively revealed that LH had no effect on c-Ski mRNA expression in the cultured granulosa cells regardless of LH treatment. Though Ski protein is absent in granulosa cells of preovulatory follicle, its mRNA (c-Ski) was expressed and the level was unchanged even after LH surge. Taken together, these results demonstrated that Ski protein expression is induced in granulosa cells upon luteinization, and suggested that its expression is regulated post-transcriptionally. Moreover, expression of mRNA of Arkadia, an E3 ubiquitin ligases, in luteinizing granulosa cells in vivo was assessed by realtime-PCR. The levels of Arkadia mRNA expression were unchanged during follicular growth and postovulatory luteinization. These findings suggest that Ski protein level may be regulated during luteinization at translational and/or post-translational level but not by Arkadia.

• Reproductive and Developmental Biology
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• v.35 no.3
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• pp.341-348
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• 2011

Sloan-Kettering virus gene product of a cellular protooncogene c-Ski is an unique nuclear pro-oncoprotein and belongs to the Ski/Sno proto-oncogene family. Ski plays multiple roles in a variety of cell types, it can induce both oncogenic transformation and terminal muscle differentiation when expressed at high levels. The aim of the present study was to locate Ski protein in rat ovaries in order to predict the possible involvement of Ski in follicular development and atresia. First, expression of c-Ski mRNA in the ovaries of adult female rats was confirmed by RT-PCR. Then, ovaries obtained on the day of estrus were subjected to immunohistochemical analysis for Ski and proliferating cell nuclear antigen (PCNA) in combination with terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL). Ski was expressed in granulosa cells that were positive for TUNEL, but negative for PCNA, regardless of the shape and size of follicles. Expression of Ski in TUNEL-positive granulosa cells, but not in PCNA-positive granulosa cells, was also verified in immature hypophysectomized rats having a single generation of developing and atretic follicles by treatment with equine chorionic gonadotropin (eCG). These results indicate that Ski is profoundly expressed in the granulosa cells of atretic follicles, but not in growing follicles, and suggest that Ski plays a role in apoptosis of granulosa cells during follicular atresia.

• Korean Journal of Applied Biomechanics
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• v.24 no.4
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• pp.425-433
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• 2014

The purpose of the study was to investigate the effect of CAD (Computer Aided Design) based alpine mono-ski bucket design on disabled ski athletes' kinematic characteristics. Two national team ski athletes with LW11 disabilities (Locomotion Winter Classification) category for sit ski participated in both pre and post experiment. Both of the subjects performed 3 trials of carved turn on a ski slope under two conditions. Where, subject "A" performed pre experiment with personal bucket and post experiment with the newly developed CAD based bucket whereas, Subject "B" as control subject performed both pre and post experiment with his personal bucket. For the experiment, 24 Infrared cameras were positioned on the ski slope which covered the path of the ski turn. Also, motion capture suit with reflective markers were worn by both subjects. In the result, decrement in medial/lateral displacement of COM, anterior/posterior displacement of COM, flexion/extension angle of trunk as well as velocity losing rate of COM was observed in subject "A" when using the newly developed CAD based bucket. In contrast, no larger effect on performance was observed when using personal buckets. In conclusion, the findings obtained from the study indicated effectiveness of newly developed CAD based bucket by reducing excessive movement of hip and trunk which is an important factor to perform an effective turn.

• Journal of the Ergonomics Society of Korea
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• v.17 no.1
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• pp.115-123
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• 1998

We study the ski wear which are compared at the materials and the designes and their human physiological and phychological response during exercise in a cold and air-conditioned enviroments. Five men exercises in the experiment room with four types of ski-wears : two of one-piece and two of two-piece : two of special material and two of a normal material, respectively. We keep the environment at $-5^{\circ}C$ and speed of 3.6 mile/hr during the measurement of 13 points, which is a mean model of the Muju ski-resort at January 1996. We conclude the followings : 1. The ski-wear with special materials have higher than the normal type at mean skin temperature and rectal temperature. 2. Changes of temperature withing the clothes during the exercise is small, but the humidity within the clothes abruptly increases because of the weight loss. 3. Type A ski-wear with the special material has $295.5g/m^2hr$ weight loss, which is higher, and type D ski-wear is smaller 4. The special material shows comfortable in the thermal sensation. 5. In the design aspect of the ski-wears, the two-piece type ski-wear shows higher skin temperature and temperature & humidity within the clothes than the one-piece type due to the effect of the multiplicity.

• Biomolecules & Therapeutics
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• v.4 no.1
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• pp.19-31
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• 1996

This study was performed to determine the subacute toxicities of SKI306X, an antiinflammatory herbal extract, in rats. SKI306X was administered orally to rats once a day for 4 weeks at doses of 0.3, 1.0, and 3.0 g/kg/ day. Each group consisted of 20 male and 20 female rats, including 5 male and 5 female rats per group for an interim study at the end of 2-week administration and for a 2-week recovery study, respectively. Throughout the study, all rats survived and no adverse clinical signs were observed. Although male rats treated with high dose (3.0 g/kg/day) of SKI306X showed slight loss of body weight (approximately 5%) in comparison with control animals during the administration period, their body weight loss was normally restored during the recovery period. No significant change was found in all hematological parameters of SKI306X-treated groups except for the decreased number of red blood cells in all female groups at the interim study. Statistically significant changes were observed in several blood enzyme levels of SKI306X-treated groups; however, most of these significant changes were within normal range and statistically significant values did not show dose-related responses. In SKI306X-treated groups, the absolute and relative weights of liver, heart, and stomach were statistically different from those of control group, but these differences disappeared at the end of recovery period and also drug-related gross and histopathological findings in these organs were not found. No other drug-related gross and histopathological findings were observed. It is concluded from the results of this study that non-toxic dose of SKI306X was estimated to be between 0.3 and 1.0 g/kg/day and the maximum tolerated dose of SKI306X was assumed to be higher than 3.0 g/kg/day.