• Imaging Science in Dentistry
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• 제47권3호
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• pp.157-164
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• 2017

Purpose: This study determined and compared the distances from the maxillary root apices of posterior teeth to the floor of the maxillary sinus, or maxillary sinus distances(MSDs), and the distances from the mandibular root apices of the posterior teeth to the mandibular canal, or mandibular canal distances(MCDs), in Thai subjects with skeletal open bite and skeletal normal bite. Materials and Methods: Pretreatment cone-beam computed tomography (CBCT) images were obtained from 30 Thai orthodontic patients (15 patients with skeletal normal bite and 15 with skeletal open bite) whose ages ranged from 14 to 28 years. The CBCT images of the patients were processed and measured using the Romexis Viewer program. The MSDs and MCDs from the root apices of the maxillary and mandibular second premolar, first molar, and second molar to the maxillary sinus floor or the mandibular canal were measured perpendicularly to the occlusal plane. The Student t test was used for comparisons between the 2 groups. Results: The greatest mean MSDs were from the root apex of the second premolars in both groups, whereas the least mean MSDs were from the mesiobuccal root apex of the second molars. The greatest mean MCDs were from the mesial root apex of the first molars, whereas the least mean MCDs were from the distal root apex of the second molars. Conclusion: There were no differences in the mean MSDs or the mean MCDs between the skeletal normal bite group and the skeletal open bite group.

• 대한골관절종양학회지
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• 제8권2호
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• pp.48-53
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• 2002

상피암의 인접 골격근으로의 직접 전파는 많이 보고되었으나, 골격근으로의 원격전이는 드물고 특히 다발성 전이는 매우 드문 것으로 알려져 있다. 골격근내의 가변적인 혈류량, 근수축이나 난류성 혈류 등과 같은 물리적인 요인, 골격근내의 산성 환경, 젖산, 세포외 기질의 단백분해효소 억제인자 등이 골격근으로의 원격 전이를 억제하는 원인으로 제시되고 있다. 저자들은 최근 다발성 골격근 전이를 동반한 신장암(이행성 상피세포암) 1례를 경험하였기에 이를 보고하는 바이다.

• Nutrition Research and Practice
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• 제12권3호
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• pp.222-232
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• 2018

BACKGROUND/OBJECTIVES: Since gain or loss of skeletal muscle mass is a gradual event and occurs due to a combination of lifestyle factors, assessment of dietary factors related to skeletal muscle is complicated. The aim of this study was to investigate the changes in total energy intake according to the level of skeletal muscle mass. SUBJECTS/METHODS: A total of 8,165 subjects ${\geq}30years$ of age from the Korean National Health and Nutrition Examination Surveys (KNHANES) 2008-2011 were included in the analysis, and multivariate-adjusted regression analyses were performed to analyze the association of the quartiles of sarcopenia index (SI) with energy intake of the study population after adjusting for age and metabolic parameters. RESULTS: The increase in SI quartile was in proportion to the gradual decrease in systemic lipids and the anthropometric measurement of fat accumulation (P < 0.001). Subjects in higher SI quartiles tended to consume more total energy and energy-producing nutrients than those in lower quartiles (P < 0.001). After age, body weight, alcohol consumption, and metabolic parameters were adjusted in the analysis, total energy intake gradually increased according to the increase in SI quartile, and the association between total energy intake and SI was more pronounced in men. However, the risk (odd ratio) of having a low SI was not affected by any single macronutrient intake. CONCLUSION: In this study, total energy intake was positively associated with SI and relative skeletal mass in both men and women. However, no significant association or a weak association was observed between any single macronutrient intake and skeletal muscle mass. The data indicated that acquiring more energy intake within the normal range of energy consumption may help to maintain skeletal muscle mass.

• 대한소아치과학회지
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• 제46권3호
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• pp.233-238
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• 2019

본 연구의 목적은 한국 소아청소년 표준 골연령 도표를 이용하여 평가한 SMI 및 MP3 단계별 골연령을 조사하여 최대 성장기에 해당하는 단계를 알아보고, 이를 통해 성장 중인 부정교합 환자의 치료 계획 수립, 치료방법 및 시기에 중요한 영향을 미치는 성장 발육평가 자료를 제공하고자 함이다. 이대목동병원 소아청소년과에 내원한 363명의 환자의 수완부 방사선 사진에서 한국 소아 청소년의 표준 골연령 도표를 바탕으로 영상의학과 의사에 의해 판정된 골연령을 조사하였다. 동일한 방사선 사진에서 평가된 SMI 및 MP3 단계에 따른 평균 골연령을 산출하였다. 본 연구 결과 사춘기 최대 성장기가 남아에서는 SMI 4 - 5단계 및 MP3 FG - G단계, 여아에서는 SMI 3 - 4단계 및 MP3 F - FG단계에서 나타남을 확인하였다.

• Asian-Australasian Journal of Animal Sciences
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• 제32권6호
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• pp.757-766
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• 2019

Objective: MicroRNAs are a class of endogenous small regulatory RNAs that regulate cell proliferation, differentiation and apoptosis. Recent studies on miRNAs are mainly focused on mice, human and pig. However, the studies on miRNAs in skeletal muscle of sheep are not comprehensive. Methods: RNA-seq technology was used to perform genomic analysis of miRNAs in prenatal and postnatal skeletal muscle of sheep. Targeted genes were predicted using miRanda software and miRNA-mRNA interactions were verified by quantitative real-time polymerase chain reaction. To further investigate the function of miRNAs, candidate targeted genes were enriched for analysis using gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) enrichment. Results: The results showed total of 1,086 known miRNAs and 40 new candidate miRNAs were detected in prenatal and postnatal skeletal muscle of sheep. In addition, 345 miRNAs (151 up-regulated, 94 down-regulated) were differentially expressed. Moreover, miRanda software was performed to predict targeted genes of miRNAs, resulting in a total of 2,833 predicted targets, especially miR-381 which targeted multiple muscle-related mRNAs. Furthermore, GO and KEGG pathway analysis confirmed that targeted genes of miRNAs were involved in development of skeletal muscles. Conclusion: This study supplements the miRNA database of sheep, which provides valuable information for further study of the biological function of miRNAs in sheep skeletal muscle.

• Proceedings of the National Institute of Ecology of the Republic of Korea
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• 제3권1호
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• pp.32-40
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• 2022

The trade-off between morphology and physical function may vary according to ecological traits. Taking a quantitative approach, we attempted to analyze the differences in the skeletal shape of the lower body and limbs in relation to the ecological traits of four anuran species (Dryophytes japonicus, Glandirana rugosa, Pelophylax nigromaculatus, and Lithobates catesbeianus) occurring in South Korea. Body size, locomotor mode, microhabitat, trophic positions, and predator defense mechanisms were selected for the ecological traits of the anurans. The pelvis, ilium, and urostyle, which are associated with locomotor performance, were selected for the skeletal shape of the lower body. The ratio of limbs, which is related to locomotor mode and microhabitat, was confirmed by analyzing the skeletons of the forelimbs (radio-ulnar and humerus) and hindlimbs (femur and tibiofibular). Both landmark-based geometric morphometrics and traditional methods were used for skeletal shape comparison. The skeletal shape of the lower body was completely different among the four species, whereas the ratio of the limbs was only different in D. japonicus. The skeletal shape of the lower body may be related to body mass and predator defense mechanisms, whereas the ratio of the limbs was related to the locomotor mode and microhabitat. Quantifying these morphological differences among various species can help elucidate the mechanisms of behavioral and morphological changes in response to ecological effects.

• Imaging Science in Dentistry
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• 제52권1호
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• pp.19-25
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• 2022

Purpose: This study evaluated the distance from the posterior root apices to the maxillary sinus floor (MSF) and the frequency of roots touching or protruding through the MSF using cone-beam computed tomography (CBCT). Materials and Methods: This study included 100 subjects divided into different vertical and anteroposterior skeletal growth patterns. On CBCT images, the distance from the posterior root apices to MSF was measured and the frequency of roots touching or protruding through the MSF was evaluated using NNT software (version 5.3.0.0; ImageWorks, Elmsford, NY, USA). Results: No statistically significant differences were found in the distance from the posterior root apices to the MSF among vertical skeletal groups (P>0.05). The palatal roots of the first molar and the palatal, mesio-buccal and disto-buccal roots of the second molars had significantly less distance from MSF in skeletal class II than in class III (P<0.05). The high-angle group had the highest frequencies of roots touching or protruding into the maxillary sinus (49.8%); the lowest proportion of these roots was found in skeletal class III (28.3%) and the highest proportion in class II (50.3%). Males had shorter distances from the posterior root apices to the MSF and higher frequencies of roots protruding through or touching the MSF than females. Conclusion: Anteroposterior skeletal growth patterns and sex affected the distances from the maxillary posterior roots to the MSF. The frequency of roots protruding into or touching the sinus was affected by both vertical and anteroposterior skeletal groups and sex. These findings have implications for dental practice.

• 운동영양학회지
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• 제17권2호
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• pp.35-42
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• 2013

The purpose of this study was to identify the effects of gene expression of endoplasmic reticulum (ER) stress in skeletal muscle and adipose tissue on acute exhaustive exercise. Thirty-five Sparague Dawley male rats were divided into a control group (CON, n = 7) and a exhaustive exercise group (n = 28), immediately after exhaustive exercise group (n = 7), after 30 minutes exhaustive exercise group (n = 7), after 60 minutes exhaustive exercise group (n = 7), after 180 minutes exhaustive exercise group (n = 7). As a result, changes in the composition of the blood serum triglyceride concentration increased significantly in immediately after exhaustive exercise group, On the contrary, blood glucose showed a significantly decreased (p < .05). Homeostasis of energy metabolism due to exhaustive exercise as a result of the mechanism of action of skeletal muscle in the glycogenolysis and absorption, which indicates that the process of means. On the other hand, a result of examining changes in endoplasmic reticulum stress-related proteins in skeletal muscle and adipose tissue, JNK1 except in skeletal muscle BiP, ATF4, CHOP, GRP78 mRNA increased significantly immediately after exercise, and after 30 minutes returned to normal levels that could be confirmed (p < .05). BiP mRNA in adipose tissue show a similar pattern and skeletal muscle increased significantly immediately after exercise, but other changes in the specificity of the endoplasmic reticulum stress-related proteins also did not appear. In conclusion, Exercise applies and exercise training duration and exercise intensity as well as research on the interaction of the endoplasmic reticulum stress-related genes should be study continuously, to be more clear.

• Endocrinology and Metabolism
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• 제37권2호
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• pp.333-343
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• 2022

Background Homocysteine has been drawing attention with a closed linkage with skeletal muscle. However, the association of hyperhomocysteinemia with decreased skeletal muscle mass remains unclear. We aimed to investigate the association of hyperhomocysteinemia with low skeletal muscle mass (LMM) in asymptomatic adults. Methods This was a cross-sectional study of 114,583 community-dwelling adults without cancer, stroke, or cardiovascular diseases who underwent measurements of plasma homocysteine and body composition analysis from 2012 to 2018. Hyperhomocysteinemia was defined as >15 µmol/L. Skeletal muscle mass index (SMI) was calculated based on appendicular muscle mass (kg)/height (m)². Participants were classified into three groups based on SMI: "normal," "mildly low," and "severely low." Results The prevalence of hyperhomocysteinemia was the highest in subjects with severely LMM (12.9%), followed by those with mildly LMM (9.8%), and those with normal muscle mass (8.5%) (P for trend <0.001). In a multivariable logistic regression model, hyperhomocysteinemia was significantly associated with having a mildly LMM (odds ratio [OR], 1.305; 95% confidence interval [CI], 1.224 to 1.392) and severely LMM (OR, 1.958; 95% CI, 1.667 to 2.286), respectively. One unit increment of log-transformed homocysteine was associated with 1.360 and 2.169 times higher risk of having mildly LMM and severely LMM, respectively. Conclusion We demonstrated that elevated homocysteine has an independent association with LMM in asymptomatic adults, supporting that hyperhomocysteinemia itself can be a risk for decline in skeletal musculature.

• 대한치과교정학회지
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• 제30권2호
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• pp.143-157
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• 2000

본 연구는 성장중인 부정교합 환자의 진단이나 치료계획의 수립, 치료방법 및 시기, 예후등을 결정하는데 중요한 판단의 지침이 되는 치아성숙도와 경추 및 수완부 골 성숙도의 연령별 성숙정도와 이들 상호간의 연관성을 규명하여 개인의 보다 정확하고 효율적인 성장정도를 평가하기 위해 조선대학교 치과대학 부속치과병원 교정과에 내원한 환자중, 동일한 날짜에 촬영된 측모두부방사선규격사진과 수완부방사선사진 및 파노라마사진이 모두 있으며, 성장발육에 영향을 미칠 수 있는 구개파열 및 구순열등의 선천적 기형이 없는 1055명 (남자 458명, 여자 597명)을 연구대상으로 하여 상, 하악의 견치, 제1소구치, 제2소구치, 제2대구치의 치아성숙도와 경추 (CVMI)및 수완부 (SMI)의 골성숙도를 측정하여 다음과 같은 결과를 얻었다. 1. 남녀모두에서 치아성숙도와 경추 및 수완부 골성숙도 사이에 통계적으로 유의한 상관관계가 있었다 (P<0.001). 2. 남녀모두에서 수완부 골성숙도와 경추의 골성숙도 사이에 0.91-0.93의 높은 상관관계를 보였다. 3. 남녀모두에서 수완부 골성숙도와 상,하악의 견치, 제1소구치, 제2소구치 성숙도 사이에 0.8이상의 높은 상관관계를 보였다. 4. 경추의 골성숙도는 상악견치의 성숙도와 0.8의 높은 상관관켸를 보였다. 5. 남녀모두에서 연령별 경추 및 수완부의 골성숙단계와 치아성숙단계를 구하였다. 이상을 종합해볼 때, 경추 및 수완부 골성숙도와 치아성숙도는 개인의 사춘기 성장정도를 평가하여 부정교합 환자의 진단 및 치료계획을 수립하는데 유용한 정보를 제공할 수 있을 것으로 생각된다.면 서울시 환자가 전체 내원 환자의 $70\%$이상 차지하는 것으로 조사되었으며 서울시 내원환자중 연세대학교 치과병원을 중심으로 반경 3-6km의 거주자가 $32.3\%$로 가장 높게 나타났고 반경 9Km이내에서 전체의 $69\%$를 차지하였다. 4. 수평피개보다는 수직피개가 치근흡수에 미치는 영향이 컸으며 개방교합의 경향이 커질수록 치근흡수의 빈도가 높았다. 5. 개개 치아에서 나타나는 부정교합의 특징에 대해서는 반대교합과 개방교합을 함께 나타내는 치아에서 치근흡수의 빈도가 가장 높았다.를 보이지 않았는데 이는 다른 연구 결과와 유사한 결과이다.고 사료된다. 6. 치료전에는 차이가 없던 남,여군 사이에 치료후에 차이가 나타나는 것은 치료 효과에 관계없이 남여에 따른 성장양상의 차이가 그대로 표현된 것으로 사료된다. 연구는 거대 편도를 가진 기능성 III급 부정 교합자의 구개 편도 절제술 전후의 인두강, 설골, 두부 위치의 변화 양상에 대해 알아보기 위해 단국 대학교 부속 치과 병원 교정과에 내원한 남녀 환자 42명을 대상으로 연구하여 다음과 같은 결론을 얻었다. $55.19\%$로 첨가량이 증가하면서 두 항목 모두 크게 감소하는 결과를 보였다. 색도를 분석한 결과 L값, a값, b값 모두 표고버섯 분말 함량이 증가하면서 감소하였고, 모든 처리구에서 기존 무첨가구와 극히 현저한 차이를 보이는 것으로 나타났다. 시료별 관능검사 결과에서 색 (color), 먹을때의 느낌 (chewiness)과 단맛(sweetness)의 경우 무첨가구와