• Asian Pacific Journal of Cancer Prevention
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• v.15 no.6
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• pp.2571-2576
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• 2014

Background: Published studies on the association between the exonuclease 1 (EXO1) Glu589Lys polymorphism and cancer susceptibility have yielded conflicting results. Thus, a meta-analysis of published studies was performed to assess the possible association. Materials and Methods: All eligible case-control studies published up to January 2013 on the association between the EXO1 Glu589Lys polymorphism and cancer susceptibility were identified by searching PubMed, Web of Science, Science Direct and hand search. Either fixed-effect or random-effect models were used to calculate pooled odds ratios (ORs) with 95% confidence intervals (CIs) using the Comprehensive Meta-Analysis software version 2.2. Results: A total of 4,391 cancer cases and 4,339 controls from 10 studies were included. Overall, no significant association between the EXO1 Glu589Lys polymorphism and cancer susceptibility was observed in either genetic model. However; in subgroup analyses by cancer type, a significant association between EXO1 Glu589Lys and lung cancer risk was found (Lys vs Glu: OR=1.23, 95%CI=1.07-1.41, $p_{heterogeneity}$=0.05). Further, subgroup analysis by ethnicity indicated that there was a statistically increased cancer risk in Asians (Lys vs Glu: OR=1.42, 95%CI=1.30-1.55, $p_{heterogeneity}$=0.07; Lys/Lys vs Glu/Glu: OR=1.93, 95%CI=1.20-3.12, $p_{heterogeneity}$=0.01; Lys/Lys+Glu/Lys vs Glu/Glu: OR=1.52, 95%CI=1.37-1.68, $p_{heterogeneity}$=0.42; Lys/Lys vs Glu/Lys+Glu/Glu: OR=1.68, 95%CI=1.07-2.65, $p_{heterogeneity}$=0.02). However, significant association was absent in Caucasians. Conclusions: This meta-analysis suggests, for the first time, that the EXO1 Glu589Lys polymorphism is not associated with overall cancer susceptibility, although marginal associations were found for lung cancer and Asian subgroups. Additional well-designed studies with larger sample size focusing on different ethnicities and cancer types are needed to confirm these findings.

• Proceedings of the Korean Geotechical Society Conference
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• 2006.03a
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• pp.939-948
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• 2006

The structural anisotropy and heterogeneity of rock mass, caused by discontinuities and weak zones, have a great influence on the deformation behavior of tunnel. Tunnel construction in these complex ground conditions is very difficult. No matter how excellent a geological investigation is, local uncertainties of rock mass conditions still remain. Under these uncertain circumstances, an accurate forecast of the ground conditions ahead of the advancing tunnel face is indispensable to safe and economic tunnel construction. This paper presents the effect of anisotropy and heterogeneity of the rock masses to be excavated by numerical analysis. The influences of distance from weak zone, the size or dimension, the different stiffness and the orientation of weak zones are analysedby 2-D and 3-D finite element analysis. By analysing these numerical results, the tunnel behavior due to excavation can be well understood and the prediction of rock mass condition ahead of tunnel face can be possible.

• Journal of Soil and Groundwater Environment
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• v.16 no.6
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• pp.1-9
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• 2011

A bibliographical review of Gy sampling theory for particulate materials was conducted to provide readers with useful means to reduce errors in soil contamination investigation. According to the Gy theory, the errors caused by the heterogeneous nature of soil include; the fundamental error (FE) caused by physical and chemical constitutional heterogeneity, the grouping and segregation error (GE) aroused from gravitational force, long-range heterogeneous fluctuation error ($CE_2$), the periodic heterogeneity fluctuation error ($CE_3$), and the materialization error (ME) generated during physical process of sample treatment. However, the accurate estimation of $CE_2$ and $CE_3$ cannot be estimated easily and only increasing sampling locations can reduce the magnitude of the errors. In addition, incremental sampling is the only method to reduce GE while grab sampling should be avoided as it introduces uncertainty and errors to the sampling process. Correct preparation and operation of sampling tools are important factors in reducing the incremental delimitation error (DE) and extraction error (EE) which are resulted from physical processes in the sampling. Therefore, Gy sampling theory can be used efficiently in planning a strategy for soil investigations of non-volatile and non-reactive samples.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.10
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• pp.4943-4946
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• 2012

Studies have reported an association between the TERT rs2736098 single nucleotide polymorphism (SNP) and cancer susceptibility, but the results remain inconclusive. Toprovide a more precise estimation of the relationship, a meta-analysis of 8 published studies including 8,070 cases and 10,239 controls was performed. Stratification by sample size, genotyping method, source of controls and ethnicity were used to explore the source of heterogeneity. In the overall analysis, no significant association was found between the TERT rs2736098 polymorphism and cancer risk. However, the result showed the rs2736098 was significantly associated with an increased cancer risk and the heterogeneity was effectively decreased for homozygote comparison by removal of two studies: OR = 1.337 (95% CI = 1.183-1.511; Pheterogeneity = 0.087). In the subgroup analysis by ethnicity, a significantly increased risk of cancers was found among Asians (OR = 1.413, 95% CI = 1.187-1.683 for AA versus GG). Our meta-analysis did not show that the TERT rs2736098 plays an important role in cancer risk. More studies with larger sample size and well-matched controls are needed to confirm the findings.

• The KIPS Transactions:PartC
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• v.12C no.3 s.99
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• pp.443-448
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• 2005

Efficient using of the web cache is becoming important factors that decide system management efficiency in the web base system. The cache performance depends heavily on the replacement algorithm which dynamically selects a suitable subset of objects for caching in a finite cache space. In this paper, the web caching algorithm is proposed for the efficient operation of the web base system. The algorithm is designed based on a divided scope that considered size reference characteristic and heterogeneity on web object. With the experiment environment, the algorithm is compared with conservative replacement algorithms, we have confirmed more than $15\%$ of an performance improvement.

• Computers and Concrete
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• v.2 no.5
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• pp.345-366
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• 2005

This work presents an assessment of the computational performance of a vector-parallel implementation of probabilistic model for concrete cracking in 3D. This paper shows the continuing efforts towards code optimization as reported in earlier works Paz, et al. (2002a,b and 2003). The probabilistic crack approach is based on the direct Monte Carlo method. Cracking is accounted by means of 3D interface elements. This approach considers that all nonlinearities are restricted to interface elements modeling cracks. The heterogeneity governs the overall cracking behavior and related size effects on concrete fracture. Computational kernels in the implementation are the inexact Newton iterative driver to solve the non-linear problem and a preconditioned conjugate gradient (PCG) driver to solve linearized equations, using an element by element (EBE) strategy to compute matrix-vector products. In particular the paper analyzes code behavior using OpenMP directives in parallel vector processors (PVP), such as the CRAY SV1 and CRAY T94. The impact of the memory architecture on code performance, and also some strategies devised to circumvent this issue are addressed by numerical experiment.

• Journal of Technology Innovation
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• v.12 no.1
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• pp.189-218
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• 2004

In this paper, we estimate consumers' preferences for the key attributes of the future mobile telecommunication terminal using conjoint analysis. For statistical model, we estimate the mixed legit model which can reflect the heterogeneity of consumers' preferences, using the Bayesian approach with Gibbs sampling. The results show that there are large variations in consumers' preferences for the attributes of the future mobile telecommunication terminal, which justifies our using of mixed logit model. Also, the results show that most consumers prefer the medium size display and keyboard as input equipment. Additionally, far from general prediction, the results show that many consumers are indifferent to whether the future mobile telecommunication terminal is able to provide high quality internet service or not, and to operate many application programs and programs originally designed for PC. From those results, we can obtain some important implications for the R＆D strategies. Additionally, the results on the heterogeneity of consumers' preferences reveal that it is possible that the complete device convergence may not happen.

• Korean Journal of Environmental Biology
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• v.21 no.4
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• pp.337-341
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• 2003

Habitat heterogeneity can enhance biological diversity by providing variation in structural diversity. This paper reviewed heterogeneous habitat serves as a population stability and superior demographic performance (e.g., high density, survivorship, reproductive rate) can be observed compared with organisms with inferior demographic performance. The idea of habitat variation has been further developed in modelling. Furthermore the size and configuration (distribution) of a patch (of a particular habitat type) become effective for the stability of population through hiding places and food resources. Species diversity is related to habitat complexity that provides structural diversity to ground -dwelling organisms. Finally coarse woody debris can enhance habitat complexity thus stabilizing population fluctuation and increasing survivorship.

• Asia pacific journal of information systems
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• v.24 no.4
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• pp.531-557
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• 2014

Although the area of information security planning and management has gained an increased attention, not much discussion was available on the role and the impact of the board members towards a firm's security management and governance decisions. In this research, we draw on corporate governance and the organizational demography literature to conduct an exploratory empirical study on the association between the board structure of a firm and the possibility of information security breaches. Our results show that the board size, the average age/tenure and the heterogeneity of age could reduce the possibility of security breaches while the proportion of independent directors and the heterogeneity of tenure could increase it. Our findings shed lights on the important role played by the board when managing information security risks in organizations.

• International Journal of Advanced Culture Technology
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• v.9 no.1
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• pp.1-6
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• 2021

This study aims to test the relationship between the change in population size and population composition and crime changes. The analytical model includes variables representing changes in population size and population composition, three dependent variables for crime changes, and three control variables. Changes in popuvpdllation size and population composition are measured by indicators such as population size, gender, age groups, and immigrants and foreign workers, and crime changes by felonious, burglary, and violent crime volumes. The sample includes 154 cities and counties in South Korea, and the sample period is from 2010 to 2017. As a result of the analysis, I examine that the decrease in the number of young and men are likely to lead to a decline in felonious and violent crimes, but a high rate of the elderly and the increasing racial heterogeneity are likely to accelerate the fear and worries about crimes.