• 한국멀티미디어학회논문지
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• 제23권8호
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• pp.903-914
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• 2020

In this paper, we present a novel algorithm to generate a 3D model of patient-specific orbital implant, which is finally produced by the 3D printer. Given CT (computed tomography) scan data of the defective orbital wall or floor, we compose the depth image of the defect site by using the depth buffering, which is a computer graphics technology. From the depth image, we compute the 3D surface which fills the broken part by interpolating the points around the broken part. By thickening the 3D surface, we get the 3D volume mesh of the orbital implant. Our algorithm generates the patient-specific orbital implant whose shape is accurately coincident to the broken part of the orbit. It provides the significant time efficiency for manufacturing the implant with supporting high user convenience.

• Journal of Pharmaceutical Investigation
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• 제22권4호
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• pp.251-266
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• 1992

A major problem with the peptide-based drugs is that these drugs must generally be administered by injection. Therefore, there is considerable research interest in alternative routes of delivery, such as buccal, nasal, gastrointestinal route and etc. Site-specific drug delivery to the colon, as an alternative to parenteral drug delivery, is of interest for the delivery of peptide-based drugs as well as the delivery of low molecular weight drugs for the treatment of colonic disease, This review describes some considerations of colon-specific drug delivery using hydrogels.

• BMB Reports
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• 제29권1호
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• pp.27-31
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• 1996

Using topoisomerase II (topo II) isozyme-specific antibodies, we investigated the phosphorylation of topo $II{\alpha}$ in mitotic HeLa cells. Topo $II{\alpha}$ was specifically modified in the mitotic cells, resulting in slow migration on SDS-polyacrylamide gel electrophoresis. To characterize the nature of this modification, we treated the nuclear extracts prepared from the mitotic cells with alkaline phosphatase. After the treatment with alkaline phosphatase, the slowly migrated band disappeared and instead a normal (170 kDa) topo $II{\alpha}$ band appeared. These results indicate that human topo $II{\alpha}$ is modified at a specific site(s) in M phase by phosphorylation, supporting the possibility that M phase-specific phosphorylation of topo II is critical for mitotic chromosome condensation and segregation.

• BMB Reports
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• 제31권6호
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• pp.525-535
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• 1998

A critical step in the faithful translation of genetic information is specific tRNA recognition by aminoacyl-tRNA synthetases. These enzymes catalyze the covalent attachment of particular amino acids to the terminal adenosine of cognate tRNA substrates. In general, there is one synthetase for each of the twenty amino acids and each enzyme must discriminate against all of the cellular tRNAs that are specific for the nineteen noncognate amino acids. Primary sequence information combined with structural data have resulted in the division of the twenty synthetases into two classes. In recent years, several high-resolution co-crystal structures along with biochemical data have led to an increased understanding of tRNA recognition by synthetases of both classes. The anticodon sequence and the amino acid acceptor stem are the most common locations for critical recognition elements. This review will focus on acceptor stem discrimination by class II synthetases. In particular, the results of in vitro aminoacylation assays and site-directed and atomic group mutagenesis studies will be discussed. These studies have revealed that even subtle atomic determinants can provide signals for specific tRNA aminoacylation.

• Nuclear Engineering and Technology
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• 제54권5호
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• pp.1781-1788
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• 2022

The containment building Kori Unit 1 may require sequential steps for full decommissioning. This study assumes that the containment building is to be used as an auxiliary building that handles nuclear power systems and materials during decommissioning before conversion into a greenfield. Through the derivation of guidelines and dose evaluation, it was confirmed whether the radiation workers were satisfied with the ALARA decision. The specific modeling of the external radiation exposure was performed based on the facility investigation procedures. The external radiation specific derived concentration guideline levels (DCGLs) for radiation workers in containment building were obtained using the RESRAD-BUILD code and were applied to the VISIPLAN 3D ALARA Planning Tool code to calculate the working dose and check worker safety. The derivation of site-specific and realistic DCGLs and dose evaluation via 3D modeling can contribute to the scenario development for the decommission and remediation of containment building.

• Genomics & Informatics
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• 제12권3호
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• pp.80-86
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• 2014

Foldback intercoil (FBI) DNA is formed by the folding back at one point of a non-helical parallel track of double-stranded DNA at as sharp as $180^{\circ}$ and the intertwining of two double helixes within each other's major groove to form an intercoil with a diameter of 2.2 nm. FBI DNA has been suggested to mediate intra-molecular homologous recombination of a deletion and inversion. Inter-molecular homologous recombination, known as site-specific insertion, on the other hand, is mediated by the direct perpendicular approach of the FBI DNA tip, as the attP site, onto the target DNA, as the attB site. Transposition of DNA transposons involves the pairing of terminal inverted repeats and 5-7-bp tandem target duplication. FBI DNA configuration effectively explains simple as well as replicative transposition, along with the involvement of an enhancer element. The majority of diverse retrotransposable elements that employ a target site duplication mechanism is also suggested to follow the FBI DNA-mediated perpendicular insertion of the paired intercoil ends by non-homologous end-joining, together with gap filling. A genome-wide perspective of transposable elements in light of FBI DNA is discussed.

• 대한수의학회지
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• 제41권3호
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• pp.343-350
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• 2001

The neutralization epitopes of the outer capsid protein VP4 of a porcine rotavirus, Gottfried strain, were studied using neutralizing monocolonal antibodies(N-MAbs). Eight N-MAbs which are specific for the VP4 of Gottfried strain were used for analyzing the antigenic sites of VP4. Three different approaches were used for this analysis; i)testing the serological reactivity of each N-MAb against different G and P types of human and animal rotavirusese ii) analyzing N-MAb-resistant viral escape mutants and iii) performing nucleotide sequence analysis of the VP4 gene of each N-MAb-resistant viral escape mutant. From experimental results, at least four antigenic sites(I, II, III, and IV) were identified. Antigenic site I recognized by N-MAbs 24B9, 23G10, and 26A2 was separated from antigenic site II recognized by N-MAbs 30H5, 32B3, and 29B3. However, these antigenic sites were overlapped with antigenic site III recognized by N-MAb 21A1. The other antigenic site IV recognized by N-MAb 16D2 was separated from antigenic sites I, II, and III.

• 생약학회지
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• 제32권3호통권126호
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• pp.212-218
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• 2001

The water extracts of 82 Korean medicinal herbs were prepared and were examined for the binding affinity on the glycine binding site of NMDA (N-methyl-D-aspartate) receptor prepared by the synaptic membranes from the forebrains of male Sprague-Dawley rats. Among the tested, the extracts of Dioscoreae Rhizoma, Hoveniae Semen cum Fructus, Astragali Radix, Armeniacae Semen, Huttuynia cordata Herba, Acanthopanacis Cortex, Aurantii nobilis Pericarpium, Phellinus linteus, Amomi Fructus, Artemisiae capillaris Herba, Polyporus, Agastachis Herba and of Galli Stomachichum Corium were found to exhibit significant competitions with $[^3H]-MDL$ 105,519 for the glycine specific binding site of NMDA receptor in a dose dependent manner, respectively.

• 방사성폐기물학회지
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• 제4권4호
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• pp.353-363
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• 2006

원자력시설 해체부지를 재이용하는 과정에서 유발될 수 있는 방사선학적 리스크를 사전에 선별하기 위한 목적으로 단순화된 방사선량 평가모델을 개발하고, 이를 Microsoft $Excel{\circledR}$ 스프레드시트와 내장된 Visual Basic 및 마크로 기능을 활용하여 기능별로 모듈화된 평가도구를 구현하였다. 이와 함께 부지 특성자료가 불충분할 경우 신속한 사전평가를 위해 적용할 수 있는 일련의 입력변수 값 목록을 제안하였다. 동일한 조건에서 이 연구에서 개발된 평가도구를 이용해 유도한 사전 선별준위가 RESRAD Ver.6.2를 이용해 계산된 유도농도지침한계 및 독일 방사선방호령에 규정된 핵종별 부지 재이용 기준농도를 합리적으로 근사할 수 있음을 확인하였다.

• 한국조리학회지
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• 제6권1호
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• pp.123-149
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• 2000

As a result of their web sites about 25 food services, it shows that only 20% of food services are conducting transactions online. As a whole food services in general have mastered the basics of setting up a web site, and it is revealed that some web sites with high average score are using flash s/w, which has a considerable interest in graphic. Family restaurant is the highest in average score and icecream is the lowest. The best individual site is Tonyromas site of Family restaurant sector, the second best site is TGI Friday's of the same Family restaurant sector, the third Pizzahut of pizza sector, and the fourth Lotteria site of Fast food sector. It is suggest that this preliminary study could be advanced by extending the sample size and a program of more extensive statistical analysis by devising. Also it is shows that it is possible for B2B transaction and B2C transaction to be conducted more actively It is suggested that Pizza(60%) and Icecream(40%) of food products which are small in size and easy to be ordered and delivered can be feasible and successful in transactions online. In conclusion, it is very important to keep the contents of web sites up-to-date and attractive to customers, and to establish several ways which can enable customers to interact with food services to induce a dialogue with customers, and it is necessary to introduce new technologies for specific differences of their own sites.