• Title/Summary/Keyword: Sire Model

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Evaluation of a New Fine-mapping Method Exploiting Linkage Disequilibrium: a Case Study Analysing a QTL with Major Effect on Milk Composition on Bovine Chromosome 14

  • Kim, JongJoo;Georges, Michel
    • Asian-Australasian Journal of Animal Sciences
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    • v.15 no.9
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    • pp.1250-1256
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    • 2002
  • A novel fine-mapping method exploiting linkage disequilibrium (LD) was applied to better refine the quantitative trait loci (QTL) positions for milk production traits on bovine chromosome 14 in the pedigree comprising 22 paternal half-sib families of a Black-and-White Holstein-Friesian grand-daughter design in the Netherlands for a total of 1,034 sons. The chromosome map was constructed with the 31 genetic markers spanning 90 Kosambi cM with the average inter-marker distance of 3.5 cM. The linkage analyses, in which the effects of sire QTL alleles were assumed random and the random factor of the QTL allelic effects was incorporated into the Animal Model, found the QTL for milk, fat, and protein yield and fat and protein % with the Lod scores of 10.9, 2.3, 6.0, 25.4 and 3.2, respectively. The joint analyses including LD information by use of multi-marker haplotypes highly increased the evidence of the QTL (Lod scores were 25.1, 20.9, 11.0, 85.7 and 17.4 for the corresponding traits, respectively). The joint analyses including DGAT markers in the defined haplotypes again increased the QTL evidence and the most likely QTL positions for the five traits coincided with the position of the DGAT gene, supporting the hypothesis of the direct causal involvement of the DGAT gene. This study strongly indicates that the exploitation of LD information will allow additional gains of power and precision in finding and localising QTL of interest in livestock species, on the condition of high marker density around the QTL region.

Determining Method of Factors for Effective Real Time Background Modeling (효과적인 실시간 배경 모델링을 위한 환경 변수 결정 방법)

  • Lee, Jun-Cheol;Ryu, Sang-Ryul;Kang, Sung-Hwan;Kim, Sung-Ho
    • Journal of KIISE:Software and Applications
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    • v.34 no.1
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    • pp.59-69
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    • 2007
  • In the video with a various environment, background modeling is important for extraction and recognition the moving object. For this object recognition, many methods of the background modeling are proposed in a process of preprocess. Among these there is a Kumar method which represents the Queue-based background modeling. Because this has a fixed period of updating examination of the frame, there is a limit for various system. This paper use a background modeling based on the queue. We propose the method that major parameters are decided as adaptive by background model. They are the queue size of the sliding window, the sire of grouping by the brightness of the visual and the period of updating examination of the frame. In order to determine the factors, in every process, RCO (Ratio of Correct Object), REO (Ratio of Error Object) and UR (Update Ratio) are considered to be the standard of evaluation. The proposed method can improve the existing techniques of the background modeling which is unfit for the real-time processing and recognize the object more efficient.

Mitigating the Side-effect of Starting New Session in Multimedia Streaming using Multi-zoned Disk (구역분할 디스크를 사용하는 멀티미디어 서버에서 새로운 세션 시작에 따른 스케줄링 지연 현상의 최소화)

  • Cho, Kyeong-Sun;Won, You-Jip;Shin, Il-Hoon;Koh, Kern
    • Journal of KIISE:Computer Systems and Theory
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    • v.31 no.8
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    • pp.445-452
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    • 2004
  • Zoning technology of disk improved the performance of disk subsystem with increase of storage capacity and average transfer bandwidth. SCAN disk scheduling with double buffering is used to utilize the performance of zoned disk in multimedia system. However, this method has a problem that generates jitter when the number of steams increases. In this article, we propose the novel approach, pre-buffering policy, to overcome this problem. Pre-buffering avoids jitter by buffering the lack of data before starting service, which is estimated from the current cycle length and the maximum cycle length. We can calculate cycle length, data sire needed in each cycle and the possible lack of data caused by the increase of the number of streams using the numerical model of disk subsystem. Pre-buffering can be applied for multimedia systems and contribute to provide clients with high quality service without jitter.

Visual design teacher competency evaluation model study (시각디자인 교사역량 평가 모델 연구)

  • SUN, PENG
    • Journal of the International Relations & Interdisciplinary Education
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    • v.2 no.1
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    • pp.29-41
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    • 2022
  • In recent years, visual design has become an emerging industry that creates production value in various countries, and visual design teachers have become a key factor affecting the development of designers and even the trend of the design industry. Therefore, the requirements for the ability of visual design teachers have become particularly important. This study takes the visual communication teachers in colleges and universities as the research object. Focus on the composition of competencies that teachers have when performing their duties. First of all, through document sorting, it is based on the five aspects of knowledge ability, teaching ability, practical ability, management ability and professional ethics. A Likert scale questionnaire was developed on the evaluation of visual design teachers' competencies by interviewing 10 visual design industry experts and conducting two Delphi method interviews. This research refers to the relevant literatures such as curriculum research and teaching objective research of design major, and discusses the evaluation standards of visual design teachers' abilities in colleges and universities. Expert interviews have sorted out 12 criteria and 36 sub-criteria about visual design teachers' abilities, and verified their rationality through expert return visits. The establishment of this evaluation standard provides a certain theoretical basis for visual design teachers' ability evaluation and self-cognition.

Estimation of Genetic Parameters for Gestation Length, Wean to First Service, Litter Size and Stillborn Piglets in a Closed Nucleus Swine Breeding Herd (특정 종돈집단의 임신기간, 이유후초종부일, 총산자수 및 사산에 대한 유전모수 추정)

  • Lee, Deukhwan;Son, Jihyun
    • Journal of Animal Science and Technology
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    • v.55 no.5
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    • pp.389-398
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    • 2013
  • This study was conducted to investigate the genetic relationships among four reproductive traits. Data for this study were 7616 records from 1910 Landrace (L) and 10,454 records from 2283 Yorkshire (Y) in a closed nucleus swine herd. Traits considered on this study were gestation length (GL), total number of piglets born (TNB), wean to first service (WFS), and number of stillborn per litter (NSB). Heritabilities and genetic correlations were estimated by using the Bayesian inferences via Gibbs sampling in a four trait linear-threshold repeatability animal mixed model by designating NSB as a categorical trait in the L and Y purebred populations. Effects on the statistical model were considered for parity, contemporary group as fixed and service sire, permanent environmental, animal additive genetic effects as random. Estimates of heritability were 0.21, 0.23, 0.16, and 0.09 for GL, WFS, TNB, and NSB in the L population and 0.35, 0.16, 0.14 and 0.10 for corresponding traits in the Y population, respectively. Genetic correlation for GL was -0.59 and -0.28 with TNB and -0.58 and -0.17 with NSB in the L and Y populations, respectively. The NSB was positively correlated with TNB in the L and Y populations in genetic and environmental aspects. Therefore, the NSB should be taken into account in selecting sows for improving prolificacy of dam line breeding swine stock.

Genome-wide Association Study to Identify Quantitative Trait Loci for Meat and Carcass Quality Traits in Berkshire

  • Iqbal, Asif;Kim, You-Sam;Kang, Jun-Mo;Lee, Yun-Mi;Rai, Rajani;Jung, Jong-Hyun;Oh, Dong-Yup;Nam, Ki-Chang;Lee, Hak-Kyo;Kim, Jong-Joo
    • Asian-Australasian Journal of Animal Sciences
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    • v.28 no.11
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    • pp.1537-1544
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    • 2015
  • Meat and carcass quality attributes are of crucial importance influencing consumer preference and profitability in the pork industry. A set of 400 Berkshire pigs were collected from Dasan breeding farm, Namwon, Chonbuk province, Korea that were born between 2012 and 2013. To perform genome wide association studies (GWAS), eleven meat and carcass quality traits were considered, including carcass weight, backfat thickness, pH value after 24 hours (pH24), Commission Internationale de l'Eclairage lightness in meat color (CIE L), redness in meat color (CIE a), yellowness in meat color (CIE b), filtering, drip loss, heat loss, shear force and marbling score. All of the 400 animals were genotyped with the Porcine 62K SNP BeadChips (Illumina Inc., USA). A SAS general linear model procedure (SAS version 9.2) was used to pre-adjust the animal phenotypes before GWAS with sire and sex effects as fixed effects and slaughter age as a covariate. After fitting the fixed and covariate factors in the model, the residuals of the phenotype regressed on additive effects of each single nucleotide polymorphism (SNP) under a linear regression model (PLINK version 1.07). The significant SNPs after permutation testing at a chromosome-wise level were subjected to stepwise regression analysis to determine the best set of SNP markers. A total of 55 significant (p<0.05) SNPs or quantitative trait loci (QTL) were detected on various chromosomes. The QTLs explained from 5.06% to 8.28% of the total phenotypic variation of the traits. Some QTLs with pleiotropic effect were also identified. A pair of significant QTL for pH24 was also found to affect both CIE L and drip loss percentage. The significant QTL after characterization of the functional candidate genes on the QTL or around the QTL region may be effectively and efficiently used in marker assisted selection to achieve enhanced genetic improvement of the trait considered.

Development of Sumulation Model for Breeding Schemes of Hanwoo(Korean Cattle) (한우의 개량 체계 모의실험을 위한 모형 개발)

  • Ju, J.C.;Kim, N.S.
    • Journal of Animal Science and Technology
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    • v.44 no.5
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    • pp.507-518
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    • 2002
  • A multiple-trait stochastic computer simulation model was constructed to predict the breeding schemes and selection methods on Hanwoo(Korean cattle). The model could be used four kinds of selection criteria (random, phenotype and true or estimated breeding values). At the test run in various population size for 20 years, all estimated parameters of the each simulated populations were resulted similar to input parameters. The deviations between input and output values of parameter in the large population were smaller than in the small population. The simulated results obtained from ten small populations consisted with one sire and ten dams in each population for 500 years were as follows; Inbreeding coefficients of population were similar to theoretical estimating function. Mean values of each traits selected were randomly drifted by generation, but they were converged into a value when inbreeding coefficients came close to one. Additive genetic variances within each population were reduced by generation, and they were converged into zero when inbreeding coefficients came close to one. These results indicated that the simulated populations hold to statistical properties of input parameters.

Performance Analysis of Mobility Support Protocols for IPv6 over Wireless LAN (IEEE 802.11 무선랜 환경에서의 이동성 지원 IPv6프로토콜의 성능분석)

  • Hwang Seung-Hee;Han Youn-Hee;Hwang Chong-Sun
    • Journal of KIISE:Information Networking
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    • v.32 no.3
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    • pp.391-403
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    • 2005
  • Several nv6 mobility support protocols for mobile Internet services are proposed in IETP : Mobile Ipv6, Hierarchical Mobile Ipv6, and Fast Handovers over Mobile Ipv6. Recently, IEEE 802.11 network has also been widely deployed in public areas for mobile Internet services. In the near future, IPv6 mobility support over IEEE 802.11 network is expected to be a key function to actualize the All If-based mobile various services. For appropriate application of these protocols, the IPv6 mobility support protocols should be analyzed according to their characteristics in terms of signaling, handover latency, lost packets, and required buffer sire as well as the impact of lower layer such as IEEE 802.11 network. In this paper, we analyze the performance of the protocols over IEEE 802.11 network. We define a packet-level traffic model, a network system model, and a mobility model. From these models, we construct a framework for the performance analysis. We also make cost functions to formalize each protocol's performance. Lastly, we analyze the effect of varying parameters used to show diverse numerical results, and compare with each other. From the analysis results, it is concluded that each Protocol has contrary or contrastive advantages with other Protocols, so there is no protocol that holds a dominant position.

Genome-wide association study of carcass weight in commercial Hanwoo cattle

  • Edea, Zewdu;Jeoung, Yeong Ho;Shin, Sung-Sub;Ku, Jaeul;Seo, Sungbo;Kim, Il-Hoi;Kim, Sang-Wook;Kim, Kwan-Suk
    • Asian-Australasian Journal of Animal Sciences
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    • v.31 no.3
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    • pp.327-334
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    • 2018
  • Objective: The objective of the present study was to validate genes and genomic regions associated with carcass weight using a low-density single nucleotide polymorphism (SNP) Chip in Hanwoo cattle breed. Methods: Commercial Hanwoo steers (n = 220) were genotyped with 20K GeneSeek genomic profiler BeadChip. After applying the quality control of criteria of a call rate ${\geq}90%$ and minor allele frequency (MAF) ${\geq}0.01$, a total of 15,235 autosomal SNPs were left for genome-wide association (GWA) analysis. The GWA tests were performed using single-locus mixed linear model. Age at slaughter was fitted as fixed effect and sire included as a covariate. The level of genome-wide significance was set at $3.28{\times}10^{-6}$ (0.05/15,235), corresponding to Bonferroni correction for 15,235 multiple independent tests. Results: By employing EMMAX approach which is based on a mixed linear model and accounts for population stratification and relatedness, we identified 17 and 16 loci significantly (p<0.001) associated with carcass weight for the additive and dominant models, respectively. The second most significant (p = 0.000049) SNP (ARS-BFGL-NGS-28234) on bovine chromosome 4 (BTA4) at 21 Mb had an allele substitution effect of 43.45 kg. Some of the identified regions on BTA2, 6, 14, 22, and 24 were previously reported to be associated with quantitative trait loci for carcass weight in several beef cattle breeds. Conclusion: This is the first genome-wide association study using SNP chips on commercial Hanwoo steers, and some of the loci newly identified in this study may help to better DNA markers that determine increased beef production in commercial Hanwoo cattle. Further studies using a larger sample size will allow confirmation of the candidates identified in this study.

A Whole Genome Association Study to Detect Single Nucleotide Polymorphisms for Carcass Traits in Hanwoo Populations

  • Lee, Y.-M.;Han, C.-M.;Li, Yi;Lee, J.-J.;Kim, L.H.;Kim, J.-H.;Kim, D.-I.;Lee, S.-S.;Park, B.-L.;Shin, H.-D.;Kim, K.-S.;Kim, N.-S.;Kim, Jong-Joo
    • Asian-Australasian Journal of Animal Sciences
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    • v.23 no.4
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    • pp.417-424
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    • 2010
  • The purpose of this study was to detect significant SNPs for carcass quality traits using DNA chips of high SNP density in Hanwoo populations. Carcass data of two hundred and eighty nine steers sired by 30 Korean proven sires were collected from two regions; the Hanwoo Improvement Center of National Agricultural Cooperative Federation in Seosan, Chungnam province and the commercial farms in Gyeongbuk province. The steers in Seosan were born between spring and fall of 2006 and those in Gyeonbuk between falls of 2004 and 2005. The former steers were slaughtered at approximately 24 months, while the latter steers were fed six months longer before slaughter. Among the 55,074 SNPs in the Illumina bovine 50K chip, a total of 32,756 available SNPs were selected for whole genome association study. After adjusting for the effects of sire, region and slaughter age, phenotypes were regressed on each SNP using a simple linear regression model. For the significance threshold, 0.1% point-wise p value from F distribution was used for each SNP test. Among the significant SNPs for a trait, the best set of SNP markers were selected using a stepwise regression procedure, and inclusion and exclusion of each SNP out of the model was determined at the p<0.001 level. A total of 118 SNPs were detected; 15, 20, 22, 28, 20, and 13 SNPs for final weight before slaughter, carcass weight, backfat thickness, weight index, longissimus dorsi muscle area, and marbling score, respectively. Among the significant SNPs, the best set of 44 SNPs was determined by stepwise regression procedures with 7, 9, 6, 9, 7, and 6 SNPs for the respective traits. Each set of SNPs per trait explained 20-40% of phenotypic variance. The number of detected SNPs per trait was not great in whole genome association tests, suggesting additional phenotype and genotype data are required to get more power to detect the trait-related SNPs with high accuracy for estimation of the SNP effect. These SNP markers could be applied to commercial Hanwoo populations via marker-assisted selection to verify the SNP effects and to improve genetic potentials in successive generations of the Hanwoo populations.