• Journal of Pharmacopuncture
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• v.17 no.3
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• pp.31-39
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• 2014

Objectives: This study was performed to analyze the toxicity and to find the lethal dose of the test substance Water-soluble Carthami-flos pharmacopuncture (WCF) when used as a single intravenous-dose in 6-week-old, male and female Sprague-Dawley rats. Methods: The experiment was conducted at Biotoxtech according to Good Laboratory Practices. 20 female and 20 male Spague-Dawley rats were divided into 4 groups of 5 female and 5 male animals per group. The rats in the three experimental groups received single intravenous injections with 0.125-mL, 0.25-mL and 0.5-mL/animal doses of WCF, Groups 2, 3, and 4, respectively, and the control group, Group 1, received a single intravenous injection with a 0.5-mL dose of normal saline. Clinical signs were observed and body weight measurements were carried out for 14 days following the injections. At the end of the observation period, hematology, clinical chemistry, histopathological tests and necropsy were performed on the injected parts. Results: No deaths occurred in any of the groups. Also, no significant changes in body weight, hematological parameters or clinical chemistry test results between the control group and the experimental groups were observed. Visual inspection after necropsy showed no abnormalities. Histopathological tests on the injected parts showed no significant differences, except for Group 1 females; however, the result was spontaneous generation and had no toxicological meaning because it was not dose-dependent. Therefore, this study showed that WCF had no effect on the injected parts in terms of clinical signs, body weight, hematology, clinical chemistry, and necropsy. Conclusion: As a result of single intravenous-dose tests of the test substance WCF in 4 groups of rats, the lethal dose for both males and females exceeded 0.5 mL/animal. Therefore, WCF is a relatively safe pharmacopuncture that can be used for treatment, but further studies should be performed.

• Journal of Life Science
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• v.26 no.2
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• pp.204-211
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• 2016

The objective of this study was to obtain acute (single) oral dose toxicity information on Lactobacillus-fermented Araliae Continentalis Radix aqueous extracts (fACR) in female and male ICR mice, as compared with Araliae Continentalis Radix aqueous extracts (ACR). After administering a single oral dose of fACR, no treatment-related mortalities were observed within 14 days after the end of treatment up to 2,000 mg/kg, the maximum dosage for rodents of both sexes; moreover, no fACR treatment-related changes in the body and organ weights, clinical signs, necropsy, and histopathological findings were detected in this experiment. In addition, no ACR 2,000 mg/kg treatment-related mortalities, clinical signs, body and organ weights, or gross and histopathological findings were observed, as compared with equal genders of vehicle control. The results obtained in this study suggest that fACR is non-toxic in mice and is, therefore, likely to be safe for clinical use. The LD₅₀ and approximate LD in female mice and male mice, respectively, were considered after a single oral dose of fACR over 2,000 mg/kg, the maximum dosage for rodents. In addition, no specific targets or clinical signs were detected in the present study. ACR 2,000 mg/kg-treated mice also did not show any treatment-related mortalities, clinical signs, changes to body and organ weights, or gross and histopathological findings, as compared with equal genders of vehicle control.

• The Korean Journal of Nuclear Medicine
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• v.5 no.2
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• pp.19-40
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• 1971

Since the iron balance is maintained by regulated intestinal absorption rather than regulated excretion, there have been many reports concerning the factors which may influence the intestinal iron absorption. As the liver is the largest iron storage organ of the body, any hepatocellular damage may result in disturbances in iron metabolism, e,g., frequent co-existence of hemochromatosis and liver cirrhosis, or elevated serum iron level and increased iron absorption rate in patients with infectious hepatitis or cirrhosis. In one effort to demonstrate the influence of hepatocellular damage on intestinal iron absortion, the iron absorption rate was measured in the rabbits whose livers were injured by a single subcutaneous injection of carbon tetrachloride (doses ranging from 0.15 to 0.5cc per kg of body weight) or by a single irradiation of 2,000 to 16,000 rads with $^{60}Co$ on the liver locally. A single oral dose of $1{\mu}Ci\;of\;^{59}Fe$-citrate with 0.5mg of ferrous citrate was fed in the fasting state, 24 hours after hepatic damage had been induced, without any reducing or chelating agents, and stool was collected for one week thereafter. Serum iron levels, together with conventional liver function tests, were measured at 24, 48, 72, 120 and 168 hours after liver damage had been induced. All animals were sacrificed upon the completing of the one week's test period and tissue specimens were prepared for H-E and Gomori's iron stain. Following are the results. 1. Normal iron absorption rate of the rabbit was $41.72{\pm}3.61%$ when 0.5mg of iron was given in the fasting state, as measured by subtracting the amount recovered in stool collected for 7 days from the amount given. The test period of 7 days is adequate, for only 1% of the iron given was excreted thereafter. 2. The intestinal iron absorption rate and serum iron level were significantly increased when the animal was poisoned by a single subcutaneous injection of 0.15cc. per kg. of body weight of carbon tetrachloride or more, or the liver was irradiated with a single dose of 12,000 rads or more. The results of liver function tests which were done simultaneously remained within normal limit except SGOT and SGPT which were somewhat increased. 3. In each case, there has been good correlation between the extent of liver cell damage and degree of increased iron absorption rate or serum iron level. 4. The method of liver damage appeared to make no obvious difference in the pattern of iron deposit in liver. This may be partly due to the fact that tissue specimens were obtained too late, for by this time the elevated serum iron level had returned within normal range and the pathological changes were almost healed. 5. The possible factors and relationship between intestinal iron absorption and hepatic parenchymal cell damage has been discussed.

• Asian-Australasian Journal of Animal Sciences
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• v.30 no.8
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• pp.1066-1073
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• 2017

Objective: Growth-related traits are important economic traits in the swine industry. However, the genetic mechanism of growth-related traits is little known. The aim of this study was to screen the candidate genes and molecular markers associated with body dimension and body weight traits in pigs. Methods: A genome-wide association study (GWAS) on body dimension and body weight traits was performed in a White $Duroc{\times}Erhualian$ $F_2$ intercross by the illumina PorcineSNP60K Beadchip. A mixed linear model was used to assess the association between single nucleotide polymorphisms (SNPs) and the phenotypes. Results: In total, 611 and 79 SNPs were identified significantly associated with body dimension traits and body weight respectively. All SNPs but 62 were located into 23 genomic regions (quantitative trait loci, QTLs) on 14 autosomal and X chromosomes in Sus scrofa Build 10.2 assembly. Out of the 23 QTLs with the suggestive significance level ($5{\times}10^{-4}$), three QTLs exceeded the genome-wide significance threshold ($1.15{\times}10^{-6}$). Except the one on Sus scrofa chromosome (SSC) 7 which was reported previously all the QTLs are novel. In addition, we identified 5 promising candidate genes, including cell division cycle 7 for abdominal circumference, pleiomorphic adenoma gene 1 and neuropeptides B/W receptor 1 for both body weight and cannon bone circumference on SSC4, phosphoenolpyruvate carboxykinase 1, and bone morphogenetic protein 7 for hip circumference on SSC17. Conclusion: The results have not only demonstrated a number of potential genes/loci associated with the growth-related traits in pigs, but also laid a foundation for studying the genes' role and further identifying causative variants underlying these loci.

• Journal of the Korean Society of Clothing and Textiles
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• v.12 no.3 s.28
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• pp.277-284
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• 1988

The purpose of study was to measure to body Surface area and the rational rate of Korean adult's women. The subjects are 20 years old to 49 years old women (Their bust width ranges from 74.5 to 101.5 cm, the height from 144.6 to 163.3 cm, the weight from 44.2 to 74.0 kg, Rohrer Index from 1. 02 to 1. 89). As the experimental method, both the gypsum method, by which the shape of body can be copied as it is, and weighing method, from which planed body surface area can be measured with consistant thickness of polypropylene film used. The results were obtained as follows. 1. After dividing the Korean adult's women into four groups (single and married women in their twenties, those in their thirties, those in their fourties). The change of body surface area was reviewed in accordance with age groups. No great difference among age group was showed in whole body surface area. 2. average value of body surface area is 1, 514m^2 and the part of trunk shows the biggest difference to the age groups. 3. After dividing the middle of body into two groups, the relation of symmetry of each parts is reviewed with difference in body surface area. The results shows that the part of head & neck and lower limbs are symmetrical. The part of trunk and upper limbs are unsymmetrical. 4. Regional rates of each part of whole body surface area are follows. head $4.98\%$, each-lobes $0.46\%$, neck $2.01\%$, face$2.48\%$, upper trunk $19.64\%$, lower trunk $13.91\%$, upper armpits $1.76\%$, lower armpits $12.52\%$, hands $4.64\%$, thighs $18.89\%$, lower legs$13.10\%$, feet $6.01\%$.

• Journal of the Korea Computer Graphics Society
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• v.26 no.4
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• pp.9-15
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• 2020

Having a virtual talking face along with a virtual body increases immersion in VR applications. As virtual reality (VR) techniques develop, various applications are increasing including multi-user social networking and education applications that involve talking avatars. Due to a lack of sensory information for full face and body motion capture in consumer-grade VR, most VR applications do not show a synced talking face and body. We propose a novel method, targeted for VR applications, for talking face synced with audio with an upper-body inverse kinematics. Our system presents a mirrored avatar of a user himself in single-user applications. We implement the mirroring in a single user environment and by visualizing a synced conversational partner in multi-user environment. We found that a realistic talking face avatar is more influential than an un-synced talking avatar or an invisible avatar.

• Journal of IKEEE
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• v.7 no.1 s.12
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• pp.22-31
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• 2003

Conventional stimulus patterns have used DC for discrimination of acupoint and meridian which is the basic object of diagnosis and medical treatment in oriental medicine. Those discriminate conduction points by stimulation on body skin with DC. But, it is insufficient to reliability in discrimination ratio, coincident ratio, body effect, reproductivity. Therefore, this paper has extracted the optimal parameter of frequency and waveform in order to improve conventional pattern, and proposed the SPAC(Single Power Alternative Current) stimulus pattern applying that. Also, We proposes algorithm which is able to discriminate with low pressure of the electrode by displaying in the level meter both the absolution and relation value of the skin current. It can decrease pain and body effect by electrode pressure and discriminate acupoint regardless of skin current in difficult discrimination spot. We have compared the performance of system applying the extracted optimal parameter and algorithm. We have compared discrimination, coincident ratio of both conduction point and traditional acupoints by acupoint stimulation pattern. In the results, we confirmed reliability of SPAC stimulus pattern.

• Proceedings of the Korea Society of Environmental Toocicology Conference
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• 2002.10a
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• pp.172-172
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• 2002

Previously, we reported a novel polymeric micellar solubilizer, Aceporol 330, that showed relatively low toxic effects when it was compared with that of Cremophor EL which is currently being used for paclitaxel. In this study, we have developed a new micellar solubilizer, Aceporol 460, that has 3-4 times higher loding capacity for paclitaxel than Aceporol 330. The single-dose and the repeated-dose toxicity of Aceporol 460 were evaluated in ICR mice. For single dose toxicity test, male and female mice were randomly assigned to one of five study groups to receive, and injected intravenously with dosages of 0, 3, 4mL Cremophor EL/kgbody weight, and 3, 4mL Aceporol 460/kg body weight, respectively. In both male and female mice, LD50 for Aceporol 460 can not he determined even at the maximal administrable dosage, 4mL/kg due to the high viscosity of chemical and there was no significant change in body weight, hematological and serum biochemical analysis, organ weight, and histopathological examination compared with that of Cremophor EL. For the repeated dose toxicity test, male and female mice were given the dosage of 0, 1.6mL Cremophor EL/kgbody weight/day, and 1.6mL Aceporol 460/kg body weight/day for 2 weeks. Results of repeated dose toxicity tests for 2 weeks suggested that Aceporol 460 treated group show no significant toxicological findings with body weight, hematological and serum biochemical analysis, organ weight, urinalysis, and ophthalmoscopic and histopathological examination compared with that of Cremophor EL. These results indicate that Aceporol 460 have higher paclitaxeL-loading capacity than Aceporol 330 and less toxic effects than Cremophor EL in male and female mice.

• Journal of the Korean Society of Clothing and Textiles
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• v.27 no.11
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• pp.1260-1269
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• 2003

This paper endeavors to examine the most suitable formal dress design for mid-aged men who lives in Kwangju, the Republic of Korea. Visual effect in associate design is considered with adjustment, figured and the body type. There are partly similarity differences in associate design visual effect by one's shape and clothes design. Firstly, in thin type, striped figured suit is the most attractive. Single adjustment suit with striped figured tend to be attractive, young and modernistic. Single adjustment without figured is felt the mellowest. Secondly, in standard type, the suit without figured is perceived the most attractive and masculine. The suit with striped figured is looked more young. Single adjustment suit without figured is the most attractive and mellow also single adjustment with figured is felt the youngest. Double adjustment without figured is felt mellow and with striped figured is felt the most modernistic and familiar. Also double adjustment suit with check figured is felt more modernistic. Thirdly, in pyknic type, the solid figured and striped figured of the suits are felt more masculine and single without figured is thought attractive. Single adjustment with check figured is common image. Also, double adjustment with stripe figured is perceived attractive. In conclusion, the adjustment, number of button and figure are very important facts for the clothes for giving whole visual effect of men's suit.

• Journal of the Korean Society of School Health
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• v.31 no.3
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• pp.167-177
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• 2018

Purpose: This study examined the factors that affect suicidal ideation among Korean adolescents according to their family type. Methods: The data of the 2017 Korea Youth Risk Behavior Web-based Survey was used in this study. Out of 62,276, a total of 60,077 adolescents (51,367 adolescents from two-parent families and 8,710 adolescents from single-parent families) were included in the analysis. Results: This study demonstrated that the level of suicidal ideation of the adolescents in single-parent families was significantly higher than that of the adolescents in two-parent families. The factors that affect suicidal ideation among the two-parent family adolescents were gender, grade, economic status, academic performance, smoking, drinking, physical activity, subjective health status, subjective body image, subjective happiness, stress, and depression. The factors that affect suicidal ideation among the single-parent family adolescents included gender, grade, smoking, subjective health status, subjective happiness, stress and depression. Conclusion: Single-parent family adolescents are likely to have a higher level of suicidal ideation along with higher levels of depression and stress and lower levels of subjective health and happiness, compared to single-parent family adolescents. For this higher-risk group of suicidal ideation, more thoughtful attentions and proactive policies are needed to manage their mental health and stress in school and family situations.