• Journal of Gastric Cancer
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• v.16 no.3
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• pp.177-181
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• 2016

Purpose: The International Organization for Standardization-5fluorouracil (FU) 10 trial found that bolus 5-FU and l-leucovorin was not inferior to S-1 in the treatment of gastric cancer (GC). Continuous 5-FU and the rapid injection of 5-FU have different anti-cancer effects. Thus, bolus 5-FU and l-leucovorin treatment might be useful for oral FU-resistant GC. Materials and Methods: We retrospectively analyzed the medical records of all patients with S-1 or capecitabine-resistant, unresectable, or recurrent GC treated with bolus 5-FU and l-leucovorin between January 2010 and December 2015 at Hokkaido University Hospital. The bolus 5-FU and l-leucovorin regimen consisted of intravenous l-leucovorin ($250mg/m^2/2h$) and bolus 5-FU ($600mg/m^2$) administered once weekly followed by a 2-week rest period; each cycle was repeated every 8 weeks. Results: A total of 14 patients were identified. The disease control rate was 35.7%. The median progression-free survival was 1.6 months (95% confidence interval [CI], 1.3~2.0 months), and the median overall survival was 6.3 months (95% CI, 4.7~7.9 months). No patient died from treatment-related causes. The most common severe adverse event associated with bolus 5-FU and l-leucovorin was neutropenia, which occurred in 21.4% of patients. Conclusions: Bolus 5-FU and l-leucovorin treatment might be useful for oral FU-resistant GC. We are planning a multi-center prospective phase II trial to evaluate the efficacy and safety of bolus 5-FU and l-leucovorin treatment for pre-treated unresectable or recurrent GC to confirm the results of this limited, retrospective study.

• Journal of Astronomy and Space Sciences
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• v.13 no.2
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• pp.149-162
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• 1996

The results of space radiation experiments carried out on board the first two Korean technology demonstration microsatellites are presented in this paper. The first satellite, KITSAT-1, launched in August 1992, carries a radiation monitoring payload called cosmic ray experiment(CRE) for characterizing the low-earth orbit(LEO) radiation environment. The CRE consists of two sub-systems: the cosmic particle experiment (CPE) and the total dose experiment(TDE). In addition, single event upset(SEU)rates of the program memory and the RAM disk are also monitored. The second satellite, KITSAT-2, launched in September 1993, carries a newly developed 32-bit on-board computer(OBC), KASCOM(KAIST satellite computer in addition to OBC186. SEUs ocurred in the KASCOM, as well as in the program memory and RAM disk memory, have been monitored since the beginning of the satellite operation. These two satellites, which are very similar in structures but different in orbits, provide a unique opportunity to study the effects of the radiation environment characterized by the orbit.

• Structural Engineering and Mechanics
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• v.73 no.4
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• pp.427-436
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• 2020

The use of final IGS precise orbit and clock products for high-rate GNSS-PPP proved its effectiveness in capturing dynamic displacement of engineering structures caused by earthquakes. However, the main drawback of using the final products is that they are available after approximately two weeks of data collection, which is not suitable for timely measures after an event. In this study, the use of ultra-rapid products (observed part), which are available after a few hours of data collection, and rapid products, which are available in less than 24 hrs, are investigated and their results are compared to the more precise final products. The tests are designed such that harmonic oscillations with different frequencies and amplitudes and ground motion of a simulated real earthquake are generated using a single axis shake table and the PPP was used to capture these movements by monitoring time-change of the table positions. To evaluate the accuracy of PPP using ultra-rapid, rapid and final products, their results were compared with relative GNSS positioning and LVDT (Linear Variable Differential Transformer) data, treated as reference. The results show that the high-rate GNSS-PPP solutions based on the three products can capture frequencies of harmonic oscillations and dynamic displacement with good accuracy. There were slight differences between ultra-rapid, rapid and final products, where some of the tested events indicated that the latter two produced are more accurate and provide better results compared to the ultra-rapid product for monitoring short-term dynamic displacements.

• Korean Journal of Remote Sensing
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• v.15 no.4
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• pp.289-295
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• 1999

Space Physics Sensor (SPS) on-board the KOMPSAT-1 consists of the High Energy Particle Detector (HEPD) and the Ionospheric Measurement Sensor (IMS). The HEPD is to characterize the low altitude high energy particle environment and the effects on the microelectronics due to these high energy particles. It is composed of four sensors: Proton and Electron Spectrometer(PES), Linear Energy Transfer Spectrometer (LET), Total Dose Monitor (TDM), and Single Event Monitor (SEM). 35 MeV proton beam from the medical KCCH cyclotron, at Korea Cancer Center Hospital in Seoul, is used to calibrate the PES. Primary proton beam of 35MeV scattered by polypropylene target is converted to various energy protons according to the elastic collision kinematics. In this calibration, the threshold level of the proton in the PES can be determined and the energy ranges of PES channels are also calibrated.

• The Journal of Korean Medicine
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• v.44 no.2
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• pp.132-148
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• 2023

Objectives: The purpose of this study is to determine the clinical features of post-acute COVID-19 syndrome and the effectiveness and safety of Korean medicine treatment at the Public health center. Methods: The study was conducted among 11 patients with post-acute COVID-19 syndrome who attended a single public health center from January to December 2022. We retrospectively analyzed the charts of 11 patients and collected clinical characteristics, previous treatments, Korean medicine treatments, outcome variables (Numeral Rating Scale (NRS), Leicester Cough Questionnaire (LCQ), Visual Analog Scale (VAS)), adverse events, etc. Results: Of the 11 patients, six were women, and the average age of all patients was 68.27±12.31 years. The most common symptom were cough(n=9, 81.82%) and sore throat(n=9, 81.82%), followed by sputum, fatigue, rhinorrhea, and loss of appetite, etc. All 11 patients were treated with herbal medicine, with Samso-eum(n=6, 54.55%), Yeonkyopaedok-san(n=5, 45.45%), and Haengso-tang(n=3, 27.27%) being the most commonly used. After herbal medicine treatment, the median cough NRS decreased from 5 to 1, and the median sore throat NRS decreased from 4 to 1, both of which were statistically significant. One patient reported adverse event of dyspepsia and heartburn, but it was mild. Conclusions: The study presented the clinical features of the post-acute COVID-19 syndrome and suggested that Korean medicine treatment at public health centers may be effective and safe in alleviating associated symptoms.

• Earthquakes and Structures
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• v.23 no.3
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• pp.271-282
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• 2022

Seismic resisting self-centering bridge piers with high energy dissipation and negligible residual displacement after an earthquake event are focus topics of current structural engineering. The energy dissipation components of typical bridge piers are often relatively single; and exhibit a certain level of damage under earthquakes, leading to large residual displacements and low cumulative energy dissipation. In this paper, a novel socket self-centering bridge pier with a hybrid energy dissipation system is proposed. The seismic resilience of bridge piers can be improved through the rational design of annular grooves and rubber cushions. The seismic response was evaluated through the finite element method. The effects of rubber cushion thickness, annular groove depth, axial compression ratio, and lateral strength contribution ratio of rubber cushion on the seismic behavior of bridge piers are systematically studied. The results show that the annular groove depth has the greatest influence on the seismic performance of the bridge pier. Especially, the lateral strength contribution ratio of the rubber cushion mainly depends on the depth of the annular groove. The axial compression ratio has a significant effect on the ultimate bearing capacity. Finally, the seismic design method is proposed according to the influence of the above research parameters on the seismic performance of bridge piers, and the method is validated by an example. It is suggested that the range of lateral strength contribution ratio of rubber cushion is 0.028 ~ 0.053.

• Korean Journal of Applied Biomechanics
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• v.16 no.3
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• pp.137-148
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• 2006

The purpose of this study was to compare muscle activity in the lower extremity during walking wearing jogging and roller shoes. Twelve male middle school students (age: 15.0 yrs, height 173.7 cm, weight 587.7 N) who have no known musculoskeletal disorders were recruited as the subjects. Seven pairs of surface electrodes (QEMG8, Laxtha Korea, gain = 1,000, input impedance >$1012{\Omega}$, CMMR >100 dB) were attached to the right-hand side of the body to monitor the rectus femoris (RF), vastus medialis (VM), vastus lateralis (VL), biceps femoris (BF), tibialis anterior (TA), and medial (GM) and lateral gastrocnemius (GL) while subjects walked wearing roller and jogging shoes in random order at a speed of 1.1 m/s. An event sync unit with a bright LED light was used to synchronize the video and EMG recordings. EMG data were filtered using a 10 Hz to 350 Hz Butterworth band-passdigital filter and further normalized to the respective maximum voluntary isometric contraction EMG levels. For each trial being analyzed, five critical instants and four phases were identified from the recording. Averaged IEMG and peak IEMG were determined for each trial. For each dependent variable, paired t-test was performed to test if significant difference existed between shoe conditions (p<.05). The VM, TA, BF, and GM activities during the initial double limb stance and the initial single limb stance reduced significantly when going from jogging shoe to roller shoe condition. The decrease in EMG levels in those muscles indicated that the subjects locked the ankle and knee joints in an awkward fashion to compensate for the imbalance. Muscle activity in the GM for the roller shoe condition was significantly greater than the corresponding value for the jogging shoe condition during the terminal double limb stance and the terminal single limb stance. Because the subjects tried to keep their upper body weight in front of the hip to prevent falling backward, the GM activity for the roller shoe condition increased. It seems that there are differences in muscle activity between roller shoe and jogging shoe conditions. The differences in EMG pattern may be caused primarily by the altered position of ankle, knee, and center of mass throughout the walking cycle. Future studies should examine joint kinematics during walking with roller shoes.

• Radiation Oncology Journal
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• v.32 no.3
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• pp.198-207
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• 2014

Purpose: To evaluate the effects of total body irradiation (TBI), as a conditioning regimen prior to allogeneic stem cell transplantation (allo-SCT), in pediatric acute leukemia patients. Materials and Methods: From January 2001 to December 2011, 28 patients, aged less than 18 years, were treated with TBI-based conditioning for allo-SCT in our institution. Of the 28 patients, 21 patients were diagnosed with acute lymphoblastic leukemia (ALL, 75%) and 7 were diagnosed with acute myeloid leukemia (AML, 25%). TBI was completed 4 days or 1 day before stem cell infusion. Patients underwent radiation therapy with bilateral parallel opposing fields and 6-MV X-rays. The Kaplan-Meier method was used to calculate survival outcomes. Results: The 2-year event-free survival and overall survival rates were 66% and 56%, respectively (71.4% and 60.0% in AML patients vs. 64.3% and 52.4% in ALL patients, respectively). Treatment related mortality rate were 25%. Acute and chronic graft-versus-host disease was a major complication; other complications included endocrine dysfunction and pulmonary complications. Common complications from TBI were nausea (89%) and cataracts (7.1%). Conclusion: The efficacy and toxicity data in this study of TBI-based conditioning to pediatric acute leukemia patients were comparable with previous studies. However, clinicians need to focus on the acute and chronic complications related to allo-SCT.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.17 no.3
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• pp.178-187
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• 2005

A reliability analysis model f3r studying the influence of joint distribution of wave heights and periods on wave un-up is presented in this paper. From the definition of failure mode related to wave run-up, a reliability function may be formulated which can be considered uncertainties of water level. In particular, the reliability analysis model can be directly taken into account statistical properties and distributions of wave periods by considering wave period in the reliability function to be a random variable. Also, variations of wave height distribution conditioned to mean wave periods can be taken into account correctly. By comparison of results of additional reliability analysis using extreme distributions with those resulted from joint distribution of wave height and periods, it is found that probabilities of failure evaluated by the latter is larger than those by the former. Although the freeboard of sloped-breakwater structures can be determined by extreme distribution based on the long-term measurements, it may be necessary to investigate additionally into wave run-up by using the present reliability analysis model formulated to consider joint distribution of a single storm event. In addition, it may be found that the effect of spectral bandwidth parameter on reliability index may be little, but the effect of wave height distribution conditioned to mean wave periods is straightforward. Therefore, it may be confirmed that effects of wave periods on the probability of failure of wave run-up may be taken into account through the conditional distribution of wave heights. Finally, the probabilities of failure with respect to freeboard of sloped-breakwater structures can be estimated by which the rational determination of crest level of sloped-breakwater structures may be possible.

• Journal of Korean Society on Water Environment
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• v.26 no.5
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• pp.841-849
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• 2010

Soil erosion is an natural phenomenon. However accelerated soil erosion has caused many environmental problems. To reduce soil loss from a watershed, many management practices have been proposed worldwide. To develop proper and efficient soil erosion best management practices, soil erosion rates should be estimated spatially and temporarily. The Universal Soil Loss Equation (USLE) and USLE-based soil erosion and sediment modelling systems have been developed and tested in many countries. The Sediment Assessment Tool for Effective Erosion Control (SATEEC) system has been developed and enhanced to provide ease-of-use interface to the USLE users. However many researchers and decision makers have requested to enhance the SATEEC system for simulation of soil erosion and sediment reflecting effects of single storm event. Thus, the SATEEC R factors were estimated based on 5 day antecedent rainfall data. The SATEEC 2.1 daily R factor was applied to the study watershed and it was found that the R2 and EI values (0.776 and 0.776 for calibration and 0.927 and 0.911 for validation) with the daily R were greater than those (0.721 and 0.720 for calibration and 0.906 and 0.881 for validation) with monthly R, which was available in the SATEEC 2.0 system. As shown in this study, the SATEEC with daily R can be used to estimate soil erosion and sediment yield at a watershed scale with higher accuracy. Thus the SATEEC with daily R can be efficiently used to develop site-specific soil erosion best management practices based on spatial and temporal analysis of soil erosion and sediment yield at a daily-time step, which was not possible with USLE-based soil erosion modeling system.