• Archives of Pharmacal Research
• /
• v.21 no.5
• /
• pp.508-513
• /
• 1998

The hepatoprotective effect of DA-9601, a quality-controlled extract of artemisisa asiatica, on liver damage induced by acetaminophen (APAP) and carbon tetrachloride ($CCI_{4}$) was investigated by means of serum-biochemical, hepatic-biochemical, and histopathological examinations. Doses of Da-9601 (10, 30, or 100 mg/kg) were administered intragastrically to each rat on three consecutive days i.e. 48 h, 24 h and 2 h before a single administration of APAP (640 mg/kg, i.p.) or $CCI_{4}$ (2 ml/kg, p.o.). Four h and 24 h after hepatotoxin treatment, the animals were sacrificed for evaluation of liver damage. Pretreatment of Da-9601 reduced the elevation of serum ALT, AST. LDH and histopathological changes such as centrilobular necrosis, vacuolar degeneration and inflammatory cell infiltration dose-dependently. Da-9601 also prevented APAP- and $CCI_{4}$-induced hepatic glutathione (GSH) depletion and $CCI_{4}$-induced increase of hepatic malondialdehyde (MDA), a parameter of lipid peroxidation, in a chemically induced liver injury by complex mechanisms which involve prevention of lipid peroxidation and preservation of hepatic GSH.

• Molecular & Cellular Toxicology
• /
• v.4 no.4
• /
• pp.285-292
• /
• 2008

Crocin is one of the major components of gardenia fruit and saffron which are widely used as natural food colorants and as traditional Chinese medicines. However, the genotoxicity data on crocin are not sufficient for safety evaluation. The purpose of this study was the examination of the genotoxicity on crocin from gardenia yellow in bacterial and mammalian cells, using various genotoxic battery testing assays and the influence of crocin on methyl methanesulfonate (MMS) and ${H_2}{O_2}$-induced DNA damage in vitro, using single cell gel electrophoresis (comet) assay. From results, no considerable mutagenicity and clastogenicity were seen in bacteria and mammalian cells treated with crocin, by Ames test, chromosomal aberration assay, ${tk}^{+/-}$ gene forward mutation assay and comet assay. And, post-treatment with crocin significantly suppressed ${H_2}{O_2}$-induced DNA damage in a dose-dependent manner. In conclusion, the findings of the present study and other previous observations indicate that crocin has no genotoxic potential. And it showed that crocin clearly repressed the genotoxic potency of ${H_2}{O_2}$. These results suggest that anti-oxidative effects of crocin may be involved in the protective effects of DNA damage.

• Food Science and Biotechnology
• /
• v.16 no.6
• /
• pp.879-883
• /
• 2007

This study examined whether dietary supplementation with sea tangle alters the intestinal morphology of streptozotocin-induced diabetic rats and affects the glucose absorption rate. Forty male Sprague-Dawley rats were divided into 2 groups and fed either a control (AIN76-based) diet or a sea tangle-supplemented diet. After 3 weeks, 10 rats in each group received an intramuscular injection of streptozotocin (45 mg/kg BW), and feeding was continued for 3 additional weeks. Dietary supplementation with sea tangle resulted in a lower fasting plasma glucose level compared with the control diet in diabetic rats. Scanning electron micrographs revealed serious damage to the jejunal villi of diabetic rats fed the control diet, whereas supplementation with sea tangle alleviated the damage. In a separate experiment, 20 male Sprague-Dawley rats were divided into 2 groups and fed either a control diet or a sea tangle-supplemented diet for 5 weeks, and fasted rats were subjected to in situ single-pass perfusion. The glucose absorption rate determined in the absence of digesta was decreased by 34% in the jejunum of rats fed a sea tangle diet compared with those fed a control diet. In conclusion, sea tangle supplementation lowered glucose absorption rate, altered intestinal morphology, and appeared to protect villi from damage caused by diabetes mellitus.

• Magazine of the Korean Society of Agricultural Engineers
• /
• v.44 no.4
• /
• pp.107-113
• /
• 2002

The pipe framed and arch shape plastic greenhouse, which is the most popular greenhouse in Korea, is relatively weak in snowdrift. Reinforcement of rigid frame or column is required to reduce the damage from heavy snow in this type. But additional rigid frames or columns decrease light transmissivity or workability, and increase construction cost. So it is desirable to prepare some temporary poles and to install them when the warning of heavy snow is announced. This study was carried out to develop the temporary pole supporting system using galvanized steel pipes for plastic housing and to evaluate the safe snow load on a temporary pole. A pipe connector, which is inserted in the top of pipe used in the temporary pole and supports the center purline, was designed and manufactured to be able to carry the upper loads safely. And a bearing plate was safely designed and manufactured in order to carry the loads acting on it to the ground. When temporary poles of ${\phi}$ 25 pipe are installed at 2.4m interval, it shows that the single span plastic greenhouses with 5~7 m width are able to support the additional snow depth of 13.9~25.3 cm beyond the snow load supported by main frame.

• Structural Engineering and Mechanics
• /
• v.53 no.2
• /
• pp.355-372
• /
• 2015

This paper identifies the effects of infill wall existence and arrangement in the seismic response of steel frame structures. The methodology followed was based on the utilisation of overall seismic response indicators that distil the complexity of structural response in a single value hence enabling their straightforward comparative and statistical post process. The overall structure damage index after Park/Ang ($OSDI_{PA}$) and the maximum inter-story drift ratio (MISDR) have been selected as widely utilized structural seismic response parameters in contemporary state of art. In this respect a set of 225 Greek antiseismic code (EAK) spectrum compatible artificial accelerograms have been created and a series of non-linear dynamic analyses have been executed. Data were obtained through nonlinear dynamic analyses carried on an indicative steel frame structure with 5 different infill wall topologies. Results indicated the significant overall contribution of infill walls with a reduction that ranged 35-47% of the maximum and 74-81% of the average recorded $OSDI_{PA}$ values followed by an overall reduction of 64-67% and 58-61% for the respective maximum and average recorded MISDR values demonstrating the relative benefits of infill walls presence overall as well as localised with similar reductions observed in 1st level damage indicators.

• Structural Engineering and Mechanics
• /
• v.56 no.5
• /
• pp.871-897
• /
• 2015

This paper presents a novel method based on sensitivity of structural response for identifying both the system parameters and input excitation force of a bridge. This method, referred to as "Adjoint Variable Method", is a sensitivity-based finite element model updating method. The computational cost of sensitivity analyses is the main concern associated with damage detection by these methods. The main advantage of proposed method is inclusion of an analytical method to augment the accuracy and speed of the solution. The reliable performance of the method to precisely indentify the location and intensity of all types of predetermined single, multiple and random damages over the whole domain of moving vehicle speed is shown. A comparison study is also carried out to demonstrate the relative effectiveness and upgraded performance of the proposed method in comparison to the similar ordinary sensitivity analysis methods. Moreover, various sources of error including the effects of noise and primary errors on the numerical stability of the proposed method are discussed.

• Journal of the Korea institute for structural maintenance and inspection
• /
• v.2 no.4
• /
• pp.137-147
• /
• 1998

The neural net application was tried to develop the technique for monitoring the health status of a steel truss bridge which was scaled down to 1/15 of the real bridge for the laboratory experiments. The damage scenarios were chosen as 7 cases. The dynamic behavior, which was changed due to the breakage of the members, of the bridge was investigated by finite element analysis. The bridge consists of single spam, and eight (8) main structural subsystems. The loading vehicle, which weighs as 100 kgf, was operated by the servo-motor controller. The accelerometers were bonded on the surface of 7 cross-beams to measure the dynamic behavior induced by the abnormal structural condition. Artificial neural network technique was used to determine the severity of the damage. At first, the neural net was learnt by the results of finite element analysis, and also, the maximum detection error was 3.65 percents. Another neural net was also learnt, and verified by the experimental results, and in this case, the maximum detection error was 1.05 percents. In future study, neural net is necessary to be learnt and verified by various data from the real bridge.

• Geomechanics and Engineering
• /
• v.21 no.3
• /
• pp.289-300
• /
• 2020

Estimating the damage induced by an explosion around a blast hole has always been a challenging issue in geotechnical engineering. It is difficult to determine an exact dimension for damage zone since many parameters are involved in the formation of failures, and there are some uncertainties lying in these parameters. Thus, the present study adopted a probabilistic approach towards this problem. First, a reliability model of the problem was established and the failure probability of induced damage was calculated. Then, the corresponding exceedance risk curve was developed indicating the relation between the failure probability and the cracked zone radius. The obtained risk curve indicated that the failure probability drops dramatically by increasing the cracked zone radius so that the probability of exceedance for any crack length greater than 4.5 m is less than 5%. Moreover, the effect of each parameter involved in the probability of failure, including blast hole radius, explosive density, detonation velocity, and tensile strength of the rock, was evaluated by using a sensitivity analysis. Finally, the impact of the decoupling ratio on the reduction of failures was investigated and the location of its maximum influence was demonstrated around the blast point.

• Explosives and Blasting
• /
• v.37 no.3
• /
• pp.25-33
• /
• 2019

Controlling the blast-induced damage zone(BDZ) in mining excavation is a significant issue for the safety of employees and the maintenance of facilities. Numerous studies have been conducted to accurately predict the BDZ in underground mining. This study employed the dynamic fracture process analysis (DFPA) to estimate the BDZ from a single hole blasting. The estimated BDZ were compared with the results obtained by Swedish empirical equation. The DFPA was also used to investigate the control mechanism of BDZ and fracture plane formation around perimeter holes for underground mining blasting.

• Journal of the Korean Society of Safety
• /
• v.34 no.3
• /
• pp.102-110
• /
• 2019

This paper describes the work and results of the preliminary Probabilistic Safety Assessment (PSA) for a research reactor in the design phase. This preliminary PSA was undertaken to assess the level of safety for the design of a research reactor and to evaluate whether it is probabilistically safe to operate and reliable to use. The scope of the PSA described here is a Level 1 PSA which addresses the risks associated with core damage. After reviewing the documents and its conceptual design, eight typical initiating events are selected regarding internal events during the normal operation of the reactor. Simple fault tree models for the PSA are developed instead of the detailed model at this conceptual design stage. A total of 32 core damage accident sequences for an internal event analysis were identified and quantified using the AIMS-PSA. LOCA-I has a dominant contribution to the total CDF by a single initiating event. The CDF from the internal events of a research reactor is estimated to be 7.38E-07/year. The CDF for the representative initiating events is less than 1.0E-6/year even though conservative assumptions are used in reliability data. The conceptual design of the research reactor is designed to be sufficiently safe from the viewpoint of safety.